We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00031
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PURL: https://purl.expasy.org/prosite/signature/PS00031
Direct ScanProsite submission
General information about the entry
| Entry name [info] | NUCLEAR_REC_DBD_1 |
| Accession [info] | PS00031 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00031 |
Name and characterization of the entry
| Description [info] | Nuclear hormones receptors DNA-binding region signature. |
| Pattern [info] |
C-x(2)-C-x(1,2)-[DENAVSPHKQT]-x(5,6)-[HNY]-[FY]-x(4)-C-x(2)-C-x(2)-F(2)- x-R. |
Numerical results [info]
| Total number of hits | 462 in 462 different sequences |
| Number of true positive hits | 462 in 462 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 11 |
| Number of 'partial' sequences | 9 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 97.67 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Site [info] | zinc at position 1 |
| Site [info] | zinc at position 3 |
| Site [info] | zinc at position 10 |
| Site [info] | zinc at position 12 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
462 sequences
7UP1_DROME (P16375), 7UP2_DROME (P16376), ANDR_AQUCT (Q7T1K4), ANDR_CANLF (Q9TT90), ANDR_CROCR (Q8MIK0), ANDR_EULFC (O97776), ANDR_HUMAN (P10275), ANDR_MACFA (O97952), ANDR_MACMU (Q6QT55), ANDR_MOUSE (P19091), ANDR_PANTR (O97775), ANDR_PAPHA (O97960), ANDR_PIG(Q9GKL7), ANDR_RABIT (P49699), ANDR_RAT(P15207), CNR14_CAEEL (P41830), COT1_BOVIN (Q9TTR8), COT1_HUMAN (P10589), COT1_MOUSE (Q60632), COT2_BOVIN (Q9TTR7), COT2_CHICK (Q90733), COT2_HUMAN (P24468), COT2_MOUSE (P43135), COT2_RAT(O09018), DAF12_CAEEL (G5EFF5), DSF_DROME (Q9VML1), E75BB_DROME (P13055), E75BC_DROME (P17671), E75_CHOFU (O01639), E75_GALME (P50239), E75_MANSE (Q08893), E75_METEN (O77245), E78C_DROME (P45447), ECR_AEDAE (P49880), ECR_BOMMO (P49881), ECR_CHITE (P49882), ECR_DROME (P34021), ECR_HELVI (O18473), ECR_LUCCU (O18531), ECR_MANSE (P49883), EGON_DROME (P15370), ERR1_CANLF (Q6QMY5), ERR1_HUMAN (P11474), ERR1_MOUSE (O08580), ERR1_RAT(Q5QJV7), ERR2_HUMAN (O95718), ERR2_MOUSE (Q61539), ERR2_RAT(P11475), ERR3_HUMAN (P62508), ERR3_MOUSE (P62509), ERR3_PONAB (Q5RAM2), ERR3_RAT(P62510), ESR1_BOVIN (P49884), ESR1_CHICK (P06212), ESR1_DANRE (P57717), ESR1_FELCA (Q53AD2), ESR1_HORSE (Q9TV98), ESR1_HUMAN (P03372), ESR1_ICTPU (Q9YHZ7), ESR1_MESAU (Q9QZJ5), ESR1_MOUSE (P19785), ESR1_ONCMY (P16058), ESR1_OREAU (P50240), ESR1_ORENI (Q9YH33), ESR1_ORYLA (P50241), ESR1_PAGMA (O42132), ESR1_PIG(Q29040), ESR1_RAT(P06211), ESR1_SALSA (P50242), ESR1_SHEEP (P49885), ESR1_SPAAU (Q9PVZ9), ESR1_TAEGU (Q91250), ESR1_XENLA (P81559), ESR21_CARAU (Q9W669), ESR22_CARAU (Q9IAL9), ESR2_ANGJA (O13012), ESR2_BOVIN (Q9XSB5), ESR2_CALJA (Q95171), ESR2_CHICK (Q9PTU5), ESR2_COTJA (O93511), ESR2_HUMAN (Q92731), ESR2_ICTPU (Q9IAK1), ESR2_MICUN (P57781), ESR2_MOUSE (O08537), ESR2_ONCMY (P57782), ESR2_ORENI (Q9YH32), ESR2_PIG(Q9XSW2), ESR2_RAT(Q62986), ESR2_SHEEP (Q9TU15), ESR2_SPAAU (Q9W6M2), ESR2_STUVU (Q9PVE2), ESR3_MICUN (P57783), FAX1_CAEEL (G5EDJ0), FTF1B_DROME (Q05192), FTZF1_BOMMO (P49867), FTZF1_DROME (P33244), GAG_AVIER (P03373), GCNFA_DANRE (Q9PU65), GCNFB_DANRE (Q4V8R7), GCR_AOTNA (P79686), GCR_CALJA (Q6XLJ0), GCR_CAVPO (P49115), GCR_HUMAN (P04150), GCR_MOUSE (P06537), GCR_ONCMY (P49843), GCR_PAROL (O73673), GCR_PIG (Q9N1U3), GCR_PONAB (Q5R9P5), GCR_RABIT (P59667), GCR_RAT (P06536), GCR_SAGOE (P79269), GCR_SAIBB (O13186), GCR_SAISC (O46567), GCR_SHEEP (P35547), GCR_TUPBE (Q95267), GCR_XENLA (P49844), HIZR1_CAEEL (G5ED47), HNF4A_HUMAN (P41235), HNF4A_MOUSE (P49698), HNF4A_RAT (P22449), HNF4A_XENLA (Q91766), HNF4B_XENLA (P79926), HNF4G_HUMAN (Q14541), HNF4G_MOUSE (Q9WUU6), HNF4_DROME (P49866), HR38_BOMMO (P49870), HR38_DROME (P49869), HR3_DROME (P31396), HR3_GALME (P49868), HR3_MANSE (Q08882), HR4_DROME (Q9W539), HR78_DROME (Q24142), HR96_DROME (Q24143), KNIR_DROME (P10734), KNIR_DROVI (Q24753), KNRL_DROME (P13054), MCR_AOTNA (Q3YC04), MCR_HUMAN (P08235), MCR_MOUSE (Q8VII8), MCR_RAT (P22199), MCR_SAIBB (Q4JM28), MCR_SAISC (Q9N0W8), MCR_TUPBE (Q29131), MCR_XENLA (Q91573), N2C1A_XENLA (Q6GN21), N2C1B_XENLA (Q66J63), N2F1A_DANRE (Q06725), N2F1B_DANRE (Q6PH18), NH100_CAEEL (O17611), NH103_CAEEL (O16359), NH106_CAEEL (O16966), NH111_CAEEL (O45521), NH114_CAEEL (G5EEM0), NH115_CAEEL (O16662), NH121_CAEEL (Q9TZ99), NH124_CAEEL (O16391), NH125_CAEEL (O17082), NH127_CAEEL (O18087), NH133_CAEEL (O16354), NH134_CAEEL (O16361), NH136_CAEEL (O01930), NH150_CAEEL (O17573), NH153_CAEEL (O01929), NH154_CAEEL (O01931), NH164_CAEEL (O17657), NH169_CAEEL (O17706), NH174_CAEEL (O17748), NH209_CAEEL (Q21806), NH217_CAEEL (O02305), NH268_CAEEL (O17930), NHR10_CAEEL (P41999), NHR11_CAEEL (Q23294), NHR12_CAEEL (Q21701), NHR13_CAEEL (Q9N4Q7), NHR14_CAEEL (O02151), NHR16_CAEEL (Q27521), NHR18_CAEEL (O16360), NHR19_CAEEL (Q09528), NHR1_CAEEL (Q21878), NHR1_ONCVO (Q25604), NHR20_CAEEL (Q09565), NHR22_CAEEL (Q09587), NHR23_CAEEL (P41828), NHR25_CAEEL (Q19345), NHR28_CAEBR (A8XNK6), NHR28_CAEEL (Q17905), NHR2_CAEEL (Q10902), NHR31_CAEEL (Q18192), NHR34_CAEEL (Q21006), NHR35_CAEEL (Q17771), NHR3_CAEEL (Q9XTJ4), NHR40_CAEEL (Q22127), NHR41_CAEEL (Q9N4B8), NHR42_CAEEL (O76828), NHR44_CAEEL (Q22555), NHR47_CAEEL (Q17370), NHR48_CAEEL (Q94407), NHR49_CAEEL (O45666), NHR4_CAEEL (O45436), NHR52_CAEEL (O17928), NHR53_CAEEL (O17933), NHR54_CAEEL (O45460), NHR55_CAEEL (O16962), NHR57_CAEEL (O16425), NHR59_CAEEL (Q9TXJ1), NHR5_CAEEL (Q9NA51), NHR60_CAEEL (O17898), NHR61_CAEEL (O62389), NHR62_CAEEL (O02279), NHR64_CAEEL (O44960), NHR65_CAEEL (O45907), NHR66_CAEEL (H2KYJ8), NHR67_CAEEL (Q9XVV3), NHR68_CAEEL (Q9XXM8), NHR69_CAEEL (P91829), NHR6_CAEEL (P41829), NHR71_CAEEL (Q9GTD4), NHR76_CAEEL (Q65CM0), NHR77_CAEEL (O02316), NHR79_CAEEL (O18141), NHR7_CAEEL (Q20765), NHR80_CAEEL (Q8ITW8), NHR85_CAEEL (Q9XUK7), NHR86_CAEEL (Q965W2), NHR89_CAEEL (O02235), NHR8_CAEEL (Q9XYB7), NHR90_CAEEL (O17025), NHR91_CAEEL (Q9U2R6), NHR96_CAEEL (Q95X91), NHR97_CAEEL (Q9BJK5), NHR98_CAEEL (Q966I0), NHR9_CAEEL (Q23489), NR1D1_BOVIN (Q08E02), NR1D1_HUMAN (P20393), NR1D1_MOUSE (Q3UV55), NR1D1_RAT (Q63503), NR1D1_SHEEP (B3SV56), NR1D2_HUMAN (Q14995), NR1D2_MOUSE (Q60674), NR1D2_RAT (Q63504), NR1H2_BOVIN (Q5BIS6), NR1H2_HUMAN (P55055), NR1H2_MOUSE (Q60644), NR1H2_RAT (Q62755), NR1H3_BOVIN (Q5E9B6), NR1H3_HUMAN (Q13133), NR1H3_MOUSE (Q9Z0Y9), NR1H3_RAT (Q62685), NR1H4_BOVIN (Q3SZL0), NR1H4_HUMAN (Q96RI1), NR1H4_MOUSE (Q60641), NR1H4_RAT (Q62735), NR1I2_HUMAN (O75469), NR1I2_MACMU (Q8SQ01), NR1I2_MOUSE (O54915), NR1I2_RAT (Q9R1A7), NR1I3_CALUR (P62044), NR1I3_HUMAN (Q14994), NR1I3_MACMU (Q8MIM3), NR1I3_MOUSE (O35627), NR1I3_PANTR (A2T7D9), NR1I3_PUSSI (P62045), NR1I3_RAT (Q9QUS1), NR2C1_BOVIN (A0JNE3), NR2C1_HUMAN (P13056), NR2C1_MACFA (Q95K90), NR2C1_MOUSE (Q505F1), NR2C1_PONAB (Q5RCZ5), NR2C1_RAT (Q8VIJ4), NR2C1_XENTR (Q28CK1), NR2C2_HUMAN (P49116), NR2C2_MOUSE (P49117), NR2C2_RAT (P55094), NR2E1_CHICK (Q91379), NR2E1_HUMAN (Q9Y466), NR2E1_MOUSE (Q64104), NR2E1_ORYLA (Q9YGL3), NR2E1_XENLA (P70052), NR2E3_BOVIN (Q9TTF0), NR2E3_HUMAN (Q9Y5X4), NR2E3_MOUSE (Q9QXZ7), NR2F5_DANRE (Q06726), NR2F6_HUMAN (P10588), NR2F6_MOUSE (P43136), NR2F6_RAT (O09017), NR4A1_BOVIN (Q0V8F0), NR4A1_CANLF (P51666), NR4A1_HUMAN (P22736), NR4A1_MOUSE (P12813), NR4A1_RAT (P22829), NR4A1_XENLA (Q04913), NR4A2_BOVIN (Q08E53), NR4A2_HUMAN (P43354), NR4A2_MOUSE (Q06219), NR4A2_PONAB (Q5R5Y4), NR4A2_RAT (Q07917), NR4A2_XENTR (A4IIG7), NR4A3_HUMAN (Q92570), NR4A3_MOUSE (Q9QZB6), NR4A3_RAT (P51179), NR5A2_CHICK (O42101), NR5A2_DANRE (Q90YL6), NR5A2_HUMAN (O00482), NR5A2_MOUSE (P45448), NR5A2_RAT (Q9QWM1), NR6A1_HUMAN (Q15406), NR6A1_MOUSE (Q64249), NR6A1_PIG (A0P8Z4), NR6A1_XENLA (P70033), NR6A1_XENTR (Q66JK1), ODR7_CAEEL (P41933), PPARA_CANLF (Q95N78), PPARA_CAVPO (O35507), PPARA_HUMAN (Q07869), PPARA_MOUSE (P23204), PPARA_PHACI (Q8HYL6), PPARA_RAT (P37230), PPARA_XENLA (P37232), PPARD_CANLF (Q0ZAQ8), PPARD_HUMAN (Q03181), PPARD_MOUSE (P35396), PPARD_XENLA (P37233), PPARG_BOVIN (O18971), PPARG_CANLF (Q4U3Q4), PPARG_CRIGR (P57797), PPARG_HUMAN (P37231), PPARG_MACMU (O18924), PPARG_MOUSE (P37238), PPARG_PIG (O62807), PPARG_RABIT (O19052), PPARG_RAT (O88275), PPARG_XENLA (P37234), PRGR_ATEPA (A7XW25), PRGR_CANLF (Q9GLW0), PRGR_CHICK (P07812), PRGR_CHLAE (A7X8C9), PRGR_COLGU (A7X8D2), PRGR_GORGO (A7X8B7), PRGR_HUMAN (P06401), PRGR_HYLLA (A7X8C2), PRGR_MACSY (A7X8C4), PRGR_MOUSE (Q00175), PRGR_PANPA (A7X8B5), PRGR_PANTR (A7X8B3), PRGR_PAPAN (A7X8C7), PRGR_PITIR (A7XW20), PRGR_PONPY (A7X8B9), PRGR_RABIT (P06186), PRGR_RANDY (Q8AYI2), PRGR_RAT(Q63449), PRGR_SAPAP (A7XW16), PRGR_SHEEP (Q28590), PRGR_TRAOB (A7X8D4), RARAA_DANRE (Q90271), RARAB_DANRE (Q7ZTI3), RARA_CANLF (Q5FBR4), RARA_CHICK (Q90966), RARA_HUMAN (P10276), RARA_MOUSE (P11416), RARA_NOTVI (P18514), RARA_TAKRU (Q9W5Z3), RARA_XENLA (P51126), RARB_CHICK (P22448), RARB_COTJA (Q9W6B3), RARB_HUMAN (P10826), RARB_MOUSE (P22605), RARB_NOTVI (P18515), RARGA_DANRE (Q91392), RARGB_DANRE (A2T928), RARG_HUMAN (P13631), RARG_MOUSE (P18911), RARG_NOTVI (P18516), RARG_XENLA (P28699), RORAA_DANRE (F1QLY4), RORAB_DANRE (F1QJF4), RORA_HUMAN (P35398), RORA_MOUSE (P51448), RORB_HUMAN (Q92753), RORB_MOUSE (Q8R1B8), RORB_RAT(P45446), RORG_HUMAN (P51449), RORG_MOUSE (P51450), RORG_PONAB (Q5RAP4), RXRAA_DANRE (A2T929), RXRAB_DANRE (Q90415), RXRA_HUMAN (P19793), RXRA_MOUSE (P28700), RXRA_RAT(Q05343), RXRA_XENLA (P51128), RXRBA_DANRE (Q7SYN5), RXRBB_DANRE (Q90417), RXRB_CANLF (Q5TJF7), RXRB_HUMAN (P28702), RXRB_MOUSE (P28704), RXRB_RAT(P49743), RXRGA_DANRE (Q90416), RXRGB_DANRE (Q6DHP9), RXRG_BOVIN (Q0VC20), RXRG_CHICK (P28701), RXRG_HUMAN (P48443), RXRG_MOUSE (P28705), RXRG_PIG(Q0GFF6), RXRG_PONAB (Q5REL6), RXRG_RAT(Q5BJR8), RXRG_XENLA (P51129), RXR_BIOGL (Q8T5C6), RXR_LYMST (Q5I7G2), SHR2_STRPU (Q26622), STF1_BOVIN (Q04752), STF1_HORSE (Q9GKL2), STF1_HUMAN (Q13285), STF1_MOUSE (P33242), STF1_NOTEU (Q95L87), STF1_PIG(P79387), STF1_RAT(P50569), THAA_DANRE (Q98867), THAA_PAROL (Q91241), THAA_XENLA (P15204), THAB_PAROL (Q91242), THAB_XENLA (P18115), THA_APTPA (O42295), THA_AQUCT (Q02777), THA_CAIMO (Q90382), THA_CHICK (P04625), THA_HIPHI (Q9W6N4), THA_HUMAN (P10827), THA_MOUSE (P63058), THA_NECMA (O57606), THA_PIG (O97716), THA_PYGAD (O42450), THA_RAT (P63059), THA_SALSA (Q9W785), THA_SHEEP (Q28570), THBA_XENLA (P18117), THBB_XENLA (P18119), THB_AQUCT (Q02965), THB_CAIMO (P68305), THB_CHICK (P68306), THB_DANRE (Q9PVE4), THB_HUMAN (P10828), THB_MOUSE (P37242), THB_PAROL (Q91279), THB_RAT (P18113), THB_SHEEP (Q28571), TLL_DROME (P18102), TLL_DROVI (O16845), UNC55_CAEEL (G5ECR9), USP_BOMMO (P49700), USP_CHOFU (O76202), USP_DROME (P20153), USP_MANSE (P54779), VDRA_DANRE (Q9PTN2), VDRB_DANRE (Q1L673), VDR_BOVIN (Q28037), VDR_CHICK (O42392), VDR_COTJA (P49701), VDR_HUMAN (P11473), VDR_MOUSE (P48281), VDR_PIG (A3RGC1), VDR_RAT (P13053), VDR_SAGOE (Q95MH5), VDR_XENLA (O13124)» more
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| UniProtKB/Swiss-Prot False negative sequences |
11 sequences
NH108_CAEEL (O45449), NH130_CAEEL (O16963), NH167_CAEEL (O17683), NH176_CAEEL (O45365), NH197_CAEEL (O17931), NH199_CAEEL (O17934), NH213_CAEEL (O18048), NH218_CAEEL (O18086), NHR27_CAEEL (G5EGN8), NHR43_CAEEL (Q18299), NHR51_CAEEL (O17927)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
9 sequences
ESR1_ANOCA (Q9YHT3), ESR1_ASPUN (Q91424), ESR1_MACMU (P49886), ESR1_MICUN (P57753), ESR2_MACMU (Q9TTE5), PRGR_NOTEU (P79373), THA_ELECQ (Q9PUA8), THA_ONCMY (Q9W6I9), THA_SPAAU (O57568)» more |
| PDB [Detailed view] |
112 PDB
pdb_00001a6y; pdb_00001by4; pdb_00001cit; pdb_00001dsz; pdb_00001ga5; pdb_00001gdc; pdb_00001glu; pdb_00001hcp; pdb_00001hcq; pdb_00001hlz; pdb_00001hra; pdb_00001kb2; pdb_00001kb4; pdb_00001kb6; pdb_00001lat; pdb_00001lo1; pdb_00001r0n; pdb_00001r0o; pdb_00001r4i; pdb_00001r4o; pdb_00001r4r; pdb_00001rgd; pdb_00001rxr; pdb_00001ynw; pdb_00002a66; pdb_00002c7a; pdb_00002ebl; pdb_00002env; pdb_00002ff0; pdb_00002gda; pdb_00002han; pdb_00002nll; pdb_00003cbb; pdb_00003dzu; pdb_00003dzy; pdb_00003e00; pdb_00003fyl; pdb_00003g6p; pdb_00003g6q; pdb_00003g6r; pdb_00003g6t; pdb_00003g6u; pdb_00003g8u; pdb_00003g8x; pdb_00003g97; pdb_00003g99; pdb_00003g9i; pdb_00003g9j; pdb_00003g9m; pdb_00003g9o; pdb_00003g9p; pdb_00003m9e; pdb_00004aa6; pdb_00004cn2; pdb_00004cn3; pdb_00004cn5; pdb_00004cn7; pdb_00004hn5; pdb_00004hn6; pdb_00004iqr; pdb_00004nqa; pdb_00004tnt; pdb_00004umm; pdb_00005cbx; pdb_00005cby; pdb_00005cbz; pdb_00005cc0; pdb_00005cc1; pdb_00005e69; pdb_00005e6a; pdb_00005e6b; pdb_00005e6c; pdb_00005e6d; pdb_00005emc; pdb_00005emp; pdb_00005emq; pdb_00005krb; pdb_00005l0m; pdb_00005uan; pdb_00005va0; pdb_00005va7; pdb_00006bqu; pdb_00006bse; pdb_00006bsf; pdb_00006cfn; pdb_00006fbq; pdb_00006fbr; pdb_00006fx0; pdb_00006l6l; pdb_00006l6q; pdb_00006lc1; pdb_00006x6d; pdb_00006x6e; pdb_00006xwg; pdb_00006xwh; pdb_00007kw7; pdb_00007prv; pdb_00007prw; pdb_00007wnh; pdb_00007xv6; pdb_00007xv8; pdb_00007xv9; pdb_00007xvn; pdb_00008cef; pdb_00008ffv; pdb_00008ffw; pdb_00008hbm; pdb_00008ifo; pdb_00008j54; pdb_00008pki; pdb_00008rm6; pdb_00008rm7 » more |