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Entry: PS00099

General information about the entry

Entry name [info] THIOLASE_3
Accession [info] PS00099
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
22-FEB-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00092
Associated ProRule [info] PRU10020

Name and characterization of the entry

Description [info] Thiolases active site.
Pattern [info] 
[AG]-[LIVMA]-[STAGCLIVM]-[STAG]-[LIVMA]-C-{Q}-[AG]-x-[AG]-x-[AG]-x-[SAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_01 which contains 569'213 sequence entries.


Total number of hits 300 in 300 different sequences
Number of true positive hits 260 in 260 different sequences
Number of 'unknown' hits 0
Number of false positive hits 40 in 40 different sequences
Number of false negative sequences 45
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 86.67 %
Recall (true positives / (true positives + false negatives)) 85.25 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 260 sequences 

ATOB_ECOLI  (P76461    ), ATOB_HAEIN  (P44873    ), ATOB_PSEAE  (Q9I2A8    ), 

BKTB_CUPNH  (Q0KBP1    ), CATF_ACIAD  (Q43935    ), ECHB_BOVIN  (O46629    ), 
ECHB_HUMAN  (P55084    ), ECHB_MACFA  (Q8HXX4    ), ECHB_MOUSE  (Q99JY0    ), 
ECHB_PANTR  (Q5R1W7    ), ECHB_RAT    (Q60587    ), ECHH_CAEEL  (P34255    ), 
ER10A_ASPFC (B0XMC1    ), ER10A_ASPFU (Q4WLA8    ), ER10A_GIBZE (I1RMA2    ), 
ER10B_GIBZE (I1RY81    ), ERG10_SACMO (P10551    ), ERG10_SCHPO (Q9UQW6    ), 
ERG10_YEAST (P41338    ), FADA4_MYCBO (P66927    ), FADA4_MYCLE (P46707    ), 
FADA4_MYCS2 (A0R1Y7    ), FADA4_MYCTO (P9WG68    ), FADA4_MYCTU (P9WG69    ), 
FADA_ACIAD  (Q6FF69    ), FADA_ACIB3  (B7H1I1    ), FADA_ACIB5  (B7I3P0    ), 
FADA_ACIBC  (B2I2J8    ), FADA_ACIBS  (B0VLX5    ), FADA_ACIBT  (A3M1H9    ), 
FADA_ACIBY  (B0VE46    ), FADA_AERHH  (A0KEL0    ), FADA_AERS4  (A4STF3    ), 
FADA_ALCBS  (Q0VNZ7    ), FADA_ALIF1  (Q5E8X7    ), FADA_ALIFM  (B5FEW7    ), 
FADA_ALISL  (B6EGU1    ), FADA_BACSU  (O32177    ), FADA_CHRSD  (Q1QUW9    ), 
FADA_CITK8  (A8ACZ3    ), FADA_COLP3  (Q489W4    ), FADA_CROS8  (A7MQM5    ), 
FADA_ECO24  (A7ZU50    ), FADA_ECO57  (Q8X8J4    ), FADA_ECOHS  (A8A6V0    ), 
FADA_ECOK1  (A1AI32    ), FADA_ECOL5  (Q0TAL1    ), FADA_ECOL6  (Q8FBI3    ), 
FADA_ECOLI  (P21151    ), FADA_ECOUT  (Q1R467    ), FADA_ENT38  (A4WFX5    ), 
FADA_ENTCL  (Q9F0Y6    ), FADA_ERWT9  (B2VFE0    ), FADA_ESCF3  (B7LTZ0    ), 
FADA_HAHCH  (Q2SD23    ), FADA_IDILO  (Q5QXH8    ), FADA_KLEP7  (A6TGM3    ), 
FADA_MARMS  (A6VVM8    ), FADA_MARN8  (A1TZR8    ), FADA_PECAS  (Q6DAP6    ), 
FADA_PECCP  (C6DI66    ), FADA_PHOLL  (Q7MZ91    ), FADA_PHOPR  (Q6LW07    ), 
FADA_PSE14  (Q48GW4    ), FADA_PSEA6  (Q15ZF4    ), FADA_PSEF5  (Q4KFC3    ), 
FADA_PSEFR  (P28790    ), FADA_PSEPF  (Q3K9D9    ), FADA_PSESM  (Q87ZB3    ), 
FADA_PSET1  (Q3IJ24    ), FADA_PSEU2  (Q4ZRA1    ), FADA_PSEU5  (A4VKA4    ), 
FADA_PSYA2  (Q4FQC7    ), FADA_PSYCK  (Q1Q8K0    ), FADA_PSYWF  (A5WH98    ), 
FADA_SALCH  (Q57HM7    ), FADA_SALPA  (Q5PKQ3    ), FADA_SALTI  (P0A2H8    ), 
FADA_SALTY  (P0A2H7    ), FADA_SERP5  (A8G8D0    ), FADA_SHEAM  (A1S1I7    ), 
FADA_SHEB5  (A3CYJ3    ), FADA_SHEB8  (A6WH99    ), FADA_SHEDO  (Q12TB5    ), 
FADA_SHEFN  (Q08A40    ), FADA_SHELP  (A3Q8U3    ), FADA_SHEON  (Q8EKS0    ), 
FADA_SHEPC  (A4Y1B5    ), FADA_SHESA  (A0KR49    ), FADA_SHESM  (Q0HPB8    ), 
FADA_SHESR  (Q0I0T4    ), FADA_SHESW  (A1RDW3    ), FADA_SHIBS  (Q31UE3    ), 
FADA_SHIDS  (Q32A20    ), FADA_SHIF8  (Q0SZ35    ), FADA_SHIFL  (Q83PG2    ), 
FADA_SHISS  (Q3YVC2    ), FADA_VIBC3  (A5F464    ), FADA_VIBCH  (Q9KNI0    ), 
FADA_VIBPA  (Q87TP0    ), FADA_VIBVU  (Q8DDK5    ), FADA_VIBVY  (Q7MQI0    ), 
FADA_YERE8  (A1JIG3    ), FADA_YERP3  (A7FDF1    ), FADA_YERPA  (Q1C2C3    ), 
FADA_YERPE  (Q8ZAM9    ), FADA_YERPN  (Q1CNA0    ), FADA_YERPP  (A4TR28    ), 
FADA_YERPS  (Q66FR9    ), FADI_ALTMD  (B4RTU9    ), FADI_CITK8  (A8ADP1    ), 
FADI_COLP3  (Q47ZB6    ), FADI_CROS8  (A7MH80    ), FADI_ECO24  (A7ZPF9    ), 
FADI_ECO27  (B7UFZ9    ), FADI_ECO45  (B7MGV8    ), FADI_ECO55  (B7LBJ6    ), 
FADI_ECO57  (Q8XCN9    ), FADI_ECO5E  (B5YXY5    ), FADI_ECO7I  (B7NP25    ), 
FADI_ECO81  (B7MY17    ), FADI_ECO8A  (B7M6M3    ), FADI_ECOBW  (C4ZVN3    ), 
FADI_ECODH  (B1X9L5    ), FADI_ECOHS  (A8A2L1    ), FADI_ECOK1  (A1ADI9    ), 
FADI_ECOL5  (Q0TFA5    ), FADI_ECOL6  (Q8FFG3    ), FADI_ECOLC  (B1IXA4    ), 
FADI_ECOLI  (P76503    ), FADI_ECOLU  (B7N5V3    ), FADI_ECOSE  (B6I6Q5    ), 
FADI_ECOSM  (B1LME8    ), FADI_ECOUT  (Q1R971    ), FADI_ENT38  (A4WCW7    ), 
FADI_ERWT9  (B2VJ10    ), FADI_ESCF3  (B7LLC9    ), FADI_IDILO  (Q5QXN5    ), 
FADI_KLEP3  (B5XVW1    ), FADI_KLEP7  (A6TC20    ), FADI_PECAS  (Q6D2L6    ), 
FADI_PECCP  (C6DAL8    ), FADI_PHOLL  (Q7N287    ), FADI_PSEA6  (Q15VA3    ), 
FADI_PSET1  (Q3IEE3    ), FADI_SALA4  (B5EZS0    ), FADI_SALAR  (A9MJ36    ), 
FADI_SALCH  (Q57LW5    ), FADI_SALDC  (B5FPN2    ), FADI_SALEP  (B5R3S0    ), 
FADI_SALHS  (B4TCA9    ), FADI_SALNS  (B4SZR1    ), FADI_SALPA  (Q5PCX7    ), 
FADI_SALPB  (A9N452    ), FADI_SALPC  (C0PZX5    ), FADI_SALPK  (B5BBA0    ), 
FADI_SALSV  (B4TQC3    ), FADI_SALTI  (Q8Z4Y9    ), FADI_SALTY  (Q8ZNA6    ), 
FADI_SERP5  (A8GH87    ), FADI_SHEAM  (A1S7L7    ), FADI_SHEB2  (B8EE97    ), 
FADI_SHEB5  (A3D685    ), FADI_SHEB8  (A6WQ26    ), FADI_SHEB9  (A9KTW7    ), 
FADI_SHEDO  (Q12P12    ), FADI_SHEFN  (Q07ZP7    ), FADI_SHEHH  (B0TL22    ), 
FADI_SHELP  (A3QFP4    ), FADI_SHEON  (Q8ECP6    ), FADI_SHEPA  (A8H5T2    ), 
FADI_SHEPC  (A4Y898    ), FADI_SHEPW  (B8CPY7    ), FADI_SHESA  (A0KV75    ), 
FADI_SHESH  (A8FTR6    ), FADI_SHESM  (Q0HKD2    ), FADI_SHESR  (Q0HWN4    ), 
FADI_SHESW  (A1RI91    ), FADI_SHEWM  (B1KKT1    ), FADI_SHIB3  (B2TWV5    ), 
FADI_SHIBS  (Q31YB6    ), FADI_SHIDS  (Q32DJ3    ), FADI_SHIF8  (Q0T2E5    ), 
FADI_SHIFL  (Q83K95    ), FADI_SHISS  (Q3YZM1    ), FADI_YERE8  (A1JK23    ), 
FADI_YERP3  (A7FGK0    ), FADI_YERPA  (Q1C659    ), FADI_YERPB  (B2K8J6    ), 
FADI_YERPE  (Q8ZD46    ), FADI_YERPG  (A9R7W9    ), FADI_YERPN  (Q1CHK1    ), 
FADI_YERPP  (A4TM83    ), FADI_YERPS  (Q668V0    ), FADI_YERPY  (B1JGG1    ), 
KAT1_PETHY  (C8YNG6    ), PAAJ_ECOLI  (P0C7L2    ), PAAJ_ECOLX  (P0C7L3    ), 
PCAF_ACIAD  (Q43974    ), PCAF_PSEAE  (Q9I6R0    ), PCAF_PSEKB  (Q8VPF1    ), 
PCAF_PSEPU  (Q51956    ), THIA_CANTR  (Q12598    ), THIB_CANTR  (Q04677    ), 
THIC1_ARATH (Q8S4Y1    ), THIC2_ARATH (Q9FIK7    ), THIC_HUMAN  (Q9BWD1    ), 
THIC_MOUSE  (Q8CAY6    ), THIC_RAT    (Q5XI22    ), THIK1_ARATH (Q8LF48    ), 
THIK2_ARATH (Q56WD9    ), THIK5_ARATH (Q570C8    ), THIKA_CANTR (P33290    ), 
THIKA_MOUSE (Q921H8    ), THIKA_RAT   (P21775    ), THIKB_CANTR (P33291    ), 
THIKB_MOUSE (Q8VCH0    ), THIKB_RAT   (P07871    ), THIK_ENCCU  (Q8SVA6    ), 
THIK_HUMAN  (P09110    ), THIK_YARLI  (Q05493    ), THIK_YEAST  (P27796    ), 
THILA_XENLA (Q6NU46    ), THILB_XENLA (Q6GN02    ), THIL_ALLVD  (P45369    ), 
THIL_BOVIN  (Q29RZ0    ), THIL_CHRVO  (Q9ZHI1    ), THIL_CUPNH  (P14611    ), 
THIL_DANRE  (Q6AZA0    ), THIL_HUMAN  (P24752    ), THIL_MACFA  (Q8HXY6    ), 
THIL_MOUSE  (Q8QZT1    ), THIL_PARDE  (P54810    ), THIL_RAT    (P17764    ), 
THIL_RHIME  (P50174    ), THIL_SHIZO  (P07097    ), THIL_SYNY3  (P73825    ), 
THIL_THIVI  (P45363    ), THIL_XENTR  (Q5BKN8    ), THIM_BOVIN  (Q3T0R7    ), 
THIM_HUMAN  (P42765    ), THIM_MOUSE  (Q8BWT1    ), THIM_PONAB  (Q5RES5    ), 
THIM_RAT    (P13437    ), THLA_CLOAB  (P45359    ), THLA_STAA3  (Q2FJQ9    ), 
THLA_STAA8  (Q2G124    ), THLA_STAAB  (Q2YVF5    ), THLA_STAAC  (Q5HIU0    ), 
THLA_STAAM  (Q99WM3    ), THLA_STAAN  (Q7A7L2    ), THLA_STAAR  (Q6GJW4    ), 
THLA_STAAS  (Q6GCB8    ), THLA_STAAW  (Q8NY95    ), THLA_STAEQ  (Q5HS07    ), 
THLA_STAES  (Q8CQN7    ), THLA_SYNWW  (Q0AVM3    ), THL_BACSU   (P45855    ), 
Y0859_MYCTU (O53871    ), YQEF_ECOLI  (Q46939    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 45 sequences 

ER10B_ASPFC (B0YA65    ), ER10B_ASPFU (Q4WCL5    ), ERG10_CANAL (A0A1D8PH52), 

FADA5_MYCTU (I6XHI4    ), FADA6_MYCTU (I6XHJ3    ), FADA_PSEA7  (A6V383    ), 
FADA_PSEAB  (Q02PH7    ), FADA_PSEAE  (Q9HZJ3    ), FADA_PSEE4  (Q1I7D5    ), 
FADA_PSEMY  (A4XSM9    ), FADA_PSEOL  (Q93Q11    ), FADA_PSEP1  (A5W6G9    ), 
FADA_PSEPK  (Q88L01    ), FADA_PSEPU  (Q9R9W0    ), FADA_SACD2  (Q21KB1    ), 
FADI_AERHH  (A0KK76    ), FADI_AERS4  (A4SMT9    ), FADI_ALIF1  (Q5E3U0    ), 
FADI_ALIFM  (B5FGB5    ), FADI_PHOPR  (Q6LTK4    ), FADI_VIBC3  (A5F2P1    ), 
FADI_VIBCH  (Q9KT59    ), FADI_VIBPA  (Q87MM2    ), FADI_VIBVU  (Q8DB48    ), 
FADI_VIBVY  (Q7MIS4    ), SCP2_BOVIN  (P07857    ), SCP2_CHICK  (Q07598    ), 
SCP2_HUMAN  (P22307    ), SCP2_MOUSE  (P32020    ), SCP2_RABIT  (O62742    ), 
SCP2_RAT    (P11915    ), THIL1_DICDI (Q86AD9    ), THILH_CAEEL (Q22100    ), 
THIL_YARLI  (Q6L8K7    ), VRAB_STAA1  (Q9KWK4    ), VRAB_STAAC  (Q5HIA0    ), 
VRAB_STAAM  (Q7A2W9    ), VRAB_STAAN  (Q7A768    ), VRAB_STAAR  (Q6GJ93    ), 
VRAB_STAAS  (Q6GBR1    ), VRAB_STAAW  (Q7A1P9    ), VRAB_STAEQ  (Q5HRH3    ), 
VRAB_STAES  (Q8CTR0    ), VRAB_STAHJ  (Q4L3Q1    ), YHFS_BACSU  (O07618    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

THIL_PIG    (P14610    ), THLA_CLODI  (P45362    ), THLA_CLOPA  (P81347    )


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			40 sequences
			


			
ACON_BOVIN  (P20004    ), ACON_CAEEL  (P34455    ), ACON_HUMAN  (Q99798    ), 

			
ACON_MOUSE  (Q99KI0    ), ACON_PIG    (P16276    ), ACON_RAT    (Q9ER34    ), 
ARGJ_OSTLU  (A4S1K1    ), FINC_CHICK  (P11722    ), J1I_HCMVA   (P09711    ), 
MYCN_MOUSE  (P03966    ), MYST1_ORYSJ (Q8LI34    ), PER1_VOLCA  (P81131    ), 
SSTT_ALIF1  (Q5DZC3    ), SSTT_CAMFF  (A0RNW2    ), SSTT_DESPS  (Q6AS08    ), 
SSTT_ENTFA  (Q82ZN5    ), SSTT_PHOPR  (Q6LG82    ), SSTT_PSYIN  (A1SS94    ), 
SSTT_SHEAM  (A1S7P9    ), SSTT_SHELP  (A3QCX7    ), SSTT_SHEON  (Q8ECL5    ), 
SSTT_SHESA  (A0KV41    ), SSTT_SHESM  (Q0HKG6    ), SSTT_SHESR  (Q0HWR8    ), 
SSTT_SHESW  (A1RI59    ), SSTT_STRP1  (Q9A1E0    ), SSTT_STRP3  (P0DF78    ), 
SSTT_STRP6  (Q5XDS5    ), SSTT_STRP8  (Q8P2K3    ), SSTT_STRPB  (Q1JDG4    ), 
SSTT_STRPC  (Q1JND7    ), SSTT_STRPD  (Q1JII6    ), SSTT_STRPF  (Q1J8E1    ), 
SSTT_STRPG  (A2RGC2    ), SSTT_STRPM  (Q48V75    ), SSTT_STRPQ  (P0DF79    ), 
SSTT_VIBCH  (Q9KNC9    ), SSTT_VIBPA  (Q87FP8    ), SSTT_VIBVU  (Q8D4Q1    ), 
SSTT_VIBVY  (Q7MGA3    )


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			85 PDB
			


			1AFW; 1DLU; 1DLV; 1DM3; 1M1O; 1M1T; 1M3K; 1M3Z; 1M4S; 1M4T; 1NL7; 1OU6; 
			
				1PXT; 1QFL; 1WDK; 1WDL; 1WDM; 1WL4; 1WL5; 2C7Y; 2C7Z; 2D3T; 2F2S; 2IB7; 
				2IB8; 2IB9; 2IBU; 2IBW; 2IBY; 2IIK; 2VTZ; 2VU0; 2VU1; 2VU2; 2WKT; 2WKU; 
				2WKV; 2WL4; 2WL5; 2WL6; 2WU9; 3GOA; 4B3H; 4B3I; 4B3J; 4C2J; 4C2K; 4NZS; 
				4O99; 4O9A; 4O9C; 4W61; 4WYR; 4WYS; 4XL2; 5F0V; 5F38; 5LP7; 5XYJ; 5XZ5; 
				5ZQZ; 5ZRV; 6DV2; 6L2C; 6L2G; 7LBZ; 7LCA; 7LCL; 7LD2; 7LDC; 7LDT; 7LDU; 
				7LDV; 7LDW; 7O1G; 7O1I; 7O1J; 7O1K; 7O1L; 7O1M; 7O4Q; 7O4R; 7O4S; 7O4T; 
				7O4V
			
			

			» more

				
	





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