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PROSITE entry PS00110


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PURL: https://purl.expasy.org/prosite/signature/PS00110

Direct ScanProsite submission
General information about the entry

Entry name [info] PYRUVATE_KINASE
Accession [info] PS00110
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUL-1999 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00101

Name and characterization of the entry

Description [info] Pyruvate kinase active site signature.
Pattern [info] 
[LIVAC]-x-[LIVM](2)-[SAPCV]-K-[LIV]-E-[NKRST]-x-[DEQHS]-[GSTA]-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 79 in 79 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 94.05 %
Recall (true positives / (true positives + false negatives)) 78.22 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] magnesium at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 79 sequences 

KPYA_RICCO  (Q43117), KPYA_TOBAC  (Q40545), KPYC_ARATH  (O65595), 

KPYC_SOLTU  (P22200), KPYC_SOYBN  (Q42806), KPYC_TOBAC  (Q42954), 
KPYG_RICCO  (P55964), KPYG_TOBAC  (Q40546), KPYK1_AGRVI (P70789), 
KPYK1_CANGA (Q6FIS9), KPYK1_ECO57 (P0AD62), KPYK1_ECOLI (P0AD61), 
KPYK1_SALTI (Q8Z6K2), KPYK1_SALTY (P77983), KPYK1_SYNY3 (Q55863), 
KPYK1_TRYBB (P30615), KPYK1_YEAST (P00549), KPYK2_AGRVI (Q44473), 
KPYK2_CANGA (Q6FV12), KPYK2_ECOLI (P21599), KPYK2_SALTY (Q8ZNW0), 
KPYK2_SYNY3 (P73534), KPYK2_TRYBB (P30616), KPYK2_YEAST (P52489), 
KPYK_AGABI  (O94122), KPYK_ASPNG  (Q12669), KPYK_BACLI  (P51181), 
KPYK_BACSU  (P80885), KPYK_BORBU  (O51323), KPYK_BUCAI  (P57404), 
KPYK_BUCAP  (Q8K9M3), KPYK_BUCBP  (Q89AI8), KPYK_CANAL  (P46614), 
KPYK_CLOPE  (Q46289), KPYK_COREF  (Q8FP04), KPYK_CORGL  (Q46078), 
KPYK_DEBHA  (Q6BS75), KPYK_DICDI  (Q54RF5), KPYK_DROME  (O62619), 
KPYK_EIMTE  (O44006), KPYK_EMENI  (P22360), KPYK_EREGS  (Q759A9), 
KPYK_GEOSE  (Q02499), KPYK_HAEIN  (P43924), KPYK_HYPJE  (P31865), 
KPYK_KLULA  (Q875M9), KPYK_LACK1  (Q875S4), KPYK_LACLA  (Q07637), 
KPYK_LEIME  (Q27686), KPYK_METEA  (O05118), KPYK_METJA  (Q57572), 
KPYK_MYCGE  (P47458), KPYK_MYCIT  (P94939), KPYK_MYCPN  (P78031), 
KPYK_MYCTO  (P9WKE4), KPYK_MYCTU  (P9WKE5), KPYK_NAUCA  (Q875Z9), 
KPYK_NEUCR  (Q7RVA8), KPYK_SCHPO  (Q10208), KPYK_SPOPS  (P51182), 
KPYK_STAS1  (Q49YC7), KPYK_THELN  (Q56301), KPYK_TRYBO  (Q27788), 
KPYK_YARLI  (P30614), KPYM_CHICK  (P00548), KPYM_FELCA  (P11979), 
KPYM_HUMAN  (P14618), KPYM_MOUSE  (P52480), KPYM_PONAB  (Q5NVN0), 
KPYM_RABIT  (P11974), KPYM_RAT(P11980), KPYM_XENLA  (Q92122), 
KPYR_CANLF  (Q29536), KPYR_HUMAN  (P30613), KPYR_MOUSE  (P53657), 
KPYR_RAT(P12928), PKP1_ARATH  (Q9LIK0), PKP2_ARATH  (Q9FLW9), 
PKP3_ARATH  (Q93Z53)
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

KPYK_AERPE  (Q9YEU2), KPYK_CHLMU  (Q9PK61), KPYK_CHLPN  (Q9Z984), 

KPYK_CHLT2  (B0B7Q0), KPYK_CHLTR  (P0CE21), KPYK_CLOAB  (O08309), 
KPYK_LACDE  (P34038), KPYK_PYRAE  (Q8ZYE0), KPYK_STAA3  (Q2FG40), 
KPYK_STAA8  (Q2FXM9), KPYK_STAAB  (Q2YTE3), KPYK_STAAC  (Q5HF76), 
KPYK_STAAM  (Q99TG5), KPYK_STAAN  (Q7A559), KPYK_STAAR  (Q6GG09), 
KPYK_STAAS  (Q6G8M9), KPYK_STAAW  (Q7A0N4), KPYK_STAEQ  (Q5HNK7), 
KPYK_STAES  (Q8CS69), KPYK_STAHJ  (Q4L739), KPYK_THEAC  (P32044), 
KPYK_THEMA  (Q9WY51)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 4 sequences 

KPYK1_PHOLE (O30853), KPYK_CLOPA  (P81344), KPYK_LEIBR  (Q04668), 

KPYK_SPICI  (P19680)
» more

UniProtKB/Swiss-Prot
False positive sequences		 5 sequences 

ABITM_DROME (Q9VFR1), AROB_BRUA2  (Q2YR43), AROB_BRUAB  (Q57AM9), 

DNAB_HAEIN  (P45256), MQO_CAMJE   (P56954)
» more

PDB
[Detailed view]		 164 PDB

pdb_00001a3w; pdb_00001a3x; pdb_00001a49; pdb_00001a5u; pdb_00001aqf; pdb_00001e0t; pdb_00001e0u; pdb_00001f3w; pdb_00001f3x; pdb_00001pkl; pdb_00001pkm; pdb_00001pkn; pdb_00001pky; pdb_00001t5a; pdb_00001zjh; pdb_00002e28; pdb_00002g50; pdb_00002vgb; pdb_00002vgf; pdb_00002vgg; pdb_00002vgi; pdb_00003bjf; pdb_00003bjt; pdb_00003e0v; pdb_00003e0w; pdb_00003g2g; pdb_00003gqy; pdb_00003gr4; pdb_00003h6o; pdb_00003hqn; pdb_00003hqo; pdb_00003hqp; pdb_00003hqq; pdb_00003is4; pdb_00003ktx; pdb_00003me3; pdb_00003n25; pdb_00003pp7; pdb_00003qv6; pdb_00003qv7; pdb_00003qv8; pdb_00003srd; pdb_00003srf; pdb_00003srh; pdb_00003srk; pdb_00003u2z; pdb_00004b2d; pdb_00004fxf; pdb_00004fxj; pdb_00004g1n; pdb_00004hyv; pdb_00004hyw; pdb_00004ima; pdb_00004ip7; pdb_00004jpg; pdb_00004kct; pdb_00004kcu; pdb_00004kcv; pdb_00004kcw; pdb_00004qg6; pdb_00004qg8; pdb_00004qg9; pdb_00004qgc; pdb_00004rpp; pdb_00004wj8; pdb_00004yj5; pdb_00004yng; pdb_00005sc8; pdb_00005sc9; pdb_00005sca; pdb_00005scb; pdb_00005scc; pdb_00005scd; pdb_00005sce; pdb_00005scf; pdb_00005scg; pdb_00005sch; pdb_00005sci; pdb_00005scj; pdb_00005sck; pdb_00005scl; pdb_00005sdt; pdb_00005wrp; pdb_00005ws8; pdb_00005ws9; pdb_00005wsa; pdb_00005wsb; pdb_00005wsc; pdb_00005x0i; pdb_00005x1v; pdb_00005x1w; pdb_00006b6u; pdb_00006ech; pdb_00006eck; pdb_00006gg3; pdb_00006gg4; pdb_00006gg5; pdb_00006gg6; pdb_00006ito; pdb_00006jfb; pdb_00006k0k; pdb_00006nn4; pdb_00006nn5; pdb_00006nn7; pdb_00006nn8; pdb_00006nu1; pdb_00006nu5; pdb_00006nub; pdb_00006ttf; pdb_00006tth; pdb_00006tti; pdb_00006ttq; pdb_00006v74; pdb_00006v75; pdb_00006v76; pdb_00006wp3; pdb_00006wp4; pdb_00006wp5; pdb_00006wp6; pdb_00007frv; pdb_00007frw; pdb_00007frx; pdb_00007fry; pdb_00007frz; pdb_00007fs0; pdb_00007fs1; pdb_00007fs2; pdb_00007fs3; pdb_00007fs4; pdb_00007fs5; pdb_00007fs6; pdb_00007fs7; pdb_00007fs8; pdb_00007fs9; pdb_00007fsa; pdb_00007fsb; pdb_00007fsc; pdb_00007fsd; pdb_00007l21; pdb_00007qdn; pdb_00007qzu; pdb_00007r6y; pdb_00008edq; pdb_00008edr; pdb_00008eds; pdb_00008edt; pdb_00008eq0; pdb_00008eq1; pdb_00008eq3; pdb_00008eu4; pdb_00008f5t; pdb_00008f5u; pdb_00008f6m; pdb_00008g2e; pdb_00008hgf; pdb_00008hmq; pdb_00008hmr; pdb_00008hms; pdb_00008hmu; pdb_00008tbs; pdb_00008tbt; pdb_00008tbu; pdb_00008x4r; pdb_00008xfd
» more