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PROSITE entry PS00110


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00110
Entry name [info] PYRUVATE_KINASE
Accession [info] PS00110
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUL-1999 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00101

Name and characterization of the entry

Description [info] Pyruvate kinase active site signature.
Pattern [info] 
[LIVAC]-x-[LIVM](2)-[SAPCV]-K-[LIV]-E-[NKRST]-x-[DEQHS]-[GSTA]-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 79 in 79 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 94.05 %
Recall (true positives / (true positives + false negatives)) 78.22 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] magnesium at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 79 sequences 

KPYA_RICCO  (Q43117), KPYA_TOBAC  (Q40545), KPYC_ARATH  (O65595), 

KPYC_SOLTU  (P22200), KPYC_SOYBN  (Q42806), KPYC_TOBAC  (Q42954), 
KPYG_RICCO  (P55964), KPYG_TOBAC  (Q40546), KPYK1_AGRVI (P70789), 
KPYK1_CANGA (Q6FIS9), KPYK1_ECO57 (P0AD62), KPYK1_ECOLI (P0AD61), 
KPYK1_SALTI (Q8Z6K2), KPYK1_SALTY (P77983), KPYK1_SYNY3 (Q55863), 
KPYK1_TRYBB (P30615), KPYK1_YEAST (P00549), KPYK2_AGRVI (Q44473), 
KPYK2_CANGA (Q6FV12), KPYK2_ECOLI (P21599), KPYK2_SALTY (Q8ZNW0), 
KPYK2_SYNY3 (P73534), KPYK2_TRYBB (P30616), KPYK2_YEAST (P52489), 
KPYK_AGABI  (O94122), KPYK_ASPNG  (Q12669), KPYK_BACLI  (P51181), 
KPYK_BACSU  (P80885), KPYK_BORBU  (O51323), KPYK_BUCAI  (P57404), 
KPYK_BUCAP  (Q8K9M3), KPYK_BUCBP  (Q89AI8), KPYK_CANAL  (P46614), 
KPYK_CLOPE  (Q46289), KPYK_COREF  (Q8FP04), KPYK_CORGL  (Q46078), 
KPYK_DEBHA  (Q6BS75), KPYK_DICDI  (Q54RF5), KPYK_DROME  (O62619), 
KPYK_EIMTE  (O44006), KPYK_EMENI  (P22360), KPYK_EREGS  (Q759A9), 
KPYK_GEOSE  (Q02499), KPYK_HAEIN  (P43924), KPYK_HYPJE  (P31865), 
KPYK_KLULA  (Q875M9), KPYK_LACK1  (Q875S4), KPYK_LACLA  (Q07637), 
KPYK_LEIME  (Q27686), KPYK_METEA  (O05118), KPYK_METJA  (Q57572), 
KPYK_MYCGE  (P47458), KPYK_MYCIT  (P94939), KPYK_MYCPN  (P78031), 
KPYK_MYCTO  (P9WKE4), KPYK_MYCTU  (P9WKE5), KPYK_NAUCA  (Q875Z9), 
KPYK_NEUCR  (Q7RVA8), KPYK_SCHPO  (Q10208), KPYK_SPOPS  (P51182), 
KPYK_STAS1  (Q49YC7), KPYK_THELN  (Q56301), KPYK_TRYBO  (Q27788), 
KPYK_YARLI  (P30614), KPYM_CHICK  (P00548), KPYM_FELCA  (P11979), 
KPYM_HUMAN  (P14618), KPYM_MOUSE  (P52480), KPYM_PONAB  (Q5NVN0), 
KPYM_RABIT  (P11974), KPYM_RAT(P11980), KPYM_XENLA  (Q92122), 
KPYR_CANLF  (Q29536), KPYR_HUMAN  (P30613), KPYR_MOUSE  (P53657), 
KPYR_RAT(P12928), PKP1_ARATH  (Q9LIK0), PKP2_ARATH  (Q9FLW9), 
PKP3_ARATH  (Q93Z53)
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

KPYK_AERPE  (Q9YEU2), KPYK_CHLMU  (Q9PK61), KPYK_CHLPN  (Q9Z984), 

KPYK_CHLT2  (B0B7Q0), KPYK_CHLTR  (P0CE21), KPYK_CLOAB  (O08309), 
KPYK_LACDE  (P34038), KPYK_PYRAE  (Q8ZYE0), KPYK_STAA3  (Q2FG40), 
KPYK_STAA8  (Q2FXM9), KPYK_STAAB  (Q2YTE3), KPYK_STAAC  (Q5HF76), 
KPYK_STAAM  (Q99TG5), KPYK_STAAN  (Q7A559), KPYK_STAAR  (Q6GG09), 
KPYK_STAAS  (Q6G8M9), KPYK_STAAW  (Q7A0N4), KPYK_STAEQ  (Q5HNK7), 
KPYK_STAES  (Q8CS69), KPYK_STAHJ  (Q4L739), KPYK_THEAC  (P32044), 
KPYK_THEMA  (Q9WY51)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 4 sequences 

KPYK1_PHOLE (O30853), KPYK_CLOPA  (P81344), KPYK_LEIBR  (Q04668), 

KPYK_SPICI  (P19680)
» more

UniProtKB/Swiss-Prot
False positive sequences		 5 sequences 

ABITM_DROME (Q9VFR1), AROB_BRUA2  (Q2YR43), AROB_BRUAB  (Q57AM9), 

DNAB_HAEIN  (P45256), MQO_CAMJE   (P56954)
» more

PDB
[Detailed view]		 164 PDB

1A3W; 1A3X; 1A49; 1A5U; 1AQF; 1E0T; 1E0U; 1F3W; 1F3X; 1PKL; 1PKM; 1PKN; 1PKY; 1T5A; 1ZJH; 2E28; 2G50; 2VGB; 2VGF; 2VGG; 2VGI; 3BJF; 3BJT; 3E0V; 3E0W; 3G2G; 3GQY; 3GR4; 3H6O; 3HQN; 3HQO; 3HQP; 3HQQ; 3IS4; 3KTX; 3ME3; 3N25; 3PP7; 3QV6; 3QV7; 3QV8; 3SRD; 3SRF; 3SRH; 3SRK; 3U2Z; 4B2D; 4FXF; 4FXJ; 4G1N; 4HYV; 4HYW; 4IMA; 4IP7; 4JPG; 4KCT; 4KCU; 4KCV; 4KCW; 4QG6; 4QG8; 4QG9; 4QGC; 4RPP; 4WJ8; 4YJ5; 4YNG; 5SC8; 5SC9; 5SCA; 5SCB; 5SCC; 5SCD; 5SCE; 5SCF; 5SCG; 5SCH; 5SCI; 5SCJ; 5SCK; 5SCL; 5SDT; 5WRP; 5WS8; 5WS9; 5WSA; 5WSB; 5WSC; 5X0I; 5X1V; 5X1W; 6B6U; 6ECH; 6ECK; 6GG3; 6GG4; 6GG5; 6GG6; 6ITO; 6JFB; 6K0K; 6NN4; 6NN5; 6NN7; 6NN8; 6NU1; 6NU5; 6NUB; 6TTF; 6TTH; 6TTI; 6TTQ; 6V74; 6V75; 6V76; 6WP3; 6WP4; 6WP5; 6WP6; 7FRV; 7FRW; 7FRX; 7FRY; 7FRZ; 7FS0; 7FS1; 7FS2; 7FS3; 7FS4; 7FS5; 7FS6; 7FS7; 7FS8; 7FS9; 7FSA; 7FSB; 7FSC; 7FSD; 7L21; 7QDN; 7QZU; 7R6Y; 8EDQ; 8EDR; 8EDS; 8EDT; 8EQ0; 8EQ1; 8EQ3; 8EU4; 8F5T; 8F5U; 8F6M; 8G2E; 8HGF; 8HMQ; 8HMR; 8HMS; 8HMU; 8TBS; 8TBT; 8TBU; 8X4R; 8XFD
» more