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PROSITE entry PS00021


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General information about the entry

Entry name [info] KRINGLE_1
Accession [info] PS00021
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-SEP-2002 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00020

Name and characterization of the entry

Description [info] Kringle domain signature.
Pattern [info] 
[FY]-C-[RH]-[NS]-x(7,8)-[WY]-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 198 in 99 different sequences
Number of true positive hits 193 in 94 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.47 %
Recall (true positives / (true positives + false negatives)) 98.97 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 16
Site [info] disulfide at position 2
Site [info] disulfide at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 94 sequences 

APOA_HUMAN  (P08519), APOA_MACMU  (P14417), CAM1_CAEEL  (G5EGK5), 

FA12_CAVPO  (Q04962), FA12_HUMAN  (P00748), FA12_MOUSE  (Q80YC5), 
FA12_PIG(O97507), FA12_RAT(D3ZTE0), HABP2_BOVIN (Q5E9Z2), 
HABP2_HUMAN (Q14520), HABP2_MOUSE (Q8K0D2), HABP2_RAT   (Q6L711), 
HGFA_CANLF  (Q6QNF4), HGFA_HUMAN  (Q04756), HGFA_MOUSE  (Q9R098), 
HGFL_BOVIN  (Q24K22), HGFL_HUMAN  (P26927), HGFL_MOUSE  (P26928), 
HGF_BOVIN   (Q76BS1), HGF_CANLF   (Q867B7), HGF_FELCA   (Q9BH09), 
HGF_HUMAN   (P14210), HGF_MOUSE   (Q08048), HGF_RAT (P17945), 
KREM1_HUMAN (Q96MU8), KREM1_MOUSE (Q99N43), KREM1_RAT   (Q924S4), 
KREM1_XENLA (Q90Y90), KREM2_HUMAN (Q8NCW0), KREM2_MOUSE (Q8K1S7), 
LPAL2_HUMAN (Q16609), MST1L_HUMAN (Q2TV78), MUSK_CHICK  (Q8AXY6), 
NETR_GORGO  (Q5G270), NETR_HUMAN  (P56730), NETR_MACMU  (Q5G267), 
NETR_MOUSE  (O08762), NETR_NOMLE  (Q5G268), NETR_PANTR  (Q5G271), 
NETR_PONPY  (Q5G269), NETR_RAT(G3V801), NETR_SAGLB  (Q5G265), 
NETR_TRAPH  (Q5G266), P3IP1_BOVIN (Q1RMT9), P3IP1_DANRE (Q7SXB3), 
P3IP1_HUMAN (Q96FE7), P3IP1_MOUSE (Q7TMJ8), P3IP1_PONAB (Q5RCS3), 
P3IP1_RAT   (Q56A20), PLMN_BOVIN  (P06868), PLMN_CANLF  (P80009), 
PLMN_CAPHI  (Q7M323), PLMN_ERIEU  (Q29485), PLMN_HORSE  (P80010), 
PLMN_HUMAN  (P00747), PLMN_MACMU  (P12545), PLMN_MOUSE  (P20918), 
PLMN_NOTEU  (O18783), PLMN_PETMA  (P33574), PLMN_PIG(P06867), 
PLMN_PONAB  (Q5R8X6), PLMN_RAT(Q01177), PLMN_SHEEP  (P81286), 
ROR1_DROME  (Q24488), ROR1_HUMAN  (Q01973), ROR1_MOUSE  (Q9Z139), 
ROR2_DROME  (Q9V6K3), ROR2_HUMAN  (Q01974), ROR2_MOUSE  (Q9Z138), 
THRB_BOVIN  (P00735), THRB_HUMAN  (P00734), THRB_MOUSE  (P19221), 
THRB_PIG(Q19AZ8), THRB_PONAB  (Q5R537), THRB_RAT(P18292), 
TPA_BOVIN   (Q28198), TPA_HUMAN   (P00750), TPA_MOUSE   (P11214), 
TPA_PIG (Q8SQ23), TPA_PONAB   (Q5R8J0), TPA_RAT (P19637), 
UROK_BOVIN  (Q05589), UROK_CHICK  (P15120), UROK_HUMAN  (P00749), 
UROK_MOUSE  (P06869), UROK_PAPCY  (P16227), UROK_PIG(P04185), 
UROK_PONAB  (Q5RF29), UROK_RABIT  (Q8MHY7), UROK_RAT(P29598), 
URT1_DESRO  (P98119), URT2_DESRO  (P15638), URTB_DESRO  (P98121), 
URTG_DESRO  (P49150)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

FA12_BOVIN  (P98140), SVH1_CAEEL  (Q17800)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
THRB_SALSA  (P84122)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			5 sequences
			


			
CO1EA_CONGR (J7GY56), M7J_CONCN   (P0DKQ6), O1641_CONMI (Q3YEG4), 

			
O1VA_CONGR  (A0A2I4QAG8), PWAP_HALLA  (P84811)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			122 PDB
			


			1A0H; 1B2I; 1BHT; 1CEA; 1CEB; 1GMN; 1GMO; 1GP9; 1HPJ; 1HPK; 1I5K; 1I71; 
			
				1JFN; 1KDU; 1KI0; 1KIV; 1KRN; 1NK1; 1NL1; 1NL2; 1PK2; 1PK4; 1PKR; 1PMK; 
				1PML; 1TPK; 1URK; 2DOH; 2DOI; 2FD6; 2FEB; 2HPP; 2HPQ; 2I9A; 2I9B; 2K4R; 
				2K51; 2KNF; 2L0S; 2PF1; 2PF2; 2PK4; 2QJ2; 2QJ4; 2SPT; 3BT1; 3BT2; 3E6P; 
				3HN4; 3K65; 3KIV; 3LAQ; 3MKP; 3NXP; 3SP8; 3U73; 4A5T; 4BV5; 4BV7; 4BVC; 
				4BVD; 4BVV; 4BVW; 4CIK; 4D3C; 4DUR; 4DUU; 4HZH; 4IUA; 4K24; 4KIV; 4NZQ; 
				4O03; 5COE; 5CP9; 5CS1; 5CS3; 5CS5; 5CS9; 5CSQ; 5CT1; 5CT2; 5CT3; 5EDK; 
				5EDM; 5FWS; 5FWT; 5FWU; 5FWV; 5FWW; 5HPG; 5Z55; 6BA5; 6BAN; 6BJR; 6C2W; 
				6OG4; 6OQJ; 6OQK; 6OSH; 6OSN; 6OSV; 6RX7; 6UZ4; 6UZ5; 7BZT; 7BZU; 7ME4; 
				7MO7; 7MO8; 7MO9; 7MOA; 7MOB; 7OCL; 7OCM; 7TNG; 7TPP; 8TCE; 8UF7; 8UQ6; 
				8V8Z; 8V9B
			
			

			» more