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PROSITE entry PS00071


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General information about the entry

Entry name [info] GAPDH
Accession [info] PS00071
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00069
Associated ProRule [info] PRU10009

Name and characterization of the entry

Description [info] Glyceraldehyde 3-phosphate dehydrogenase active site.
Pattern [info]
[ASV]-S-C-[NT]-T-{S}-x-[LIM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 409 in 409 different sequences
Number of true positive hits 393 in 393 different sequences
Number of 'unknown' hits 0
Number of false positive hits 16 in 16 different sequences
Number of false negative sequences 25
Number of 'partial' sequences 9
Precision (true positives / (true positives + false positives)) 96.09 %
Recall (true positives / (true positives + false negatives)) 94.02 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
393 sequences

E4PD_CITK8  (A8APE1), E4PD_CROS8  (A7MJQ2), E4PD_ECO24  (A7ZR35), 
E4PD_ECO27  (B7UHW9), E4PD_ECO45  (B7MMA9), E4PD_ECO55  (B7LFI3), 
E4PD_ECO57  (P0A9B8), E4PD_ECO5E  (B5YQB9), E4PD_ECO7I  (B7NHY6), 
E4PD_ECO81  (B7MZM0), E4PD_ECO8A  (B7LYU4), E4PD_ECOBW  (C5A0J7), 
E4PD_ECODH  (B1XEL0), E4PD_ECOHS  (A8A467), E4PD_ECOK1  (A1AFB1), 
E4PD_ECOL5  (Q0TDS9), E4PD_ECOL6  (P0A9B7), E4PD_ECOLC  (B1IT76), 
E4PD_ECOLI  (P0A9B6), E4PD_ECOLU  (B7N7H3), E4PD_ECOSE  (B6I761), 
E4PD_ECOSM  (B1LDD2), E4PD_ECOUT  (Q1R7A6), E4PD_EDWI9  (C5BAU7), 
E4PD_ENT38  (A4WE72), E4PD_ERWT9  (B2VF24), E4PD_ESCF3  (B7LPD5), 
E4PD_KLEP3  (B5XUB7), E4PD_KLEP7  (A6TDT2), E4PD_PECAS  (Q6D086), 
E4PD_PECCP  (C6DFH8), E4PD_PHOLL  (Q7N7Z6), E4PD_PROMH  (B4EUH7), 
E4PD_PSYIN  (A1SVN9), E4PD_SALA4  (B5F5J5), E4PD_SALAR  (A9MRF0), 
E4PD_SALCH  (Q57K44), E4PD_SALDC  (B5FUI3), E4PD_SALEP  (B5QXJ7), 
E4PD_SALG2  (B5RE31), E4PD_SALHS  (B4THF4), E4PD_SALNS  (B4T5H2), 
E4PD_SALPA  (Q5PJI5), E4PD_SALPB  (A9N3Q6), E4PD_SALPC  (C0PY46), 
E4PD_SALPK  (B5BFN5), E4PD_SALSV  (B4TV39), E4PD_SALTI  (Q8XGA4), 
E4PD_SALTY  (Q7CPU5), E4PD_SHEAM  (A1S9A4), E4PD_SHEB2  (B8E5U5), 
E4PD_SHEDO  (Q12QA4), E4PD_SHEFN  (Q087Q7), E4PD_SHEHH  (B0TUC0), 
E4PD_SHELP  (A3QAX7), E4PD_SHEON  (Q8EIB2), E4PD_SHEPA  (A8H0M9), 
E4PD_SHEPC  (A4Y3R9), E4PD_SHEPW  (B8CU41), E4PD_SHESA  (A0L0K7), 
E4PD_SHESM  (Q0HM63), E4PD_SHESR  (Q0HRM3), E4PD_SHESW  (A1RN69), 
E4PD_SHIB3  (B2U0U3), E4PD_SHIBS  (Q31WI6), E4PD_SHIDS  (Q32BY7), 
E4PD_SHIF8  (Q0T0X3), E4PD_SHIFL  (P0A9B9), E4PD_SHISS  (Q3YXU5), 
E4PD_YERE8  (A1JPR1), E4PD_YERPA  (Q1CB62), E4PD_YERPE  (Q7CGS4), 
E4PD_YERPN  (Q1CEY2), E4PD_YERPS  (Q666Q0), G3P1_AGABI  (P32635), 
G3P1_BACCE  (Q4MQ58), G3P1_BACSU  (P09124), G3P1_CAEEL  (P04970), 
G3P1_CANGA  (Q6FPW3), G3P1_DROME  (P07486), G3P1_ECO57  (P0A9B4), 
G3P1_ECOLI  (P0A9B2), G3P1_GIAIN  (P53429), G3P1_GLORO  (O16027), 
G3P1_KLULA  (P17819), G3P1_KLUMA  (P84998), G3P1_METAC  (P58837), 
G3P1_METBF  (Q46AH5), G3P1_MUCCL  (Q9C136), G3P1_NOSS1  (P80506), 
G3P1_SCHPO  (P78958), G3P1_STAAC  (Q5HHP5), G3P1_STAAM  (P0A036), 
G3P1_STAAN  (P99136), G3P1_STAAR  (Q6GIL8), G3P1_STAAS  (Q6GB58), 
G3P1_STAAW  (P0A037), G3P1_STAEQ  (Q5HQV4), G3P1_STAES  (Q8CPY5), 
G3P1_STRAE  (P54226), G3P1_STRAW  (Q82IZ2), G3P1_SYNY3  (P49433), 
G3P1_TRIKO  (P17729), G3P1_TRIV2  (P34916), G3P1_YEAST  (P00360), 
G3P2_AGABI  (P32636), G3P2_BACSU  (O34425), G3P2_CAEBR  (P32809), 
G3P2_CAEEL  (P17329), G3P2_CANGA  (Q6FSM4), G3P2_DANRE  (Q5MJ86), 
G3P2_DROME  (P07487), G3P2_DROPS  (O44104), G3P2_DROSU  (O44105), 
G3P2_ECO57  (P58072), G3P2_KLULA  (Q6CX23), G3P2_KLUMA  (Q01077), 
G3P2_METAC  (P58838), G3P2_METBF  (Q465K9), G3P2_MUCCL  (Q96UF2), 
G3P2_NOSS1  (P58554), G3P2_SCHPO  (O43026), G3P2_STAAC  (Q5HF86), 
G3P2_STAAM  (P64180), G3P2_STAAN  (P99067), G3P2_STAAR  (Q6GG19), 
G3P2_STAAS  (Q6G8N9), G3P2_STAAW  (P64181), G3P2_STAEQ  (Q5HNL7), 
G3P2_STAES  (Q8CNY0), G3P2_STRAE  (E3VWI2), G3P2_SYNY3  (P80505), 
G3P2_TRIKO  (P17730), G3P2_TRIV2  (P34917), G3P2_YEAST  (P00358), 
G3P3_CAEBR  (P32810), G3P3_CAEEL  (P17330), G3P3_KLUMA  (P84999), 
G3P3_MUCCL  (Q96UF1), G3P3_NOSS1  (P58559), G3P3_TRIV2  (P34918), 
G3P3_YEAST  (P00359), G3P4_CAEEL  (P17331), G3PA1_ARATH (P25856), 
G3PA2_ARATH (Q9LPW0), G3PA_CHLRE  (P50362), G3PA_CHOCR  (P34919), 
G3PA_GRAGA  (P30724), G3PA_GUITH  (O09452), G3PA_MAIZE  (P09315), 
G3PA_PEA(P12858), G3PA_SCEVA  (Q8VXQ9), G3PA_SINAL  (P09672), 
G3PA_SPIOL  (P19866), G3PA_TOBAC  (P09043), G3PB_ARATH  (P25857), 
G3PB_PEA(P12859), G3PB_SPIOL  (P12860), G3PB_TOBAC  (P09044), 
G3PC1_ARATH (P25858), G3PC1_HORVU (P26517), G3PC1_MAIZE (P08735), 
G3PC1_ORYSJ (Q0J8A4), G3PC2_ARATH (Q9FX54), G3PC2_MAIZE (Q09054), 
G3PC2_ORYSJ (Q7FAH2), G3PC3_MAIZE (Q43247), G3PC3_ORYSJ (Q6K5G8), 
G3PC_ANTMA  (P25861), G3PC_CHLRE  (P49644), G3PC_CHOCR  (P34920), 
G3PC_CRAPL  (Q42671), G3PC_CUPNH  (P50321), G3PC_DIACA  (P34921), 
G3PC_GINBI  (Q39769), G3PC_GRAGA  (P54270), G3PC_LEIME  (Q01558), 
G3PC_MAGLI  (P26518), G3PC_MESCR  (P17878), G3PC_ORYSI  (A2YQT7), 
G3PC_PEA(P34922), G3PC_PETCR  (P26519), G3PC_PETHY  (P26520), 
G3PC_PHYPA  (P34923), G3PC_PINSY  (P34924), G3PC_RANAC  (P26521), 
G3PC_SCEVA  (Q8VXQ8), G3PC_SINAL  (P04796), G3PC_TAXBA  (Q41595), 
G3PC_TOBAC  (P09094), G3PC_TRYBB  (P10097), G3PG_CRIFA  (O96423), 
G3PG_LEIME  (Q27890), G3PG_TRYBB  (P22512), G3PG_TRYCR  (P22513), 
G3PP1_ARATH (Q9SAJ6), G3PP2_ARATH (Q5E924), G3PP_CUPNH  (P50322), 
G3PT_BOVIN  (Q2KJE5), G3PT_HUMAN  (O14556), G3PT_MACFA  (Q4R3T1), 
G3PT_MOUSE  (Q64467), G3PT_RAT(Q9ESV6), G3P_AERPE   (Q9YFS9), 
G3P_AJECA   (Q9HFX1), G3P_AMAMU   (P55071), G3P_AQUAE   (O67161), 
G3P_ARCFU   (O28542), G3P_ASPNG   (Q12552), G3P_ASPOR   (Q9HGY7), 
G3P_ATLHE   (P24750), G3P_ATRNU   (P34783), G3P_BACFR   (Q59199), 
G3P_BLUHO   (Q00640), G3P_BOLED   (Q00301), G3P_BORBU   (P46795), 
G3P_BORHE   (P46796), G3P_BOVIN   (P10096), G3P_BRUMA   (P48812), 
G3P_BUCAI   (P57384), G3P_BUCAP   (Q07234), G3P_BUCBP   (Q89AK1), 
G3P_CANAW   (Q92211), G3P_CANLF   (Q28259), G3P_CERSP   (P29272), 
G3P_CHICK   (P00356), G3P_CHLMU   (Q9PJN6), G3P_CHLPN   (Q9Z7T0), 
G3P_CHLT2   (B0B879), G3P_CHLTR   (P0CE13), G3P_CITFR   (P24748), 
G3P_CLAP2   (Q00584), G3P_CLOAB   (O52631), G3P_CLOPA   (Q59309), 
G3P_COCHE   (P29497), G3P_COCIM   (Q1DTF9), G3P_COCLU   (P28844), 
G3P_COCP7   (Q8J1H3), G3P_COLGL   (P35143), G3P_COLLI   (O57479), 
G3P_COLLN   (P54117), G3P_CORGL   (Q01651), G3P_COTJA   (Q05025), 
G3P_CRIGR   (P17244), G3P_CRYNB   (P0CN75), G3P_CRYNJ   (P0CN74), 
G3P_CRYPA   (P19089), G3P_CUTCU   (Q9Y796), G3P_DANRE   (Q5XJ10), 
G3P_DEBHA   (Q6BMK0), G3P_DICDI   (Q94469), G3P_DROHY   (Q01597), 
G3P_ECHMU   (Q27652), G3P_ECOL6   (P0A9B3), G3P_EMENI   (P20445), 
G3P_EREGS   (Q757I2), G3P_ESCF3   (B7LQ20), G3P_ESCFE   (P0C8Z1), 
G3P_FELCA   (Q9N2D5), G3P_GEOSE   (P00362), G3P_GLOMM   (Q4U3L0), 
G3P_HAEIN   (P44304), G3P_HALMA   (Q5V061), G3P_HALS3   (B0R2M2), 
G3P_HALSA   (Q9HSS7), G3P_HALVA   (Q48335), G3P_HELPJ   (Q9ZKT0), 
G3P_HELPY   (P55971), G3P_HEYCO   (P15115), G3P_HOMAM   (P00357), 
G3P_HUMAN   (P04406), G3P_HYPAT   (P87197), G3P_HYPBU   (A2BLC6), 
G3P_JACOR   (P80534), G3P_KITAU   (Q59800), G3P_KLEPN   (P24164), 
G3P_LACDT   (P55070), G3P_LENED   (Q9UR38), G3P_LYOSH   (Q92243), 
G3P_MASBA   (Q9N655), G3P_MESAU   (P51640), G3P_META3   (A6UUN9), 
G3P_METB6   (A7IB57), G3P_METBR   (P19314), G3P_METBU   (Q12XM4), 
G3P_METFE   (P10618), G3P_METFO   (P19315), G3P_METHJ   (Q2FNA2), 
G3P_METJA   (Q58546), G3P_METKA   (P58839), G3P_METM5   (A4FZL2), 
G3P_METM6   (A9A6M9), G3P_METM7   (A6VIW4), G3P_METMA   (Q8PTD3), 
G3P_METMP   (Q6M0E6), G3P_METS3   (A5ULT9), G3P_METS5   (A4YHA5), 
G3P_METST   (Q2NEN0), G3P_METTH   (O27090), G3P_METVS   (A6URW1), 
G3P_MONPU   (P53430), G3P_MOUSE   (P16858), G3P_MUSPF   (A3FKF7), 
G3P_MYCAV   (P94915), G3P_MYCBO   (P64179), G3P_MYCBP   (A0A0H3MAB5), 
G3P_MYCGE   (P47543), G3P_MYCLE   (P46713), G3P_MYCPN   (P75358), 
G3P_MYCS2   (A0QWW2), G3P_MYCTO   (P9WN82), G3P_MYCTU   (P9WN83), 
G3P_NATPD   (Q3IUT3), G3P_NEUCR   (P54118), G3P_OGAPD   (O59841), 
G3P_OMPOL   (Q8TFJ2), G3P_ONCMY   (O42259), G3P_ONCVO   (O01360), 
G3P_PANVR   (P56649), G3P_PARBA   (Q8X1X3), G3P_PELSI   (Q5R2J2), 
G3P_PHACH   (Q01982), G3P_PHANO   (Q9P8C0), G3P_PHARH   (O13507), 
G3P_PHYIN   (P26988), G3P_PICPA   (Q92263), G3P_PICTO   (Q6L125), 
G3P_PIG (P00355), G3P_PODAS   (P32637), G3P_PONAB   (Q5RAB4), 
G3P_PRIM3   (P23722), G3P_PSEAE   (P27726), G3P_PSEVU   (P24751), 
G3P_PYRAB   (Q9V1P1), G3P_PYRAE   (Q8ZWK7), G3P_PYRAR   (A4WIW2), 
G3P_PYRCJ   (A3MTU1), G3P_PYRFU   (P61879), G3P_PYRHO   (O59494), 
G3P_PYRIL   (A1RV79), G3P_PYRNV   (B1YD06), G3P_PYRWO   (P61880), 
G3P_RABIT   (P46406), G3P_RALN1   (P52694), G3P_RAT (P04797), 
G3P_RHIMI   (Q8NK47), G3P_SACS2   (P39460), G3P_SALTI   (P0A1P1), 
G3P_SALTY   (P0A1P0), G3P_SCHCO   (P32638), G3P_SCHMA   (P20287), 
G3P_SCLSC   (Q96US8), G3P_SERMA   (P24166), G3P_SEROD   (P24753), 
G3P_SHEEP   (Q28554), G3P_SHIBC   (I2BA89), G3P_SHIBL   (P0DJO7), 
G3P_SHIFL   (P0A9B5), G3P_SORMA   (Q8WZN0), G3P_SPECI   (Q4KYY3), 
G3P_STAAU   (P0A038), G3P_STREQ   (Q59906), G3P_STRP1   (P0C0G7), 
G3P_STRP3   (P0DB18), G3P_STRP6   (Q5XDW3), G3P_STRP8   (P68777), 
G3P_STRPQ   (P0DB19), G3P_STRPY   (P0C0G6), G3P_SULAC   (Q4J940), 
G3P_SULIA   (C3N6F0), G3P_SULIK   (C4KHW5), G3P_SULIL   (C3MQN0), 
G3P_SULIM   (C3MWN0), G3P_SULIN   (C3NGT6), G3P_SULIY   (C3NEV8), 
G3P_SULTO   (Q971K2), G3P_THEAC   (Q9HJ69), G3P_THEAQ   (P00361), 
G3P_THEKO   (Q5JHB5), G3P_THEMA   (P17721), G3P_THEON   (B6YUU0), 
G3P_THESM   (C6A312), G3P_THEVO   (Q97BJ8), G3P_TREPA   (O83816), 
G3P_USTMA   (P09317), G3P_WICCF   (Q9UVC0), G3P_XANFL   (P51009), 
G3P_XENLA   (P51469), G3P_YARLI   (Q6CCU7), G3P_ZYGRO   (P08439), 
G3P_ZYMMO   (P09316), GAP2_PSEAB  (Q02PG5), HEPG_ASPOR  (Q2U0J7)
» more

UniProtKB/Swiss-Prot
False negative sequences
25 sequences

E4PD_AERHH  (A0KGD2), E4PD_AERS4  (A4SRF2), E4PD_ALIF1  (Q5E7R0), 
E4PD_ALIFM  (B5F9T4), E4PD_ALISL  (B6EMW1), E4PD_ALTMD  (B4RWC5), 
E4PD_COLP3  (Q47XD5), E4PD_IDILO  (Q5QVL6), E4PD_PHOPR  (Q6LMN0), 
E4PD_PSEA6  (Q15QK3), E4PD_PSET1  (Q3ILL8), E4PD_TOLAT  (C4L9J3), 
E4PD_VIBC1  (A7MTQ2), E4PD_VIBC3  (A5F9G1), E4PD_VIBCH  (P0C6C2), 
E4PD_VIBPA  (Q87LL0), E4PD_VIBVU  (Q8DCA1), E4PD_VIBVY  (Q7MHL0), 
G3P_KLEAE   (P24163), G3P_LACDE   (O32755), G3P_LACLA   (P52987), 
G3P_MELGA   (O57672), G3P_METMJ   (A3CYG8), G3P_PLESA   (Q9UW96), 
G3P_STRCO   (Q9Z518)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
9 sequences

G3P2_BACCE  (P83077), G3PB_POPEU  (P84544), G3PC2_HORVU (P08477), 
G3PC_PSEMZ  (P85954), G3PT_MESAU  (P86211), G3P_CAVPO   (P70685), 
G3P_CHAMQ   (C0HLQ6), G3P_NAEFO   (P83601), PS5_PINST   (P84721)
» more

UniProtKB/Swiss-Prot
False positive sequences
16 sequences

BLAA_STRCI  (P33651), CARL1_MOUSE (Q6EDY6), DDB1_DROME  (Q9XYZ5), 
ERYA1_SACER (Q03131), GNKL2_PICSI (D5A8I3), MATK_VACFA  (Q6E4Q3), 
NU133_DROME (Q9VCW3), PATB_ASPCL  (A1CFK9), PGLR1_COLLN (Q00446), 
RBL4_ARATH  (F4JBM4), RIBZ_CLOD6  (Q180E3), RL7L_HUMAN  (Q6DKI1), 
SIBD_DICDI  (Q54JA4), SIK3_DANRE  (Q6NSM8), TGFB3_CHICK (P16047), 
XYLT_DROME  (Q7KVA1)
» more

PDB
[Detailed view]
137 PDB

1A7K; 1B7G; 1CER; 1CF2; 1CRW; 1DBV; 1DC3; 1DC4; 1DC5; 1DC6; 1DSS; 1GAD; 1GAE; 1GD1; 1GPD; 1GYP; 1GYQ; 1HDG; 1I32; 1I33; 1IHX; 1IHY; 1J0X; 1JN0; 1K3T; 1ML3; 1NBO; 1QXS; 1RM3; 1RM4; 1RM5; 1S7C; 1SZJ; 1U8F; 1ZNQ; 2CZC; 2DBV; 2EP7; 2G82; 2GD1; 2HKI; 2I5P; 2PKQ; 2PKR; 2VYN; 2VYV; 2X0N; 2X5J; 2XF8; 2YYY; 3CMC; 3DBV; 3DMT; 3E5R; 3E6A; 3GPD; 3H9E; 3HJA; 3IDS; 3K2B; 3K73; 3L6O; 3LC1; 3LC2; 3LC7; 3LVF; 3PFW; 3PYM; 3QV1; 3RVD; 3V1Y; 3VAZ; 4DBV; 4GPD; 4IQ8; 4K9D; 4O59; 4O63; 4WNC; 4WNI; 4Z0H; 5C7I; 5C7L; 5C7O; 5DDI; 5O0V; 5T73; 5TSO; 5ZA0; 6ADE; 6FZH; 6IO4; 6IO6; 6IOJ; 6IQ6; 6ITE; 6KEZ; 6LGJ; 6M61; 6OK4; 6QUN; 6QUQ; 6UTM; 6UTN; 6UTO; 6WYC; 6X2E; 6YND; 6YNE; 6YNF; 6YNH; 7JH0; 7JWK; 7Q53; 7Q54; 7Q55; 7Q56; 7Q57; 7U4S; 7U5M; 7ZQ3; 7ZQ4; 7ZQK; 8DE5; 8DNS; 8G12; 8G13; 8G14; 8G15; 8G16; 8G17; 8HRO; 8HRP; 8HRQ; 8HRR; 8HRS; 8P5F
» more