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PROSITE entry PS00031


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00031
Entry name [info] NUCLEAR_REC_DBD_1
Accession [info] PS00031
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00031

Name and characterization of the entry

Description [info] Nuclear hormones receptors DNA-binding region signature.
Pattern [info] 
C-x(2)-C-x(1,2)-[DENAVSPHKQT]-x(5,6)-[HNY]-[FY]-x(4)-C-x(2)-C-x(2)-F(2)-
x-R.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 462 in 462 different sequences
Number of true positive hits 462 in 462 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 11
Number of 'partial' sequences 9
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 97.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] zinc at position 1
Site [info] zinc at position 3
Site [info] zinc at position 10
Site [info] zinc at position 12
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 462 sequences 

7UP1_DROME  (P16375), 7UP2_DROME  (P16376), ANDR_AQUCT  (Q7T1K4), 

ANDR_CANLF  (Q9TT90), ANDR_CROCR  (Q8MIK0), ANDR_EULFC  (O97776), 
ANDR_HUMAN  (P10275), ANDR_MACFA  (O97952), ANDR_MACMU  (Q6QT55), 
ANDR_MOUSE  (P19091), ANDR_PANTR  (O97775), ANDR_PAPHA  (O97960), 
ANDR_PIG(Q9GKL7), ANDR_RABIT  (P49699), ANDR_RAT(P15207), 
CNR14_CAEEL (P41830), COT1_BOVIN  (Q9TTR8), COT1_HUMAN  (P10589), 
COT1_MOUSE  (Q60632), COT2_BOVIN  (Q9TTR7), COT2_CHICK  (Q90733), 
COT2_HUMAN  (P24468), COT2_MOUSE  (P43135), COT2_RAT(O09018), 
DAF12_CAEEL (G5EFF5), DSF_DROME   (Q9VML1), E75BB_DROME (P13055), 
E75BC_DROME (P17671), E75_CHOFU   (O01639), E75_GALME   (P50239), 
E75_MANSE   (Q08893), E75_METEN   (O77245), E78C_DROME  (P45447), 
ECR_AEDAE   (P49880), ECR_BOMMO   (P49881), ECR_CHITE   (P49882), 
ECR_DROME   (P34021), ECR_HELVI   (O18473), ECR_LUCCU   (O18531), 
ECR_MANSE   (P49883), EGON_DROME  (P15370), ERR1_CANLF  (Q6QMY5), 
ERR1_HUMAN  (P11474), ERR1_MOUSE  (O08580), ERR1_RAT(Q5QJV7), 
ERR2_HUMAN  (O95718), ERR2_MOUSE  (Q61539), ERR2_RAT(P11475), 
ERR3_HUMAN  (P62508), ERR3_MOUSE  (P62509), ERR3_PONAB  (Q5RAM2), 
ERR3_RAT(P62510), ESR1_BOVIN  (P49884), ESR1_CHICK  (P06212), 
ESR1_DANRE  (P57717), ESR1_FELCA  (Q53AD2), ESR1_HORSE  (Q9TV98), 
ESR1_HUMAN  (P03372), ESR1_ICTPU  (Q9YHZ7), ESR1_MESAU  (Q9QZJ5), 
ESR1_MOUSE  (P19785), ESR1_ONCMY  (P16058), ESR1_OREAU  (P50240), 
ESR1_ORENI  (Q9YH33), ESR1_ORYLA  (P50241), ESR1_PAGMA  (O42132), 
ESR1_PIG(Q29040), ESR1_RAT(P06211), ESR1_SALSA  (P50242), 
ESR1_SHEEP  (P49885), ESR1_SPAAU  (Q9PVZ9), ESR1_TAEGU  (Q91250), 
ESR1_XENLA  (P81559), ESR21_CARAU (Q9W669), ESR22_CARAU (Q9IAL9), 
ESR2_ANGJA  (O13012), ESR2_BOVIN  (Q9XSB5), ESR2_CALJA  (Q95171), 
ESR2_CHICK  (Q9PTU5), ESR2_COTJA  (O93511), ESR2_HUMAN  (Q92731), 
ESR2_ICTPU  (Q9IAK1), ESR2_MICUN  (P57781), ESR2_MOUSE  (O08537), 
ESR2_ONCMY  (P57782), ESR2_ORENI  (Q9YH32), ESR2_PIG(Q9XSW2), 
ESR2_RAT(Q62986), ESR2_SHEEP  (Q9TU15), ESR2_SPAAU  (Q9W6M2), 
ESR2_STUVU  (Q9PVE2), ESR3_MICUN  (P57783), FAX1_CAEEL  (G5EDJ0), 
FTF1B_DROME (Q05192), FTZF1_BOMMO (P49867), FTZF1_DROME (P33244), 
GAG_AVIER   (P03373), GCNFA_DANRE (Q9PU65), GCNFB_DANRE (Q4V8R7), 
GCR_AOTNA   (P79686), GCR_CALJA   (Q6XLJ0), GCR_CAVPO   (P49115), 
GCR_HUMAN   (P04150), GCR_MOUSE   (P06537), GCR_ONCMY   (P49843), 
GCR_PAROL   (O73673), GCR_PIG (Q9N1U3), GCR_PONAB   (Q5R9P5), 
GCR_RABIT   (P59667), GCR_RAT (P06536), GCR_SAGOE   (P79269), 
GCR_SAIBB   (O13186), GCR_SAISC   (O46567), GCR_SHEEP   (P35547), 
GCR_TUPBE   (Q95267), GCR_XENLA   (P49844), HIZR1_CAEEL (G5ED47), 
HNF4A_HUMAN (P41235), HNF4A_MOUSE (P49698), HNF4A_RAT   (P22449), 
HNF4A_XENLA (Q91766), HNF4B_XENLA (P79926), HNF4G_HUMAN (Q14541), 
HNF4G_MOUSE (Q9WUU6), HNF4_DROME  (P49866), HR38_BOMMO  (P49870), 
HR38_DROME  (P49869), HR3_DROME   (P31396), HR3_GALME   (P49868), 
HR3_MANSE   (Q08882), HR4_DROME   (Q9W539), HR78_DROME  (Q24142), 
HR96_DROME  (Q24143), KNIR_DROME  (P10734), KNIR_DROVI  (Q24753), 
KNRL_DROME  (P13054), MCR_AOTNA   (Q3YC04), MCR_HUMAN   (P08235), 
MCR_MOUSE   (Q8VII8), MCR_RAT (P22199), MCR_SAIBB   (Q4JM28), 
MCR_SAISC   (Q9N0W8), MCR_TUPBE   (Q29131), MCR_XENLA   (Q91573), 
N2C1A_XENLA (Q6GN21), N2C1B_XENLA (Q66J63), N2F1A_DANRE (Q06725), 
N2F1B_DANRE (Q6PH18), NH100_CAEEL (O17611), NH103_CAEEL (O16359), 
NH106_CAEEL (O16966), NH111_CAEEL (O45521), NH114_CAEEL (G5EEM0), 
NH115_CAEEL (O16662), NH121_CAEEL (Q9TZ99), NH124_CAEEL (O16391), 
NH125_CAEEL (O17082), NH127_CAEEL (O18087), NH133_CAEEL (O16354), 
NH134_CAEEL (O16361), NH136_CAEEL (O01930), NH150_CAEEL (O17573), 
NH153_CAEEL (O01929), NH154_CAEEL (O01931), NH164_CAEEL (O17657), 
NH169_CAEEL (O17706), NH174_CAEEL (O17748), NH209_CAEEL (Q21806), 
NH217_CAEEL (O02305), NH268_CAEEL (O17930), NHR10_CAEEL (P41999), 
NHR11_CAEEL (Q23294), NHR12_CAEEL (Q21701), NHR13_CAEEL (Q9N4Q7), 
NHR14_CAEEL (O02151), NHR16_CAEEL (Q27521), NHR18_CAEEL (O16360), 
NHR19_CAEEL (Q09528), NHR1_CAEEL  (Q21878), NHR1_ONCVO  (Q25604), 
NHR20_CAEEL (Q09565), NHR22_CAEEL (Q09587), NHR23_CAEEL (P41828), 
NHR25_CAEEL (Q19345), NHR28_CAEBR (A8XNK6), NHR28_CAEEL (Q17905), 
NHR2_CAEEL  (Q10902), NHR31_CAEEL (Q18192), NHR34_CAEEL (Q21006), 
NHR35_CAEEL (Q17771), NHR3_CAEEL  (Q9XTJ4), NHR40_CAEEL (Q22127), 
NHR41_CAEEL (Q9N4B8), NHR42_CAEEL (O76828), NHR44_CAEEL (Q22555), 
NHR47_CAEEL (Q17370), NHR48_CAEEL (Q94407), NHR49_CAEEL (O45666), 
NHR4_CAEEL  (O45436), NHR52_CAEEL (O17928), NHR53_CAEEL (O17933), 
NHR54_CAEEL (O45460), NHR55_CAEEL (O16962), NHR57_CAEEL (O16425), 
NHR59_CAEEL (Q9TXJ1), NHR5_CAEEL  (Q9NA51), NHR60_CAEEL (O17898), 
NHR61_CAEEL (O62389), NHR62_CAEEL (O02279), NHR64_CAEEL (O44960), 
NHR65_CAEEL (O45907), NHR66_CAEEL (H2KYJ8), NHR67_CAEEL (Q9XVV3), 
NHR68_CAEEL (Q9XXM8), NHR69_CAEEL (P91829), NHR6_CAEEL  (P41829), 
NHR71_CAEEL (Q9GTD4), NHR76_CAEEL (Q65CM0), NHR77_CAEEL (O02316), 
NHR79_CAEEL (O18141), NHR7_CAEEL  (Q20765), NHR80_CAEEL (Q8ITW8), 
NHR85_CAEEL (Q9XUK7), NHR86_CAEEL (Q965W2), NHR89_CAEEL (O02235), 
NHR8_CAEEL  (Q9XYB7), NHR90_CAEEL (O17025), NHR91_CAEEL (Q9U2R6), 
NHR96_CAEEL (Q95X91), NHR97_CAEEL (Q9BJK5), NHR98_CAEEL (Q966I0), 
NHR9_CAEEL  (Q23489), NR1D1_BOVIN (Q08E02), NR1D1_HUMAN (P20393), 
NR1D1_MOUSE (Q3UV55), NR1D1_RAT   (Q63503), NR1D1_SHEEP (B3SV56), 
NR1D2_HUMAN (Q14995), NR1D2_MOUSE (Q60674), NR1D2_RAT   (Q63504), 
NR1H2_BOVIN (Q5BIS6), NR1H2_HUMAN (P55055), NR1H2_MOUSE (Q60644), 
NR1H2_RAT   (Q62755), NR1H3_BOVIN (Q5E9B6), NR1H3_HUMAN (Q13133), 
NR1H3_MOUSE (Q9Z0Y9), NR1H3_RAT   (Q62685), NR1H4_BOVIN (Q3SZL0), 
NR1H4_HUMAN (Q96RI1), NR1H4_MOUSE (Q60641), NR1H4_RAT   (Q62735), 
NR1I2_HUMAN (O75469), NR1I2_MACMU (Q8SQ01), NR1I2_MOUSE (O54915), 
NR1I2_RAT   (Q9R1A7), NR1I3_CALUR (P62044), NR1I3_HUMAN (Q14994), 
NR1I3_MACMU (Q8MIM3), NR1I3_MOUSE (O35627), NR1I3_PANTR (A2T7D9), 
NR1I3_PUSSI (P62045), NR1I3_RAT   (Q9QUS1), NR2C1_BOVIN (A0JNE3), 
NR2C1_HUMAN (P13056), NR2C1_MACFA (Q95K90), NR2C1_MOUSE (Q505F1), 
NR2C1_PONAB (Q5RCZ5), NR2C1_RAT   (Q8VIJ4), NR2C1_XENTR (Q28CK1), 
NR2C2_HUMAN (P49116), NR2C2_MOUSE (P49117), NR2C2_RAT   (P55094), 
NR2E1_CHICK (Q91379), NR2E1_HUMAN (Q9Y466), NR2E1_MOUSE (Q64104), 
NR2E1_ORYLA (Q9YGL3), NR2E1_XENLA (P70052), NR2E3_BOVIN (Q9TTF0), 
NR2E3_HUMAN (Q9Y5X4), NR2E3_MOUSE (Q9QXZ7), NR2F5_DANRE (Q06726), 
NR2F6_HUMAN (P10588), NR2F6_MOUSE (P43136), NR2F6_RAT   (O09017), 
NR4A1_BOVIN (Q0V8F0), NR4A1_CANLF (P51666), NR4A1_HUMAN (P22736), 
NR4A1_MOUSE (P12813), NR4A1_RAT   (P22829), NR4A1_XENLA (Q04913), 
NR4A2_BOVIN (Q08E53), NR4A2_HUMAN (P43354), NR4A2_MOUSE (Q06219), 
NR4A2_PONAB (Q5R5Y4), NR4A2_RAT   (Q07917), NR4A2_XENTR (A4IIG7), 
NR4A3_HUMAN (Q92570), NR4A3_MOUSE (Q9QZB6), NR4A3_RAT   (P51179), 
NR5A2_CHICK (O42101), NR5A2_DANRE (Q90YL6), NR5A2_HUMAN (O00482), 
NR5A2_MOUSE (P45448), NR5A2_RAT   (Q9QWM1), NR6A1_HUMAN (Q15406), 
NR6A1_MOUSE (Q64249), NR6A1_PIG   (A0P8Z4), NR6A1_XENLA (P70033), 
NR6A1_XENTR (Q66JK1), ODR7_CAEEL  (P41933), PPARA_CANLF (Q95N78), 
PPARA_CAVPO (O35507), PPARA_HUMAN (Q07869), PPARA_MOUSE (P23204), 
PPARA_PHACI (Q8HYL6), PPARA_RAT   (P37230), PPARA_XENLA (P37232), 
PPARD_CANLF (Q0ZAQ8), PPARD_HUMAN (Q03181), PPARD_MOUSE (P35396), 
PPARD_XENLA (P37233), PPARG_BOVIN (O18971), PPARG_CANLF (Q4U3Q4), 
PPARG_CRIGR (P57797), PPARG_HUMAN (P37231), PPARG_MACMU (O18924), 
PPARG_MOUSE (P37238), PPARG_PIG   (O62807), PPARG_RABIT (O19052), 
PPARG_RAT   (O88275), PPARG_XENLA (P37234), PRGR_ATEPA  (A7XW25), 
PRGR_CANLF  (Q9GLW0), PRGR_CHICK  (P07812), PRGR_CHLAE  (A7X8C9), 
PRGR_COLGU  (A7X8D2), PRGR_GORGO  (A7X8B7), PRGR_HUMAN  (P06401), 
PRGR_HYLLA  (A7X8C2), PRGR_MACSY  (A7X8C4), PRGR_MOUSE  (Q00175), 
PRGR_PANPA  (A7X8B5), PRGR_PANTR  (A7X8B3), PRGR_PAPAN  (A7X8C7), 
PRGR_PITIR  (A7XW20), PRGR_PONPY  (A7X8B9), PRGR_RABIT  (P06186), 
PRGR_RANDY  (Q8AYI2), PRGR_RAT(Q63449), PRGR_SAPAP  (A7XW16), 
PRGR_SHEEP  (Q28590), PRGR_TRAOB  (A7X8D4), RARAA_DANRE (Q90271), 
RARAB_DANRE (Q7ZTI3), RARA_CANLF  (Q5FBR4), RARA_CHICK  (Q90966), 
RARA_HUMAN  (P10276), RARA_MOUSE  (P11416), RARA_NOTVI  (P18514), 
RARA_TAKRU  (Q9W5Z3), RARA_XENLA  (P51126), RARB_CHICK  (P22448), 
RARB_COTJA  (Q9W6B3), RARB_HUMAN  (P10826), RARB_MOUSE  (P22605), 
RARB_NOTVI  (P18515), RARGA_DANRE (Q91392), RARGB_DANRE (A2T928), 
RARG_HUMAN  (P13631), RARG_MOUSE  (P18911), RARG_NOTVI  (P18516), 
RARG_XENLA  (P28699), RORAA_DANRE (F1QLY4), RORAB_DANRE (F1QJF4), 
RORA_HUMAN  (P35398), RORA_MOUSE  (P51448), RORB_HUMAN  (Q92753), 
RORB_MOUSE  (Q8R1B8), RORB_RAT(P45446), RORG_HUMAN  (P51449), 
RORG_MOUSE  (P51450), RORG_PONAB  (Q5RAP4), RXRAA_DANRE (A2T929), 
RXRAB_DANRE (Q90415), RXRA_HUMAN  (P19793), RXRA_MOUSE  (P28700), 
RXRA_RAT(Q05343), RXRA_XENLA  (P51128), RXRBA_DANRE (Q7SYN5), 
RXRBB_DANRE (Q90417), RXRB_CANLF  (Q5TJF7), RXRB_HUMAN  (P28702), 
RXRB_MOUSE  (P28704), RXRB_RAT(P49743), RXRGA_DANRE (Q90416), 
RXRGB_DANRE (Q6DHP9), RXRG_BOVIN  (Q0VC20), RXRG_CHICK  (P28701), 
RXRG_HUMAN  (P48443), RXRG_MOUSE  (P28705), RXRG_PIG(Q0GFF6), 
RXRG_PONAB  (Q5REL6), RXRG_RAT(Q5BJR8), RXRG_XENLA  (P51129), 
RXR_BIOGL   (Q8T5C6), RXR_LYMST   (Q5I7G2), SHR2_STRPU  (Q26622), 
STF1_BOVIN  (Q04752), STF1_HORSE  (Q9GKL2), STF1_HUMAN  (Q13285), 
STF1_MOUSE  (P33242), STF1_NOTEU  (Q95L87), STF1_PIG(P79387), 
STF1_RAT(P50569), THAA_DANRE  (Q98867), THAA_PAROL  (Q91241), 
THAA_XENLA  (P15204), THAB_PAROL  (Q91242), THAB_XENLA  (P18115), 
THA_APTPA   (O42295), THA_AQUCT   (Q02777), THA_CAIMO   (Q90382), 
THA_CHICK   (P04625), THA_HIPHI   (Q9W6N4), THA_HUMAN   (P10827), 
THA_MOUSE   (P63058), THA_NECMA   (O57606), THA_PIG (O97716), 
THA_PYGAD   (O42450), THA_RAT (P63059), THA_SALSA   (Q9W785), 
THA_SHEEP   (Q28570), THBA_XENLA  (P18117), THBB_XENLA  (P18119), 
THB_AQUCT   (Q02965), THB_CAIMO   (P68305), THB_CHICK   (P68306), 
THB_DANRE   (Q9PVE4), THB_HUMAN   (P10828), THB_MOUSE   (P37242), 
THB_PAROL   (Q91279), THB_RAT (P18113), THB_SHEEP   (Q28571), 
TLL_DROME   (P18102), TLL_DROVI   (O16845), UNC55_CAEEL (G5ECR9), 
USP_BOMMO   (P49700), USP_CHOFU   (O76202), USP_DROME   (P20153), 
USP_MANSE   (P54779), VDRA_DANRE  (Q9PTN2), VDRB_DANRE  (Q1L673), 
VDR_BOVIN   (Q28037), VDR_CHICK   (O42392), VDR_COTJA   (P49701), 
VDR_HUMAN   (P11473), VDR_MOUSE   (P48281), VDR_PIG (A3RGC1), 
VDR_RAT (P13053), VDR_SAGOE   (Q95MH5), VDR_XENLA   (O13124)
» more

UniProtKB/Swiss-Prot
False negative sequences		 11 sequences 

NH108_CAEEL (O45449), NH130_CAEEL (O16963), NH167_CAEEL (O17683), 

NH176_CAEEL (O45365), NH197_CAEEL (O17931), NH199_CAEEL (O17934), 
NH213_CAEEL (O18048), NH218_CAEEL (O18086), NHR27_CAEEL (G5EGN8), 
NHR43_CAEEL (Q18299), NHR51_CAEEL (O17927)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 9 sequences 

ESR1_ANOCA  (Q9YHT3), ESR1_ASPUN  (Q91424), ESR1_MACMU  (P49886), 

ESR1_MICUN  (P57753), ESR2_MACMU  (Q9TTE5), PRGR_NOTEU  (P79373), 
THA_ELECQ   (Q9PUA8), THA_ONCMY   (Q9W6I9), THA_SPAAU   (O57568)
» more

PDB
[Detailed view]		 112 PDB

1A6Y; 1BY4; 1CIT; 1DSZ; 1GA5; 1GDC; 1GLU; 1HCP; 1HCQ; 1HLZ; 1HRA; 1KB2; 1KB4; 1KB6; 1LAT; 1LO1; 1R0N; 1R0O; 1R4I; 1R4O; 1R4R; 1RGD; 1RXR; 1YNW; 2A66; 2C7A; 2EBL; 2ENV; 2FF0; 2GDA; 2HAN; 2NLL; 3CBB; 3DZU; 3DZY; 3E00; 3FYL; 3G6P; 3G6Q; 3G6R; 3G6T; 3G6U; 3G8U; 3G8X; 3G97; 3G99; 3G9I; 3G9J; 3G9M; 3G9O; 3G9P; 3M9E; 4AA6; 4CN2; 4CN3; 4CN5; 4CN7; 4HN5; 4HN6; 4IQR; 4NQA; 4TNT; 4UMM; 5CBX; 5CBY; 5CBZ; 5CC0; 5CC1; 5E69; 5E6A; 5E6B; 5E6C; 5E6D; 5EMC; 5EMP; 5EMQ; 5KRB; 5L0M; 5UAN; 5VA0; 5VA7; 6BQU; 6BSE; 6BSF; 6CFN; 6FBQ; 6FBR; 6FX0; 6L6L; 6L6Q; 6LC1; 6X6D; 6X6E; 6XWG; 6XWH; 7KW7; 7PRV; 7PRW; 7WNH; 7XV6; 7XV8; 7XV9; 7XVN; 8CEF; 8FFV; 8FFW; 8HBM; 8IFO; 8J54; 8PKI; 8RM6; 8RM7
» more