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PROSITE entry PS00099


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00099
Entry name [info] THIOLASE_3
Accession [info] PS00099
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00092
Associated ProRule [info] PRU10020

Name and characterization of the entry

Description [info] Thiolases active site.
Pattern [info] 
[AG]-[LIVMA]-[STAGCLIVM]-[STAG]-[LIVMA]-C-{Q}-[AG]-x-[AG]-x-[AG]-x-[SAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 301 in 301 different sequences
Number of true positive hits 260 in 260 different sequences
Number of 'unknown' hits 0
Number of false positive hits 41 in 41 different sequences
Number of false negative sequences 50
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 86.38 %
Recall (true positives / (true positives + false negatives)) 83.87 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 260 sequences 

AACT1_ARATH (Q9FIK7), ACCT2_ARATH (Q8S4Y1), ATOB_ECOLI  (P76461), 

ATOB_HAEIN  (P44873), ATOB_PSEAE  (Q9I2A8), BKTB_CUPNH  (Q0KBP1), 
CATF_ACIAD  (Q43935), ECHB_BOVIN  (O46629), ECHB_HUMAN  (P55084), 
ECHB_MACFA  (Q8HXX4), ECHB_MOUSE  (Q99JY0), ECHB_PANTR  (Q5R1W7), 
ECHB_RAT(Q60587), ECHH_CAEEL  (P34255), ER10A_ASPFC (B0XMC1), 
ER10A_ASPFU (Q4WLA8), ER10A_GIBZE (I1RMA2), ER10B_GIBZE (I1RY81), 
ERG10_SACMO (P10551), ERG10_SCHPO (Q9UQW6), ERG10_YEAST (P41338), 
FADA4_MYCBO (P66927), FADA4_MYCLE (P46707), FADA4_MYCS2 (A0R1Y7), 
FADA4_MYCTO (P9WG68), FADA4_MYCTU (P9WG69), FADA_ACIAD  (Q6FF69), 
FADA_ACIB3  (B7H1I1), FADA_ACIB5  (B7I3P0), FADA_ACIBC  (B2I2J8), 
FADA_ACIBS  (B0VLX5), FADA_ACIBT  (A3M1H9), FADA_ACIBY  (B0VE46), 
FADA_AERHH  (A0KEL0), FADA_AERS4  (A4STF3), FADA_ALCBS  (Q0VNZ7), 
FADA_ALIF1  (Q5E8X7), FADA_ALIFM  (B5FEW7), FADA_ALISL  (B6EGU1), 
FADA_BACSU  (O32177), FADA_CHRSD  (Q1QUW9), FADA_CITK8  (A8ACZ3), 
FADA_COLP3  (Q489W4), FADA_CROS8  (A7MQM5), FADA_ECO24  (A7ZU50), 
FADA_ECO57  (Q8X8J4), FADA_ECOHS  (A8A6V0), FADA_ECOK1  (A1AI32), 
FADA_ECOL5  (Q0TAL1), FADA_ECOL6  (Q8FBI3), FADA_ECOLI  (P21151), 
FADA_ECOUT  (Q1R467), FADA_ENT38  (A4WFX5), FADA_ENTCL  (Q9F0Y6), 
FADA_ERWT9  (B2VFE0), FADA_ESCF3  (B7LTZ0), FADA_HAHCH  (Q2SD23), 
FADA_IDILO  (Q5QXH8), FADA_KLEP7  (A6TGM3), FADA_MARMS  (A6VVM8), 
FADA_MARN8  (A1TZR8), FADA_PECAS  (Q6DAP6), FADA_PECCP  (C6DI66), 
FADA_PHOLL  (Q7MZ91), FADA_PHOPR  (Q6LW07), FADA_PSE14  (Q48GW4), 
FADA_PSEA6  (Q15ZF4), FADA_PSEF5  (Q4KFC3), FADA_PSEFR  (P28790), 
FADA_PSEPF  (Q3K9D9), FADA_PSESM  (Q87ZB3), FADA_PSET1  (Q3IJ24), 
FADA_PSEU2  (Q4ZRA1), FADA_PSYA2  (Q4FQC7), FADA_PSYCK  (Q1Q8K0), 
FADA_PSYWF  (A5WH98), FADA_SALCH  (Q57HM7), FADA_SALPA  (Q5PKQ3), 
FADA_SALTI  (P0A2H8), FADA_SALTY  (P0A2H7), FADA_SERP5  (A8G8D0), 
FADA_SHEAM  (A1S1I7), FADA_SHEB5  (A3CYJ3), FADA_SHEB8  (A6WH99), 
FADA_SHEDO  (Q12TB5), FADA_SHEFN  (Q08A40), FADA_SHELP  (A3Q8U3), 
FADA_SHEON  (Q8EKS0), FADA_SHEPC  (A4Y1B5), FADA_SHESA  (A0KR49), 
FADA_SHESM  (Q0HPB8), FADA_SHESR  (Q0I0T4), FADA_SHESW  (A1RDW3), 
FADA_SHIBS  (Q31UE3), FADA_SHIDS  (Q32A20), FADA_SHIF8  (Q0SZ35), 
FADA_SHIFL  (Q83PG2), FADA_SHISS  (Q3YVC2), FADA_STUS1  (A4VKA4), 
FADA_VIBC3  (A5F464), FADA_VIBCH  (Q9KNI0), FADA_VIBPA  (Q87TP0), 
FADA_VIBVU  (Q8DDK5), FADA_VIBVY  (Q7MQI0), FADA_YERE8  (A1JIG3), 
FADA_YERP3  (A7FDF1), FADA_YERPA  (Q1C2C3), FADA_YERPE  (Q8ZAM9), 
FADA_YERPN  (Q1CNA0), FADA_YERPP  (A4TR28), FADA_YERPS  (Q66FR9), 
FADI_ALTMD  (B4RTU9), FADI_CITK8  (A8ADP1), FADI_COLP3  (Q47ZB6), 
FADI_CROS8  (A7MH80), FADI_ECO24  (A7ZPF9), FADI_ECO27  (B7UFZ9), 
FADI_ECO45  (B7MGV8), FADI_ECO55  (B7LBJ6), FADI_ECO57  (Q8XCN9), 
FADI_ECO5E  (B5YXY5), FADI_ECO7I  (B7NP25), FADI_ECO81  (B7MY17), 
FADI_ECO8A  (B7M6M3), FADI_ECOBW  (C4ZVN3), FADI_ECODH  (B1X9L5), 
FADI_ECOHS  (A8A2L1), FADI_ECOK1  (A1ADI9), FADI_ECOL5  (Q0TFA5), 
FADI_ECOL6  (Q8FFG3), FADI_ECOLC  (B1IXA4), FADI_ECOLI  (P76503), 
FADI_ECOLU  (B7N5V3), FADI_ECOSE  (B6I6Q5), FADI_ECOSM  (B1LME8), 
FADI_ECOUT  (Q1R971), FADI_ENT38  (A4WCW7), FADI_ERWT9  (B2VJ10), 
FADI_ESCF3  (B7LLC9), FADI_IDILO  (Q5QXN5), FADI_KLEP3  (B5XVW1), 
FADI_KLEP7  (A6TC20), FADI_PECAS  (Q6D2L6), FADI_PECCP  (C6DAL8), 
FADI_PHOLL  (Q7N287), FADI_PSEA6  (Q15VA3), FADI_PSET1  (Q3IEE3), 
FADI_SALA4  (B5EZS0), FADI_SALAR  (A9MJ36), FADI_SALCH  (Q57LW5), 
FADI_SALDC  (B5FPN2), FADI_SALEP  (B5R3S0), FADI_SALHS  (B4TCA9), 
FADI_SALNS  (B4SZR1), FADI_SALPA  (Q5PCX7), FADI_SALPB  (A9N452), 
FADI_SALPC  (C0PZX5), FADI_SALPK  (B5BBA0), FADI_SALSV  (B4TQC3), 
FADI_SALTI  (Q8Z4Y9), FADI_SALTY  (Q8ZNA6), FADI_SERP5  (A8GH87), 
FADI_SHEAM  (A1S7L7), FADI_SHEB2  (B8EE97), FADI_SHEB5  (A3D685), 
FADI_SHEB8  (A6WQ26), FADI_SHEB9  (A9KTW7), FADI_SHEDO  (Q12P12), 
FADI_SHEFN  (Q07ZP7), FADI_SHEHH  (B0TL22), FADI_SHELP  (A3QFP4), 
FADI_SHEON  (Q8ECP6), FADI_SHEPA  (A8H5T2), FADI_SHEPC  (A4Y898), 
FADI_SHEPW  (B8CPY7), FADI_SHESA  (A0KV75), FADI_SHESH  (A8FTR6), 
FADI_SHESM  (Q0HKD2), FADI_SHESR  (Q0HWN4), FADI_SHESW  (A1RI91), 
FADI_SHEWM  (B1KKT1), FADI_SHIB3  (B2TWV5), FADI_SHIBS  (Q31YB6), 
FADI_SHIDS  (Q32DJ3), FADI_SHIF8  (Q0T2E5), FADI_SHIFL  (Q83K95), 
FADI_SHISS  (Q3YZM1), FADI_YERE8  (A1JK23), FADI_YERP3  (A7FGK0), 
FADI_YERPA  (Q1C659), FADI_YERPB  (B2K8J6), FADI_YERPE  (Q8ZD46), 
FADI_YERPG  (A9R7W9), FADI_YERPN  (Q1CHK1), FADI_YERPP  (A4TM83), 
FADI_YERPS  (Q668V0), FADI_YERPY  (B1JGG1), KAT1_PETHY  (C8YNG6), 
PAAJ_ECOLI  (P0C7L2), PAAJ_ECOLX  (P0C7L3), PCAF_ACIAD  (Q43974), 
PCAF_PSEAE  (Q9I6R0), PCAF_PSEKB  (Q8VPF1), PCAF_PSEPU  (Q51956), 
THIA_CANTR  (Q12598), THIB_CANTR  (Q04677), THIC_HUMAN  (Q9BWD1), 
THIC_MOUSE  (Q8CAY6), THIC_RAT(Q5XI22), THIK1_ARATH (Q8LF48), 
THIK2_ARATH (Q56WD9), THIK5_ARATH (Q570C8), THIKA_CANTR (P33290), 
THIKA_MOUSE (Q921H8), THIKA_RAT   (P21775), THIKB_CANTR (P33291), 
THIKB_MOUSE (Q8VCH0), THIKB_RAT   (P07871), THIK_ENCCU  (Q8SVA6), 
THIK_HUMAN  (P09110), THIK_YARLI  (Q05493), THIK_YEAST  (P27796), 
THILA_XENLA (Q6NU46), THILB_XENLA (Q6GN02), THIL_ALLVD  (P45369), 
THIL_BOVIN  (Q29RZ0), THIL_CHRVO  (Q9ZHI1), THIL_CUPNH  (P14611), 
THIL_DANRE  (Q6AZA0), THIL_HUMAN  (P24752), THIL_MACFA  (Q8HXY6), 
THIL_MOUSE  (Q8QZT1), THIL_PARDE  (P54810), THIL_RAT(P17764), 
THIL_RHIME  (P50174), THIL_SHIZO  (P07097), THIL_SYNY3  (P73825), 
THIL_THIVI  (P45363), THIL_XENTR  (Q5BKN8), THIM_BOVIN  (Q3T0R7), 
THIM_HUMAN  (P42765), THIM_MOUSE  (Q8BWT1), THIM_PONAB  (Q5RES5), 
THIM_RAT(P13437), THLA_CLOAB  (P45359), THLA_STAA3  (Q2FJQ9), 
THLA_STAA8  (Q2G124), THLA_STAAB  (Q2YVF5), THLA_STAAC  (Q5HIU0), 
THLA_STAAM  (Q99WM3), THLA_STAAN  (Q7A7L2), THLA_STAAR  (Q6GJW4), 
THLA_STAAS  (Q6GCB8), THLA_STAAW  (Q8NY95), THLA_STAEQ  (Q5HS07), 
THLA_STAES  (Q8CQN7), THLA_SYNWW  (Q0AVM3), THL_BACSU   (P45855), 
Y0859_MYCTU (O53871), YQEF_ECOLI  (Q46939)
» more

UniProtKB/Swiss-Prot
False negative sequences		 50 sequences 

BBSB_GEOMG  (Q39VG1), BBSB_THAAR  (Q9KJF3), ER10B_ASPFC (B0YA65), 

ER10B_ASPFU (Q4WCL5), ERG10_CANAL (A0A1D8PH52), FADA5_MYCTU (I6XHI4), 
FADA6_MYCTU (I6XHJ3), FADA_ECTM1  (A4XSM9), FADA_ECTOL  (Q93Q11), 
FADA_PSEA7  (A6V383), FADA_PSEAB  (Q02PH7), FADA_PSEAE  (Q9HZJ3), 
FADA_PSEE4  (Q1I7D5), FADA_PSEP1  (A5W6G9), FADA_PSEPK  (Q88L01), 
FADA_PSEPU  (Q9R9W0), FADA_SACD2  (Q21KB1), FADI_AERHH  (A0KK76), 
FADI_AERS4  (A4SMT9), FADI_ALIF1  (Q5E3U0), FADI_ALIFM  (B5FGB5), 
FADI_PHOPR  (Q6LTK4), FADI_VIBC3  (A5F2P1), FADI_VIBCH  (Q9KT59), 
FADI_VIBPA  (Q87MM2), FADI_VIBVU  (Q8DB48), FADI_VIBVY  (Q7MIS4), 
SCP2_BOVIN  (P07857), SCP2_CHICK  (Q07598), SCP2_HUMAN  (P22307), 
SCP2_MOUSE  (P32020), SCP2_RABIT  (O62742), SCP2_RAT(P11915), 
THIL1_DICDI (Q86AD9), THILH_CAEEL (Q22100), THIL_YARLI  (Q6L8K7), 
THIOL_METJA (Q58944), THIOL_METTH (O26884), THIOL_METTL (A0A384E138), 
VRAB_STAA1  (Q9KWK4), VRAB_STAAC  (Q5HIA0), VRAB_STAAM  (Q7A2W9), 
VRAB_STAAN  (Q7A768), VRAB_STAAR  (Q6GJ93), VRAB_STAAS  (Q6GBR1), 
VRAB_STAAW  (Q7A1P9), VRAB_STAEQ  (Q5HRH3), VRAB_STAES  (Q8CTR0), 
VRAB_STAHJ  (Q4L3Q1), YHFS_BACSU  (O07618)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

THIL_PIG(P14610), THLA_CLODI  (P45362), THLA_CLOPA  (P81347)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			41 sequences
			


			
ACON_BOVIN  (P20004), ACON_CAEEL  (P34455), ACON_HUMAN  (Q99798), 

			
ACON_MOUSE  (Q99KI0), ACON_PIG(P16276), ACON_RAT(Q9ER34), 
ARGJ_OSTLU  (A4S1K1), FINC_CHICK  (P11722), J1I_HCMVA   (P09711), 
LUZ_ARMOS   (A0A3G9K3N1), MYCN_MOUSE  (P03966), MYST1_ORYSJ (Q8LI34), 
PER1_VOLCA  (P81131), SSTT_ALIF1  (Q5DZC3), SSTT_CAMFF  (A0RNW2), 
SSTT_DESPS  (Q6AS08), SSTT_ENTFA  (Q82ZN5), SSTT_PHOPR  (Q6LG82), 
SSTT_PSYIN  (A1SS94), SSTT_SHEAM  (A1S7P9), SSTT_SHELP  (A3QCX7), 
SSTT_SHEON  (Q8ECL5), SSTT_SHESA  (A0KV41), SSTT_SHESM  (Q0HKG6), 
SSTT_SHESR  (Q0HWR8), SSTT_SHESW  (A1RI59), SSTT_STRP1  (Q9A1E0), 
SSTT_STRP3  (P0DF78), SSTT_STRP6  (Q5XDS5), SSTT_STRP8  (Q8P2K3), 
SSTT_STRPB  (Q1JDG4), SSTT_STRPC  (Q1JND7), SSTT_STRPD  (Q1JII6), 
SSTT_STRPF  (Q1J8E1), SSTT_STRPG  (A2RGC2), SSTT_STRPM  (Q48V75), 
SSTT_STRPQ  (P0DF79), SSTT_VIBCH  (Q9KNC9), SSTT_VIBPA  (Q87FP8), 
SSTT_VIBVU  (Q8D4Q1), SSTT_VIBVY  (Q7MGA3)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			107 PDB
			


			1AFW; 1DLU; 1DLV; 1DM3; 1M1O; 1M1T; 1M3K; 1M3Z; 1M4S; 1M4T; 1NL7; 1OU6; 
			
				1PXT; 1QFL; 1WDK; 1WDL; 1WDM; 1WL4; 1WL5; 2C7Y; 2C7Z; 2D3T; 2F2S; 2IB7; 
				2IB8; 2IB9; 2IBU; 2IBW; 2IBY; 2IIK; 2VTZ; 2VU0; 2VU1; 2VU2; 2WKT; 2WKU; 
				2WKV; 2WL4; 2WL5; 2WL6; 2WU9; 3GOA; 4B3H; 4B3I; 4B3J; 4C2J; 4C2K; 4NZS; 
				4O99; 4O9A; 4O9C; 4W61; 4WYR; 4WYS; 4XL2; 5F0V; 5F38; 5LP7; 5XYJ; 5XZ5; 
				5ZQZ; 5ZRV; 6DV2; 6L2C; 6L2G; 7LBZ; 7LCA; 7LCL; 7LD2; 7LDC; 7LDT; 7LDU; 
				7LDV; 7LDW; 7O1G; 7O1I; 7O1J; 7O1K; 7O1L; 7O1M; 7O4Q; 7O4R; 7O4S; 7O4T; 
				7O4V; 8BNR; 8BNU; 8BRJ; 8GQH; 8GQJ; 8OPU; 8OPV; 8OPW; 8OPX; 8OPY; 8OQL; 
				8OQM; 8OQN; 8OQO; 8OQP; 8OQQ; 8OQR; 8OQS; 8OQT; 8OQU; 8OQV; 8PF8
			
			

			» more