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PROSITE entry PS00075


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00075
Entry name [info] DHFR_1
Accession [info] PS00075
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00072

Name and characterization of the entry

Description [info] Dihydrofolate reductase (DHFR) domain signature.
Pattern [info] 
[LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-[FYIV]-x(3)-[STIQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 90 in 90 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.77 %
Recall (true positives / (true positives + false negatives)) 93.75 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 90 sequences 

DRTS1_ARATH (Q05762), DRTS2_ARATH (Q05763), DRTS_DAUCA  (P45350), 

DRTS_LEIAM  (P16126), DRTS_LEIMA  (P07382), DRTS_MAIZE  (O81395), 
DRTS_ORYSJ  (Q2QRX6), DRTS_PARTE  (Q27828), DRTS_PLABA  (Q27713), 
DRTS_PLACH  (P20712), DRTS_PLAFK  (P13922), DRTS_PLAVI  (O02604), 
DRTS_PLAVN  (P46103), DRTS_SOYBN  (P51820), DRTS_TOXGO  (Q07422), 
DRTS_TRYBB  (Q27783), DRTS_TRYCR  (Q27793), DYR10_ECOLX (Q04515), 
DYR13_ECOLX (Q59408), DYR15_ECOLX (P78218), DYR1_ECOLX  (P00382), 
DYR1_HALMA  (Q5V3R2), DYR2_HALMA  (Q5V600), DYR3_SALTM  (P12833), 
DYR5_ECOLX  (P11731), DYR6_PROMI  (P95524), DYR7_ECOLX  (P27422), 
DYR8_ECOLX  (P0ABQ7), DYR8_SHISO  (P0ABQ8), DYR9_ECOLX  (Q59397), 
DYRA_HALVD  (P15093), DYRA_STAAU  (P13955), DYRB_HALVO  (Q9UWQ4), 
DYR_AEDAL   (P28019), DYR_BACSU   (P11045), DYR_BOVIN   (P00376), 
DYR_BPT4(P04382), DYR_BUCAI   (P57243), DYR_BUCAP   (Q8K9Z8), 
DYR_BUCBP   (Q89AV2), DYR_CAEEL   (Q93341), DYR_CANAX   (P22906), 
DYR_CHICK   (P00378), DYR_CITFR   (P31073), DYR_CRYNJ   (Q07801), 
DYR_DROME   (P17719), DYR_ECOL6   (P0ABQ5), DYR_ECOLI   (P0ABQ4), 
DYR_ENTFC   (P00380), DYR_HAEIN   (P43791), DYR_HELVI   (Q9U8B8), 
DYR_HHV8P   (Q2HRC6), DYR_HUMAN   (P00374), DYR_KLEAE   (P31074), 
DYR_LACCA   (P00381), DYR_LACLA   (Q59487), DYR_MESAU   (P04753), 
DYR_MOUSE   (P00375), DYR_MYCBO   (P0A547), DYR_MYCGE   (P47470), 
DYR_MYCLE   (Q9CBW1), DYR_MYCPN   (P78028), DYR_MYCPU   (Q98Q32), 
DYR_MYCTO   (P9WNX0), DYR_MYCTU   (P9WNX1), DYR_NEIGO   (P04174), 
DYR_NEIMA   (Q9JSQ9), DYR_NEIMB   (Q9K168), DYR_PIG (P00377), 
DYR_PNECA   (P16184), DYR_RAT (Q920D2), DYR_SCHMA   (G4VJD6), 
DYR_SCHPO   (P36591), DYR_SHIFL   (P0ABQ6), DYR_SHV21   (P09503), 
DYR_SHV24   (P27421), DYR_SHV2C   (P22573), DYR_STAAC   (Q5HFZ7), 
DYR_STAAM   (P0A016), DYR_STAAN   (P99079), DYR_STAAR   (Q6GGY1), 
DYR_STAAS   (Q6G9D5), DYR_STAAU   (P0A017), DYR_STAAW   (Q8NWQ9), 
DYR_STAEP   (P0C0P0), DYR_STAEQ   (Q5HPB1), DYR_STAES   (P0C0P1), 
DYR_STAHA   (Q54277), DYR_STRPN   (Q54801), DYR_YEAST   (P07807)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

DRTS_CRIFA  (Q23695), DRTS_MIMIV  (Q5UQG3), DYR2_HUMAN  (Q86XF0), 

DYR_ENCCU   (O62583), DYR_THEMA   (Q60034), DYR_UREPA   (Q9PR30)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

Y2900_MYCTO (P9WJP8), Y2900_MYCTU (P9WJP9), Y2924_MYCBO (P65409)


				
	

	

		PDB
[Detailed view]		
		
			457 PDB
			


			1AI9; 1AO8; 1AOE; 1BOZ; 1BZF; 1CD2; 1DAJ; 1DDR; 1DDS; 1DF7; 1DG5; 1DG7; 
			
				1DG8; 1DHF; 1DIS; 1DIU; 1DLR; 1DR1; 1DR2; 1DR3; 1DR4; 1DR5; 1DR6; 1DR7; 
				1DRA; 1DRE; 1DRF; 1DRH; 1DYH; 1DYI; 1DYJ; 1DYR; 1E26; 1HFP; 1HFQ; 1HFR; 
				1IA1; 1IA2; 1IA3; 1IA4; 1J3I; 1J3J; 1J3K; 1JOL; 1JOM; 1JUV; 1KLK; 1KMS; 
				1KMV; 1LUD; 1LY3; 1LY4; 1M78; 1M79; 1M7A; 1MVS; 1MVT; 1OHJ; 1OHK; 1PD8; 
				1PD9; 1PDB; 1RA1; 1RA2; 1RA3; 1RA8; 1RA9; 1RB2; 1RB3; 1RC4; 1RD7; 1RE7; 
				1RF7; 1RG7; 1RH3; 1RX1; 1RX2; 1RX3; 1RX4; 1RX5; 1RX6; 1RX7; 1RX8; 1RX9; 
				1S3U; 1S3V; 1S3W; 1S3Y; 1TDR; 1U72; 1VDR; 1VJ3; 1YHO; 2ANO; 2ANQ; 2BL9; 
				2BLA; 2BLB; 2BLC; 2C2S; 2C2T; 2CD2; 2CIG; 2D0K; 2DHF; 2FZH; 2FZI; 2FZJ; 
				2H2Q; 2HM9; 2HQP; 2INQ; 2L28; 2LF1; 2W3A; 2W3B; 2W3M; 2W9G; 2W9H; 2W9S; 
				2W9T; 3CD2; 3CL9; 3CLB; 3D80; 3D84; 3DAU; 3DFR; 3DG8; 3DGA; 3DRC; 3EIG; 
				3F8Y; 3F8Z; 3F91; 3FRA; 3FRB; 3FRD; 3FRE; 3FRF; 3FS6; 3FY8; 3FY9; 3FYV; 
				3FYW; 3GHC; 3GHV; 3GHW; 3GI2; 3GYF; 3HBB; 3I8A; 3INV; 3IRM; 3IRN; 3IRO; 
				3IX9; 3K45; 3K47; 3K74; 3KFY; 3L3R; 3LG4; 3M08; 3M09; 3N0H; 3NTZ; 3NU0; 
				3NXO; 3NXR; 3NXT; 3NXV; 3NXX; 3NXY; 3NZ6; 3NZ9; 3NZA; 3NZB; 3NZC; 3NZD; 
				3OAF; 3OCH; 3QFX; 3QL3; 3QLR; 3QLS; 3QLW; 3QYL; 3QYO; 3R33; 3RG9; 3S3V; 
				3S7A; 3SGY; 3SH2; 3SQY; 3SR5; 3SRQ; 3SRR; 3SRS; 3SRU; 3SRW; 3TD8; 3VCO; 
				4CD2; 4DDR; 4DFR; 4ECK; 4EIG; 4EIL; 4EIZ; 4EJ1; 4FGG; 4FGH; 4FHB; 4G8Z; 
				4G95; 4GH8; 4H95; 4H96; 4H97; 4HOE; 4HOF; 4I13; 4I1N; 4IXE; 4IXF; 4IXG; 
				4KAK; 4KBN; 4KD7; 4KEB; 4KFJ; 4KJJ; 4KJK; 4KJL; 4KL9; 4KLX; 4KM0; 4KM2; 
				4KNE; 4KY4; 4KYA; 4LAE; 4LAG; 4LAH; 4LEK; 4M2X; 4M6J; 4M6K; 4M6L; 4NX6; 
				4NX7; 4PDJ; 4QHV; 4QJC; 4QJZ; 4X5F; 4X5G; 4X5H; 4X5I; 4X5J; 4XE6; 4XEC; 
				5CC9; 5CCC; 5DFR; 5E8Q; 5EAJ; 5HF0; 5HF2; 5HPB; 5HQY; 5HQZ; 5HSR; 5HSU; 
				5HT4; 5HT5; 5HUI; 5HVB; 5HVE; 5ISP; 5ISQ; 5IST; 5JA3; 5JG0; 5SCM; 5SCN; 
				5SCO; 5SCP; 5SCQ; 5SCR; 5SCS; 5SCT; 5SCU; 5SCV; 5SCW; 5SCX; 5SCY; 5SCZ; 
				5SD0; 5SD1; 5SD2; 5SD3; 5SD4; 5SD5; 5SD6; 5SD7; 5SD8; 5SD9; 5SDA; 5SDB; 
				5SSS; 5SST; 5SSU; 5SSV; 5SSW; 5T0L; 5U26; 5U27; 5UIH; 5UII; 5UIO; 5UIP; 
				5UJF; 5UJX; 5W3Q; 5Z6F; 5Z6J; 5Z6K; 5Z6L; 5Z6M; 6A7C; 6A7E; 6AOG; 6AOH; 
				6AOI; 6CQA; 6CW7; 6CXK; 6CYV; 6DAV; 6DDP; 6DDS; 6DDW; 6DE4; 6DFR; 6E4E; 
				6MR9; 6MT8; 6MTH; 6N1S; 6N1T; 6ND2; 6NNC; 6NND; 6NNH; 6NNI; 6P9Z; 6PBO; 
				6PR6; 6PR7; 6PR8; 6PR9; 6PRA; 6PRB; 6PRD; 6VCJ; 6VS5; 6VS6; 6VS8; 6VSD; 
				6VSE; 6VSF; 6VSG; 6VV6; 6VVB; 6XG4; 6XG5; 7CTW; 7D3Z; 7D49; 7D4L; 7D4X; 
				7D6G; 7DFR; 7ESE; 7F3B; 7F3Y; 7F3Z; 7FGW; 7FGX; 7FGY; 7FPL; 7FPM; 7FPN; 
				7FPO; 7FPP; 7FPQ; 7FPR; 7FPS; 7FPT; 7FPU; 7FPV; 7FPW; 7FPX; 7FPY; 7FPZ; 
				7FQ0; 7FQ1; 7FQ2; 7FQ3; 7FQ4; 7FQ5; 7FQ6; 7FQ7; 7FQ8; 7FQ9; 7FQA; 7FQB; 
				7FQC; 7FQD; 7FQE; 7FQF; 7FQG; 7LVC; 7MQP; 7MYM; 7NAE; 7R6G; 7REB; 7REG; 
				7RGJ; 7RGK; 7RGO; 7T7Q; 7T7S; 7XI7; 8COP; 8COQ; 8COW; 8COX; 8CQ8; 8CQ9; 
				8CQA; 8DAE; 8DAI; 8DFR; 8G4Z; 8G50; 8HCO; 8RHT; 8UCX; 8UVZ; 8UW0; 8VZ4; 
				8WGN
			
			

			» more