PROSITE logo

PROSITE entry PS00110


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] PYRUVATE_KINASE
Accession [info] PS00110
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUL-1999 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00101

Name and characterization of the entry

Description [info] Pyruvate kinase active site signature.
Pattern [info] 
[LIVAC]-x-[LIVM](2)-[SAPCV]-K-[LIV]-E-[NKRST]-x-[DEQHS]-[GSTA]-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 79 in 79 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 94.05 %
Recall (true positives / (true positives + false negatives)) 78.22 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] magnesium at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 79 sequences 

KPYA_RICCO  (Q43117), KPYA_TOBAC  (Q40545), KPYC_ARATH  (O65595), 

KPYC_SOLTU  (P22200), KPYC_SOYBN  (Q42806), KPYC_TOBAC  (Q42954), 
KPYG_RICCO  (P55964), KPYG_TOBAC  (Q40546), KPYK1_AGRVI (P70789), 
KPYK1_CANGA (Q6FIS9), KPYK1_ECO57 (P0AD62), KPYK1_ECOLI (P0AD61), 
KPYK1_SALTI (Q8Z6K2), KPYK1_SALTY (P77983), KPYK1_SYNY3 (Q55863), 
KPYK1_TRYBB (P30615), KPYK1_YEAST (P00549), KPYK2_AGRVI (Q44473), 
KPYK2_CANGA (Q6FV12), KPYK2_ECOLI (P21599), KPYK2_SALTY (Q8ZNW0), 
KPYK2_SYNY3 (P73534), KPYK2_TRYBB (P30616), KPYK2_YEAST (P52489), 
KPYK_AGABI  (O94122), KPYK_ASPNG  (Q12669), KPYK_BACLI  (P51181), 
KPYK_BACSU  (P80885), KPYK_BORBU  (O51323), KPYK_BUCAI  (P57404), 
KPYK_BUCAP  (Q8K9M3), KPYK_BUCBP  (Q89AI8), KPYK_CANAL  (P46614), 
KPYK_CLOPE  (Q46289), KPYK_COREF  (Q8FP04), KPYK_CORGL  (Q46078), 
KPYK_DEBHA  (Q6BS75), KPYK_DICDI  (Q54RF5), KPYK_DROME  (O62619), 
KPYK_EIMTE  (O44006), KPYK_EMENI  (P22360), KPYK_EREGS  (Q759A9), 
KPYK_GEOSE  (Q02499), KPYK_HAEIN  (P43924), KPYK_HYPJE  (P31865), 
KPYK_KLULA  (Q875M9), KPYK_LACK1  (Q875S4), KPYK_LACLA  (Q07637), 
KPYK_LEIME  (Q27686), KPYK_METEA  (O05118), KPYK_METJA  (Q57572), 
KPYK_MYCGE  (P47458), KPYK_MYCIT  (P94939), KPYK_MYCPN  (P78031), 
KPYK_MYCTO  (P9WKE4), KPYK_MYCTU  (P9WKE5), KPYK_NAUCC  (Q875Z9), 
KPYK_NEUCR  (Q7RVA8), KPYK_SCHPO  (Q10208), KPYK_SPOPS  (P51182), 
KPYK_STAS1  (Q49YC7), KPYK_THELN  (Q56301), KPYK_TRYBO  (Q27788), 
KPYK_YARLI  (P30614), KPYM_CHICK  (P00548), KPYM_FELCA  (P11979), 
KPYM_HUMAN  (P14618), KPYM_MOUSE  (P52480), KPYM_PONAB  (Q5NVN0), 
KPYM_RABIT  (P11974), KPYM_RAT(P11980), KPYM_XENLA  (Q92122), 
KPYR_CANLF  (Q29536), KPYR_HUMAN  (P30613), KPYR_MOUSE  (P53657), 
KPYR_RAT(P12928), PKP1_ARATH  (Q9LIK0), PKP2_ARATH  (Q9FLW9), 
PKP3_ARATH  (Q93Z53)
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

KPYK_AERPE  (Q9YEU2), KPYK_CHLMU  (Q9PK61), KPYK_CHLPN  (Q9Z984), 

KPYK_CHLT2  (B0B7Q0), KPYK_CHLTR  (P0CE21), KPYK_CLOAB  (O08309), 
KPYK_LACDE  (P34038), KPYK_PYRAE  (Q8ZYE0), KPYK_STAA3  (Q2FG40), 
KPYK_STAA8  (Q2FXM9), KPYK_STAAB  (Q2YTE3), KPYK_STAAC  (Q5HF76), 
KPYK_STAAM  (Q99TG5), KPYK_STAAN  (Q7A559), KPYK_STAAR  (Q6GG09), 
KPYK_STAAS  (Q6G8M9), KPYK_STAAW  (Q7A0N4), KPYK_STAEQ  (Q5HNK7), 
KPYK_STAES  (Q8CS69), KPYK_STAHJ  (Q4L739), KPYK_THEAC  (P32044), 
KPYK_THEMA  (Q9WY51)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 4 sequences 

KPYK1_PHOLE (O30853), KPYK_CLOPA  (P81344), KPYK_LEIBR  (Q04668), 

KPYK_SPICI  (P19680)
» more

UniProtKB/Swiss-Prot
False positive sequences		 5 sequences 

ABITM_DROME (Q9VFR1), AROB_BRUA2  (Q2YR43), AROB_BRUAB  (Q57AM9), 

DNAB_HAEIN  (P45256), MQO_CAMJE   (P56954)
» more

PDB
[Detailed view]		 162 PDB

1A3W; 1A3X; 1A49; 1A5U; 1AQF; 1E0T; 1E0U; 1F3W; 1F3X; 1PKL; 1PKM; 1PKN; 1PKY; 1T5A; 1ZJH; 2E28; 2G50; 2VGB; 2VGF; 2VGG; 2VGI; 3BJF; 3BJT; 3E0V; 3E0W; 3G2G; 3GQY; 3GR4; 3H6O; 3HQN; 3HQO; 3HQP; 3HQQ; 3IS4; 3KTX; 3ME3; 3N25; 3PP7; 3QV6; 3QV7; 3QV8; 3SRD; 3SRF; 3SRH; 3SRK; 3U2Z; 4B2D; 4FXF; 4FXJ; 4G1N; 4HYV; 4HYW; 4IMA; 4IP7; 4JPG; 4KCT; 4KCU; 4KCV; 4KCW; 4QG6; 4QG8; 4QG9; 4QGC; 4RPP; 4WJ8; 4YJ5; 4YNG; 5SC8; 5SC9; 5SCA; 5SCB; 5SCC; 5SCD; 5SCE; 5SCF; 5SCG; 5SCH; 5SCI; 5SCJ; 5SCK; 5SCL; 5SDT; 5WRP; 5WS8; 5WS9; 5WSA; 5WSB; 5WSC; 5X0I; 5X1V; 5X1W; 6B6U; 6ECH; 6ECK; 6GG3; 6GG4; 6GG5; 6GG6; 6ITO; 6JFB; 6K0K; 6NN4; 6NN5; 6NN7; 6NN8; 6NU1; 6NU5; 6NUB; 6TTF; 6TTH; 6TTI; 6TTQ; 6V74; 6V75; 6V76; 6WP3; 6WP4; 6WP5; 6WP6; 7FRV; 7FRW; 7FRX; 7FRY; 7FRZ; 7FS0; 7FS1; 7FS2; 7FS3; 7FS4; 7FS5; 7FS6; 7FS7; 7FS8; 7FS9; 7FSA; 7FSB; 7FSC; 7FSD; 7L21; 7QDN; 7QZU; 7R6Y; 8EDQ; 8EDR; 8EDS; 8EDT; 8EQ0; 8EQ1; 8EQ3; 8EU4; 8F5T; 8F5U; 8F6M; 8G2E; 8HGF; 8HMQ; 8HMR; 8HMS; 8HMU; 8TBS; 8TBT; 8TBU
» more