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PROSITE entry PS00067


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00067
Entry name [info] 3HCDH
Accession [info] PS00067
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00065

Name and characterization of the entry

Description [info] 3-hydroxyacyl-CoA dehydrogenase signature.
Pattern [info] 
[DNES]-x(2)-[GA]-F-[LIVMFYA]-x-[NT]-R-x(3)-[PA]-[LIVMFY]-[LIVMFYST]-
x(5,6)-[LIVMFYCT]-[LIVMFYEAH]-x(2)-[GVE].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 221 in 221 different sequences
Number of true positive hits 220 in 220 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 19
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.55 %
Recall (true positives / (true positives + false negatives)) 92.05 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 220 sequences 

AIM1_ARATH  (Q9ZPI6), CRYL1_BOVIN (Q8SPX7), CRYL1_HUMAN (Q9Y2S2), 

CRYL1_MOUSE (Q99KP3), CRYL1_PONAB (Q5RDZ2), CRYL1_RABIT (P14755), 
CRYL1_RAT   (Q811X6), ECHA_HUMAN  (P40939), ECHA_MOUSE  (Q8BMS1), 
ECHA_PIG(Q29554), ECHA_RAT(Q64428), ECHP_DANRE  (Q6NYL3), 
ECHP_HUMAN  (Q08426), ECHP_MOUSE  (Q9DBM2), ECHP_PONAB  (Q5R5M8), 
ECHP_RAT(P07896), FADB_ACIAD  (Q6FF68), FADB_ACIB3  (B7H1I0), 
FADB_ACIB5  (B7I3P1), FADB_ACIBC  (B2I2J9), FADB_ACIBS  (B0VLX4), 
FADB_ACIBY  (B0VE45), FADB_AERHH  (A0KEL1), FADB_AERS4  (A4STF2), 
FADB_ALIF1  (Q5E8X6), FADB_ALIFM  (B5FEW8), FADB_ALISL  (B6EGU2), 
FADB_CITK8  (A8ACZ4), FADB_COLP3  (Q489W3), FADB_CROS8  (A7MQP0), 
FADB_ECO24  (A7ZU51), FADB_ECO27  (B7UNH4), FADB_ECO45  (B7MHD1), 
FADB_ECO55  (B7L9A7), FADB_ECO57  (Q8X8I2), FADB_ECO5E  (B5YY93), 
FADB_ECO7I  (B7NV20), FADB_ECO81  (B7N2F2), FADB_ECO8A  (B7M649), 
FADB_ECOBW  (C5A020), FADB_ECODH  (B1XAK8), FADB_ECOHS  (A8A6V1), 
FADB_ECOL5  (Q0TAL0), FADB_ECOL6  (Q8FBI2), FADB_ECOLC  (B1IW61), 
FADB_ECOLI  (P21177), FADB_ECOLU  (B7NFE7), FADB_ECOSE  (B6I4I6), 
FADB_ECOSM  (B1LM32), FADB_ECOUT  (Q1R466), FADB_ECTM1  (A4XSM8), 
FADB_ECTOL  (Q93Q12), FADB_ENT38  (A4WFX4), FADB_ENTCL  (Q9F0Y7), 
FADB_ESCF3  (B7LTY9), FADB_IDILO  (Q5QXH7), FADB_KLEP3  (B5XYH0), 
FADB_KLEP7  (A6TGM4), FADB_PECAS  (Q6DAP5), FADB_PHOLL  (Q7MZ92), 
FADB_PHOPR  (Q6LW06), FADB_PSE14  (Q48GW3), FADB_PSEA7  (A6V382), 
FADB_PSEA8  (B7UYR6), FADB_PSEAB  (Q02PH8), FADB_PSEAE  (Q9HZJ2), 
FADB_PSEE4  (Q1I7D4), FADB_PSEF5  (Q4KFC4), FADB_PSEFR  (P28793), 
FADB_PSEFS  (C3K613), FADB_PSEP1  (A5W6H0), FADB_PSEPF  (Q3K9D8), 
FADB_PSEPG  (B0KH74), FADB_PSEPK  (Q88L02), FADB_PSEPU  (Q9AHY3), 
FADB_PSEPW  (B1J5A5), FADB_PSESM  (Q87ZB2), FADB_PSEU2  (Q4ZRA0), 
FADB_PSYA2  (Q4FQC6), FADB_PSYCK  (Q1Q8J9), FADB_PSYWF  (A5WH99), 
FADB_SALA4  (B5EZW0), FADB_SALCH  (Q57HM6), FADB_SALEP  (B5QW85), 
FADB_SALG2  (B5RFL6), FADB_SALNS  (B4SZ85), FADB_SALPA  (Q5PKQ2), 
FADB_SALPB  (A9MYB0), FADB_SALPK  (B5BIZ0), FADB_SALSV  (B4TNZ1), 
FADB_SALTI  (Q8Z3C6), FADB_SALTY  (Q9L6L5), FADB_SERP5  (A8G8D1), 
FADB_SHEAM  (A1S1I8), FADB_SHEB2  (B8E3R3), FADB_SHEB5  (A3CYJ4), 
FADB_SHEB8  (A6WHA0), FADB_SHEB9  (A9KU91), FADB_SHEFN  (Q08A39), 
FADB_SHEHH  (B0TLB9), FADB_SHELP  (A3Q8U4), FADB_SHEON  (Q8EKR9), 
FADB_SHEPA  (A8GYG0), FADB_SHEPC  (A4Y1B6), FADB_SHEPW  (B8CH91), 
FADB_SHESA  (A0KR50), FADB_SHESH  (A8FP63), FADB_SHESM  (Q0HPB7), 
FADB_SHESR  (Q0I0T3), FADB_SHESW  (A1RDW6), FADB_SHEWM  (B1KCZ3), 
FADB_SHIB3  (B2TVJ5), FADB_SHIDS  (Q32A21), FADB_SHIF8  (Q0SZ36), 
FADB_SHIFL  (Q83PG1), FADB_SHISS  (Q3YVC1), FADB_STUS1  (A4VKA3), 
FADB_VIBA3  (B7VGL4), FADB_VIBC1  (A7N1D2), FADB_VIBC3  (A5F465), 
FADB_VIBCH  (Q9KNI1), FADB_VIBCM  (C3LSI3), FADB_VIBPA  (Q87TN9), 
FADB_VIBVU  (Q8DDK6), FADB_VIBVY  (Q7MQH9), FADB_YERE8  (A1JIG4), 
FADB_YERP3  (A7FDF2), FADB_YERPA  (Q1C2C4), FADB_YERPB  (B2K0Z6), 
FADB_YERPE  (Q8ZAN0), FADB_YERPG  (A9R754), FADB_YERPN  (Q1CN99), 
FADB_YERPP  (A4TR27), FADB_YERPS  (Q66FR8), FADB_YERPY  (B1JP63), 
FADJ_ALIF1  (Q5E3U1), FADJ_CITK8  (A8ADP2), FADJ_CROS8  (A7MH81), 
FADJ_ECO24  (A7ZPF8), FADJ_ECO27  (B7UFZ8), FADJ_ECO45  (B7MGV7), 
FADJ_ECO55  (B7LBJ5), FADJ_ECO57  (Q8XCP2), FADJ_ECO5E  (B5YXY4), 
FADJ_ECO7I  (B7NP24), FADJ_ECO81  (B7MY16), FADJ_ECO8A  (B7M6M2), 
FADJ_ECOBW  (C4ZVN2), FADJ_ECODH  (B1X9L4), FADJ_ECOHS  (A8A2L0), 
FADJ_ECOK1  (A1ADI8), FADJ_ECOL5  (Q0TFA6), FADJ_ECOL6  (Q8FFG4), 
FADJ_ECOLC  (B1IXA5), FADJ_ECOLI  (P77399), FADJ_ECOLU  (B7N5V2), 
FADJ_ECOSE  (B6I6Q4), FADJ_ECOSM  (B1LME7), FADJ_ECOUT  (Q1R972), 
FADJ_ENT38  (A4WCW6), FADJ_ESCF3  (B7LLD0), FADJ_IDILO  (Q5QXM1), 
FADJ_KLEP3  (B5XVW2), FADJ_KLEP7  (A6TC19), FADJ_PECAS  (Q6D2L7), 
FADJ_PECCP  (C6DAL7), FADJ_PHOLL  (Q7N288), FADJ_PHOPR  (Q6LTK3), 
FADJ_SALA4  (B5EZR9), FADJ_SALCH  (Q57LW6), FADJ_SALDC  (B5FPN1), 
FADJ_SALEP  (B5R3R9), FADJ_SALG2  (B5RCL3), FADJ_SALHS  (B4TCA8), 
FADJ_SALNS  (B4SZR0), FADJ_SALPA  (Q5PCX6), FADJ_SALPB  (A9N453), 
FADJ_SALPK  (B5BBA1), FADJ_SALSV  (B4TQC2), FADJ_SALTI  (Q8Z4Z0), 
FADJ_SALTY  (Q8ZNA7), FADJ_SERP5  (A8GH86), FADJ_SHIB3  (B2TWV4), 
FADJ_SHIBS  (Q31YB7), FADJ_SHIDS  (Q32DJ4), FADJ_SHIF8  (Q0T2E6), 
FADJ_SHIFL  (Q83QQ0), FADJ_SHISS  (Q3YZM2), FADJ_VIBC1  (A7MS61), 
FADJ_VIBC3  (A5F2P2), FADJ_VIBCH  (Q9KT58), FADJ_VIBPA  (Q87MM3), 
FADJ_VIBVU  (Q8DB47), FADJ_VIBVY  (Q7MIS5), FADJ_YERE8  (A1JK30), 
FADJ_YERP3  (A7FGK1), FADJ_YERPA  (Q1C660), FADJ_YERPE  (Q8ZD45), 
FADJ_YERPN  (Q1CHK2), FADJ_YERPP  (A4TM82), FADJ_YERPS  (Q668V1), 
FHMCD_RHILO (Q988C8), HBD_BACSU   (P45856), HBD_BRADU   (Q45223), 
HBD_CLOAB   (P52041), HBD_CLODI   (P45364), HBD_DEIRA   (Q9RVG1), 
HBD_SYNWW   (Q0AVM2), HBD_THETC   (P77851), HCDH1_CAEEL (P34439), 
HCDH2_CAEEL (P41938), HCDH_HUMAN  (Q16836), HCDH_MOUSE  (Q61425), 
HCDH_PIG(P00348), HCDH_RAT(Q9WVK7), MFP2_ARATH  (Q9ZPI5), 
MFPA_BRANA  (O49809), MFPA_CUCSA  (Q39659), MFP_ORYSJ   (Q8W1L6), 
PAAH_ECOLI  (P76083)
» more

UniProtKB/Swiss-Prot
False negative sequences		 19 sequences 

CRYL1_PIG   (Q8SQ26), FAD3_RICFE  (Q4UL32), FAD3_RICPR  (Q9ZCZ1), 

FAD3_RICTY  (Q68WH7), FADB2_MYCTO (P9WNP6), FADB2_MYCTU (P9WNP7), 
FADJ_SHEAM  (A1S7L6), FADJ_SHEB5  (A3D684), FADJ_SHEB8  (A6WQ25), 
FADJ_SHEFN  (Q07ZP8), FADJ_SHEHH  (B0TL21), FADJ_SHELP  (A3QFP3), 
FADJ_SHEON  (Q8ECP7), FADJ_SHEPC  (A4Y897), FADJ_SHESA  (A0KV76), 
FADJ_SHESM  (Q0HKD1), FADJ_SHESR  (Q0HWN3), FADJ_SHESW  (A1RI92), 
HCDH_DEIRA  (P83589)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

HBD_CLOPA   (P81343)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
LCYD2_ORYSJ (Q5JNT6)


				
	

	

		PDB
[Detailed view]		
		
			49 PDB
			


			1F0Y; 1F12; 1F14; 1F17; 1IL0; 1LSJ; 1LSO; 1M76; 1WDK; 1WDL; 1WDM; 1ZCJ; 
			
				2D3T; 2HDH; 2WTB; 2X58; 3ADO; 3ADP; 3F3S; 3HAD; 3HDH; 3MOG; 3RQS; 3ZW8; 
				3ZW9; 3ZWA; 3ZWB; 3ZWC; 4J0E; 4J0F; 4OM8; 5MGB; 5OMO; 5ZQZ; 5ZRV; 6AA8; 
				6ACQ; 6DV2; 6TNM; 6YSV; 6YSW; 6Z5F; 6Z5O; 6Z5V; 6ZIB; 6ZIC; 8BNR; 8BNU; 
				8BRJ
			
			

			» more