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PROSITE entry PS00062


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00062
Entry name [info] ALDOKETO_REDUCTASE_2
Accession [info] PS00062
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00061

Name and characterization of the entry

Description [info] Aldo/keto reductase family signature 2.
Pattern [info] 
[LIVMFY]-x(8)-{L}-[KREQ]-{K}-[LIVM]-G-[LIVM]-[SC]-N-[FY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 170 in 170 different sequences
Number of true positive hits 167 in 167 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 37
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 98.24 %
Recall (true positives / (true positives + false negatives)) 81.86 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 167 sequences 

6DCS_SOYBN  (P26690), A1A1A_DANRE (Q6AZW2), A1A1B_DANRE (Q568L5), 

AK1A1_BOVIN (Q3ZCJ2), AK1A1_CHICK (Q5ZK84), AK1A1_CRIGR (O70473), 
AK1A1_HUMAN (P14550), AK1A1_MOUSE (Q9JII6), AK1A1_PIG   (P50578), 
AK1A1_PONAB (Q5R5D5), AK1A1_RAT   (P51635), AK1A1_XENLA (Q6GMC7), 
AK1A1_XENTR (Q28FD1), AK1BA_HUMAN (O60218), AK1BF_HUMAN (C9JRZ8), 
AK1C1_HUMAN (Q04828), AK1C1_MACFA (Q95JH7), AK1C1_MACFU (Q95JH6), 
AK1C1_PONAB (Q5REQ0), AK1C2_HUMAN (P52895), AK1C3_HUMAN (P42330), 
AK1C3_PONAB (Q5R7C9), AK1C4_HUMAN (P17516), AK1C4_MACFA (Q95JH5), 
AK1C4_MACFU (Q95JH4), AK1CA_RAT   (D3ZF77), AK1CD_MESAU (P82809), 
AK1CD_MOUSE (Q8VC28), AK1CL_MOUSE (Q91WR5), AK1CL_RAT   (Q6AYQ2), 
AK1CN_HORSE (Q1XAA8), AK1CO_HORSE (Q6W8P9), AK1D1_HUMAN (P51857), 
AK1D1_MOUSE (Q8VCX1), AK1D1_RABIT (Q9TV64), AK1D1_RAT   (P31210), 
AK2E4_BOMMO (H9JTG9), AKC1H_MOUSE (Q8K023), AKC1H_RAT   (P51652), 
AKCL2_HUMAN (Q96JD6), AKCL2_MACFA (Q4R802), AKCL2_MOUSE (Q9DCT1), 
AKCL2_PIG   (P82125), AKCL2_RAT   (Q5U1Y4), AKRC8_ARATH (O80944), 
AKRC9_ARATH (Q0PGJ6), AKRCA_ARATH (Q84TF0), AKRCB_ARATH (Q9M338), 
AKR_CITSI   (P0DXG9), AKR_MELAZ   (P0DXH7), ALD1_MOUSE  (P21300), 
ALD1_RAT(Q5RJP0), ALD2_CRIGR  (O08782), ALD2_MOUSE  (P45377), 
ALDR_BOVIN  (P16116), ALDR_DROME  (M9PF61), ALDR_ENCCU  (Q8SSK6), 
ALDR_HORVU  (P23901), ALDR_HUMAN  (P15121), ALDR_MOUSE  (P45376), 
ALDR_PIG(P80276), ALDR_RABIT  (P15122), ALDR_RAT(P07943), 
ALDX_SPOSA  (P27800), ALRA_DICDI  (Q6IMN8), ALRB_DICDI  (Q54NZ7), 
ALRC_DICDI  (Q55FL3), ARA1_YEAST  (P38115), COR11_PAPSO (Q9SQ70), 
COR12_PAPSO (Q9SQ69), COR13_PAPSO (Q9SQ68), COR14_PAPSO (Q9SQ67), 
COR15_PAPSO (B9VRJ2), COR2_PAPSO  (Q9SQ64), CPRC1_CANPA (Q76L37), 
CRO_AQUCT   (P17264), CRO_RANTE   (P02532), DDBX_BOVIN  (P52898), 
DHB5_MOUSE  (P70694), DHGRD_AGRFC (A9CEY6), DHGRD_NOVAD (Q2G5J3), 
DIDH_RAT(P23457), DKGA_ECO57  (Q8XBT6), DKGA_ECOLI  (Q46857), 
DKGA_SALTI  (P58744), DKGA_SALTY  (Q8ZM06), DKGA_YERPE  (Q8ZI40), 
DKGB_CORSS  (P15339), DKGB_ECO57  (Q8X7Z7), DKGB_ECOLI  (P30863), 
DKGB_SALTI  (Q8Z988), DKGB_SALTY  (Q8ZRM7), DKGB_YERPE  (Q8ZH36), 
DMAS1_MAIZE (B4F9A4), DMAS1_ORYSJ (Q10PE7), GALUR_FRAAN (O49133), 
GAR1_HYPJE  (Q3ZFI7), GCY1_YEAST  (P14065), GRE3_YEAST  (P38715), 
GR_BACSU(O32210), GS69_BACSU  (P80874), IOLS_BACSU  (P46336), 
KAR_YEAST   (Q07551), MER_ERYCB   (E7C196), NADO1_ORYSJ (Q7G764), 
NADO2_ORYSJ (Q7G765), PE2R_RABIT  (P80508), PGFS1_BOVIN (P05980), 
PGFS2_BOVIN (P52897), PGFS_LEIMA  (P22045), PGFS_TRYBB  (Q9GV41), 
PGFS_TRYCC  (Q4DJ07), PLR1_ARATH  (Q56Y42), REDX2_CATRO (A0A2P1GIY9), 
S6PD_MALDO  (P28475), STORR_PAPSO (P0DKI7), XYL1_ARTOC  (C5FFQ7), 
XYL1_ASPCL  (A1CRI1), XYL1_ASPFC  (B0XNR0), XYL1_ASPFN  (B8N195), 
XYL1_ASPFU  (Q4WJT9), XYL1_ASPNC  (A2Q8B5), XYL1_ASPNG  (Q9P8R5), 
XYL1_ASPOR  (Q2UKD0), XYL1_ASPTN  (Q0CUL0), XYL1_CANBO  (Q8X195), 
XYL1_CANPA  (Q6Y0Z3), XYL1_CANTE  (O74237), XYL1_CANTR  (O13283), 
XYL1_EMENI  (Q5BGA7), XYL1_HYPJE  (Q876L8), XYL1_KLULA  (P49378), 
XYL1_NEOFI  (A1D4E3), XYL1_PICGU  (O94735), XYL1_PICST  (P31867), 
XYL1_PYRO7  (G4N708), XYL1_SCHSH  (Q9P430), XYL2_CANTR  (P87039), 
Y1669_ARATH (Q94A68), Y1669_MYCLB (B8ZS00), Y1669_MYCLE (O69462), 
Y1744_MYCMM (B2HIJ9), Y1918_MYCSJ (A3PXS9), Y1919_MYCSJ (A3PXT0), 
Y1938_MYCSS (Q1BAN7), Y1984_MYCSK (A1UEC5), Y1985_MYCSK (A1UEC6), 
Y1987_MYCUA (A0PQ11), Y2161_MYCVP (A1T726), Y2407_MYCS2 (A0QV09), 
Y2408_MYCS2 (A0QV10), Y2971_MYCTO (P9WQA4), Y2971_MYCTU (P9WQA5), 
Y2993_MYCBP (A1KMW6), Y2996_MYCBO (Q7TXI6), Y2999_MYCTA (A5U6Y1), 
Y3007_MYCPA (Q73VK6), Y3816_MYCA1 (A0QJ99), Y4149_MYCPA (Q73SC5), 
Y4483_MYCA1 (A0QL30), YBN4_SCHPO  (O42888), YDG7_SCHPO  (Q10494), 
YJ66_YEAST  (P47137), YKW2_SCHPO  (Q9C1X5), YOF5_CAEEL  (Q09632), 
YPR1_YEAST  (Q12458), YTBE_BACSU  (O34678)
» more

UniProtKB/Swiss-Prot
False negative sequences		 37 sequences 

AKCL1_HUMAN (Q5T2L2), AKR1_ORYSI  (B8ASB2), AKR1_ORYSJ  (Q0JE32), 

AKR1_SOYBN  (C6TBN2), AKR2_ORYSI  (A2XRZ0), AKR2_ORYSJ  (Q7XT99), 
AKR3_ORYSI  (A2XRZ6), AKR3_ORYSJ  (Q7XQ45), AKRMG_ECOLI (P77256), 
AKR_SYNY3   (P74308), ALKR1_ARATH (Q9C5B9), ALKR2_ARATH (Q84M96), 
ALKR3_ARATH (O22707), ALKR4_ARATH (Q93ZN2), ALKR5_ARATH (Q9ASZ9), 
ALKR6_ARATH (F4HPY8), ARA2_YEAST  (Q04212), DKGA_CORSC  (P06632), 
DTDH_MUCMU  (Q01213), FCDH_PSESP  (Q52472), GALDH_ARATH (O81884), 
GLD1_HYPJE  (Q0GYU5), GLD2_HYPJE  (Q0GYU4), I3ACR_SCHPO (O13848), 
MORA_PSEPU  (Q02198), MORA_RABIT  (P82810), PERR_RAUSE  (Q3L181), 
PLR1_SCHPO  (O14295), PLR1_YEAST  (Q06494), PLR2_SCHPO  (O94521), 
PRD1_PYRO7  (G4MZI3), XYL1_PACTA  (P78736), Y4205_MYCGI (A4TE41), 
YER5_SCHPO  (O14088), YEZB_SCHPO  (O14125), YH5B_SCHPO  (O94315), 
YRPG_BACSU  (O05408)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

CROB_LEPLU  (P49261), DHGP_ASPNG  (P55804)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			3 sequences
			


			
CO6A1_XENLA (Q801S8), CUE3_YEAST  (P53137), SFH2_ARATH  (F4JVA9)


				
	

	

		PDB
[Detailed view]		
		
			366 PDB
			


			1ABN; 1ADS; 1AE4; 1AFS; 1AH0; 1AH3; 1AH4; 1AZ1; 1AZ2; 1C9W; 1CWN; 1DLA; 
			
				1EF3; 1EKO; 1EL3; 1FRB; 1HQT; 1IEI; 1IHI; 1J96; 1JEZ; 1K8C; 1LWI; 1MAR; 
				1MI3; 1MRQ; 1MZR; 1PWL; 1PWM; 1PYF; 1PZ0; 1PZ1; 1Q13; 1Q5M; 1R38; 1RAL; 
				1RY0; 1RY8; 1S1P; 1S1R; 1S2A; 1S2C; 1SM9; 1T40; 1T41; 1US0; 1VBJ; 1X96; 
				1X97; 1X98; 1XF0; 1XGD; 1XJB; 1YE4; 1YE6; 1Z3N; 1Z89; 1Z8A; 1Z9A; 1ZQ5; 
				1ZUA; 2ACQ; 2ACR; 2ACS; 2ACU; 2AGT; 2ALR; 2BGQ; 2BGS; 2DUX; 2DUZ; 2DV0; 
				2F2K; 2F38; 2FGB; 2FVL; 2FZ8; 2FZ9; 2FZB; 2FZD; 2HDJ; 2HE5; 2HE8; 2HEJ; 
				2HV5; 2HVN; 2HVO; 2I16; 2I17; 2IKG; 2IKH; 2IKI; 2IKJ; 2INE; 2INZ; 2IPF; 
				2IPG; 2IPJ; 2IPW; 2IQ0; 2IQD; 2IS7; 2ISF; 2J8T; 2NVC; 2NVD; 2P5N; 2PD5; 
				2PD9; 2PDB; 2PDC; 2PDF; 2PDG; 2PDH; 2PDI; 2PDJ; 2PDK; 2PDL; 2PDM; 2PDN; 
				2PDP; 2PDQ; 2PDU; 2PDW; 2PDX; 2PDY; 2PEV; 2PF8; 2PFH; 2PZN; 2QXW; 2R24; 
				2VDG; 2WZM; 2WZT; 3B3D; 3BCJ; 3BUR; 3BUV; 3BV7; 3C3U; 3CAQ; 3CAS; 3CAV; 
				3CMF; 3COT; 3CV6; 3CV7; 3D3F; 3DN5; 3DOP; 3F7J; 3FJN; 3FX4; 3G1R; 3G5E; 
				3GHR; 3GHS; 3GHT; 3GHU; 3GUG; 3H4G; 3H7R; 3H7U; 3LBO; 3LD5; 3LEN; 3LEP; 
				3LN3; 3LQG; 3LQL; 3LZ3; 3LZ5; 3M0I; 3M4H; 3M64; 3MB9; 3MC5; 3NTY; 3O3R; 
				3ONB; 3ONC; 3P2V; 3Q65; 3Q67; 3QKZ; 3R43; 3R58; 3R6I; 3R7M; 3R8G; 3R8H; 
				3R94; 3RX2; 3RX3; 3RX4; 3S3G; 3T42; 3U2C; 3UFY; 3UG8; 3UGR; 3UWE; 3UZW; 
				3UZX; 3UZY; 3UZZ; 3V35; 3V36; 3WCZ; 3WG6; 4DBS; 4DBU; 4DBW; 4DZ5; 4F40; 
				4FA3; 4FAL; 4FAM; 4FZI; 4G5D; 4GA8; 4GAB; 4GAC; 4GCA; 4GIE; 4GQ0; 4GQG; 
				4H7C; 4HMN; 4I5X; 4ICC; 4IGS; 4IJC; 4IJR; 4JIH; 4JII; 4JIR; 4JQ1; 4JQ2; 
				4JQ3; 4JQ4; 4JQA; 4JTQ; 4JTR; 4L1W; 4L1X; 4LAU; 4LAZ; 4LB3; 4LB4; 4LBR; 
				4LBS; 4NKC; 4OTK; 4PR4; 4PRR; 4PRT; 4PUU; 4PUW; 4Q7B; 4QBX; 4QR6; 4QX4; 
				4QXI; 4RPQ; 4WDT; 4WDU; 4WDW; 4WDX; 4WEV; 4WRH; 4XO6; 4XO7; 4XVD; 4XVE; 
				4XZH; 4XZI; 4XZL; 4XZM; 4XZN; 4YS1; 4YU1; 4YVP; 4YVV; 4YVX; 4ZFC; 5HA7; 
				5HNT; 5HNU; 5LIK; 5LIU; 5LIW; 5LIX; 5LIY; 5M2F; 5OU0; 5OUJ; 5OUK; 5UXF; 
				5Y7N; 5Z6T; 5Z6U; 6A7A; 6A7B; 6F2U; 6F78; 6F7R; 6F81; 6F82; 6F84; 6F8O; 
				6GXK; 6IJX; 6M7K; 6SYW; 6T27; 6T3P; 6T5G; 6T7Q; 6TD8; 6TUC; 6TUF; 6TXP; 
				6XUM; 6Y03; 6Y1P; 7BBY; 7BBZ; 7BC0; 7BC1; 7C7F; 7C7G; 7C7H; 7MBF; 7WQM; 
				7WQR; 7WQS; 7X3L; 7X3M; 7X3O; 8A4N; 8AE9; 8AQG; 8AQP; 8AUU; 8B34; 8B3N; 
				8B3R; 8B66; 8BBS; 8BJL; 8CNF; 8CNP; 8FH5; 8FH6; 8FH7; 8FH8; 8FH9; 8I0C; 
				8JP1; 8JP2; 8OZ2; 8P2R; 8RB6; 9FFD
			
			

			» more