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PROSITE entry PS00063


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PURL: https://purl.expasy.org/prosite/signature/PS00063

Direct ScanProsite submission
General information about the entry

Entry name [info] ALDOKETO_REDUCTASE_3
Accession [info] PS00063
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00061

Name and characterization of the entry

Description [info] Aldo/keto reductase family putative active site signature.
Pattern [info] 
[LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x-
{LVRI}-[LIVMFA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 194 in 194 different sequences
Number of true positive hits 131 in 131 different sequences
Number of 'unknown' hits 0
Number of false positive hits 63 in 63 different sequences
Number of false negative sequences 73
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 67.53 %
Recall (true positives / (true positives + false negatives)) 64.22 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site(?) at position 8
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 131 sequences 

6DCS_SOYBN  (P26690), A1A1A_DANRE (Q6AZW2), A1A1B_DANRE (Q568L5), 

AK1A1_BOVIN (Q3ZCJ2), AK1A1_CHICK (Q5ZK84), AK1A1_CRIGR (O70473), 
AK1A1_HUMAN (P14550), AK1A1_MOUSE (Q9JII6), AK1A1_PIG   (P50578), 
AK1A1_PONAB (Q5R5D5), AK1A1_RAT   (P51635), AK1A1_XENLA (Q6GMC7), 
AK1A1_XENTR (Q28FD1), AK1BA_HUMAN (O60218), AK1C1_HUMAN (Q04828), 
AK1C1_MACFA (Q95JH7), AK1C1_MACFU (Q95JH6), AK1C1_PONAB (Q5REQ0), 
AK1C2_HUMAN (P52895), AK1C3_HUMAN (P42330), AK1C3_PONAB (Q5R7C9), 
AK1C4_HUMAN (P17516), AK1C4_MACFA (Q95JH5), AK1C4_MACFU (Q95JH4), 
AK1CA_RAT   (D3ZF77), AK1CN_HORSE (Q1XAA8), AK1CO_HORSE (Q6W8P9), 
AK1D1_HUMAN (P51857), AK1D1_MOUSE (Q8VCX1), AK1D1_RABIT (Q9TV64), 
AK1D1_RAT   (P31210), AK2E4_BOMMO (H9JTG9), AKC1H_MOUSE (Q8K023), 
AKC1H_RAT   (P51652), AKCL1_HUMAN (Q5T2L2), AKCL2_MOUSE (Q9DCT1), 
AKCL2_PIG   (P82125), AKCL2_RAT   (Q5U1Y4), AKRC8_ARATH (O80944), 
AKRC9_ARATH (Q0PGJ6), AKRCA_ARATH (Q84TF0), AKRCB_ARATH (Q9M338), 
AKR_CITSI   (P0DXG9), AKR_MELAZ   (P0DXH7), ALD1_MOUSE  (P21300), 
ALD2_CRIGR  (O08782), ALD2_MOUSE  (P45377), ALDR_BOVIN  (P16116), 
ALDR_DROME  (M9PF61), ALDR_HORVU  (P23901), ALDR_HUMAN  (P15121), 
ALDR_MOUSE  (P45376), ALDR_PIG(P80276), ALDR_RABIT  (P15122), 
ALDR_RAT(P07943), ALRB_DICDI  (Q54NZ7), ARA1_YEAST  (P38115), 
COR11_PAPSO (Q9SQ70), COR12_PAPSO (Q9SQ69), COR13_PAPSO (Q9SQ68), 
COR14_PAPSO (Q9SQ67), COR15_PAPSO (B9VRJ2), COR2_PAPSO  (Q9SQ64), 
CRO_AQUCT   (P17264), CRO_RANTE   (P02532), DDBX_BOVIN  (P52898), 
DHB5_MOUSE  (P70694), DIDH_RAT(P23457), DKGA_ECO57  (Q8XBT6), 
DKGA_ECOLI  (Q46857), DKGA_SALTI  (P58744), DKGA_SALTY  (Q8ZM06), 
DKGA_YERPE  (Q8ZI40), DKGB_CORSS  (P15339), DMAS1_HORVU (Q0PCF4), 
DMAS1_MAIZE (B4F9A4), DMAS1_ORYSJ (Q10PE7), DMS1A_WHEAT (W5DYE3), 
DMS1B_WHEAT (A0A1D5XGW0), DMS1D_WHEAT (A0A1X9QHJ0), DTDH_MUCMU  (Q01213), 
GAR1_HYPJE  (Q3ZFI7), GCY1_YEAST  (P14065), GLD2_HYPJE  (Q0GYU4), 
GRE3_YEAST  (P38715), GR_BACSU(O32210), MER_ERYCB   (E7C196), 
MIOX_MOUSE  (Q9QXN5), MIOX_RAT(Q9QXN4), MORA_PSEPU  (Q02198), 
MRP1_RAT(Q8CG09), NADO1_ORYSJ (Q7G764), NADO2_ORYSJ (Q7G765), 
PE2R_RABIT  (P80508), PGFS1_BOVIN (P05980), PGFS2_BOVIN (P52897), 
PGFS_LEIMA  (P22045), PGFS_TRYCC  (Q4DJ07), S6PD_MALDO  (P28475), 
STORR_PAPSO (P0DKI7), XYL1_ARTOC  (C5FFQ7), XYL1_ASPCL  (A1CRI1), 
XYL1_ASPFC  (B0XNR0), XYL1_ASPFN  (B8N195), XYL1_ASPFU  (Q4WJT9), 
XYL1_ASPNC  (A2Q8B5), XYL1_ASPNG  (Q9P8R5), XYL1_ASPOR  (Q2UKD0), 
XYL1_ASPTN  (Q0CUL0), XYL1_CANBO  (Q8X195), XYL1_CANPA  (Q6Y0Z3), 
XYL1_CANTE  (O74237), XYL1_CANTR  (O13283), XYL1_EMENI  (Q5BGA7), 
XYL1_NEOFI  (A1D4E3), XYL1_PICGU  (O94735), XYL1_PICST  (P31867), 
XYL1_SCHSH  (Q9P430), XYL2_CANTR  (P87039), Y1918_MYCSJ (A3PXS9), 
Y1919_MYCSJ (A3PXT0), Y1938_MYCSS (Q1BAN7), Y1984_MYCSK (A1UEC5), 
Y1985_MYCSK (A1UEC6), Y2408_MYCS2 (A0QV10), Y4205_MYCGI (A4TE41), 
YER5_SCHPO  (O14088), YJ66_YEAST  (P47137), YOF5_CAEEL  (Q09632), 
YPR1_YEAST  (Q12458), YTBE_BACSU  (O34678)
» more

UniProtKB/Swiss-Prot
False negative sequences		 73 sequences 

AK1BF_HUMAN (C9JRZ8), AK1CD_MESAU (P82809), AK1CD_MOUSE (Q8VC28), 

AK1CL_MOUSE (Q91WR5), AK1CL_RAT   (Q6AYQ2), AKCL2_HUMAN (Q96JD6), 
AKCL2_MACFA (Q4R802), AKR1_ORYSI  (B8ASB2), AKR1_ORYSJ  (Q0JE32), 
AKR1_SOYBN  (C6TBN2), AKR2_ORYSI  (A2XRZ0), AKR2_ORYSJ  (Q7XT99), 
AKR3_ORYSI  (A2XRZ6), AKR3_ORYSJ  (Q7XQ45), AKRMG_ECOLI (P77256), 
AKR_SYNY3   (P74308), ALDX_SPOSA  (P27800), ALKR1_ARATH (Q9C5B9), 
ALKR2_ARATH (Q84M96), ALKR3_ARATH (O22707), ALKR4_ARATH (Q93ZN2), 
ALKR5_ARATH (Q9ASZ9), ALKR6_ARATH (F4HPY8), ALRA_DICDI  (Q6IMN8), 
ALRC_DICDI  (Q55FL3), ARA2_YEAST  (Q04212), DHGRD_AGRFC (A9CEY6), 
DHGRD_NOVAD (Q2G5J3), DKGA_CORSC  (P06632), DKGB_ECO57  (Q8X7Z7), 
DKGB_ECOLI  (P30863), DKGB_SALTI  (Q8Z988), DKGB_SALTY  (Q8ZRM7), 
DKGB_YERPE  (Q8ZH36), FCDH_PSESP  (Q52472), GALDH_ARATH (O81884), 
GLD1_HYPJE  (Q0GYU5), GS69_BACSU  (P80874), I3ACR_SCHPO (O13848), 
IOLS_BACSU  (P46336), KAR_YEAST   (Q07551), MORA_RABIT  (P82810), 
PERR_RAUSE  (Q3L181), PGFS_TRYBB  (Q9GV41), PLR1_SCHPO  (O14295), 
PLR1_YEAST  (Q06494), PLR2_SCHPO  (O94521), PRD1_PYRO7  (G4MZI3), 
XYL1_HYPJE  (Q876L8), XYL1_KLULA  (P49378), XYL1_PACTA  (P78736), 
XYL1_PYRO7  (G4N708), Y1669_MYCLB (B8ZS00), Y1669_MYCLE (O69462), 
Y1744_MYCMM (B2HIJ9), Y1987_MYCUA (A0PQ11), Y2161_MYCVP (A1T726), 
Y2407_MYCS2 (A0QV09), Y2971_MYCTO (P9WQA4), Y2971_MYCTU (P9WQA5), 
Y2993_MYCBP (A1KMW6), Y2996_MYCBO (Q7TXI6), Y2999_MYCTA (A5U6Y1), 
Y3007_MYCPA (Q73VK6), Y3816_MYCA1 (A0QJ99), Y4149_MYCPA (Q73SC5), 
Y4483_MYCA1 (A0QL30), YBN4_SCHPO  (O42888), YDG7_SCHPO  (Q10494), 
YEAE_ECOLI  (P76234), YEZB_SCHPO  (O14125), YH5B_SCHPO  (O94315), 
YKW2_SCHPO  (Q9C1X5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

CROB_LEPLU  (P49261), DHGP_ASPNG  (P55804)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			63 sequences
			


			
AAP1_ARATH  (Q42400), AAP6_ARATH  (P92934), ATPFD_MYCA9 (B1MLV9), 

			
BST1_EREGS  (Q752Q2), CK024_HUMAN (Q96F05), DEXH4_ARATH (Q9C6G0), 
EIF3C_ASPOR (Q2U0Q9), EIF3C_ASPTN (Q0CVT0), EIF3C_BOMMO (Q0ZB76), 
FAD3_RICPR  (Q9ZCZ1), FGFP3_MOUSE (Q1HCM0), H34_TETTS   (Q22RG7), 
HMUV_PHOLL  (Q7N3S7), LPIN2_MOUSE (Q99PI5), MACBH_PSEPF (Q3KE48), 
MEIKN_HUMAN (A0A087WXM9), MURC_BART1  (A9IWA4), MUTS_AGRFC  (Q8UIF2), 
MUTS_AZOC5  (A8I275), MUTS_BARHE  (Q6G542), MUTS_BARQU  (Q6G0X1), 
MUTS_BART1  (A9ILT1), MUTS_BRUA2  (Q2YNZ0), MUTS_BRUA4  (A6WV86), 
MUTS_BRUAB  (Q57FM9), MUTS_BRUC2  (A9M792), MUTS_BRUME  (Q8YES6), 
MUTS_BRUO2  (A5VN83), MUTS_BRUSI  (B0CIQ5), MUTS_BRUSU  (Q8G310), 
MUTS_CHESB  (Q11B27), MUTS_RHIEC  (Q2KD76), MUTS_RHIJ3  (Q1MMA5), 
NAGS_NEUCR  (Q1K8F6), NAGS_PODAN  (B2B2C5), NIGP_LACP7  (A9KT32), 
NTND_NECSZ  (A0A455LLW5), NUP85_ARATH (Q8RXH2), OFOB2_AERPE (Q9YBX8), 
PB1_CHICK   (Q90941), PB1_HUMAN   (Q86U86), PI4KA_BOVIN (O02811), 
PI4KA_HUMAN (P42356), PI4KA_MOUSE (E9Q3L2), PI4KA_RAT   (O08662), 
PTA_DEIGD   (Q1J2D0), RL13_SACS2  (P95991), RR18_GRATL  (Q6B8S1), 
RR18_TETOB  (Q1KVT1), RS18_THET2  (P62659), RS18_THET8  (Q5SLQ0), 
RS18_THETH  (P80382), SECA_PHATC  (A0T0G5), SYE_LACGA   (Q045X9), 
SYE_LACJO   (Q74L27), TRMB_CAMFF  (A0RQ93), U507_KLULA  (Q6CSG8), 
VLMS_LECSP  (A0A024F910), XERC_RICPR  (Q9ZCE0), XERC_RICTY  (Q68VT2), 
Y109_OSHVF  (Q6R7C1), Y2014_VIBVU (Q8DB14), Y2402_VIBVY (Q7MIW1)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			342 PDB
			


			pdb_00001abn; pdb_00001ads; pdb_00001ae4; pdb_00001afs; pdb_00001ah0; pdb_00001ah3; pdb_00001ah4; pdb_00001az1; pdb_00001az2; pdb_00001c9w; pdb_00001cwn; pdb_00001dla; 
			
				pdb_00001ef3; pdb_00001eko; pdb_00001el3; pdb_00001frb; pdb_00001hqt; pdb_00001iei; pdb_00001ihi; pdb_00001j96; pdb_00001jez; pdb_00001k8c; pdb_00001lwi; pdb_00001mar; 
				pdb_00001mi3; pdb_00001mrq; pdb_00001mzr; pdb_00001pwl; pdb_00001pwm; pdb_00001q13; pdb_00001q5m; pdb_00001r38; pdb_00001ral; pdb_00001ry0; pdb_00001ry8; pdb_00001s1p; 
				pdb_00001s1r; pdb_00001s2a; pdb_00001s2c; pdb_00001sm9; pdb_00001t40; pdb_00001t41; pdb_00001us0; pdb_00001x96; pdb_00001x97; pdb_00001x98; pdb_00001xf0; pdb_00001xjb; 
				pdb_00001ye4; pdb_00001ye6; pdb_00001z3n; pdb_00001z89; pdb_00001z8a; pdb_00001z9a; pdb_00001zq5; pdb_00001zua; pdb_00002acq; pdb_00002acr; pdb_00002acs; pdb_00002acu; 
				pdb_00002agt; pdb_00002alr; pdb_00002bgq; pdb_00002bgs; pdb_00002dux; pdb_00002duz; pdb_00002dv0; pdb_00002f2k; pdb_00002f38; pdb_00002fgb; pdb_00002fvl; pdb_00002fz8; 
				pdb_00002fz9; pdb_00002fzb; pdb_00002fzd; pdb_00002hdj; pdb_00002huo; pdb_00002hv5; pdb_00002hvn; pdb_00002hvo; pdb_00002i16; pdb_00002i17; pdb_00002ikg; pdb_00002ikh; 
				pdb_00002iki; pdb_00002ikj; pdb_00002ine; pdb_00002inz; pdb_00002ipj; pdb_00002ipw; pdb_00002iq0; pdb_00002iqd; pdb_00002is7; pdb_00002isf; pdb_00002j8t; pdb_00002nvc; 
				pdb_00002nvd; pdb_00002pd5; pdb_00002pd9; pdb_00002pdb; pdb_00002pdc; pdb_00002pdf; pdb_00002pdg; pdb_00002pdh; pdb_00002pdi; pdb_00002pdj; pdb_00002pdk; pdb_00002pdl; 
				pdb_00002pdm; pdb_00002pdn; pdb_00002pdp; pdb_00002pdq; pdb_00002pdu; pdb_00002pdw; pdb_00002pdx; pdb_00002pdy; pdb_00002pev; pdb_00002pf8; pdb_00002pfh; pdb_00002pzn; 
				pdb_00002qxw; pdb_00002r24; pdb_00002vdg; pdb_00003b3d; pdb_00003bcj; pdb_00003bur; pdb_00003buv; pdb_00003bv7; pdb_00003bxd; pdb_00003c3u; pdb_00003caq; pdb_00003cas; 
				pdb_00003cav; pdb_00003cmf; pdb_00003cot; pdb_00003cv7; pdb_00003d3f; pdb_00003dn5; pdb_00003dop; pdb_00003f7j; pdb_00003fx4; pdb_00003g1r; pdb_00003g5e; pdb_00003ghr; 
				pdb_00003ghs; pdb_00003ght; pdb_00003ghu; pdb_00003gug; pdb_00003h4g; pdb_00003h7r; pdb_00003h7u; pdb_00003lbo; pdb_00003ld5; pdb_00003len; pdb_00003lep; pdb_00003lqg; 
				pdb_00003lql; pdb_00003lz3; pdb_00003lz5; pdb_00003m0i; pdb_00003m4h; pdb_00003m64; pdb_00003mb9; pdb_00003mc5; pdb_00003nty; pdb_00003onb; pdb_00003onc; pdb_00003p2v; 
				pdb_00003q65; pdb_00003q67; pdb_00003r43; pdb_00003r58; pdb_00003r6i; pdb_00003r7m; pdb_00003r8g; pdb_00003r8h; pdb_00003r94; pdb_00003rx2; pdb_00003rx3; pdb_00003rx4; 
				pdb_00003s3g; pdb_00003t42; pdb_00003u2c; pdb_00003ufy; pdb_00003ug8; pdb_00003ugr; pdb_00003uwe; pdb_00003uzw; pdb_00003uzx; pdb_00003uzy; pdb_00003uzz; pdb_00003v35; 
				pdb_00003v36; pdb_00003wcz; pdb_00004dbs; pdb_00004dbu; pdb_00004dbw; pdb_00004dz5; pdb_00004f40; pdb_00004fa3; pdb_00004fal; pdb_00004fam; pdb_00004fzi; pdb_00004g5d; 
				pdb_00004ga8; pdb_00004gab; pdb_00004gac; pdb_00004gca; pdb_00004gie; pdb_00004gq0; pdb_00004gqg; pdb_00004h7c; pdb_00004hmn; pdb_00004i5x; pdb_00004icc; pdb_00004igs; 
				pdb_00004ijc; pdb_00004ijr; pdb_00004jih; pdb_00004jii; pdb_00004jir; pdb_00004jq1; pdb_00004jq2; pdb_00004jq3; pdb_00004jq4; pdb_00004jqa; pdb_00004jtq; pdb_00004jtr; 
				pdb_00004l1w; pdb_00004l1x; pdb_00004lau; pdb_00004laz; pdb_00004lb3; pdb_00004lb4; pdb_00004lbr; pdb_00004lbs; pdb_00004nkc; pdb_00004pr4; pdb_00004prr; pdb_00004prt; 
				pdb_00004puu; pdb_00004puw; pdb_00004q7b; pdb_00004qbx; pdb_00004qr6; pdb_00004qx4; pdb_00004qxi; pdb_00004rpq; pdb_00004wdt; pdb_00004wdu; pdb_00004wdw; pdb_00004wdx; 
				pdb_00004wev; pdb_00004wrh; pdb_00004xo6; pdb_00004xo7; pdb_00004xvd; pdb_00004xve; pdb_00004xzh; pdb_00004xzi; pdb_00004xzl; pdb_00004xzm; pdb_00004xzn; pdb_00004ys1; 
				pdb_00004yu1; pdb_00004yvp; pdb_00004yvv; pdb_00004yvx; pdb_00004zfc; pdb_00005ha7; pdb_00005hnt; pdb_00005hnu; pdb_00005lik; pdb_00005liu; pdb_00005liw; pdb_00005lix; 
				pdb_00005liy; pdb_00005m2f; pdb_00005ou0; pdb_00005ouj; pdb_00005ouk; pdb_00005y7n; pdb_00005z6t; pdb_00005z6u; pdb_00006a7a; pdb_00006a7b; pdb_00006f2u; pdb_00006f78; 
				pdb_00006f7r; pdb_00006f81; pdb_00006f82; pdb_00006f84; pdb_00006f8o; pdb_00006gxk; pdb_00006ijx; pdb_00006syw; pdb_00006t27; pdb_00006t3p; pdb_00006t5g; pdb_00006t7q; 
				pdb_00006td8; pdb_00006tuc; pdb_00006tuf; pdb_00006txp; pdb_00006xum; pdb_00006y03; pdb_00006y1p; pdb_00007c7f; pdb_00007c7g; pdb_00007c7h; pdb_00007mbf; pdb_00007wqm; 
				pdb_00007wqr; pdb_00007wqs; pdb_00007x3l; pdb_00007x3m; pdb_00007x3o; pdb_00008a4n; pdb_00008ae9; pdb_00008aqg; pdb_00008aqp; pdb_00008auu; pdb_00008b34; pdb_00008b3n; 
				pdb_00008b3r; pdb_00008b66; pdb_00008bbs; pdb_00008bjl; pdb_00008cnf; pdb_00008cnp; pdb_00008fh5; pdb_00008fh6; pdb_00008fh7; pdb_00008fh8; pdb_00008fh9; pdb_00008i0c; 
				pdb_00008jp1; pdb_00008jp2; pdb_00008oz2; pdb_00008p2r; pdb_00008rb6; pdb_00009ffd
			
			

			» more