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PROSITE entry PS00095


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00095
Entry name [info] C5_MTASE_2
Accession [info] PS00095
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2003 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00089

Name and characterization of the entry

Description [info] C-5 cytosine-specific DNA methylases C-terminal signature.
Pattern [info] 
[RKQGTF]-x(2)-G-N-[SA]-[LIVF]-x-[VIP]-x-[LVMT]-x(3)-[LIVM]-x(3)-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 78 in 78 different sequences
Number of true positive hits 68 in 68 different sequences
Number of 'unknown' hits 0
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 25
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 87.18 %
Recall (true positives / (true positives + false negatives)) 73.12 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 68 sequences 

CMT2_ORYSJ  (Q5KQL9), DCM_ECO57   (P0AEE0), DCM_ECOLI   (P0AED9), 

DNM1A_ORYSJ (Q7Y1I7), DNM1B_ORYSJ (B1Q3J6), DNMT1_ARATH (P34881), 
DNMT1_BOVIN (Q24K09), DNMT1_CHICK (Q92072), DNMT1_HUMAN (P26358), 
DNMT1_MOUSE (P13864), DNMT1_PARLI (Q27746), DNMT1_RAT   (Q9Z330), 
DNMT2_ARATH (Q9M0S8), DNMT3_ARATH (Q9T0I1), DNMT4_ARATH (O23273), 
MT36_OCEIH  (Q8EL95), MTA1_THAGE  (P94147), MTAB_PICP2  (P34883), 
MTB1_BACP9  (P0DW08), MTB1_BREEP  (P10283), MTB1_HERAU  (P25262), 
MTB1_LYSSH  (P13906), MTB6_BACSF  (P43420), MTBA_ANEAE  (P19888), 
MTBB_BPSPB  (P09389), MTBF_BACIU  (P17044), MTBP_BACSU  (P68585), 
MTBP_BPPHT  (P68586), MTBR_BACIU  (P06530), MTBR_BPRH1  (P09915), 
MTBS_BPSPR  (P00476), MTC1_HERAU  (P25263), MTC2_HERAU  (P25264), 
MTD1_DESNO  (P05302), MTD1_HERAU  (P24600), MTD2_HERAU  (P25265), 
MTD5_DACSA  (P50185), MTE1_HERAU  (P25266), MTE2_ECOLX  (P05101), 
MTE8_ECOLX  (P50196), MTF1_FUSNU  (P34906), MTH1_HAEPH  (P05102), 
MTH2_HAEAE  (O30868), MTH3_HAEAE  (P20589), MTH5_HAEIN  (P45000), 
MTHA_HAEPH  (P50192), MTHT_METTF  (P29567), MTM1_MORSP  (P11408), 
MTM4_NEIGO  (P31033), MTN1_LENAE  (P50188), MTNX_NEILA  (P24581), 
MTP1_PSYTA  (O33481), MTP2_NEIGO  (P08455), MTS1_SALIN  (P09795), 
MTS2_SHISO  (P34879), MTS3_STAAU  (P16668), MTS9_STAAU  (P23737), 
MTSA_LACLC  (P34877), MTSB_LACLC  (P34878), MTSI_SPISQ  (P15840), 
MTX2_XANOR  (P52311), PMT1M_SCHPO (P40999), TRDMT_BOVIN (Q7YS61), 
TRDMT_HUMAN (O14717), TRDMT_MOUSE (O55055), TRDMT_RAT   (Q4G073), 
TRDMT_SPOFR (A0A2H1VE33), YDIP_BACSU  (O34680)
» more

UniProtKB/Swiss-Prot
False negative sequences		 25 sequences 

CMT1_ORYSJ  (A0A0P0VUY4), CMT3_ORYSJ  (C0SQ89), DNM3A_CHICK (Q4W5Z4), 

DNM3A_HUMAN (Q9Y6K1), DNM3A_MOUSE (O88508), DNM3A_RAT   (Q1LZ53), 
DNM3B_HUMAN (Q9UBC3), DNM3B_MOUSE (O88509), DRM1L_ARATH (Q9LXE5), 
DRM2_ARATH  (Q9M548), MT51_METJA  (Q57983), MTA1_CELCE  (P31974), 
MTAP_ARTPN  (D4ZX35), MTB1_BREBE  (P34905), MTB1_NEIGO  (Q59603), 
MTB5_NEIGO  (Q59605), MTC1_PBCVI  (P36216), MTD1_NEIMC  (Q9RLM4), 
MTF7_NEIGO  (Q59606), MTG1_AVIVO  (P25282), MTG2_AVIVO  (P25283), 
MTH2_HAEPA  (P15446), MTM7_METJA  (Q58600), MTN4_NEILA  (P50182), 
YDIO_BACSU  (O34939)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

MTG1_HERAU  (P25267)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			10 sequences
			


			
ATPB_MYCGI  (A4T8K2), ATPB_MYCLE  (P45823), CDAA_BACSU  (Q45589), 

			
GCY8E_DROME (Q8INF0), OBG_BORAP   (Q0SM73), OBG_BORBU   (O51722), 
OBG_BORBZ   (B7J0M7), OBG_BORGP   (Q65ZZ3), WCAF_ECOLI  (P0ACD2), 
WCAF_SHIFL  (P0ACD3)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			61 PDB
			


			10MH; 1DCT; 1FJX; 1G55; 1HMY; 1M0E; 1MHT; 1SKM; 1SVU; 2C7O; 2C7P; 2C7Q; 
			
				2C7R; 2HMY; 2HR1; 2I9K; 2UYC; 2UYH; 2UZ4; 2Z6A; 2Z6Q; 2Z6U; 2ZCJ; 3AV4; 
				3AV5; 3AV6; 3EEO; 3MHT; 3PT6; 3PT9; 3PTA; 3SWR; 3UBT; 4DA4; 4H0N; 4MHT; 
				4WXX; 4YOC; 5CIY; 5GUT; 5GUV; 5LOD; 5MHT; 5WY1; 6FDF; 6MHT; 6W8V; 6W8W; 
				6X9I; 6X9J; 6X9K; 7MHT; 7SFC; 7SFD; 7SFE; 7SFF; 7SFG; 7XI9; 7XIB; 8MHT; 
				9MHT
			
			

			» more