PROSITE entry PS00063
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Direct ScanProsite submission
General information about the entry
Entry name [info] | ALDOKETO_REDUCTASE_3 |
Accession [info] | PS00063 |
Entry type [info] | PATTERN |
Date [info] |
01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
PROSITE Doc. [info] | PDOC00061 |
Name and characterization of the entry
Description [info] | Aldo/keto reductase family putative active site signature. |
Pattern [info] |
[LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x- {LVRI}-[LIVMFA]. |
Numerical results [info]
Total number of hits | 190 in 190 different sequences |
Number of true positive hits | 127 in 127 different sequences |
Number of 'unknown' hits | 0 |
Number of false positive hits | 63 in 63 different sequences |
Number of false negative sequences | 73 |
Number of 'partial' sequences | 2 |
Precision (true positives / (true positives + false positives)) | 66.84 % |
Recall (true positives / (true positives + false negatives)) | 63.50 % |
Comments [info]
Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria) |
Maximum number of repetitions [info] | 1 |
Site [info] | active_site(?) at position 8 |
Version [info] | 2 |
Cross-references [info]
UniProtKB/Swiss-Prot True positive sequences |
127 sequences
6DCS_SOYBN (P26690), A1A1A_DANRE (Q6AZW2), A1A1B_DANRE (Q568L5), AK1A1_BOVIN (Q3ZCJ2), AK1A1_CHICK (Q5ZK84), AK1A1_CRIGR (O70473), AK1A1_HUMAN (P14550), AK1A1_MOUSE (Q9JII6), AK1A1_PIG (P50578), AK1A1_PONAB (Q5R5D5), AK1A1_RAT (P51635), AK1A1_XENLA (Q6GMC7), AK1A1_XENTR (Q28FD1), AK1BA_HUMAN (O60218), AK1C1_HUMAN (Q04828), AK1C1_MACFA (Q95JH7), AK1C1_MACFU (Q95JH6), AK1C1_PONAB (Q5REQ0), AK1C2_HUMAN (P52895), AK1C3_HUMAN (P42330), AK1C3_PONAB (Q5R7C9), AK1C4_HUMAN (P17516), AK1C4_MACFA (Q95JH5), AK1C4_MACFU (Q95JH4), AK1CA_RAT (D3ZF77), AK1CN_HORSE (Q1XAA8), AK1CO_HORSE (Q6W8P9), AK1D1_HUMAN (P51857), AK1D1_MOUSE (Q8VCX1), AK1D1_RABIT (Q9TV64), AK1D1_RAT (P31210), AK2E4_BOMMO (H9JTG9), AKC1H_MOUSE (Q8K023), AKC1H_RAT (P51652), AKCL2_MOUSE (Q9DCT1), AKCL2_PIG (P82125), AKCL2_RAT (Q5U1Y4), AKRC8_ARATH (O80944), AKRC9_ARATH (Q0PGJ6), AKRCA_ARATH (Q84TF0), AKRCB_ARATH (Q9M338), ALD1_MOUSE (P21300), ALD2_CRIGR (O08782), ALD2_MOUSE (P45377), ALDR_BOVIN (P16116), ALDR_HORVU (P23901), ALDR_HUMAN (P15121), ALDR_MOUSE (P45376), ALDR_PIG(P80276), ALDR_RABIT (P15122), ALDR_RAT(P07943), ALRB_DICDI (Q54NZ7), ARA1_YEAST (P38115), COR11_PAPSO (Q9SQ70), COR12_PAPSO (Q9SQ69), COR13_PAPSO (Q9SQ68), COR14_PAPSO (Q9SQ67), COR15_PAPSO (B9VRJ2), COR2_PAPSO (Q9SQ64), CRO_AQUCT (P17264), CRO_RANTE (P02532), DDBX_BOVIN (P52898), DHB5_MOUSE (P70694), DIDH_RAT(P23457), DKGA_ECO57 (Q8XBT6), DKGA_ECOLI (Q46857), DKGA_SALTI (P58744), DKGA_SALTY (Q8ZM06), DKGA_YERPE (Q8ZI40), DKGB_CORSS (P15339), DMAS1_HORVU (Q0PCF4), DMAS1_MAIZE (B4F9A4), DMAS1_ORYSJ (Q10PE7), DMS1A_WHEAT (W5DYE3), DMS1B_WHEAT (A0A1D5XGW0), DMS1D_WHEAT (A0A1X9QHJ0), DTDH_MUCMU (Q01213), GAR1_HYPJE (Q3ZFI7), GCY1_YEAST (P14065), GLD2_HYPJE (Q0GYU4), GRE3_YEAST (P38715), GR_BACSU(O32210), MER_ERYCB (E7C196), MIOX_MOUSE (Q9QXN5), MIOX_RAT(Q9QXN4), MORA_PSEPU (Q02198), MRP1_RAT(Q8CG09), NADO1_ORYSJ (Q7G764), NADO2_ORYSJ (Q7G765), PE2R_RABIT (P80508), PGFS1_BOVIN (P05980), PGFS2_BOVIN (P52897), PGFS_LEIMA (P22045), PGFS_TRYCC (Q4DJ07), S6PD_MALDO (P28475), STORR_PAPSO (P0DKI7), XYL1_ARTOC (C5FFQ7), XYL1_ASPCL (A1CRI1), XYL1_ASPFC (B0XNR0), XYL1_ASPFN (B8N195), XYL1_ASPFU (Q4WJT9), XYL1_ASPNC (A2Q8B5), XYL1_ASPNG (Q9P8R5), XYL1_ASPOR (Q2UKD0), XYL1_ASPTN (Q0CUL0), XYL1_CANBO (Q8X195), XYL1_CANPA (Q6Y0Z3), XYL1_CANTE (O74237), XYL1_CANTR (O13283), XYL1_EMENI (Q5BGA7), XYL1_NEOFI (A1D4E3), XYL1_PICGU (O94735), XYL1_PICST (P31867), XYL1_SCHSH (Q9P430), XYL2_CANTR (P87039), Y1918_MYCSJ (A3PXS9), Y1919_MYCSJ (A3PXT0), Y1938_MYCSS (Q1BAN7), Y1984_MYCSK (A1UEC5), Y1985_MYCSK (A1UEC6), Y2408_MYCS2 (A0QV10), Y4205_MYCGI (A4TE41), YER5_SCHPO (O14088), YJ66_YEAST (P47137), YOF5_CAEEL (Q09632), YPR1_YEAST (Q12458), YTBE_BACSU (O34678)» more
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UniProtKB/Swiss-Prot False negative sequences |
73 sequences
AK1BF_HUMAN (C9JRZ8), AK1CD_MESAU (P82809), AK1CD_MOUSE (Q8VC28), AK1CL_MOUSE (Q91WR5), AK1CL_RAT (Q6AYQ2), AKCL1_HUMAN (Q5T2L2), AKCL2_HUMAN (Q96JD6), AKCL2_MACFA (Q4R802), AKR1_ORYSI (B8ASB2), AKR1_ORYSJ (Q0JE32), AKR1_SOYBN (C6TBN2), AKR2_ORYSI (A2XRZ0), AKR2_ORYSJ (Q7XT99), AKR3_ORYSI (A2XRZ6), AKR3_ORYSJ (Q7XQ45), AKRMG_ECOLI (P77256), AKR_SYNY3 (P74308), ALDX_SPOSA (P27800), ALKR1_ARATH (Q9C5B9), ALKR2_ARATH (Q84M96), ALKR3_ARATH (O22707), ALKR4_ARATH (Q93ZN2), ALKR5_ARATH (Q9ASZ9), ALKR6_ARATH (F4HPY8), ALRA_DICDI (Q6IMN8), ALRC_DICDI (Q55FL3), ARA2_YEAST (Q04212), DHGRD_AGRFC (A9CEY6), DHGRD_NOVAD (Q2G5J3), DKGA_CORSC (P06632), DKGB_ECO57 (Q8X7Z7), DKGB_ECOLI (P30863), DKGB_SALTI (Q8Z988), DKGB_SALTY (Q8ZRM7), DKGB_YERPE (Q8ZH36), FCDH_PSESP (Q52472), GALDH_ARATH (O81884), GLD1_HYPJE (Q0GYU5), GS69_BACSU (P80874), I3ACR_SCHPO (O13848), IOLS_BACSU (P46336), KAR_YEAST (Q07551), MORA_RABIT (P82810), PERR_RAUSE (Q3L181), PGFS_TRYBB (Q9GV41), PLR1_SCHPO (O14295), PLR1_YEAST (Q06494), PLR2_SCHPO (O94521), PRD1_PYRO7 (G4MZI3), XYL1_HYPJE (Q876L8), XYL1_KLULA (P49378), XYL1_PACTA (P78736), XYL1_PYRO7 (G4N708), Y1669_MYCLB (B8ZS00), Y1669_MYCLE (O69462), Y1744_MYCMM (B2HIJ9), Y1987_MYCUA (A0PQ11), Y2161_MYCVP (A1T726), Y2407_MYCS2 (A0QV09), Y2971_MYCTO (P9WQA4), Y2971_MYCTU (P9WQA5), Y2993_MYCBP (A1KMW6), Y2996_MYCBO (Q7TXI6), Y2999_MYCTA (A5U6Y1), Y3007_MYCPA (Q73VK6), Y3816_MYCA1 (A0QJ99), Y4149_MYCPA (Q73SC5), Y4483_MYCA1 (A0QL30), YBN4_SCHPO (O42888), YDG7_SCHPO (Q10494), YEZB_SCHPO (O14125), YH5B_SCHPO (O94315), YKW2_SCHPO (Q9C1X5)» more |
UniProtKB/Swiss-Prot 'Partial' sequences |
2 sequences
CROB_LEPLU (P49261), DHGP_ASPNG (P55804) |
UniProtKB/Swiss-Prot False positive sequences |
63 sequences
AAP1_ARATH (Q42400), AAP6_ARATH (P92934), ATPFD_MYCA9 (B1MLV9), BST1_EREGS (Q752Q2), CK024_HUMAN (Q96F05), DEXH4_ARATH (Q9C6G0), EIF3C_ASPOR (Q2U0Q9), EIF3C_ASPTN (Q0CVT0), EIF3C_BOMMO (Q0ZB76), FAD3_RICPR (Q9ZCZ1), FGFP3_MOUSE (Q1HCM0), H34_TETTS (Q22RG7), HMUV_PHOLL (Q7N3S7), LPIN2_MOUSE (Q99PI5), MACBH_PSEPF (Q3KE48), MEIKN_HUMAN (A0A087WXM9), MURC_BART1 (A9IWA4), MUTS_AGRFC (Q8UIF2), MUTS_AZOC5 (A8I275), MUTS_BARHE (Q6G542), MUTS_BARQU (Q6G0X1), MUTS_BART1 (A9ILT1), MUTS_BRUA2 (Q2YNZ0), MUTS_BRUA4 (A6WV86), MUTS_BRUAB (Q57FM9), MUTS_BRUC2 (A9M792), MUTS_BRUME (Q8YES6), MUTS_BRUO2 (A5VN83), MUTS_BRUSI (B0CIQ5), MUTS_BRUSU (Q8G310), MUTS_CHESB (Q11B27), MUTS_RHIEC (Q2KD76), MUTS_RHIJ3 (Q1MMA5), NAGS_NEUCR (Q1K8F6), NAGS_PODAN (B2B2C5), NIGP_LACP7 (A9KT32), NTND_NECSZ (A0A455LLW5), NUP85_ARATH (Q8RXH2), OFOB2_AERPE (Q9YBX8), PB1_CHICK (Q90941), PB1_HUMAN (Q86U86), PI4KA_BOVIN (O02811), PI4KA_HUMAN (P42356), PI4KA_MOUSE (E9Q3L2), PI4KA_RAT (O08662), PTA_DEIGD (Q1J2D0), RL13_SACS2 (P95991), RR18_GRATL (Q6B8S1), RR18_TETOB (Q1KVT1), RS18_THET2 (P62659), RS18_THET8 (Q5SLQ0), RS18_THETH (P80382), SECA_PHATC (A0T0G5), SYE_LACGA (Q045X9), SYE_LACJO (Q74L27), TRMB_CAMFF (A0RQ93), U507_KLULA (Q6CSG8), VLMS_LECSP (A0A024F910), XERC_RICPR (Q9ZCE0), XERC_RICTY (Q68VT2), Y109_OSHVF (Q6R7C1), Y2014_VIBVU (Q8DB14), Y2402_VIBVY (Q7MIW1)» more |
PDB [Detailed view] |
341 PDB
1ABN; 1ADS; 1AE4; 1AFS; 1AH0; 1AH3; 1AH4; 1AZ1; 1AZ2; 1C9W; 1CWN; 1DLA; 1EF3; 1EKO; 1EL3; 1FRB; 1HQT; 1IEI; 1IHI; 1J96; 1JEZ; 1K8C; 1LWI; 1MAR; 1MI3; 1MRQ; 1MZR; 1PWL; 1PWM; 1Q13; 1Q5M; 1R38; 1RAL; 1RY0; 1RY8; 1S1P; 1S1R; 1S2A; 1S2C; 1SM9; 1T40; 1T41; 1US0; 1X96; 1X97; 1X98; 1XF0; 1XJB; 1YE4; 1YE6; 1Z3N; 1Z89; 1Z8A; 1Z9A; 1ZQ5; 1ZUA; 2ACQ; 2ACR; 2ACS; 2ACU; 2AGT; 2ALR; 2BGQ; 2BGS; 2DUX; 2DUZ; 2DV0; 2F2K; 2F38; 2FGB; 2FVL; 2FZ8; 2FZ9; 2FZB; 2FZD; 2HDJ; 2HUO; 2HV5; 2HVN; 2HVO; 2I16; 2I17; 2IKG; 2IKH; 2IKI; 2IKJ; 2INE; 2INZ; 2IPJ; 2IPW; 2IQ0; 2IQD; 2IS7; 2ISF; 2J8T; 2NVC; 2NVD; 2PD5; 2PD9; 2PDB; 2PDC; 2PDF; 2PDG; 2PDH; 2PDI; 2PDJ; 2PDK; 2PDL; 2PDM; 2PDN; 2PDP; 2PDQ; 2PDU; 2PDW; 2PDX; 2PDY; 2PEV; 2PF8; 2PFH; 2PZN; 2QXW; 2R24; 2VDG; 3B3D; 3BCJ; 3BUR; 3BUV; 3BV7; 3BXD; 3C3U; 3CAQ; 3CAS; 3CAV; 3CMF; 3COT; 3CV7; 3D3F; 3DN5; 3DOP; 3F7J; 3FX4; 3G1R; 3G5E; 3GHR; 3GHS; 3GHT; 3GHU; 3GUG; 3H4G; 3H7R; 3H7U; 3LBO; 3LD5; 3LEN; 3LEP; 3LQG; 3LQL; 3LZ3; 3LZ5; 3M0I; 3M4H; 3M64; 3MB9; 3MC5; 3NTY; 3ONB; 3ONC; 3P2V; 3Q65; 3Q67; 3R43; 3R58; 3R6I; 3R7M; 3R8G; 3R8H; 3R94; 3RX2; 3RX3; 3RX4; 3S3G; 3T42; 3U2C; 3UFY; 3UG8; 3UGR; 3UWE; 3UZW; 3UZX; 3UZY; 3UZZ; 3V35; 3V36; 3WCZ; 4DBS; 4DBU; 4DBW; 4DZ5; 4F40; 4FA3; 4FAL; 4FAM; 4FZI; 4G5D; 4GA8; 4GAB; 4GAC; 4GCA; 4GIE; 4GQ0; 4GQG; 4H7C; 4HMN; 4I5X; 4ICC; 4IGS; 4IJC; 4IJR; 4JIH; 4JII; 4JIR; 4JQ1; 4JQ2; 4JQ3; 4JQ4; 4JQA; 4JTQ; 4JTR; 4L1W; 4L1X; 4LAU; 4LAZ; 4LB3; 4LB4; 4LBR; 4LBS; 4NKC; 4PR4; 4PRR; 4PRT; 4PUU; 4PUW; 4Q7B; 4QBX; 4QR6; 4QX4; 4QXI; 4RPQ; 4WDT; 4WDU; 4WDW; 4WDX; 4WEV; 4WRH; 4XO6; 4XO7; 4XVD; 4XVE; 4XZH; 4XZI; 4XZL; 4XZM; 4XZN; 4YS1; 4YU1; 4YVP; 4YVV; 4YVX; 4ZFC; 5HA7; 5HNT; 5HNU; 5LIK; 5LIU; 5LIW; 5LIX; 5LIY; 5M2F; 5OU0; 5OUJ; 5OUK; 5Y7N; 5Z6T; 5Z6U; 6A7A; 6A7B; 6F2U; 6F78; 6F7R; 6F81; 6F82; 6F84; 6F8O; 6GXK; 6IJX; 6SYW; 6T27; 6T3P; 6T5G; 6T7Q; 6TD8; 6TUC; 6TUF; 6TXP; 6XUM; 6Y03; 6Y1P; 7C7F; 7C7G; 7C7H; 7MBF; 7WQM; 7WQR; 7WQS; 7X3L; 7X3M; 7X3O; 8A4N; 8AE9; 8AQG; 8AQP; 8AUU; 8B34; 8B3N; 8B3R; 8B66; 8BBS; 8BJL; 8CNF; 8CNP; 8FH5; 8FH6; 8FH7; 8FH8; 8FH9; 8I0C; 8JP1; 8JP2; 8OZ2; 8P2R; 8RB6 » more |