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PROSITE entry PS00021


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00021
Entry name [info] KRINGLE_1
Accession [info] PS00021
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-SEP-2002 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00020

Name and characterization of the entry

Description [info] Kringle domain signature.
Pattern [info] 
[FY]-C-[RH]-[NS]-x(7,8)-[WY]-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 199 in 100 different sequences
Number of true positive hits 194 in 95 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.49 %
Recall (true positives / (true positives + false negatives)) 98.98 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 16
Site [info] disulfide at position 2
Site [info] disulfide at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 95 sequences 

APOA_HUMAN  (P08519), APOA_MACMU  (P14417), CAM1_CAEEL  (G5EGK5), 

CRMPA_TOXGO (A0A7J6K144), FA12_CAVPO  (Q04962), FA12_HUMAN  (P00748), 
FA12_MOUSE  (Q80YC5), FA12_PIG(O97507), FA12_RAT(D3ZTE0), 
HABP2_BOVIN (Q5E9Z2), HABP2_HUMAN (Q14520), HABP2_MOUSE (Q8K0D2), 
HABP2_RAT   (Q6L711), HGFA_CANLF  (Q6QNF4), HGFA_HUMAN  (Q04756), 
HGFA_MOUSE  (Q9R098), HGFL_BOVIN  (Q24K22), HGFL_HUMAN  (P26927), 
HGFL_MOUSE  (P26928), HGF_BOVIN   (Q76BS1), HGF_CANLF   (Q867B7), 
HGF_FELCA   (Q9BH09), HGF_HUMAN   (P14210), HGF_MOUSE   (Q08048), 
HGF_RAT (P17945), KREM1_HUMAN (Q96MU8), KREM1_MOUSE (Q99N43), 
KREM1_RAT   (Q924S4), KREM1_XENLA (Q90Y90), KREM2_HUMAN (Q8NCW0), 
KREM2_MOUSE (Q8K1S7), LPAL2_HUMAN (Q16609), MST1L_HUMAN (Q2TV78), 
MUSK_CHICK  (Q8AXY6), NETR_GORGO  (Q5G270), NETR_HUMAN  (P56730), 
NETR_MACMU  (Q5G267), NETR_MOUSE  (O08762), NETR_NOMLE  (Q5G268), 
NETR_PANTR  (Q5G271), NETR_PONPY  (Q5G269), NETR_RAT(G3V801), 
NETR_SAGLB  (Q5G265), NETR_TRAPH  (Q5G266), P3IP1_BOVIN (Q1RMT9), 
P3IP1_DANRE (Q7SXB3), P3IP1_HUMAN (Q96FE7), P3IP1_MOUSE (Q7TMJ8), 
P3IP1_PONAB (Q5RCS3), P3IP1_RAT   (Q56A20), PLMN_BOVIN  (P06868), 
PLMN_CANLF  (P80009), PLMN_CAPHI  (Q7M323), PLMN_ERIEU  (Q29485), 
PLMN_HORSE  (P80010), PLMN_HUMAN  (P00747), PLMN_MACMU  (P12545), 
PLMN_MOUSE  (P20918), PLMN_NOTEU  (O18783), PLMN_PETMA  (P33574), 
PLMN_PIG(P06867), PLMN_PONAB  (Q5R8X6), PLMN_RAT(Q01177), 
PLMN_SHEEP  (P81286), ROR1_DROME  (Q24488), ROR1_HUMAN  (Q01973), 
ROR1_MOUSE  (Q9Z139), ROR2_DROME  (Q9V6K3), ROR2_HUMAN  (Q01974), 
ROR2_MOUSE  (Q9Z138), THRB_BOVIN  (P00735), THRB_HUMAN  (P00734), 
THRB_MOUSE  (P19221), THRB_PIG(Q19AZ8), THRB_PONAB  (Q5R537), 
THRB_RAT(P18292), TPA_BOVIN   (Q28198), TPA_HUMAN   (P00750), 
TPA_MOUSE   (P11214), TPA_PIG (Q8SQ23), TPA_PONAB   (Q5R8J0), 
TPA_RAT (P19637), UROK_BOVIN  (Q05589), UROK_CHICK  (P15120), 
UROK_HUMAN  (P00749), UROK_MOUSE  (P06869), UROK_PAPCY  (P16227), 
UROK_PIG(P04185), UROK_PONAB  (Q5RF29), UROK_RABIT  (Q8MHY7), 
UROK_RAT(P29598), URT1_DESRO  (P98119), URT2_DESRO  (P15638), 
URTB_DESRO  (P98121), URTG_DESRO  (P49150)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

FA12_BOVIN  (P98140), SVH1_CAEEL  (Q17800)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
THRB_SALSA  (P84122)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			5 sequences
			


			
CO1EA_CONGR (J7GY56), M7J_CONCN   (P0DKQ6), O1641_CONMI (Q3YEG4), 

			
O1VA_CONGR  (A0A2I4QAG8), PWAP_HALLA  (P84811)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			128 PDB
			


			1A0H; 1B2I; 1BHT; 1CEA; 1CEB; 1GMN; 1GMO; 1GP9; 1HPJ; 1HPK; 1I5K; 1I71; 
			
				1JFN; 1KDU; 1KI0; 1KIV; 1KRN; 1NK1; 1NL1; 1NL2; 1PK2; 1PK4; 1PKR; 1PMK; 
				1PML; 1TPK; 1URK; 2DOH; 2DOI; 2FD6; 2FEB; 2HPP; 2HPQ; 2I9A; 2I9B; 2K4R; 
				2K51; 2KNF; 2L0S; 2PF1; 2PF2; 2PK4; 2QJ2; 2QJ4; 2SPT; 3BT1; 3BT2; 3E6P; 
				3HN4; 3K65; 3KIV; 3LAQ; 3MKP; 3NXP; 3SP8; 3U73; 4A5T; 4BV5; 4BV7; 4BVC; 
				4BVD; 4BVV; 4BVW; 4CIK; 4D3C; 4DUR; 4DUU; 4HZH; 4IUA; 4K24; 4KIV; 4NZQ; 
				4O03; 5COE; 5CP9; 5CS1; 5CS3; 5CS5; 5CS9; 5CSQ; 5CT1; 5CT2; 5CT3; 5EDK; 
				5EDM; 5FWS; 5FWT; 5FWU; 5FWV; 5FWW; 5HPG; 5Z55; 6BA5; 6BAN; 6BJR; 6C2W; 
				6OG4; 6OQJ; 6OQK; 6OSH; 6OSN; 6OSV; 6RX7; 6UZ4; 6UZ5; 7BZT; 7BZU; 7ME4; 
				7MO7; 7MO8; 7MO9; 7MOA; 7MOB; 7OCL; 7OCM; 7TNG; 7TPP; 8OS5; 8TCE; 8UF7; 
				8UQ6; 8V8Z; 8V9B; 9CLN; 9CLS; 9CMO; 9CTH; 9FSE
			
			

			» more