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PROSITE entry PS00066


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PURL: https://purl.expasy.org/prosite/signature/PS00066

Direct ScanProsite submission
General information about the entry

Entry name [info] HMG_COA_REDUCTASE_1
Accession [info] PS00066
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00064

Name and characterization of the entry

Description [info] Hydroxymethylglutaryl-coenzyme A reductases signature 1.
Pattern [info] 
[RKH]-x-{Y}-{I}-x-{I}-{L}-D-x-M-G-x-N-x-[LIVMA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 75 in 75 different sequences
Number of true positive hits 66 in 66 different sequences
Number of 'unknown' hits 0
Number of false positive hits 9 in 9 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 88.00 %
Recall (true positives / (true positives + false negatives)) 97.06 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 66 sequences 

HMDH1_ARATH (P14891), HMDH1_ASPFU (Q4WHZ1), HMDH1_DICDI (P34135), 

HMDH1_GIBZE (I1RXX1), HMDH1_GOSHI (O64966), HMDH1_HEVBR (P29057), 
HMDH1_ORYSI (A2X8W3), HMDH1_ORYSJ (Q0DY59), HMDH1_YEAST (P12683), 
HMDH2_ARATH (P43256), HMDH2_ASPFU (Q4WSY2), HMDH2_CAPAN (Q9XEL8), 
HMDH2_DICDI (P34136), HMDH2_GOSHI (O64967), HMDH2_SOLLC (P48022), 
HMDH2_SOLTU (Q41437), HMDH2_YEAST (P12684), HMDH3_HEVBR (Q00583), 
HMDH3_ORYSJ (Q9XHL5), HMDH3_SOLTU (Q41438), HMDH_AERPE  (Q9YAS4), 
HMDH_AGRIP  (O76819), HMDH_ARCFU  (O28538), HMDH_ASPTE  (Q9Y7D2), 
HMDH_ASPTN  (Q0C8L9), HMDH_BLAGE  (P54960), HMDH_BOVIN  (A7Z064), 
HMDH_CAMAC  (P48021), HMDH_CANAL  (A0A1D8PD39), HMDH_CATRO  (Q03163), 
HMDH_CRIGR  (P00347), HMDH_CYBJA  (O74164), HMDH_DROME  (P14773), 
HMDH_FUSFU  (P0CT44), HMDH_GANLU  (B2KX91), HMDH_GIBF5  (S0DQM8), 
HMDH_HALS3  (B0R6J9), HMDH_HALVD  (Q59468), HMDH_HUMAN  (P04035), 
HMDH_MAIZE  (O24594), HMDH_MESAU  (P09610), HMDH_METJA  (Q58116), 
HMDH_METTH  (O26662), HMDH_MOUSE  (Q01237), HMDH_NICSY  (Q01559), 
HMDH_PHYB8  (Q12649), HMDH_PIG(Q1W675), HMDH_PONAB  (Q5R6N3), 
HMDH_PYRAB  (Q9V1R3), HMDH_PYRHO  (O59469), HMDH_RABIT  (Q29512), 
HMDH_RAT(P51639), HMDH_SACS2  (O08424), HMDH_SCHMA  (P16237), 
HMDH_SCHPO  (Q10283), HMDH_STRPU  (P16393), HMDH_XENLA  (P20715), 
HMGR1_CANSA (A0A7J6H013), HMGR1_PANGI (A0A0A1C3I2), HMGR2_CANSA (A0A803NI27), 
HMR2A_PANGI (A0A0A1C930), HMR2B_PANGI (U5JCC6), MLCD_PENCI  (Q8J0F4), 
MOKG_MONPI  (Q3S2U3), MVAA_PSEMV  (P13702), PBCC_EMENI  (C8VN86)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

HMDH1_SOLTU (P48020), HMDH_BORBU  (O51628)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
HMDH2_HEVBR (P29058)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			9 sequences
			


			
BP27_BPT4   (P17172), GLT2_CROSA  (Q6X1C0), LIPR3_HUMAN (Q17RR3), 

			
MSP_TRELE   (Q8RMC0), RH48_ARATH  (Q9C8S9), RN5A_MOUSE  (Q05921), 
SYP_STRA1   (Q3JZ37), SYP_STRA3   (Q8E362), SYP_STRA5   (Q8DXD8)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			40 PDB
			


			pdb_00001dq8; pdb_00001dq9; pdb_00001dqa; pdb_00001hw8; pdb_00001hw9; pdb_00001hwi; pdb_00001hwj; pdb_00001hwk; pdb_00001hwl; pdb_00001qax; pdb_00001qay; pdb_00001r31; 
			
				pdb_00001r7i; pdb_00001t02; pdb_00002q1l; pdb_00002q6b; pdb_00002q6c; pdb_00002r4f; pdb_00003bgl; pdb_00003cct; pdb_00003ccw; pdb_00003ccz; pdb_00003cd0; pdb_00003cd5; 
				pdb_00003cd7; pdb_00003cda; pdb_00003cdb; pdb_00004i4b; pdb_00004i56; pdb_00004i64; pdb_00004i6a; pdb_00004i6w; pdb_00004i6y; pdb_00007uli; pdb_00008ecg; pdb_00008gdn; 
				pdb_00008pkn; pdb_00008s6b; pdb_00008sz6; pdb_00008vlq
			
			

			» more