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PROSITE entry PS00064


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General information about the entry

Entry name [info] L_LDH
Accession [info] PS00064
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-MAY-1991 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00062
Associated ProRule [info] PRU10002

Name and characterization of the entry

Description [info] L-lactate dehydrogenase active site.
Pattern [info] 
[LIVMA]-G-[EQ]-H-G-[DN]-[ST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 306 in 306 different sequences
Number of true positive hits 298 in 298 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 13
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.39 %
Recall (true positives / (true positives + false negatives)) 95.82 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 298 sequences 

DHL2_WEICO  (P14295), LDH1_BACAN  (Q81RW4), LDH1_BACC1  (P62047), 

LDH1_BACCR  (Q81EP4), LDH1_BACCZ  (Q63CN1), LDH1_BACHK  (Q6HK31), 
LDH1_BIFL2  (E8MJ15), LDH1_BIFLO  (P59050), LDH1_CLOAB  (Q97MD1), 
LDH1_ENTFA  (Q839C1), LDH1_LACAC  (Q5FMB0), LDH1_LACJO  (P62052), 
LDH1_LACLA  (Q01462), LDH1_LACLC  (P04034), LDH1_LACPL  (P56512), 
LDH1_LISIN  (Q92F65), LDH1_LISMF  (Q724K3), LDH1_LISMO  (P33380), 
LDH1_PERPY  (P14561), LDH1_STAA1  (A7WXP7), LDH1_STAA2  (A6TY25), 
LDH1_STAA3  (Q2FK29), LDH1_STAA8  (Q2G218), LDH1_STAA9  (A5IPA9), 
LDH1_STAAB  (Q2YV38), LDH1_STAAC  (Q5HJD7), LDH1_STAAE  (A6QDL6), 
LDH1_STAAM  (P65255), LDH1_STAAN  (P65256), LDH1_STAAR  (Q6GK73), 
LDH1_STAAS  (Q6GCN4), LDH1_STAAT  (A8Z0K3), LDH1_STAAW  (P65257), 
LDH2_BACAN  (Q81K80), LDH2_BACC1  (P62048), LDH2_BACCR  (Q816G3), 
LDH2_BACCZ  (Q632G8), LDH2_BACHK  (Q6HC14), LDH2_BIFL2  (E8ME30), 
LDH2_BIFLO  (P0CW93), LDH2_ENTFA  (Q838C9), LDH2_LACAC  (Q5FKK7), 
LDH2_LACJO  (P62053), LDH2_LACLA  (Q9CII4), LDH2_LACLC  (P0C2T6), 
LDH2_LACPL  (P59390), LDH2_LISIN  (Q92BI0), LDH2_LISMF  (Q71ZD6), 
LDH2_LISMO  (Q8Y6Z6), LDH2_PERPY  (P20619), LDH2_STAA1  (A7X6Y1), 
LDH2_STAA2  (A6U4Y2), LDH2_STAA3  (Q2FDQ7), LDH2_STAA8  (Q2G1Y5), 
LDH2_STAA9  (A5IW27), LDH2_STAAB  (Q2YWF6), LDH2_STAAC  (Q5HCV0), 
LDH2_STAAE  (A6QK89), LDH2_STAAM  (P65258), LDH2_STAAN  (P99119), 
LDH2_STAAR  (Q6GDK1), LDH2_STAAS  (Q6G674), LDH2_STAAT  (P0C7U6), 
LDH2_STAAW  (Q8NUM9), LDH3_BACAN  (Q81XJ7), LDH3_BACC1  (P62049), 
LDH3_BACCR  (Q815X8), LDH3_BACCZ  (Q631X2), LDH3_BACHK  (Q6HBQ8), 
LDH6A_HUMAN (Q6ZMR3), LDH6B_BOVIN (Q3T056), LDH6B_HUMAN (Q9BYZ2), 
LDH6B_MACFA (Q4R816), LDHA_ALLMI  (Q9PW06), LDHA_AMBME  (Q9W7M6), 
LDHA_BOSMU  (A0A1F3), LDHA_BOVIN  (P19858), LDHA_CAICA  (Q98SL2), 
LDHA_CHAAC  (P69080), LDHA_CHAGU  (O93541), LDHA_CHICK  (P00340), 
LDHA_CHIRA  (P69081), LDHA_COLLI  (Q9PW07), LDHA_CYPCA  (Q9W7K5), 
LDHA_DANRE  (Q9PVK5), LDHA_DISEL  (Q9PW61), LDHA_DISMA  (O93544), 
LDHA_ELEMC  (O93542), LDHA_FUNHE  (Q92055), LDHA_GILMI  (P69083), 
LDHA_GILSE  (P69084), LDHA_GOBGI  (O93540), LDHA_HARAN  (O93537), 
LDHA_HORVU  (P22988), LDHA_HUMAN  (P00338), LDHA_LINNU  (O93545), 
LDHA_LYCDA  (Q9PW58), LDHA_MACFA  (Q9BE24), LDHA_MONDO  (Q9XT87), 
LDHA_MOUSE  (P06151), LDHA_NOTAN  (P69085), LDHA_NOTNE  (O93539), 
LDHA_PAGBO  (P69086), LDHA_PANTR  (Q5R1W9), LDHA_PARCR  (O93538), 
LDHA_PARMG  (O93543), LDHA_PATTE  (O93546), LDHA_PELSJ  (Q98SL0), 
LDHA_PIG(P00339), LDHA_PONAB  (Q5R5F0), LDHA_PYTRG  (Q9W7L3), 
LDHA_RABIT  (P13491), LDHA_RAT(P04642), LDHA_RHINC  (O93401), 
LDHA_RHIOR  (Q9P4B6), LDHA_SCEUN  (Q9W7L5), LDHA_SCEWO  (P79912), 
LDHA_SPHAG  (O13276), LDHA_SPHID  (O13277), LDHA_SPHLU  (O13278), 
LDHA_SQUAC  (P00341), LDHA_TRASE  (Q9PT43), LDHA_TREBE  (P69082), 
LDHA_XENLA  (P42120), LDHBA_DANRE (Q9PVK4), LDHBB_DANRE (Q6DGK2), 
LDHB_ALLMI  (Q9PW05), LDHB_ANAPL  (P13743), LDHB_ANGRO  (Q9YGL2), 
LDHB_BOVIN  (Q5E9B1), LDHB_CAICA  (Q98SL1), LDHB_CHICK  (P00337), 
LDHB_COLLI  (Q9PW04), LDHB_FUNHE  (P20373), LDHB_FUNPA  (P42122), 
LDHB_HORVU  (P22989), LDHB_HUMAN  (P07195), LDHB_MACFA  (Q4R5B6), 
LDHB_MONDO  (Q9XT86), LDHB_MOUSE  (P16125), LDHB_PANTR  (A5A6N7), 
LDHB_PELSJ  (Q98SK9), LDHB_PIG(P00336), LDHB_POLSE  (Q1EG91), 
LDHB_RABIT  (P13490), LDHB_RAT(P42123), LDHB_RHIOR  (Q9P4B5), 
LDHB_SCEUN  (Q9W7L4), LDHB_SCEWO  (P79913), LDHB_SQUAC  (Q9YI05), 
LDHB_TRASE  (Q9PT42), LDHB_XENLA  (P42119), LDHC_FUNHE  (Q06176), 
LDHC_HUMAN  (P07864), LDHC_MOUSE  (P00342), LDHC_PIG(Q9TSX5), 
LDHC_RAT(P19629), LDHC_VULVU  (Q29563), LDHC_XENLA  (P42121), 
LDH_ACET2   (Q8KQC4), LDH_ALLAM   (B9JTR0), LDH_BACCA   (P10655), 
LDH_BACCL   (Q59244), LDH_BACLD   (Q65NP0), LDH_BACP2   (A8F9Q8), 
LDH_BACSU   (P13714), LDH_BACVZ   (A7Z152), LDH_BIFA0   (B8DSV5), 
LDH_BORAP   (Q0SP77), LDH_BORBU   (O51114), LDH_BORBZ   (B7J121), 
LDH_BORGP   (Q662S5), LDH_BORHD   (B2S1S1), LDH_BORT9   (A1QYN6), 
LDH_CAEEL   (Q27888), LDH_CHLT3   (B3QX21), LDH_CLOB1   (A7FU32), 
LDH_CLOB6   (C3KVF0), LDH_CLOBH   (A5I1Z6), LDH_CLOBJ   (C1FMZ1), 
LDH_CLOBK   (B1IKX1), LDH_CLOBL   (A7GDK3), LDH_CLOBM   (B1L1N3), 
LDH_CLOP1   (Q0TUX8), LDH_CLOPE   (Q8XP62), LDH_CLOPS   (Q0SWR1), 
LDH_CLOTE   (Q892U0), LDH_CORDI   (P62050), LDH_COREF   (Q8FLV6), 
LDH_CORGB   (A4QHW5), LDH_CORGL   (Q8NLN0), LDH_CORJK   (Q4JY42), 
LDH_CUTAK   (Q6A9C3), LDH_DEIRA   (P50933), LDH_DESRM   (A4J898), 
LDH_DROME   (Q95028), LDH_FERNB   (A7HM89), LDH_FUSNN   (Q8RED8), 
LDH_GEODF   (B9LZ61), LDH_GEOKA   (Q5L2S0), LDH_GEOSE   (P00344), 
LDH_GEOSW   (C5D5V2), LDH_GEOTN   (A4IKL5), LDH_GLOVI   (Q7NG49), 
LDH_HALH5   (Q9K5Z8), LDH_KOSOT   (C5CGP2), LDH_LACCA   (P00343), 
LDH_LACDB   (Q04CN9), LDH_LACHE   (O32765), LDH_LACLM   (P0CI34), 
LDH_LACLN   (D8KFT1), LDH_LACPE   (P56511), LDH_LATSK   (P50934), 
LDH_LATSS   (Q38V71), LDH_LIGS1   (Q1WSG2), LDH_MACCJ   (B9E9F9), 
LDH_MAIZE   (P29038), LDH_MALP2   (Q8EUG3), LDH_MESFL   (Q6F0L9), 
LDH_MESH2   (P0C0J2), LDH_MESH7   (Q4A8M8), LDH_MESHJ   (P0C0J3), 
LDH_MESHO   (P0C0J4), LDH_MOOTA   (Q2RHG3), LDH_MYCCT   (Q2SS50), 
LDH_MYCGE   (P47698), LDH_MYCM1   (Q6KIP9), LDH_MYCMS   (P62054), 
LDH_MYCPN   (P78007), LDH_NITV2   (P62051), LDH_NITV4   (A1VG02), 
LDH_OCEIH   (Q8ELF0), LDH_PEDAC   (Q59645), LDH_PEDPA   (Q03DZ7), 
LDH_PETMA   (P33571), LDH_PETMO   (A9BGZ9), LDH_PRIMG   (P00345), 
LDH_PSELT   (A8F6M1), LDH_SALRD   (Q2S4R2), LDH_SCHPO   (Q9P7P7), 
LDH_SHOC1   (Q5WE04), LDH_STACT   (B9DN51), LDH_STAEQ   (Q5HL31), 
LDH_STAES   (Q8CMZ0), LDH_STAHJ   (Q4L941), LDH_STAS1   (Q49YJ3), 
LDH_STRA1   (Q3K1C8), LDH_STRA3   (Q8E5N4), LDH_STRA5   (Q8DZY3), 
LDH_STRE4   (C0M7H8), LDH_STREI   (Q59828), LDH_STREM   (B4U309), 
LDH_STRGC   (A8AXK9), LDH_STRMU   (P26283), LDH_STRP1   (P65259), 
LDH_STRP2   (Q04K99), LDH_STRP3   (P0DC18), LDH_STRP4   (B5E4V6), 
LDH_STRP6   (Q5XC59), LDH_STRP7   (C1C7I6), LDH_STRP8   (P65261), 
LDH_STRPB   (Q1JBQ9), LDH_STRPC   (Q1JLP1), LDH_STRPD   (Q1JGU2), 
LDH_STRPF   (Q1J6L1), LDH_STRPG   (A2REG9), LDH_STRPI   (B1IC17), 
LDH_STRPJ   (B8ZQ84), LDH_STRPM   (Q48TK0), LDH_STRPN   (P0A3M9), 
LDH_STRPQ   (P0DC19), LDH_STRPZ   (B5XLJ8), LDH_STRR6   (P0A3N0), 
LDH_STRS2   (A4W1K6), LDH_STRS7   (C0MFB5), LDH_STRSV   (A3CN70), 
LDH_STRSY   (A4VVA3), LDH_STRT1   (Q5LZ83), LDH_STRT2   (Q5M3T6), 
LDH_STRTD   (Q03K30), LDH_STRTR   (Q60009), LDH_STRU0   (B9DS53), 
LDH_STRZJ   (C1CEH8), LDH_STRZP   (C1CKW1), LDH_STRZT   (C1CR83), 
LDH_SYNJA   (Q2JRH2), LDH_SYNJB   (Q2JJQ1), LDH_THEAQ   (P13715), 
LDH_THECA   (P06150), LDH_THEMA   (P16115), LDH_THEP1   (A5IL75), 
LDH_THEP3   (B0KDA4), LDH_THEPX   (B0K226), LDH_THESQ   (B1LAF5), 
LDH_THESW   (Q7X5C9), LDH_THET2   (P62055), LDH_THET8   (Q5SJA1), 
LDH_TREDE   (P62056)
» more

UniProtKB/Swiss-Prot
False negative sequences		 13 sequences 

IND2_STRGR  (A0A0D4BSN8), LDH2_CLOAB  (Q97DC6), LDH3_LACLA  (Q9CGG8), 

LDH_BOTBR   (P93052), LDH_LIMF3   (B2GBW0), LDH_LIMRT   (Q8GMJ0), 
LDH_MYCGA   (O52354), LDH_MYCPU   (Q98PG4), LDH_PLABA   (Q7SI97), 
LDH_PLABE   (P84793), LDH_PLAFD   (Q27743), LDH_SELRU   (Q9EVR0), 
LDH_TOXGO   (Q27797)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

LDH_PLAFA   (P13774)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			8 sequences
			


			
IXTPA_CLOTE (Q891I4), MDH_ARCFU   (O08349), MDH_METJA   (Q60176), 

			
MDH_METKA   (Q8TWG5), MDH_METMP   (Q6LZI3), MTNA_CALS8  (A4XKS3), 
SPSA1_ORYSI (A2WYE9), SPSA1_ORYSJ (Q0JGK4)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			118 PDB
			


			1A5Z; 1EZ4; 1HYH; 1I0Z; 1I10; 1LDB; 1LDM; 1LDN; 1LLC; 1LLD; 1LTH; 1T2F; 
			
				1V6A; 2E37; 2LDB; 2LDX; 2V65; 2V6B; 2V6M; 2V7P; 2XXB; 2XXJ; 2ZQY; 2ZQZ; 
				3D0O; 3D4P; 3H3F; 3H3J; 3LDH; 3PQD; 3PQE; 3PQF; 3VPG; 3VPH; 3ZZN; 4A73; 
				4AJ1; 4AJ2; 4AJ4; 4AJE; 4AJH; 4AJI; 4AJJ; 4AJK; 4AJL; 4AJN; 4AJO; 4AJP; 
				4AL4; 4I8X; 4I9H; 4I9N; 4I9U; 4JNK; 4L4R; 4L4S; 4LMR; 4LN1; 4M49; 4OJN; 
				4OKN; 4QO7; 4QO8; 4QSM; 4QT0; 4R68; 4R69; 4RLS; 4ZVV; 5ES3; 5IXS; 5IXY; 
				5K0Z; 5KKC; 5LDH; 5NQB; 5NQQ; 5W8H; 5W8I; 5W8J; 5W8K; 5W8L; 5YTA; 5ZJD; 
				5ZJE; 5ZJF; 6BAD; 6BAG; 6BAX; 6BAZ; 6BB0; 6BB1; 6BB2; 6BB3; 6CEP; 6H9S; 
				6J9S; 6J9T; 6J9U; 6JML; 6LDH; 6MV8; 6MVA; 6P6U; 6Q0D; 6Q13; 6SBU; 6SBV; 
				6ZZR; 7DBJ; 7DBK; 7EPM; 7M2N; 7P4G; 8FW6; 8LDH; 9LDB; 9LDT
			
			

			» more