PROSITE logo

PROSITE entry PS00075


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] DHFR_1
Accession [info] PS00075
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00072

Name and characterization of the entry

Description [info] Dihydrofolate reductase (DHFR) domain signature.
Pattern [info] 
[LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-[FYIV]-x(3)-[STIQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 90 in 90 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.77 %
Recall (true positives / (true positives + false negatives)) 93.75 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 90 sequences 

DRTS1_ARATH (Q05762), DRTS2_ARATH (Q05763), DRTS_DAUCA  (P45350), 

DRTS_LEIAM  (P16126), DRTS_LEIMA  (P07382), DRTS_MAIZE  (O81395), 
DRTS_ORYSJ  (Q2QRX6), DRTS_PARTE  (Q27828), DRTS_PLABA  (Q27713), 
DRTS_PLACH  (P20712), DRTS_PLAFK  (P13922), DRTS_PLAVI  (O02604), 
DRTS_PLAVN  (P46103), DRTS_SOYBN  (P51820), DRTS_TOXGO  (Q07422), 
DRTS_TRYBB  (Q27783), DRTS_TRYCR  (Q27793), DYR10_ECOLX (Q04515), 
DYR13_ECOLX (Q59408), DYR15_ECOLX (P78218), DYR1_ECOLX  (P00382), 
DYR1_HALMA  (Q5V3R2), DYR2_HALMA  (Q5V600), DYR3_SALTM  (P12833), 
DYR5_ECOLX  (P11731), DYR6_PROMI  (P95524), DYR7_ECOLX  (P27422), 
DYR8_ECOLX  (P0ABQ7), DYR8_SHISO  (P0ABQ8), DYR9_ECOLX  (Q59397), 
DYRA_HALVD  (P15093), DYRA_STAAU  (P13955), DYRB_HALVO  (Q9UWQ4), 
DYR_AEDAL   (P28019), DYR_BACSU   (P11045), DYR_BOVIN   (P00376), 
DYR_BPT4(P04382), DYR_BUCAI   (P57243), DYR_BUCAP   (Q8K9Z8), 
DYR_BUCBP   (Q89AV2), DYR_CAEEL   (Q93341), DYR_CANAX   (P22906), 
DYR_CHICK   (P00378), DYR_CITFR   (P31073), DYR_CRYNJ   (Q07801), 
DYR_DROME   (P17719), DYR_ECOL6   (P0ABQ5), DYR_ECOLI   (P0ABQ4), 
DYR_ENTFC   (P00380), DYR_HAEIN   (P43791), DYR_HELVI   (Q9U8B8), 
DYR_HHV8P   (Q2HRC6), DYR_HUMAN   (P00374), DYR_KLEAE   (P31074), 
DYR_LACCA   (P00381), DYR_LACLA   (Q59487), DYR_MESAU   (P04753), 
DYR_MOUSE   (P00375), DYR_MYCBO   (P0A547), DYR_MYCGE   (P47470), 
DYR_MYCLE   (Q9CBW1), DYR_MYCPN   (P78028), DYR_MYCPU   (Q98Q32), 
DYR_MYCTO   (P9WNX0), DYR_MYCTU   (P9WNX1), DYR_NEIGO   (P04174), 
DYR_NEIMA   (Q9JSQ9), DYR_NEIMB   (Q9K168), DYR_PIG (P00377), 
DYR_PNECA   (P16184), DYR_RAT (Q920D2), DYR_SCHMA   (G4VJD6), 
DYR_SCHPO   (P36591), DYR_SHIFL   (P0ABQ6), DYR_SHV21   (P09503), 
DYR_SHV24   (P27421), DYR_SHV2C   (P22573), DYR_STAAC   (Q5HFZ7), 
DYR_STAAM   (P0A016), DYR_STAAN   (P99079), DYR_STAAR   (Q6GGY1), 
DYR_STAAS   (Q6G9D5), DYR_STAAU   (P0A017), DYR_STAAW   (Q8NWQ9), 
DYR_STAEP   (P0C0P0), DYR_STAEQ   (Q5HPB1), DYR_STAES   (P0C0P1), 
DYR_STAHA   (Q54277), DYR_STRPN   (Q54801), DYR_YEAST   (P07807)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

DRTS_CRIFA  (Q23695), DRTS_MIMIV  (Q5UQG3), DYR2_HUMAN  (Q86XF0), 

DYR_ENCCU   (O62583), DYR_THEMA   (Q60034), DYR_UREPA   (Q9PR30)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

Y2900_MYCTO (P9WJP8), Y2900_MYCTU (P9WJP9), Y2924_MYCBO (P65409)


				
	

	

		PDB
[Detailed view]		
		
			449 PDB
			


			1AI9; 1AO8; 1AOE; 1BOZ; 1BZF; 1CD2; 1DAJ; 1DDR; 1DDS; 1DF7; 1DG5; 1DG7; 
			
				1DG8; 1DHF; 1DIS; 1DIU; 1DLR; 1DR1; 1DR2; 1DR3; 1DR4; 1DR5; 1DR6; 1DR7; 
				1DRA; 1DRE; 1DRF; 1DRH; 1DYH; 1DYI; 1DYJ; 1DYR; 1E26; 1HFP; 1HFQ; 1HFR; 
				1IA1; 1IA2; 1IA3; 1IA4; 1J3I; 1J3J; 1J3K; 1JOL; 1JOM; 1JUV; 1KLK; 1KMS; 
				1KMV; 1LUD; 1LY3; 1LY4; 1M78; 1M79; 1M7A; 1MVS; 1MVT; 1OHJ; 1OHK; 1PD8; 
				1PD9; 1PDB; 1RA1; 1RA2; 1RA3; 1RA8; 1RA9; 1RB2; 1RB3; 1RC4; 1RD7; 1RE7; 
				1RF7; 1RG7; 1RH3; 1RX1; 1RX2; 1RX3; 1RX4; 1RX5; 1RX6; 1RX7; 1RX8; 1RX9; 
				1S3U; 1S3V; 1S3W; 1S3Y; 1TDR; 1U72; 1VDR; 1VJ3; 1YHO; 2ANO; 2ANQ; 2BL9; 
				2BLA; 2BLB; 2BLC; 2C2S; 2C2T; 2CD2; 2CIG; 2D0K; 2DHF; 2FZH; 2FZI; 2FZJ; 
				2H2Q; 2HM9; 2HQP; 2INQ; 2L28; 2LF1; 2W3A; 2W3B; 2W3M; 2W9G; 2W9H; 2W9S; 
				2W9T; 3CD2; 3CL9; 3CLB; 3D80; 3D84; 3DAU; 3DFR; 3DG8; 3DGA; 3DRC; 3EIG; 
				3F8Y; 3F8Z; 3F91; 3FRA; 3FRB; 3FRD; 3FRE; 3FRF; 3FS6; 3FY8; 3FY9; 3FYV; 
				3FYW; 3GHC; 3GHV; 3GHW; 3GI2; 3GYF; 3HBB; 3I8A; 3INV; 3IRM; 3IRN; 3IRO; 
				3IX9; 3K45; 3K47; 3K74; 3KFY; 3L3R; 3LG4; 3M08; 3M09; 3N0H; 3NTZ; 3NU0; 
				3NXO; 3NXR; 3NXT; 3NXV; 3NXX; 3NXY; 3NZ6; 3NZ9; 3NZA; 3NZB; 3NZC; 3NZD; 
				3OAF; 3OCH; 3QFX; 3QL3; 3QLR; 3QLS; 3QLW; 3QYL; 3QYO; 3R33; 3RG9; 3S3V; 
				3S7A; 3SGY; 3SH2; 3SQY; 3SR5; 3SRQ; 3SRR; 3SRS; 3SRU; 3SRW; 3TD8; 3VCO; 
				4CD2; 4DDR; 4DFR; 4ECK; 4EIG; 4EIL; 4EIZ; 4EJ1; 4FGG; 4FGH; 4FHB; 4G8Z; 
				4G95; 4GH8; 4H95; 4H96; 4H97; 4HOE; 4HOF; 4I13; 4I1N; 4IXE; 4IXF; 4IXG; 
				4KAK; 4KBN; 4KD7; 4KEB; 4KFJ; 4KJJ; 4KJK; 4KJL; 4KL9; 4KLX; 4KM0; 4KM2; 
				4KNE; 4KY4; 4KYA; 4LAE; 4LAG; 4LAH; 4LEK; 4M2X; 4M6J; 4M6K; 4M6L; 4NX6; 
				4NX7; 4PDJ; 4QHV; 4QJC; 4QJZ; 4X5F; 4X5G; 4X5H; 4X5I; 4X5J; 4XE6; 4XEC; 
				5CC9; 5CCC; 5DFR; 5E8Q; 5EAJ; 5HF0; 5HF2; 5HPB; 5HQY; 5HQZ; 5HSR; 5HSU; 
				5HT4; 5HT5; 5HUI; 5HVB; 5HVE; 5ISP; 5ISQ; 5IST; 5JA3; 5JG0; 5SCM; 5SCN; 
				5SCO; 5SCP; 5SCQ; 5SCR; 5SCS; 5SCT; 5SCU; 5SCV; 5SCW; 5SCX; 5SCY; 5SCZ; 
				5SD0; 5SD1; 5SD2; 5SD3; 5SD4; 5SD5; 5SD6; 5SD7; 5SD8; 5SD9; 5SDA; 5SDB; 
				5SSS; 5SST; 5SSU; 5SSV; 5SSW; 5T0L; 5U26; 5U27; 5UIH; 5UII; 5UIO; 5UIP; 
				5UJF; 5UJX; 5W3Q; 5Z6F; 5Z6J; 5Z6K; 5Z6L; 5Z6M; 6A7C; 6A7E; 6AOG; 6AOH; 
				6AOI; 6CQA; 6CW7; 6CXK; 6CYV; 6DAV; 6DDP; 6DDS; 6DDW; 6DE4; 6DFR; 6E4E; 
				6MR9; 6MT8; 6MTH; 6N1S; 6N1T; 6ND2; 6NNC; 6NND; 6NNH; 6NNI; 6P9Z; 6PBO; 
				6PR6; 6PR7; 6PR8; 6PR9; 6PRA; 6PRB; 6PRD; 6VCJ; 6VS5; 6VS6; 6VS8; 6VSD; 
				6VSE; 6VSF; 6VSG; 6VV6; 6VVB; 6XG4; 6XG5; 7CTW; 7D3Z; 7D49; 7D4L; 7D4X; 
				7D6G; 7DFR; 7ESE; 7F3B; 7F3Y; 7F3Z; 7FGW; 7FGX; 7FGY; 7FPL; 7FPM; 7FPN; 
				7FPO; 7FPP; 7FPQ; 7FPR; 7FPS; 7FPT; 7FPU; 7FPV; 7FPW; 7FPX; 7FPY; 7FPZ; 
				7FQ0; 7FQ1; 7FQ2; 7FQ3; 7FQ4; 7FQ5; 7FQ6; 7FQ7; 7FQ8; 7FQ9; 7FQA; 7FQB; 
				7FQC; 7FQD; 7FQE; 7FQF; 7FQG; 7LVC; 7MQP; 7MYM; 7NAE; 7R6G; 7REB; 7REG; 
				7RGJ; 7RGK; 7RGO; 7T7Q; 7T7S; 7XI7; 8CQA; 8DAE; 8DAI; 8DFR; 8G4Z; 8G50; 
				8HCO; 8UCX; 8UVZ; 8UW0; 8VZ4
			
			

			» more