PROSITE entry PS00025

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PURL: https://purl.expasy.org/prosite/signature/PS00025

Direct ScanProsite submission

General information about the entry

Entry name [info]	P_TREFOIL_1
Accession [info]	PS00025
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00024

Name and characterization of the entry

Description [info]	P-type 'Trefoil' domain signature.
Pattern [info]	[KRH]-x(2)-C-x-[FYPSTV]-x(3,4)-[ST]-x(3)-C-x(4)-C-C-[FYWH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	59 in 43 different sequences
Number of true positive hits	59 in 43 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	8
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	88.06 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	6
Site [info]	disulfide at position 3
Site [info]	disulfide at position 9
Site [info]	disulfide at position 11
Site [info]	disulfide at position 12
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

43 sequences

LYAG_BOVIN  (Q9MYM4), LYAG_HUMAN  (P10253), LYAG_MOUSE  (P70699),

LYAG_PONAB  (Q5R7A9), LYAG_RAT(Q6P7A9), MGA_HUMAN   (O43451), 
MLRP1_ACRMI (B3EWZ5), MLRP2_ACRMI (B3EWZ6), MUA1_XENLA  (P10667), 
MUC1_XENLA  (Q05049), SUIS_HUMAN  (P14410), SUIS_RABIT  (P07768), 
SUIS_RAT(P23739), SUIS_SUNMU  (O62653), TFF1_CANLF  (Q863T4), 
TFF1_HUMAN  (P04155), TFF1_MOUSE  (Q08423), TFF1_RAT(Q63467), 
TFF2_CANLF  (Q863J2), TFF2_HUMAN  (Q03403), TFF2_MOUSE  (Q03404), 
TFF2_PIG(P01359), TFF2_RAT(Q09030), TFF3_BOVIN  (A8YXX7), 
TFF3_CANLF  (Q863B4), TFF3_FELCA  (B4X8D9), TFF3_HUMAN  (Q07654), 
TFF3_MOUSE  (Q62395), TFF3_PIG(Q29183), TFF3_RAT(Q03191), 
XP1_XENLA   (Q00222), XP2_XENLA   (P17437), XP4_XENLA   (Q00223), 
ZP1_HUMAN   (P60852), ZP1_MOUSE   (Q62005), ZP1_RABIT   (I6M4H4), 
ZP1_RAT (O54766), ZP4_BOVIN   (Q9BH11), ZP4_FELCA   (P48834), 
ZP4_HUMAN   (Q12836), ZP4_PIG (Q07287), ZP4_RABIT   (Q00193), 
ZP4_RAT (Q8CH34)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

8 sequences

FMR1N_HUMAN (Q8N0W7), FMR1N_MOUSE (Q80ZA7), FYV1_DICDI  (B0G126),

MGAL_HUMAN  (Q2M2H8), TM190_BOVIN (E1BJD3), TM190_CANLF (E2R0A5), 
TM190_HUMAN (Q8WZ59), TM190_MOUSE (Q9D2E9)

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PDB
[Detailed view]

31 PDB

1E9T; 1HI7; 1PCP; 1PE3; 1POS; 1PS2; 1PSP; 2PSP; 2QLY; 2QMJ; 3CTT; 3L4T; 3L4U; 3L4V; 3L4W; 3L4X; 3L4Y; 3L4Z; 3LPO; 3LPP; 5KZW; 5KZX; 5NN3; 5NN4; 5NN5; 5NN6; 5NN8; 6V1C; 6V1D; 7P2Z; 7P32
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