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PROSITE entry PS00021


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PURL: https://purl.expasy.org/prosite/signature/PS00021

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General information about the entry

Entry name [info] KRINGLE_1
Accession [info] PS00021
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-SEP-2002 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00020

Name and characterization of the entry

Description [info] Kringle domain signature.
Pattern [info] 
[FY]-C-[RH]-[NS]-x(7,8)-[WY]-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 199 in 100 different sequences
Number of true positive hits 194 in 95 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.49 %
Recall (true positives / (true positives + false negatives)) 98.98 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 16
Site [info] disulfide at position 2
Site [info] disulfide at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 95 sequences 

APOA_HUMAN  (P08519), APOA_MACMU  (P14417), CAM1_CAEEL  (G5EGK5), 

CRMPA_TOXGO (A0A7J6K144), FA12_CAVPO  (Q04962), FA12_HUMAN  (P00748), 
FA12_MOUSE  (Q80YC5), FA12_PIG(O97507), FA12_RAT(D3ZTE0), 
HABP2_BOVIN (Q5E9Z2), HABP2_HUMAN (Q14520), HABP2_MOUSE (Q8K0D2), 
HABP2_RAT   (Q6L711), HGFA_CANLF  (Q6QNF4), HGFA_HUMAN  (Q04756), 
HGFA_MOUSE  (Q9R098), HGFL_BOVIN  (Q24K22), HGFL_HUMAN  (P26927), 
HGFL_MOUSE  (P26928), HGF_BOVIN   (Q76BS1), HGF_CANLF   (Q867B7), 
HGF_FELCA   (Q9BH09), HGF_HUMAN   (P14210), HGF_MOUSE   (Q08048), 
HGF_RAT (P17945), KREM1_HUMAN (Q96MU8), KREM1_MOUSE (Q99N43), 
KREM1_RAT   (Q924S4), KREM1_XENLA (Q90Y90), KREM2_HUMAN (Q8NCW0), 
KREM2_MOUSE (Q8K1S7), LPAL2_HUMAN (Q16609), MST1L_HUMAN (Q2TV78), 
MUSK_CHICK  (Q8AXY6), NETR_GORGO  (Q5G270), NETR_HUMAN  (P56730), 
NETR_MACMU  (Q5G267), NETR_MOUSE  (O08762), NETR_NOMLE  (Q5G268), 
NETR_PANTR  (Q5G271), NETR_PONPY  (Q5G269), NETR_RAT(G3V801), 
NETR_SAGLB  (Q5G265), NETR_TRAPH  (Q5G266), P3IP1_BOVIN (Q1RMT9), 
P3IP1_DANRE (Q7SXB3), P3IP1_HUMAN (Q96FE7), P3IP1_MOUSE (Q7TMJ8), 
P3IP1_PONAB (Q5RCS3), P3IP1_RAT   (Q56A20), PLMN_BOVIN  (P06868), 
PLMN_CANLF  (P80009), PLMN_CAPHI  (Q7M323), PLMN_ERIEU  (Q29485), 
PLMN_HORSE  (P80010), PLMN_HUMAN  (P00747), PLMN_MACMU  (P12545), 
PLMN_MOUSE  (P20918), PLMN_NOTEU  (O18783), PLMN_PETMA  (P33574), 
PLMN_PIG(P06867), PLMN_PONAB  (Q5R8X6), PLMN_RAT(Q01177), 
PLMN_SHEEP  (P81286), ROR1_DROME  (Q24488), ROR1_HUMAN  (Q01973), 
ROR1_MOUSE  (Q9Z139), ROR2_DROME  (Q9V6K3), ROR2_HUMAN  (Q01974), 
ROR2_MOUSE  (Q9Z138), THRB_BOVIN  (P00735), THRB_HUMAN  (P00734), 
THRB_MOUSE  (P19221), THRB_PIG(Q19AZ8), THRB_PONAB  (Q5R537), 
THRB_RAT(P18292), TPA_BOVIN   (Q28198), TPA_HUMAN   (P00750), 
TPA_MOUSE   (P11214), TPA_PIG (Q8SQ23), TPA_PONAB   (Q5R8J0), 
TPA_RAT (P19637), UROK_BOVIN  (Q05589), UROK_CHICK  (P15120), 
UROK_HUMAN  (P00749), UROK_MOUSE  (P06869), UROK_PAPCY  (P16227), 
UROK_PIG(P04185), UROK_PONAB  (Q5RF29), UROK_RABIT  (Q8MHY7), 
UROK_RAT(P29598), URT1_DESRO  (P98119), URT2_DESRO  (P15638), 
URTB_DESRO  (P98121), URTG_DESRO  (P49150)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

FA12_BOVIN  (P98140), SVH1_CAEEL  (Q17800)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
THRB_SALSA  (P84122)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			5 sequences
			


			
CO1EA_CONGR (J7GY56), M7J_CONCN   (P0DKQ6), O1641_CONMI (Q3YEG4), 

			
O1VA_CONGR  (A0A2I4QAG8), PWAP_HALLA  (P84811)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			129 PDB
			


			pdb_00001a0h; pdb_00001b2i; pdb_00001bht; pdb_00001cea; pdb_00001ceb; pdb_00001gmn; pdb_00001gmo; pdb_00001gp9; pdb_00001hpj; pdb_00001hpk; pdb_00001i5k; pdb_00001i71; 
			
				pdb_00001jfn; pdb_00001kdu; pdb_00001ki0; pdb_00001kiv; pdb_00001krn; pdb_00001nk1; pdb_00001nl1; pdb_00001nl2; pdb_00001pk2; pdb_00001pk4; pdb_00001pkr; pdb_00001pmk; 
				pdb_00001pml; pdb_00001tpk; pdb_00001urk; pdb_00002doh; pdb_00002doi; pdb_00002fd6; pdb_00002feb; pdb_00002hpp; pdb_00002hpq; pdb_00002i9a; pdb_00002i9b; pdb_00002k4r; 
				pdb_00002k51; pdb_00002knf; pdb_00002l0s; pdb_00002pf1; pdb_00002pf2; pdb_00002pk4; pdb_00002qj2; pdb_00002qj4; pdb_00002spt; pdb_00003bt1; pdb_00003bt2; pdb_00003e6p; 
				pdb_00003hn4; pdb_00003k65; pdb_00003kiv; pdb_00003laq; pdb_00003mkp; pdb_00003nxp; pdb_00003sp8; pdb_00003u73; pdb_00004a5t; pdb_00004bv5; pdb_00004bv7; pdb_00004bvc; 
				pdb_00004bvd; pdb_00004bvv; pdb_00004bvw; pdb_00004cik; pdb_00004d3c; pdb_00004dur; pdb_00004duu; pdb_00004hzh; pdb_00004iua; pdb_00004k24; pdb_00004kiv; pdb_00004nzq; 
				pdb_00004o03; pdb_00005coe; pdb_00005cp9; pdb_00005cs1; pdb_00005cs3; pdb_00005cs5; pdb_00005cs9; pdb_00005csq; pdb_00005ct1; pdb_00005ct2; pdb_00005ct3; pdb_00005edk; 
				pdb_00005edm; pdb_00005fws; pdb_00005fwt; pdb_00005fwu; pdb_00005fwv; pdb_00005fww; pdb_00005hpg; pdb_00005z55; pdb_00006ba5; pdb_00006ban; pdb_00006bjr; pdb_00006c2w; 
				pdb_00006og4; pdb_00006oqj; pdb_00006oqk; pdb_00006osh; pdb_00006osn; pdb_00006osv; pdb_00006rx7; pdb_00006uz4; pdb_00006uz5; pdb_00007bzt; pdb_00007bzu; pdb_00007me4; 
				pdb_00007mo7; pdb_00007mo8; pdb_00007mo9; pdb_00007moa; pdb_00007mob; pdb_00007ocl; pdb_00007ocm; pdb_00007tng; pdb_00007tpp; pdb_00008os5; pdb_00008rtn; pdb_00008tce; 
				pdb_00008uf7; pdb_00008uq6; pdb_00008v8z; pdb_00008v9b; pdb_00009cln; pdb_00009cls; pdb_00009cmo; pdb_00009cth; pdb_00009fse
			
			

			» more