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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00064


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PURL: https://purl.expasy.org/prosite/signature/PS00064

Direct ScanProsite submission
General information about the entry

Entry name [info] L_LDH
Accession [info] PS00064
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-MAY-1991 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00062
Associated ProRule [info] PRU10002

Name and characterization of the entry

Description [info] L-lactate dehydrogenase active site.
Pattern [info] 
[LIVMA]-G-[EQ]-H-G-[DN]-[ST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 306 in 306 different sequences
Number of true positive hits 298 in 298 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 13
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.39 %
Recall (true positives / (true positives + false negatives)) 95.82 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 298 sequences 

DHL2_WEICO  (P14295), LDH1_BACAN  (Q81RW4), LDH1_BACC1  (P62047), 

LDH1_BACCR  (Q81EP4), LDH1_BACCZ  (Q63CN1), LDH1_BACHK  (Q6HK31), 
LDH1_BIFL2  (E8MJ15), LDH1_BIFLO  (P59050), LDH1_CLOAB  (Q97MD1), 
LDH1_ENTFA  (Q839C1), LDH1_LACAC  (Q5FMB0), LDH1_LACJO  (P62052), 
LDH1_LACLA  (Q01462), LDH1_LACLC  (P04034), LDH1_LACPL  (P56512), 
LDH1_LISIN  (Q92F65), LDH1_LISMF  (Q724K3), LDH1_LISMO  (P33380), 
LDH1_PERPY  (P14561), LDH1_STAA1  (A7WXP7), LDH1_STAA2  (A6TY25), 
LDH1_STAA3  (Q2FK29), LDH1_STAA8  (Q2G218), LDH1_STAA9  (A5IPA9), 
LDH1_STAAB  (Q2YV38), LDH1_STAAC  (Q5HJD7), LDH1_STAAE  (A6QDL6), 
LDH1_STAAM  (P65255), LDH1_STAAN  (P65256), LDH1_STAAR  (Q6GK73), 
LDH1_STAAS  (Q6GCN4), LDH1_STAAT  (A8Z0K3), LDH1_STAAW  (P65257), 
LDH2_BACAN  (Q81K80), LDH2_BACC1  (P62048), LDH2_BACCR  (Q816G3), 
LDH2_BACCZ  (Q632G8), LDH2_BACHK  (Q6HC14), LDH2_BIFL2  (E8ME30), 
LDH2_BIFLO  (P0CW93), LDH2_ENTFA  (Q838C9), LDH2_LACAC  (Q5FKK7), 
LDH2_LACJO  (P62053), LDH2_LACLA  (Q9CII4), LDH2_LACLC  (P0C2T6), 
LDH2_LACPL  (P59390), LDH2_LISIN  (Q92BI0), LDH2_LISMF  (Q71ZD6), 
LDH2_LISMO  (Q8Y6Z6), LDH2_PERPY  (P20619), LDH2_STAA1  (A7X6Y1), 
LDH2_STAA2  (A6U4Y2), LDH2_STAA3  (Q2FDQ7), LDH2_STAA8  (Q2G1Y5), 
LDH2_STAA9  (A5IW27), LDH2_STAAB  (Q2YWF6), LDH2_STAAC  (Q5HCV0), 
LDH2_STAAE  (A6QK89), LDH2_STAAM  (P65258), LDH2_STAAN  (P99119), 
LDH2_STAAR  (Q6GDK1), LDH2_STAAS  (Q6G674), LDH2_STAAT  (P0C7U6), 
LDH2_STAAW  (Q8NUM9), LDH3_BACAN  (Q81XJ7), LDH3_BACC1  (P62049), 
LDH3_BACCR  (Q815X8), LDH3_BACCZ  (Q631X2), LDH3_BACHK  (Q6HBQ8), 
LDH6A_HUMAN (Q6ZMR3), LDH6B_BOVIN (Q3T056), LDH6B_HUMAN (Q9BYZ2), 
LDH6B_MACFA (Q4R816), LDHA_ALLMI  (Q9PW06), LDHA_AMBME  (Q9W7M6), 
LDHA_BOSMU  (A0A1F3), LDHA_BOVIN  (P19858), LDHA_CAICA  (Q98SL2), 
LDHA_CHAAC  (P69080), LDHA_CHAGU  (O93541), LDHA_CHICK  (P00340), 
LDHA_CHIRA  (P69081), LDHA_COLLI  (Q9PW07), LDHA_CYPCA  (Q9W7K5), 
LDHA_DANRE  (Q9PVK5), LDHA_DISEL  (Q9PW61), LDHA_DISMA  (O93544), 
LDHA_ELEMC  (O93542), LDHA_FUNHE  (Q92055), LDHA_GILMI  (P69083), 
LDHA_GILSE  (P69084), LDHA_GOBGI  (O93540), LDHA_HARAN  (O93537), 
LDHA_HORVU  (P22988), LDHA_HUMAN  (P00338), LDHA_LINNU  (O93545), 
LDHA_LYCDA  (Q9PW58), LDHA_MACFA  (Q9BE24), LDHA_MONDO  (Q9XT87), 
LDHA_MOUSE  (P06151), LDHA_NOTAN  (P69085), LDHA_NOTNE  (O93539), 
LDHA_PAGBO  (P69086), LDHA_PANTR  (Q5R1W9), LDHA_PARCR  (O93538), 
LDHA_PARMG  (O93543), LDHA_PATTE  (O93546), LDHA_PELSJ  (Q98SL0), 
LDHA_PIG(P00339), LDHA_PONAB  (Q5R5F0), LDHA_PYTRG  (Q9W7L3), 
LDHA_RABIT  (P13491), LDHA_RAT(P04642), LDHA_RHINC  (O93401), 
LDHA_RHIOR  (Q9P4B6), LDHA_SCEUN  (Q9W7L5), LDHA_SCEWO  (P79912), 
LDHA_SPHAG  (O13276), LDHA_SPHID  (O13277), LDHA_SPHLU  (O13278), 
LDHA_SQUAC  (P00341), LDHA_TRASE  (Q9PT43), LDHA_TREBE  (P69082), 
LDHA_XENLA  (P42120), LDHBA_DANRE (Q9PVK4), LDHBB_DANRE (Q6DGK2), 
LDHB_ALLMI  (Q9PW05), LDHB_ANAPL  (P13743), LDHB_ANGRO  (Q9YGL2), 
LDHB_BOVIN  (Q5E9B1), LDHB_CAICA  (Q98SL1), LDHB_CHICK  (P00337), 
LDHB_COLLI  (Q9PW04), LDHB_FUNHE  (P20373), LDHB_FUNPA  (P42122), 
LDHB_HORVU  (P22989), LDHB_HUMAN  (P07195), LDHB_MACFA  (Q4R5B6), 
LDHB_MONDO  (Q9XT86), LDHB_MOUSE  (P16125), LDHB_PANTR  (A5A6N7), 
LDHB_PELSJ  (Q98SK9), LDHB_PIG(P00336), LDHB_POLSE  (Q1EG91), 
LDHB_RABIT  (P13490), LDHB_RAT(P42123), LDHB_RHIOR  (Q9P4B5), 
LDHB_SCEUN  (Q9W7L4), LDHB_SCEWO  (P79913), LDHB_SQUAC  (Q9YI05), 
LDHB_TRASE  (Q9PT42), LDHB_XENLA  (P42119), LDHC_FUNHE  (Q06176), 
LDHC_HUMAN  (P07864), LDHC_MOUSE  (P00342), LDHC_PIG(Q9TSX5), 
LDHC_RAT(P19629), LDHC_VULVU  (Q29563), LDHC_XENLA  (P42121), 
LDH_ACET2   (Q8KQC4), LDH_ALLAM   (B9JTR0), LDH_BACCA   (P10655), 
LDH_BACCL   (Q59244), LDH_BACLD   (Q65NP0), LDH_BACP2   (A8F9Q8), 
LDH_BACSU   (P13714), LDH_BACVZ   (A7Z152), LDH_BIFA0   (B8DSV5), 
LDH_BORAP   (Q0SP77), LDH_BORBU   (O51114), LDH_BORBZ   (B7J121), 
LDH_BORGP   (Q662S5), LDH_BORHD   (B2S1S1), LDH_BORT9   (A1QYN6), 
LDH_CAEEL   (Q27888), LDH_CHLT3   (B3QX21), LDH_CLOB1   (A7FU32), 
LDH_CLOB6   (C3KVF0), LDH_CLOBH   (A5I1Z6), LDH_CLOBJ   (C1FMZ1), 
LDH_CLOBK   (B1IKX1), LDH_CLOBL   (A7GDK3), LDH_CLOBM   (B1L1N3), 
LDH_CLOP1   (Q0TUX8), LDH_CLOPE   (Q8XP62), LDH_CLOPS   (Q0SWR1), 
LDH_CLOTE   (Q892U0), LDH_CORDI   (P62050), LDH_COREF   (Q8FLV6), 
LDH_CORGB   (A4QHW5), LDH_CORGL   (Q8NLN0), LDH_CORJK   (Q4JY42), 
LDH_CUTAK   (Q6A9C3), LDH_DEIRA   (P50933), LDH_DESRM   (A4J898), 
LDH_DROME   (Q95028), LDH_FERNB   (A7HM89), LDH_FUSNN   (Q8RED8), 
LDH_GEODF   (B9LZ61), LDH_GEOKA   (Q5L2S0), LDH_GEOSE   (P00344), 
LDH_GEOSW   (C5D5V2), LDH_GEOTN   (A4IKL5), LDH_GLOVI   (Q7NG49), 
LDH_HALH5   (Q9K5Z8), LDH_KOSOT   (C5CGP2), LDH_LACCA   (P00343), 
LDH_LACDB   (Q04CN9), LDH_LACHE   (O32765), LDH_LACLM   (P0CI34), 
LDH_LACLN   (D8KFT1), LDH_LACPE   (P56511), LDH_LATSK   (P50934), 
LDH_LATSS   (Q38V71), LDH_LIGS1   (Q1WSG2), LDH_MACCJ   (B9E9F9), 
LDH_MAIZE   (P29038), LDH_MALP2   (Q8EUG3), LDH_MESFL   (Q6F0L9), 
LDH_MESH2   (P0C0J2), LDH_MESH7   (Q4A8M8), LDH_MESHJ   (P0C0J3), 
LDH_MESHO   (P0C0J4), LDH_MOOTA   (Q2RHG3), LDH_MYCCT   (Q2SS50), 
LDH_MYCGE   (P47698), LDH_MYCM1   (Q6KIP9), LDH_MYCMS   (P62054), 
LDH_MYCPN   (P78007), LDH_NITV2   (P62051), LDH_NITV4   (A1VG02), 
LDH_OCEIH   (Q8ELF0), LDH_PEDAC   (Q59645), LDH_PEDPA   (Q03DZ7), 
LDH_PETMA   (P33571), LDH_PETMO   (A9BGZ9), LDH_PRIMG   (P00345), 
LDH_PSELT   (A8F6M1), LDH_SALRD   (Q2S4R2), LDH_SCHPO   (Q9P7P7), 
LDH_SHOC1   (Q5WE04), LDH_STACT   (B9DN51), LDH_STAEQ   (Q5HL31), 
LDH_STAES   (Q8CMZ0), LDH_STAHJ   (Q4L941), LDH_STAS1   (Q49YJ3), 
LDH_STRA1   (Q3K1C8), LDH_STRA3   (Q8E5N4), LDH_STRA5   (Q8DZY3), 
LDH_STRE4   (C0M7H8), LDH_STREI   (Q59828), LDH_STREM   (B4U309), 
LDH_STRGC   (A8AXK9), LDH_STRMU   (P26283), LDH_STRP1   (P65259), 
LDH_STRP2   (Q04K99), LDH_STRP3   (P0DC18), LDH_STRP4   (B5E4V6), 
LDH_STRP6   (Q5XC59), LDH_STRP7   (C1C7I6), LDH_STRP8   (P65261), 
LDH_STRPB   (Q1JBQ9), LDH_STRPC   (Q1JLP1), LDH_STRPD   (Q1JGU2), 
LDH_STRPF   (Q1J6L1), LDH_STRPG   (A2REG9), LDH_STRPI   (B1IC17), 
LDH_STRPJ   (B8ZQ84), LDH_STRPM   (Q48TK0), LDH_STRPN   (P0A3M9), 
LDH_STRPQ   (P0DC19), LDH_STRPZ   (B5XLJ8), LDH_STRR6   (P0A3N0), 
LDH_STRS2   (A4W1K6), LDH_STRS7   (C0MFB5), LDH_STRSV   (A3CN70), 
LDH_STRSY   (A4VVA3), LDH_STRT1   (Q5LZ83), LDH_STRT2   (Q5M3T6), 
LDH_STRTD   (Q03K30), LDH_STRTR   (Q60009), LDH_STRU0   (B9DS53), 
LDH_STRZJ   (C1CEH8), LDH_STRZP   (C1CKW1), LDH_STRZT   (C1CR83), 
LDH_SYNJA   (Q2JRH2), LDH_SYNJB   (Q2JJQ1), LDH_THEAQ   (P13715), 
LDH_THECA   (P06150), LDH_THEMA   (P16115), LDH_THEP1   (A5IL75), 
LDH_THEP3   (B0KDA4), LDH_THEPX   (B0K226), LDH_THESQ   (B1LAF5), 
LDH_THESW   (Q7X5C9), LDH_THET2   (P62055), LDH_THET8   (Q5SJA1), 
LDH_TREDE   (P62056)
» more

UniProtKB/Swiss-Prot
False negative sequences		 13 sequences 

IND2_STRGR  (A0A0D4BSN8), LDH2_CLOAB  (Q97DC6), LDH3_LACLA  (Q9CGG8), 

LDH_BOTBR   (P93052), LDH_LIMF3   (B2GBW0), LDH_LIMRT   (Q8GMJ0), 
LDH_MYCGA   (O52354), LDH_MYCPU   (Q98PG4), LDH_PLABA   (Q7SI97), 
LDH_PLABE   (P84793), LDH_PLAFD   (Q27743), LDH_SELRU   (Q9EVR0), 
LDH_TOXGO   (Q27797)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

LDH_PLAFA   (P13774)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			8 sequences
			


			
IXTPA_CLOTE (Q891I4), MDH_ARCFU   (O08349), MDH_METJA   (Q60176), 

			
MDH_METKA   (Q8TWG5), MDH_METMP   (Q6LZI3), MTNA_CALS8  (A4XKS3), 
SPSA1_ORYSI (A2WYE9), SPSA1_ORYSJ (Q0JGK4)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			123 PDB
			


			pdb_00001a5z; pdb_00001ez4; pdb_00001hyh; pdb_00001i0z; pdb_00001i10; pdb_00001ldb; pdb_00001ldm; pdb_00001ldn; pdb_00001llc; pdb_00001lld; pdb_00001lth; pdb_00001t2f; 
			
				pdb_00001v6a; pdb_00002e37; pdb_00002ldb; pdb_00002ldx; pdb_00002v65; pdb_00002v6b; pdb_00002v6m; pdb_00002v7p; pdb_00002xxb; pdb_00002xxj; pdb_00002zqy; pdb_00002zqz; 
				pdb_00003d0o; pdb_00003d4p; pdb_00003h3f; pdb_00003h3j; pdb_00003ldh; pdb_00003pqd; pdb_00003pqe; pdb_00003pqf; pdb_00003vpg; pdb_00003vph; pdb_00003zzn; pdb_00004a73; 
				pdb_00004aj1; pdb_00004aj2; pdb_00004aj4; pdb_00004aje; pdb_00004ajh; pdb_00004aji; pdb_00004ajj; pdb_00004ajk; pdb_00004ajl; pdb_00004ajn; pdb_00004ajo; pdb_00004ajp; 
				pdb_00004al4; pdb_00004i8x; pdb_00004i9h; pdb_00004i9n; pdb_00004i9u; pdb_00004jnk; pdb_00004l4r; pdb_00004l4s; pdb_00004lmr; pdb_00004ln1; pdb_00004m49; pdb_00004ojn; 
				pdb_00004okn; pdb_00004qo7; pdb_00004qo8; pdb_00004qsm; pdb_00004qt0; pdb_00004r68; pdb_00004r69; pdb_00004rls; pdb_00004zvv; pdb_00005es3; pdb_00005ixs; pdb_00005ixy; 
				pdb_00005k0z; pdb_00005kkc; pdb_00005ldh; pdb_00005nqb; pdb_00005nqq; pdb_00005w8h; pdb_00005w8i; pdb_00005w8j; pdb_00005w8k; pdb_00005w8l; pdb_00005yta; pdb_00005zjd; 
				pdb_00005zje; pdb_00005zjf; pdb_00006bad; pdb_00006bag; pdb_00006bax; pdb_00006baz; pdb_00006bb0; pdb_00006bb1; pdb_00006bb2; pdb_00006bb3; pdb_00006cep; pdb_00006h9s; 
				pdb_00006j9s; pdb_00006j9t; pdb_00006j9u; pdb_00006jml; pdb_00006ldh; pdb_00006mv8; pdb_00006mva; pdb_00006p6u; pdb_00006q0d; pdb_00006q13; pdb_00006sbu; pdb_00006sbv; 
				pdb_00006zzr; pdb_00007dbj; pdb_00007dbk; pdb_00007epm; pdb_00007m2n; pdb_00007p4g; pdb_00008fw6; pdb_00008ldh; pdb_00008qde; pdb_00009bk2; pdb_00009bk3; pdb_00009dq7; 
				pdb_00009dq9; pdb_00009ldb; pdb_00009ldt
			
			

			» more