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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00076


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PURL: https://purl.expasy.org/prosite/signature/PS00076

Direct ScanProsite submission
General information about the entry

Entry name [info] PYRIDINE_REDOX_1
Accession [info] PS00076
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00073

Name and characterization of the entry

Description [info] Pyridine nucleotide-disulphide oxidoreductases class-I active site.
Pattern [info] 
G-G-x-C-[LIVA]-x(2)-G-C-[LIVM]-P.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 150 in 150 different sequences
Number of true positive hits 150 in 150 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.34 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] disulfide at position 4
Site [info] disulfide at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 150 sequences 

DLDH1_ARATH (Q9M5K3), DLDH1_BACSU (P21880), DLDH1_GEOSE (P11959), 

DLDH1_PSEAE (Q9I1L9), DLDH1_PSEPU (P09063), DLDH2_ARATH (Q9M5K2), 
DLDH2_BACSU (P54533), DLDH2_HALMA (Q5UYG6), DLDH2_PSEAE (Q9I3D1), 
DLDH2_PSEPU (P31052), DLDH3_BACSU (O34324), DLDH3_HALMA (Q5UWH2), 
DLDH3_PSEAE (Q9HUY1), DLDH3_PSEPU (P31046), DLDH_ACHLA  (P35484), 
DLDH_AZOVI  (P18925), DLDH_BOVIN  (F1N206), DLDH_BUCAI  (P57303), 
DLDH_BUCAP  (Q8K9T7), DLDH_BUCBP  (Q89AQ8), DLDH_CAEEL  (O17953), 
DLDH_CANLF  (P49819), DLDH_CHATD  (G0SB20), DLDH_CHLMU  (Q9PJI3), 
DLDH_CHLP8  (O50311), DLDH_CHLPN  (Q9Z773), DLDH_CHLTE  (Q8KCW2), 
DLDH_CHLTR  (O84561), DLDH_CORGL  (Q8NTE1), DLDH_CRIGR  (Q8CIZ7), 
DLDH_CUPNH  (P52992), DLDH_DICDI  (Q54EW8), DLDH_ECO57  (P0A9P2), 
DLDH_ECOL6  (P0A9P1), DLDH_ECOLI  (P0A9P0), DLDH_HAEIN  (P43784), 
DLDH_HALSA  (Q9HN74), DLDH_HALVD  (Q04829), DLDH_HUMAN  (P09622), 
DLDH_HYMDI  (P80647), DLDH_MACFA  (Q60HG3), DLDH_MANSE  (O18480), 
DLDH_MESAU  (Q811C4), DLDH_MOUSE  (O08749), DLDH_MYCBO  (P66005), 
DLDH_MYCGE  (P47513), DLDH_MYCLE  (Q50068), DLDH_MYCPN  (P75393), 
DLDH_MYCTO  (P9WHH8), DLDH_MYCTU  (P9WHH9), DLDH_PEA(P31023), 
DLDH_PIG(P09623), DLDH_PONAB  (Q5R4B1), DLDH_PSEFL  (P14218), 
DLDH_RAT(Q6P6R2), DLDH_RHIEC  (O05940), DLDH_RHOCA  (P95596), 
DLDH_SCHPO  (O00087), DLDH_SHIFL  (P0A9P3), DLDH_STAAC  (Q5HGY8), 
DLDH_STAAM  (P0A0E6), DLDH_STAAN  (P99084), DLDH_STAAR  (Q6GHY9), 
DLDH_STAAS  (Q6GAB8), DLDH_STAAU  (P0A0E8), DLDH_STAAW  (P0A0E7), 
DLDH_SYNY3  (P72740), DLDH_THESS  (P85207), DLDH_TRYBB  (Q04933), 
DLDH_TRYCR  (P90597), DLDH_VIBCH  (Q9KPF6), DLDH_VIBPA  (O50286), 
DLDH_YEAST  (P09624), DLDH_ZYMMO  (P50970), GASHR_MARGR (D0VWY5), 
GSHRC_ARATH (P48641), GSHRC_BRARP (O04955), GSHRC_ORYSJ (P48642), 
GSHRC_PEA   (Q43621), GSHRP_ARATH (P42770), GSHRP_PEA   (P27456), 
GSHRP_SOYBN (P48640), GSHRP_SPIOL (Q43154), GSHRP_TOBAC (P80461), 
GSHR_BURCE  (P48639), GSHR_CAEEL  (Q93379), GSHR_CALJA  (A2TIL1), 
GSHR_CANGA  (Q6FRV2), GSHR_DEBHA  (Q6BPI1), GSHR_DICDI  (Q8T137), 
GSHR_ECOLI  (P06715), GSHR_EREGS  (Q74ZK4), GSHR_HAEIN  (P43783), 
GSHR_HUMAN  (P00390), GSHR_KLULA  (Q6HA23), GSHR_MOUSE  (P47791), 
GSHR_NEUCR  (Q873E8), GSHR_NOSS1  (P48638), GSHR_PLAF7  (O15770), 
GSHR_PLAFK  (Q94655), GSHR_PSEAE  (P23189), GSHR_SCHPO  (P78965), 
GSHR_SPISP  (P11804), GSHR_STRTR  (Q60151), GSHR_YARLI  (Q6C5H4), 
GSHR_YEAST  (P41921), LEGRE_SOYBN (Q41219), LEGRE_VIGUN (Q9SPB1), 
MERA_ACICA  (Q52109), MERA_ACIFR  (P17239), MERA_ALCSP  (P94188), 
MERA_BACCE  (P16171), MERA_ENTAG  (P94702), MERA_LYSSH  (D9J041), 
MERA_PSEAI  (P00392), MERA_PSEFL  (Q51772), MERA_SERMA  (P08662), 
MERA_SHEPU  (Q54465), MERA_SHIFL  (P08332), MERA_STAAU  (P0A0E5), 
MERA_STAES  (P0A0E4), MERA_STRLI  (P30341), MTR_MYCTO   (P9WHH2), 
MTR_MYCTU   (P9WHH3), PLPD1_ARATH (A8MS68), PLPD2_ARATH (F4JLP5), 
RCLA_ECOLI  (P77212), TRXR1_BOVIN (O62768), TRXR1_CAEEL (Q17745), 
TRXR1_DROME (P91938), TRXR1_EMIHU (B9A1H3), TRXR1_HUMAN (Q16881), 
TRXR1_MOUSE (Q9JMH6), TRXR1_PONAB (Q5NVA2), TRXR1_RAT   (O89049), 
TRXR2_BOVIN (Q9N2I8), TRXR2_CAEEL (P30635), TRXR2_DROME (Q9VNT5), 
TRXR2_HUMAN (Q9NNW7), TRXR2_MOUSE (Q9JLT4), TRXR2_RAT   (Q9Z0J5), 
TRXR3_HUMAN (Q86VQ6), TRXR3_MOUSE (Q99MD6), TRXR_PLAF5  (Q25861), 
TRXR_PLAF7  (P61076), TYTR_CRIFA  (P39040), TYTR_LEIDO  (P39050), 
TYTR_TRYBB  (P39051), TYTR_TRYCO  (P13110), TYTR_TRYCR  (P28593)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

TRXR1_PIG   (Q9MYY8)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			3 sequences
			


			
DLDH_POPEU  (P84545), DLDH_SOLTU  (P80503), GSHR_RAT(P70619)


				
	

	

		PDB
[Detailed view]		
		
			105 PDB
			


			pdb_00001aog; pdb_00001bwc; pdb_00001bzl; pdb_00001dnc; pdb_00001dxl; pdb_00001ebd; pdb_00001fea; pdb_00001feb; pdb_00001fec; pdb_00001ger; pdb_00001ges; pdb_00001get; 
			
				pdb_00001geu; pdb_00001gra; pdb_00001grb; pdb_00001gre; pdb_00001grf; pdb_00001grg; pdb_00001grh; pdb_00001grt; pdb_00001gsn; pdb_00001gxf; pdb_00001h6v; pdb_00001jeh; 
				pdb_00001k4q; pdb_00001lpf; pdb_00001lvl; pdb_00001nda; pdb_00001onf; pdb_00001typ; pdb_00001tyt; pdb_00001v59; pdb_00001xan; pdb_00001zdl; pdb_00001zk7; pdb_00001zkq; 
				pdb_00001zmc; pdb_00001zmd; pdb_00001zx9; pdb_00001zy8; pdb_00002a8x; pdb_00002aaq; pdb_00002cfy; pdb_00002f5z; pdb_00002gh5; pdb_00002grt; pdb_00002hqm; pdb_00002j3n; 
				pdb_00002nvk; pdb_00002qae; pdb_00002r9z; pdb_00002rab; pdb_00002tpr; pdb_00002wba; pdb_00002zz0; pdb_00002zzb; pdb_00002zzc; pdb_00003dgh; pdb_00003dgz; pdb_00003dh9; 
				pdb_00003djg; pdb_00003djj; pdb_00003dk4; pdb_00003dk8; pdb_00003dk9; pdb_00003ean; pdb_00003eao; pdb_00003grs; pdb_00003grt; pdb_00003ii4; pdb_00003lad; pdb_00003qfa; 
				pdb_00003qfb; pdb_00003rnm; pdb_00003sqp; pdb_00004b1b; pdb_00004gr1; pdb_00004grt; pdb_00004j56; pdb_00004j57; pdb_00004jdr; pdb_00004k8d; pdb_00004kpr; pdb_00004m52; 
				pdb_00005grt; pdb_00005j5z; pdb_00005nhg; pdb_00005u8u; pdb_00005x1y; pdb_00006hg8; pdb_00006i4p; pdb_00006i4q; pdb_00006i4r; pdb_00006i4s; pdb_00006i4t; pdb_00006i4u; 
				pdb_00006i4z; pdb_00006kgy; pdb_00006kyy; pdb_00007kmy; pdb_00007psc; pdb_00007x1r; pdb_00007zyt; pdb_00008ct4; pdb_00008u0q
			
			

			» more