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PROSITE entry PS00065


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General information about the entry

Entry name [info] D_2_HYDROXYACID_DH_1
Accession [info] PS00065
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00063

Name and characterization of the entry

Description [info] D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
Pattern [info] 
[LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-G-x(13,14)-
[LIVMFT]-{A}-x-[FYWCTH]-[DNSTK].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 249 in 249 different sequences
Number of true positive hits 195 in 195 different sequences
Number of 'unknown' hits 0
Number of false positive hits 54 in 54 different sequences
Number of false negative sequences 215
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 78.31 %
Recall (true positives / (true positives + false negatives)) 47.56 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 195 sequences 

2KGR_VITVI  (A5CAL1), CTBP1_CAEEL (Q20595), CTBP1_HUMAN (Q13363), 

CTBP1_MOUSE (O88712), CTBP1_RAT   (Q9Z2F5), CTBP1_XENLA (Q9YHU0), 
CTBP2_XENLA (Q9W758), DDH2_SCHPO  (Q9P7Q1), DDH_HAEIN   (P44501), 
DDH_ZYMMO   (P30799), DHD2_LACPA  (P17584), DHGY_CUCSA  (P13443), 
DHGY_HYPME  (P36234), DHGY_METEA  (Q59516), EFUE_HORCR  (A0A2Z4HPZ6), 
FDH1_ORYSJ  (Q9SXP2), FDH2_ORYSJ  (Q67U69), FDH_ARATH   (Q9S7E4), 
FDH_CANBO   (O13437), FDH_CHATD   (G0SGU4), FDH_EMENI   (Q03134), 
FDH_NEUCR   (Q07103), FDH_PICAN   (P33677), FDH_PSESR   (P33160), 
FDH_SOLTU   (Q07511), FLDH_CLOS1  (J7SHB8), FLDH_CLOS3  (G9EZR6), 
GHRB_YERE8  (A1JT62), GHRB_YERP3  (A7FPA2), GHRB_YERPA  (Q1C3K4), 
GHRB_YERPB  (B2K7F1), GHRB_YERPE  (Q0W9V5), GHRB_YERPG  (A9R4G6), 
GHRB_YERPN  (Q1CD80), GHRB_YERPP  (A4TGN1), GHRB_YERPS  (Q663W4), 
GHRB_YERPY  (B1JH01), GOR1_YEAST  (P53839), GYAR_AERPE  (Q9YAW4), 
GYAR_KORCO  (B1L765), GYAR_PYRAB  (Q9UYR1), GYAR_PYRFU  (Q8U3Y2), 
GYAR_PYRHO  (O58320), GYAR_THEGJ  (C5A1V0), GYAR_THEKO  (Q5JEZ2), 
GYAR_THELN  (Q9C4M5), HADHA_ASPOR (Q2UH56), HPPR_PLESU  (Q65CJ7), 
HPR1_ARATH  (Q9C9W5), HPR2_ARATH  (Q9CA90), HPR_BLAHS   (C0CMQ8), 
KK1H_CURCL  (A0A348AXY0), LDHA_CLODI  (Q5U922), LDHD_ECOLI  (P52643), 
LDHD_LACDA  (P26297), LDHD_LACHE  (P30901), LDHD_LACPE  (P26298), 
LDHD_LACPL  (Q88VJ2), LDHD_LEUMC  (P51011), LDHD_PEDAC  (Q59642), 
LDHD_STAAC  (Q5HD29), LDHD_STAAM  (P63940), LDHD_STAAN  (P99116), 
LDHD_STAAR  (Q6GDS2), LDHD_STAAS  (Q6G6F1), LDHD_STAAU  (P72357), 
LDHD_STAAW  (Q8NUT2), LDHD_STAEQ  (Q5HLA0), LDHD_STAES  (Q8CN22), 
LDHD_STRA3  (Q8E6A9), LDHD_STRA5  (Q8E0N5), LDHD_STRP1  (Q99ZM2), 
LDHD_TREPA  (O83080), MORA_ASPOR  (Q2U0N3), PDXB_ACIAD  (Q6F943), 
PDXB_ACIB3  (B7GY62), PDXB_ACIB5  (B7I5Z2), PDXB_ACIBC  (B2HX89), 
PDXB_ACIBS  (B0VT23), PDXB_ACIBT  (A3M810), PDXB_ACIBY  (B0VDM7), 
PDXB_ALCBS  (Q0VQC3), PDXB_BAUCH  (Q1LTA7), PDXB_BLOFL  (Q7VRU9), 
PDXB_BLOPB  (Q492H2), PDXB_CITK8  (A8ADQ9), PDXB_CROS8  (A7MH63), 
PDXB_ECO24  (A7ZPD6), PDXB_ECO27  (B7UFX8), PDXB_ECO45  (B7MG84), 
PDXB_ECO55  (B7LBH4), PDXB_ECO57  (Q8XCR0), PDXB_ECO5E  (B5YXW1), 
PDXB_ECO7I  (B7NP01), PDXB_ECO81  (B7MXZ7), PDXB_ECO8A  (B7M6K1), 
PDXB_ECOBW  (C4ZVL3), PDXB_ECODH  (B1X931), PDXB_ECOHS  (A8A2I9), 
PDXB_ECOK1  (A1ADG9), PDXB_ECOL5  (Q0TFC6), PDXB_ECOL6  (Q8FFH2), 
PDXB_ECOLC  (B1IXM2), PDXB_ECOLI  (P05459), PDXB_ECOLU  (B7N5T2), 
PDXB_ECOSE  (B6I4U8), PDXB_ECOSM  (B1LLS6), PDXB_ECOUT  (Q1R992), 
PDXB_EDWI9  (C5B8N0), PDXB_ENT38  (A4WCV4), PDXB_ESCF3  (B7LLF0), 
PDXB_KLEP3  (B5XNR7), PDXB_LEGPA  (Q5X6I6), PDXB_LEGPH  (Q5ZX15), 
PDXB_LEGPL  (Q5WXZ0), PDXB_MARMS  (A6VXM3), PDXB_MARN8  (A1U1I8), 
PDXB_PECAS  (Q6D2N5), PDXB_PECCP  (C6DA76), PDXB_PHOLL  (Q7N2B2), 
PDXB_PORGI  (Q7MV70), PDXB_PROMH  (B4EZF9), PDXB_PSET1  (Q3IF36), 
PDXB_PSYA2  (Q4FV16), PDXB_PSYCK  (Q1QE21), PDXB_PSYWF  (A5WHK7), 
PDXB_SALA4  (B5EZQ4), PDXB_SALAR  (A9MJ55), PDXB_SALCH  (Q57LY4), 
PDXB_SALDC  (B5FPL4), PDXB_SALEP  (B5R3Q1), PDXB_SALG2  (B5RCJ5), 
PDXB_SALHS  (B4TBN9), PDXB_SALNS  (B4SZP2), PDXB_SALPA  (Q5PCV8), 
PDXB_SALPB  (A9N474), PDXB_SALPC  (C0PZZ3), PDXB_SALPK  (B5BCH6), 
PDXB_SALSV  (B4TQA6), PDXB_SALTI  (P60801), PDXB_SALTY  (P60802), 
PDXB_SERP5  (A8GH44), PDXB_SHIB3  (B2TWA2), PDXB_SHIBS  (Q31YD8), 
PDXB_SHIDS  (Q32DL6), PDXB_SHIF8  (Q0T2G5), PDXB_SHIFL  (Q83QR1), 
PDXB_SHISS  (Q3YZP1), PDXB_SODGM  (Q2NSH9), PDXB_WIGBR  (Q8D2P6), 
PDXB_YERE8  (A1JL55), PDXB_YERP3  (A7FGL9), PDXB_YERPA  (Q1C676), 
PDXB_YERPB  (B2K8H7), PDXB_YERPE  (Q8D0U3), PDXB_YERPG  (A9R7V0), 
PDXB_YERPN  (Q1CHL8), PDXB_YERPP  (A4TM66), PDXB_YERPS  (Q668W7), 
PDXB_YERPY  (B1JGI0), SER33_YEAST (P40510), SERA1_ARATH (O49485), 
SERA2_ARATH (O04130), SERA3_ARATH (Q9LT69), SERA_ARCFU  (O29445), 
SERA_BACSU  (P35136), SERA_BOVIN  (Q5EAD2), SERA_DICDI  (Q54UH8), 
SERA_ECO57  (P0A9T2), SERA_ECOL6  (P0A9T1), SERA_ECOLI  (P0A9T0), 
SERA_HAEIN  (P43885), SERA_HUMAN  (O43175), SERA_MACFA  (Q60HD7), 
SERA_METJA  (Q58424), SERA_METTH  (O27051), SERA_MOUSE  (Q61753), 
SERA_MYCBO  (P0A545), SERA_MYCLE  (O33116), SERA_MYCTO  (P9WNX2), 
SERA_MYCTU  (P9WNX3), SERA_PANTR  (A5A6P1), SERA_PIG(A5GFY8), 
SERA_PONAB  (Q5R7M2), SERA_RAT(O08651), SERA_SCHPO  (P87228), 
SERA_SHIFL  (P0A9T3), SERA_SYNY3  (P73821), SERA_YEAST  (P40054), 
TKRA_BACSU  (O32264), UBA5_DANRE  (X1WER2), VANH_ENTFA  (Q47748), 
VANH_ENTFC  (Q05709), YEAA_SCHPO  (O14075), YGDH_SCHPO  (O94574)
» more

UniProtKB/Swiss-Prot
False negative sequences		 215 sequences 

2KGR_GLUOX  (Q5FTU6), CTBP2_BOVIN (Q0VCQ1), CTBP2_HUMAN (P56545), 

CTBP2_MOUSE (P56546), CTBP2_RAT   (Q9EQH5), CTBP_ARATH  (O23702), 
CTBP_DROME  (O46036), DDH1_SCHPO  (Q9P7P8), DDH_HALMT   (Q2VEQ7), 
FDH1_YEAS7  (A6ZN46), FDH1_YEAS8  (C8ZHD6), FDH1_YEASC  (N1P3Y5), 
FDH1_YEAST  (Q08911), FDH2_YEASC  (P0CT22), FDH2_YEAST  (P0CF35), 
FDH_HORVU   (Q9ZRI8), GHRA_CITK8  (A8AI49), GHRA_CROS8  (A7MFZ8), 
GHRA_ECO27  (B7UP47), GHRA_ECO45  (B7MIH3), GHRA_ECO55  (B7LFE3), 
GHRA_ECO57  (Q8X9K1), GHRA_ECO5E  (B5YVQ3), GHRA_ECO7I  (B7NLA1), 
GHRA_ECO81  (B7MTG4), GHRA_ECO8A  (B7M907), GHRA_ECOBW  (C4ZRX4), 
GHRA_ECODH  (B1X9E7), GHRA_ECOHS  (A7ZYY6), GHRA_ECOK1  (A1A9T1), 
GHRA_ECOL5  (Q0TJ41), GHRA_ECOL6  (Q8FIT1), GHRA_ECOLC  (B1IV68), 
GHRA_ECOLI  (P75913), GHRA_ECOLU  (B7N3I0), GHRA_ECOSE  (B6I9A9), 
GHRA_ECOSM  (B1LIY1), GHRA_ECOUT  (Q1RDC8), GHRA_ENT38  (A4W948), 
GHRA_ESCF3  (B7LTA2), GHRA_KLEP3  (B5XXL3), GHRA_KLEP7  (A6T7B8), 
GHRA_PHOLL  (Q7N571), GHRA_SALA4  (B5F974), GHRA_SALAR  (A9MH27), 
GHRA_SALCH  (Q57QM2), GHRA_SALDC  (B5FL30), GHRA_SALEP  (B5QY30), 
GHRA_SALG2  (B5RBG3), GHRA_SALHS  (B4TEQ6), GHRA_SALNS  (B4T2W6), 
GHRA_SALPA  (Q5PGZ3), GHRA_SALPB  (A9N5T3), GHRA_SALPC  (C0Q872), 
GHRA_SALPK  (B5BBF3), GHRA_SALSV  (B4TSP5), GHRA_SALTI  (Q8Z7M6), 
GHRA_SALTY  (Q8ZQ30), GHRA_SERP5  (A8GD46), GHRA_SHIB3  (B2TTN6), 
GHRA_SHIBS  (Q31Z89), GHRA_SHIDS  (Q32HN5), GHRA_SHISS  (Q3Z393), 
GHRA_YERE8  (A1JRR3), GHRB_CITK8  (A8ARD9), GHRB_CROS8  (A7MKR1), 
GHRB_ECO24  (A7ZTA0), GHRB_ECO27  (B7ULB4), GHRB_ECO45  (B7MER0), 
GHRB_ECO55  (B7L6W9), GHRB_ECO57  (P58220), GHRB_ECO5E  (B5YVK6), 
GHRB_ECO7I  (B7NP49), GHRB_ECO81  (B7N1K7), GHRB_ECO8A  (B7M3H6), 
GHRB_ECOBW  (C4ZXE2), GHRB_ECODH  (B1X8G8), GHRB_ECOHS  (A8A609), 
GHRB_ECOK1  (A1AH96), GHRB_ECOL5  (Q0TBP9), GHRB_ECOL6  (Q8FCF1), 
GHRB_ECOLC  (B1IZP1), GHRB_ECOLI  (P37666), GHRB_ECOLU  (B7NEK6), 
GHRB_ECOSE  (B6I3C3), GHRB_ECOSM  (B1LJB3), GHRB_ECOUT  (Q1R543), 
GHRB_ENT38  (A4W577), GHRB_ENTAG  (P58000), GHRB_ERWT9  (B2VCD1), 
GHRB_ESCF3  (B7LTG7), GHRB_KLEP3  (B5XMZ4), GHRB_KLEP7  (A6TFG7), 
GHRB_PECAS  (Q6DB24), GHRB_PECCP  (C6DJ88), GHRB_SALA4  (B5EX58), 
GHRB_SALCH  (Q57IH8), GHRB_SALDC  (B5FLC2), GHRB_SALEP  (B5R4N3), 
GHRB_SALG2  (B5RGN1), GHRB_SALHS  (B4T938), GHRB_SALNS  (B4SWJ5), 
GHRB_SALPA  (Q5PLL9), GHRB_SALPB  (A9MUT4), GHRB_SALPC  (C0Q1A7), 
GHRB_SALPK  (B5BHT3), GHRB_SALSV  (B4TZ41), GHRB_SALTI  (Q8Z2A8), 
GHRB_SALTY  (Q8ZLA1), GHRB_SERP5  (A8G7S7), GHRB_SHIB3  (B2U573), 
GHRB_SHIBS  (Q31V71), GHRB_SHIDS  (Q328L4), GHRB_SHIF8  (Q0SZE5), 
GHRB_SHIFL  (Q83PR3), GHRB_SHISS  (Q3YVT5), GLYR1_ARATH (Q9LSV0), 
GLYR2_ARATH (F4I907), GRHPR_HUMAN (Q9UBQ7), GRHPR_MOUSE (Q91Z53), 
GYAR_THEON  (B6YWH0), GYAR_THEPD  (A1RYE4), HGDH_ACIFV  (D2RJU7), 
HPR_THEMA   (Q9X1C1), LDHD_DICDI  (Q54UF7), PDXB_AERHH  (A0KLP0), 
PDXB_AERS4  (A4SNU1), PDXB_ALIF1  (Q5E452), PDXB_ALIFM  (B5FFP0), 
PDXB_ALISL  (B6EIW3), PDXB_AZOVD  (C1DM66), PDXB_BACFN  (Q5LIR8), 
PDXB_BACFR  (Q64ZV5), PDXB_BACTN  (Q8A2E4), PDXB_CELJU  (B3PK14), 
PDXB_CHRSD  (Q1QXV7), PDXB_COLP3  (Q47XK1), PDXB_COXBN  (A9KEY5), 
PDXB_COXBR  (A9NAQ7), PDXB_COXBU  (Q83AR8), PDXB_HAHCH  (Q2SJQ9), 
PDXB_HYDCU  (Q31IH6), PDXB_IDILO  (Q5QUE2), PDXB_PHOPR  (Q6LNU2), 
PDXB_PSE14  (Q48KQ3), PDXB_PSEA6  (Q15QG8), PDXB_PSEA7  (A6V8H9), 
PDXB_PSEA8  (B7UVK4), PDXB_PSEAB  (Q02JM2), PDXB_PSEAE  (Q9I3W9), 
PDXB_PSEE4  (Q1I7B3), PDXB_PSEF5  (Q4KFD1), PDXB_PSEFS  (C3K5G7), 
PDXB_PSEMY  (A4XTK4), PDXB_PSEP1  (A5W6I8), PDXB_PSEPF  (Q3K9D1), 
PDXB_PSEPG  (B0KGD9), PDXB_PSEPK  (Q88L20), PDXB_PSEPW  (B1J5D7), 
PDXB_PSESM  (Q884R9), PDXB_PSEU2  (Q4ZVE7), PDXB_PSYIN  (A1SW94), 
PDXB_RUTMC  (A1AWW7), PDXB_SACD2  (Q21LK8), PDXB_SALRD  (Q2S0U3), 
PDXB_SHEAM  (A1S7K2), PDXB_SHEB2  (B8EEB4), PDXB_SHEB5  (A3D669), 
PDXB_SHEB8  (A6WQ07), PDXB_SHEB9  (A9KTV0), PDXB_SHEDO  (Q12P58), 
PDXB_SHEFN  (Q084S1), PDXB_SHEHH  (B0TKZ7), PDXB_SHELP  (A3QFC7), 
PDXB_SHEON  (Q8ECR2), PDXB_SHEPC  (A4Y882), PDXB_SHESA  (A0KV91), 
PDXB_SHESH  (A8FTT7), PDXB_SHESM  (Q0HKB6), PDXB_SHESP  (Q56731), 
PDXB_SHESR  (Q0HWL8), PDXB_SHESW  (A1RIA7), PDXB_SHEVD  (Q56733), 
PDXB_SHEWM  (B1KKP1), PDXB_STUS1  (A4VKJ1), PDXB_TERTT  (C5BR49), 
PDXB_TOLAT  (C4LF16), PDXB_VESOH  (A5CWD1), PDXB_VIBA3  (B7VL81), 
PDXB_VIBCH  (Q9KQ92), PDXB_VIBPA  (Q87MN8), PDXB_VIBVU  (Q8DB36), 
PDXB_VIBVY  (Q7MIT6), PTXD_STUST  (O69054), SLCC_CHRSD  (Q1QWN6), 
TKRA_DICDI  (Q54DP1), Y1556_HAEIN (P45250), Y1879_STAES (Q8CNB8), 
Y1888_STAEQ (Q5HLU4), Y2098_STAAN (Q7A417), Y2178_STAAB (Q2YYT9), 
Y2196_STAAS (Q6G716), Y2224_STAAW (Q8NV80), Y2254_STAA3 (Q2FEI9), 
Y2296_STAAC (Q5HDQ4), Y2305_STAAM (Q99RW8), Y2355_CORGL (P0C1E8), 
Y2389_STAAR (Q6GEC9), Y2577_STAA8 (Q2FVW4), Y606_STAS1  (Q49ZM5), 
Y752_STAHJ  (Q4L8G4), YGT5_YEAST  (P53100), YOAD_BACSU  (O34815), 
YP113_YEAST (Q02961), YPRB2_CORML (P0C1E9)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

YMP5_STRCH  (P43169)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			54 sequences
			


			
ADH7_YEAST  (P25377), ADHA_SYNY3  (P74721), ADH_STAA3   (Q2FJ31), 

			
ADH_STAA8   (Q2G0G1), ADH_STAAB   (Q2YSX0), ADH_STAAC   (Q5HI63), 
ADH_STAAM   (Q99W07), ADH_STAAN   (Q7A742), ADH_STAAR   (Q6GJ63), 
ADH_STAAS   (Q6GBM4), ADH_STAAW   (Q8NXU1), ADH_STAEQ   (Q5HRD6), 
ADH_STAES   (Q8CQ56), AHR_ECOLI   (P27250), CADH1_ARATH (Q9CAI3), 
CADH4_ORYSJ (Q2R114), CARB_SULAC  (Q4J8E8), DOIAD_MICEC (Q70KF0), 
GLNE_AGRFC  (Q8UGQ4), GLNE_BARHE  (Q6G488), GLNE_BARQU  (Q6G0B0), 
GLNE_RHIME  (Q92R86), MDH1_AQUAE  (O67655), PC2DH_METJA (Q57605), 
RAPB_DICDI  (Q86L51), UBA5_AEDAE  (Q17DT0), UBA5_ARATH  (O23034), 
UBA5_BOMMO  (B9VJ80), UBA5_BOVIN  (A7MAZ3), UBA5_BRAFL  (C3YZ51), 
UBA5_CAEBR  (A8XEQ8), UBA5_CAEEL  (P91430), UBA5_CHICK  (Q6IVA4), 
UBA5_CULQU  (B0WQV1), UBA5_DROAN  (D1GY43), UBA5_DROER  (B3NUC9), 
UBA5_DROGR  (B4JIY0), UBA5_DROME  (Q9VYY3), UBA5_DROMO  (B4L1K2), 
UBA5_DROPE  (B4GYC7), UBA5_DROPS  (Q29HT0), UBA5_DROSE  (B4IK21), 
UBA5_DROSI  (B4R345), UBA5_DROVI  (B4M357), UBA5_DROWI  (B4NDE5), 
UBA5_DROYA  (B4PYA4), UBA5_HUMAN  (Q9GZZ9), UBA5_MOUSE  (Q8VE47), 
UBA5_ORYSJ  (Q6K6K7), UBA5_PONAB  (Q5R8X4), UBA5_RAT(Q5M7A4), 
UBA5_XENLA  (Q3KQ23), UBA5_XENTR  (Q6GLG7), YAHK_ECOLI  (P75691)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			74 PDB
			


			1DXY; 1GDH; 1HKU; 1HL3; 1J49; 1J4A; 1MX3; 1PSD; 1SC6; 1YBA; 1YGY; 2DBQ; 
			
				2DBR; 2DBZ; 2DLD; 2FSS; 2G76; 2GO1; 2GUG; 2HU2; 2J6I; 2NAC; 2NAD; 2P9C; 
				2P9E; 2P9G; 2PA3; 3BA1; 3BAZ; 3DC2; 3DDN; 3JTM; 3N7U; 3NAQ; 3OET; 4LCE; 
				4U6Q; 4U6S; 5AOV; 5N53; 5N6C; 5NZO; 5NZP; 5NZQ; 5OFM; 5OFV; 5OFW; 5Z1Z; 
				6CDF; 6CDR; 6CWA; 6JUJ; 6JUK; 6JWG; 6JX1; 6PEX; 6PLF; 6PLG; 6RIH; 6RJ2; 
				6RJ3; 6RJ5; 6RJ6; 6T8Y; 6T8Z; 6T92; 6T94; 6V89; 7CVP; 7DKM; 7EWH; 7JP2; 
				7VA1; 8ARI
			
			

			» more