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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00042


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PURL: https://purl.expasy.org/prosite/signature/PS00042

Direct ScanProsite submission
General information about the entry

Entry name [info] HTH_CRP_1
Accession [info] PS00042
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00041

Name and characterization of the entry

Description [info] Crp-type HTH domain signature.
Pattern [info] 
[LIVM]-[STAG]-[RHNWM]-x(2)-[LIM]-[GA]-x-[LIVMFYAS]-[LIVSC]-[GA]-x-
[STACN]-x(2)-[MST]-x(1,2)-[GSTN]-R-x-[LIVMF]-x(2)-[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 57 in 57 different sequences
Number of true positive hits 56 in 56 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 25
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 98.25 %
Recall (true positives / (true positives + false negatives)) 69.14 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 56 sequences 

AADR_RHOPA  (Q01980), ANR_PSEAE   (P23926), ANR_PSEPH   (O85222), 

BTR_BORPE   (Q08530), CLP_XANAC   (Q8PQ45), CLP_XANC8   (Q4UZF6), 
CLP_XANCB   (B0RN01), CLP_XANCP   (P22260), CLP_XANE5   (Q3BYB3), 
CLP_XANOM   (Q2NYD9), CLP_XANOP   (B2SL05), CLP_XANOR   (Q5GV61), 
CRP_ECO57   (P0ACK0), CRP_ECOL6   (P0ACJ9), CRP_ECOLI   (P0ACJ8), 
CRP_HAEIN   (P29281), CRP_KLEAE   (P0A2T7), CRP_PASMU   (O05689), 
CRP_SALTY   (P0A2T6), CRP_SHIFL   (P0ACK1), CYSR_SYNE7  (P27369), 
CYSR_SYNY3  (Q55854), ETRA_SHEON  (P46148), FIXK_AZOC5  (P26488), 
FIXK_BRADU  (P29286), FIXK_RHIME  (P13295), FLP_LACCA   (P29284), 
FNRA_STUST  (P47200), FNRL_CERS4  (P51007), FNRN_RHILV  (P24290), 
FNR_AGGAC   (Q9EXQ1), FNR_BACSU   (P46908), FNR_ECO57   (P0A9E7), 
FNR_ECOL6   (P0A9E6), FNR_ECOLI   (P0A9E5), FNR_HAEIN   (P45199), 
FNR_KLEOX   (Q9AQ50), FNR_PASMU   (Q9CMY2), FNR_SALMS   (P0A2T9), 
FNR_SALTI   (Q8Z787), FNR_SALTY   (P0A2T8), FNR_SHIDY   (Q9LA24), 
FNR_SHIFL   (P0A9E8), FNR_VIBC3   (A5F890), FNR_VIBCH   (P0C6D0), 
FNR_YERPE   (Q8ZE82), HLYX_ACTPL  (P23619), LARR_LACPL  (F9USS8), 
NTCA_NOSS1  (P0A4U6), NTCA_SYNE7  (P29283), NTCA_SYNY3  (P33779), 
NTCA_TRIV2  (P0A4U7), PRFA_LISMO  (P22262), VFR_PSEAE   (P55222), 
YCF28_PORPU (P51342), YCF28_PYRYE (Q1XDE5)
» more

UniProtKB/Swiss-Prot
False negative sequences		 25 sequences 

ARCR_STAA1  (A7X715), ARCR_STAA2  (A6U515), ARCR_STAA3  (Q2FDM8), 

ARCR_STAA8  (Q2FUY1), ARCR_STAA9  (A5IW58), ARCR_STAAB  (Q2YWH5), 
ARCR_STAAC  (Q5HCR6), ARCR_STAAE  (A6QKC0), ARCR_STAAM  (Q99R06), 
ARCR_STAAN  (Q7A381), ARCR_STAAR  (Q6GDH1), ARCR_STAAS  (Q6G643), 
ARCR_STAAT  (A8Z5D0), ARCR_STAAW  (Q8NUK9), ARCR_STAEQ  (Q5HKU6), 
ARCR_STAES  (Q8CML2), ARCR_STAHJ  (Q4L9J7), CMR_MYCTO   (P9WMH4), 
CMR_MYCTU   (P9WMH5), CRPL_CORGL  (Q79VI7), CRPL_MYCTO  (P9WMH2), 
CRPL_MYCTU  (P9WMH3), CRP_THET8   (Q5SID7), YEIL_ECO57  (P0A9F0), 
YEIL_ECOLI  (P0A9E9)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

FNR_AGGAP   (Q47948), FNR_CAPOD   (Q46158), FNR_CAPSP   (Q46159)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
Y4FQ_SINFN  (P55455)


				
	

	

		PDB
[Detailed view]		
		
			101 PDB
			


			pdb_00001cgp; pdb_00001g6n; pdb_00001hw5; pdb_00001i5z; pdb_00001i6x; pdb_00001j59; pdb_00001lb2; pdb_00001o3q; pdb_00001o3r; pdb_00001o3s; pdb_00001o3t; pdb_00001omi; 
			
				pdb_00001run; pdb_00001ruo; pdb_00001zrc; pdb_00001zrd; pdb_00001zre; pdb_00001zrf; pdb_00002beo; pdb_00002bgc; pdb_00002cgp; pdb_00002gzw; pdb_00002oz6; pdb_00002wc2; 
				pdb_00002xgx; pdb_00002xhk; pdb_00002xko; pdb_00002xkp; pdb_00003fwe; pdb_00003hif; pdb_00003iwz; pdb_00003iyd; pdb_00003kcc; pdb_00003la2; pdb_00003la3; pdb_00003la7; 
				pdb_00003n4m; pdb_00003qop; pdb_00003rdi; pdb_00003rou; pdb_00003rpq; pdb_00003ryp; pdb_00003ryr; pdb_00004bh9; pdb_00004bhp; pdb_00004ft8; pdb_00004hzf; pdb_00004i01; 
				pdb_00004i02; pdb_00004i09; pdb_00004i0a; pdb_00004i0b; pdb_00004r8h; pdb_00005ciz; pdb_00005f1r; pdb_00005lej; pdb_00005lek; pdb_00005lrr; pdb_00005lrs; pdb_00005x6d; 
				pdb_00005x6e; pdb_00006b6h; pdb_00006eut; pdb_00006euu; pdb_00006euz; pdb_00006ev0; pdb_00006exk; pdb_00006exl; pdb_00006exm; pdb_00006hck; pdb_00006pb4; pdb_00006pb5; 
				pdb_00006pb6; pdb_00006qvy; pdb_00006qvz; pdb_00006qw1; pdb_00006qw2; pdb_00006qwf; pdb_00006qwh; pdb_00006qwk; pdb_00006qwm; pdb_00006t5i; pdb_00007few; pdb_00007ff0; 
				pdb_00007ff8; pdb_00007ff9; pdb_00008cb4; pdb_00008cb5; pdb_00008cb7; pdb_00008cb8; pdb_00008cbg; pdb_00008cbi; pdb_00008cbp; pdb_00008h3v; pdb_00008h40; pdb_00009gqu; 
				pdb_00009gug; pdb_00009guh; pdb_00009gui; pdb_00009guj; pdb_00009guk
			
			

			» more