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PROSITE entry PS00075


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PURL: https://purl.expasy.org/prosite/signature/PS00075

Direct ScanProsite submission
General information about the entry

Entry name [info] DHFR_1
Accession [info] PS00075
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00072

Name and characterization of the entry

Description [info] Dihydrofolate reductase (DHFR) domain signature.
Pattern [info] 
[LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-[FYIV]-x(3)-[STIQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 90 in 90 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.77 %
Recall (true positives / (true positives + false negatives)) 93.75 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 90 sequences 

DRTS1_ARATH (Q05762), DRTS2_ARATH (Q05763), DRTS_DAUCA  (P45350), 

DRTS_LEIAM  (P16126), DRTS_LEIMA  (P07382), DRTS_MAIZE  (O81395), 
DRTS_ORYSJ  (Q2QRX6), DRTS_PARTE  (Q27828), DRTS_PLABA  (Q27713), 
DRTS_PLACH  (P20712), DRTS_PLAFK  (P13922), DRTS_PLAVI  (O02604), 
DRTS_PLAVN  (P46103), DRTS_SOYBN  (P51820), DRTS_TOXGO  (Q07422), 
DRTS_TRYBB  (Q27783), DRTS_TRYCR  (Q27793), DYR10_ECOLX (Q04515), 
DYR13_ECOLX (Q59408), DYR15_ECOLX (P78218), DYR1_ECOLX  (P00382), 
DYR1_HALMA  (Q5V3R2), DYR2_HALMA  (Q5V600), DYR3_SALTM  (P12833), 
DYR5_ECOLX  (P11731), DYR6_PROMI  (P95524), DYR7_ECOLX  (P27422), 
DYR8_ECOLX  (P0ABQ7), DYR8_SHISO  (P0ABQ8), DYR9_ECOLX  (Q59397), 
DYRA_HALVD  (P15093), DYRA_STAAU  (P13955), DYRB_HALVO  (Q9UWQ4), 
DYR_AEDAL   (P28019), DYR_BACSU   (P11045), DYR_BOVIN   (P00376), 
DYR_BPT4(P04382), DYR_BUCAI   (P57243), DYR_BUCAP   (Q8K9Z8), 
DYR_BUCBP   (Q89AV2), DYR_CAEEL   (Q93341), DYR_CANAX   (P22906), 
DYR_CHICK   (P00378), DYR_CITFR   (P31073), DYR_CRYNJ   (Q07801), 
DYR_DROME   (P17719), DYR_ECOL6   (P0ABQ5), DYR_ECOLI   (P0ABQ4), 
DYR_ENTFC   (P00380), DYR_HAEIN   (P43791), DYR_HELVI   (Q9U8B8), 
DYR_HHV8P   (Q2HRC6), DYR_HUMAN   (P00374), DYR_KLEAE   (P31074), 
DYR_LACCA   (P00381), DYR_LACLA   (Q59487), DYR_MESAU   (P04753), 
DYR_MOUSE   (P00375), DYR_MYCBO   (P0A547), DYR_MYCGE   (P47470), 
DYR_MYCLE   (Q9CBW1), DYR_MYCPN   (P78028), DYR_MYCPU   (Q98Q32), 
DYR_MYCTO   (P9WNX0), DYR_MYCTU   (P9WNX1), DYR_NEIGO   (P04174), 
DYR_NEIMA   (Q9JSQ9), DYR_NEIMB   (Q9K168), DYR_PIG (P00377), 
DYR_PNECA   (P16184), DYR_RAT (Q920D2), DYR_SCHMA   (G4VJD6), 
DYR_SCHPO   (P36591), DYR_SHIFL   (P0ABQ6), DYR_SHV21   (P09503), 
DYR_SHV24   (P27421), DYR_SHV2C   (P22573), DYR_STAAC   (Q5HFZ7), 
DYR_STAAM   (P0A016), DYR_STAAN   (P99079), DYR_STAAR   (Q6GGY1), 
DYR_STAAS   (Q6G9D5), DYR_STAAU   (P0A017), DYR_STAAW   (Q8NWQ9), 
DYR_STAEP   (P0C0P0), DYR_STAEQ   (Q5HPB1), DYR_STAES   (P0C0P1), 
DYR_STAHA   (Q54277), DYR_STRPN   (Q54801), DYR_YEAST   (P07807)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

DRTS_CRIFA  (Q23695), DRTS_MIMIV  (Q5UQG3), DYR2_HUMAN  (Q86XF0), 

DYR_ENCCU   (O62583), DYR_THEMA   (Q60034), DYR_UREPA   (Q9PR30)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

Y2900_MYCTO (P9WJP8), Y2900_MYCTU (P9WJP9), Y2924_MYCBO (P65409)


				
	

	

		PDB
[Detailed view]		
		
			463 PDB
			


			pdb_00001ai9; pdb_00001ao8; pdb_00001aoe; pdb_00001boz; pdb_00001bzf; pdb_00001cd2; pdb_00001daj; pdb_00001ddr; pdb_00001dds; pdb_00001df7; pdb_00001dg5; pdb_00001dg7; 
			
				pdb_00001dg8; pdb_00001dhf; pdb_00001dis; pdb_00001diu; pdb_00001dlr; pdb_00001dr1; pdb_00001dr2; pdb_00001dr3; pdb_00001dr4; pdb_00001dr5; pdb_00001dr6; pdb_00001dr7; 
				pdb_00001dra; pdb_00001dre; pdb_00001drf; pdb_00001drh; pdb_00001dyh; pdb_00001dyi; pdb_00001dyj; pdb_00001dyr; pdb_00001e26; pdb_00001hfp; pdb_00001hfq; pdb_00001hfr; 
				pdb_00001ia1; pdb_00001ia2; pdb_00001ia3; pdb_00001ia4; pdb_00001j3i; pdb_00001j3j; pdb_00001j3k; pdb_00001jol; pdb_00001jom; pdb_00001juv; pdb_00001klk; pdb_00001kms; 
				pdb_00001kmv; pdb_00001lud; pdb_00001ly3; pdb_00001ly4; pdb_00001m78; pdb_00001m79; pdb_00001m7a; pdb_00001mvs; pdb_00001mvt; pdb_00001ohj; pdb_00001ohk; pdb_00001pd8; 
				pdb_00001pd9; pdb_00001pdb; pdb_00001ra1; pdb_00001ra2; pdb_00001ra3; pdb_00001ra8; pdb_00001ra9; pdb_00001rb2; pdb_00001rb3; pdb_00001rc4; pdb_00001rd7; pdb_00001re7; 
				pdb_00001rf7; pdb_00001rg7; pdb_00001rh3; pdb_00001rx1; pdb_00001rx2; pdb_00001rx3; pdb_00001rx4; pdb_00001rx5; pdb_00001rx6; pdb_00001rx7; pdb_00001rx8; pdb_00001rx9; 
				pdb_00001s3u; pdb_00001s3v; pdb_00001s3w; pdb_00001s3y; pdb_00001tdr; pdb_00001u72; pdb_00001vdr; pdb_00001vj3; pdb_00001yho; pdb_00002ano; pdb_00002anq; pdb_00002bl9; 
				pdb_00002bla; pdb_00002blb; pdb_00002blc; pdb_00002c2s; pdb_00002c2t; pdb_00002cd2; pdb_00002cig; pdb_00002d0k; pdb_00002dhf; pdb_00002fzh; pdb_00002fzi; pdb_00002fzj; 
				pdb_00002h2q; pdb_00002hm9; pdb_00002hqp; pdb_00002inq; pdb_00002l28; pdb_00002lf1; pdb_00002w3a; pdb_00002w3b; pdb_00002w3m; pdb_00002w9g; pdb_00002w9h; pdb_00002w9s; 
				pdb_00002w9t; pdb_00003cd2; pdb_00003cl9; pdb_00003clb; pdb_00003d80; pdb_00003d84; pdb_00003dau; pdb_00003dfr; pdb_00003dg8; pdb_00003dga; pdb_00003drc; pdb_00003eig; 
				pdb_00003f8y; pdb_00003f8z; pdb_00003f91; pdb_00003fra; pdb_00003frb; pdb_00003frd; pdb_00003fre; pdb_00003frf; pdb_00003fs6; pdb_00003fy8; pdb_00003fy9; pdb_00003fyv; 
				pdb_00003fyw; pdb_00003ghc; pdb_00003ghv; pdb_00003ghw; pdb_00003gi2; pdb_00003gyf; pdb_00003hbb; pdb_00003i8a; pdb_00003inv; pdb_00003irm; pdb_00003irn; pdb_00003iro; 
				pdb_00003ix9; pdb_00003k45; pdb_00003k47; pdb_00003k74; pdb_00003kfy; pdb_00003l3r; pdb_00003lg4; pdb_00003m08; pdb_00003m09; pdb_00003n0h; pdb_00003ntz; pdb_00003nu0; 
				pdb_00003nxo; pdb_00003nxr; pdb_00003nxt; pdb_00003nxv; pdb_00003nxx; pdb_00003nxy; pdb_00003nz6; pdb_00003nz9; pdb_00003nza; pdb_00003nzb; pdb_00003nzc; pdb_00003nzd; 
				pdb_00003oaf; pdb_00003och; pdb_00003qfx; pdb_00003ql3; pdb_00003qlr; pdb_00003qls; pdb_00003qlw; pdb_00003qyl; pdb_00003qyo; pdb_00003r33; pdb_00003rg9; pdb_00003s3v; 
				pdb_00003s7a; pdb_00003sgy; pdb_00003sh2; pdb_00003sqy; pdb_00003sr5; pdb_00003srq; pdb_00003srr; pdb_00003srs; pdb_00003sru; pdb_00003srw; pdb_00003td8; pdb_00003vco; 
				pdb_00004cd2; pdb_00004ddr; pdb_00004dfr; pdb_00004eck; pdb_00004eig; pdb_00004eil; pdb_00004eiz; pdb_00004ej1; pdb_00004fgg; pdb_00004fgh; pdb_00004fhb; pdb_00004g8z; 
				pdb_00004g95; pdb_00004gh8; pdb_00004h95; pdb_00004h96; pdb_00004h97; pdb_00004hoe; pdb_00004hof; pdb_00004i13; pdb_00004i1n; pdb_00004ixe; pdb_00004ixf; pdb_00004ixg; 
				pdb_00004kak; pdb_00004kbn; pdb_00004kd7; pdb_00004keb; pdb_00004kfj; pdb_00004kjj; pdb_00004kjk; pdb_00004kjl; pdb_00004kl9; pdb_00004klx; pdb_00004km0; pdb_00004km2; 
				pdb_00004kne; pdb_00004ky4; pdb_00004kya; pdb_00004lae; pdb_00004lag; pdb_00004lah; pdb_00004lek; pdb_00004m2x; pdb_00004m6j; pdb_00004m6k; pdb_00004m6l; pdb_00004nx6; 
				pdb_00004nx7; pdb_00004pdj; pdb_00004qhv; pdb_00004qjc; pdb_00004qjz; pdb_00004x5f; pdb_00004x5g; pdb_00004x5h; pdb_00004x5i; pdb_00004x5j; pdb_00004xe6; pdb_00004xec; 
				pdb_00005cc9; pdb_00005ccc; pdb_00005dfr; pdb_00005e8q; pdb_00005eaj; pdb_00005hf0; pdb_00005hf2; pdb_00005hpb; pdb_00005hqy; pdb_00005hqz; pdb_00005hsr; pdb_00005hsu; 
				pdb_00005ht4; pdb_00005ht5; pdb_00005hui; pdb_00005hvb; pdb_00005hve; pdb_00005isp; pdb_00005isq; pdb_00005ist; pdb_00005ja3; pdb_00005jg0; pdb_00005scm; pdb_00005scn; 
				pdb_00005sco; pdb_00005scp; pdb_00005scq; pdb_00005scr; pdb_00005scs; pdb_00005sct; pdb_00005scu; pdb_00005scv; pdb_00005scw; pdb_00005scx; pdb_00005scy; pdb_00005scz; 
				pdb_00005sd0; pdb_00005sd1; pdb_00005sd2; pdb_00005sd3; pdb_00005sd4; pdb_00005sd5; pdb_00005sd6; pdb_00005sd7; pdb_00005sd8; pdb_00005sd9; pdb_00005sda; pdb_00005sdb; 
				pdb_00005sss; pdb_00005sst; pdb_00005ssu; pdb_00005ssv; pdb_00005ssw; pdb_00005t0l; pdb_00005u26; pdb_00005u27; pdb_00005uih; pdb_00005uii; pdb_00005uio; pdb_00005uip; 
				pdb_00005ujf; pdb_00005ujx; pdb_00005w3q; pdb_00005z6f; pdb_00005z6j; pdb_00005z6k; pdb_00005z6l; pdb_00005z6m; pdb_00006a7c; pdb_00006a7e; pdb_00006aog; pdb_00006aoh; 
				pdb_00006aoi; pdb_00006cqa; pdb_00006cw7; pdb_00006cxk; pdb_00006cyv; pdb_00006dav; pdb_00006ddp; pdb_00006dds; pdb_00006ddw; pdb_00006de4; pdb_00006dfr; pdb_00006e4e; 
				pdb_00006mr9; pdb_00006mt8; pdb_00006mth; pdb_00006n1s; pdb_00006n1t; pdb_00006nd2; pdb_00006nnc; pdb_00006nnd; pdb_00006nnh; pdb_00006nni; pdb_00006p9z; pdb_00006pbo; 
				pdb_00006pr6; pdb_00006pr7; pdb_00006pr8; pdb_00006pr9; pdb_00006pra; pdb_00006prb; pdb_00006prd; pdb_00006vcj; pdb_00006vs5; pdb_00006vs6; pdb_00006vs8; pdb_00006vsd; 
				pdb_00006vse; pdb_00006vsf; pdb_00006vsg; pdb_00006vv6; pdb_00006vvb; pdb_00006xg4; pdb_00006xg5; pdb_00007ctw; pdb_00007d3z; pdb_00007d49; pdb_00007d4l; pdb_00007d4x; 
				pdb_00007d6g; pdb_00007dfr; pdb_00007ese; pdb_00007f3b; pdb_00007f3y; pdb_00007f3z; pdb_00007fgw; pdb_00007fgx; pdb_00007fgy; pdb_00007fpl; pdb_00007fpm; pdb_00007fpn; 
				pdb_00007fpo; pdb_00007fpp; pdb_00007fpq; pdb_00007fpr; pdb_00007fps; pdb_00007fpt; pdb_00007fpu; pdb_00007fpv; pdb_00007fpw; pdb_00007fpx; pdb_00007fpy; pdb_00007fpz; 
				pdb_00007fq0; pdb_00007fq1; pdb_00007fq2; pdb_00007fq3; pdb_00007fq4; pdb_00007fq5; pdb_00007fq6; pdb_00007fq7; pdb_00007fq8; pdb_00007fq9; pdb_00007fqa; pdb_00007fqb; 
				pdb_00007fqc; pdb_00007fqd; pdb_00007fqe; pdb_00007fqf; pdb_00007fqg; pdb_00007lvc; pdb_00007mqp; pdb_00007mym; pdb_00007nae; pdb_00007r6g; pdb_00007reb; pdb_00007reg; 
				pdb_00007rgj; pdb_00007rgk; pdb_00007rgo; pdb_00007t7q; pdb_00007t7s; pdb_00007xi7; pdb_00008cop; pdb_00008coq; pdb_00008cow; pdb_00008cox; pdb_00008cq8; pdb_00008cq9; 
				pdb_00008cqa; pdb_00008dae; pdb_00008dai; pdb_00008dfr; pdb_00008g4z; pdb_00008g50; pdb_00008hco; pdb_00008rht; pdb_00008ucx; pdb_00008uvz; pdb_00008uw0; pdb_00008v9r; 
				pdb_00008vz4; pdb_00008wgm; pdb_00008wgn; pdb_00009c87; pdb_00009daq; pdb_00009dar; pdb_00009kz4
			
			

			» more