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Entry: PS00110

General information about the entry

Entry name [info] PYRUVATE_KINASE
Accession [info] PS00110
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUL-1999 DATA UPDATE;
10-FEB-2021 INFO UPDATE.
PROSITE Doc. [info] PDOC00101

Name and characterization of the entry

Description [info] Pyruvate kinase active site signature.
Pattern [info] 
[LIVAC]-x-[LIVM](2)-[SAPCV]-K-[LIV]-E-[NKRST]-x-[DEQHS]-[GSTA]-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2021_01 which contains 564'277 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 79 in 79 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 94.05 %
Recall (true positives / (true positives + false negatives)) 78.22 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] magnesium at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 79 sequences 

KPYA_RICCO  (Q43117    ), KPYA_TOBAC  (Q40545    ), KPYC_ARATH  (O65595    ), 

KPYC_SOLTU  (P22200    ), KPYC_SOYBN  (Q42806    ), KPYC_TOBAC  (Q42954    ), 
KPYG_RICCO  (P55964    ), KPYG_TOBAC  (Q40546    ), KPYK1_AGRVI (P70789    ), 
KPYK1_CANGA (Q6FIS9    ), KPYK1_ECO57 (P0AD62    ), KPYK1_ECOLI (P0AD61    ), 
KPYK1_SALTI (Q8Z6K2    ), KPYK1_SALTY (P77983    ), KPYK1_SYNY3 (Q55863    ), 
KPYK1_TRYBB (P30615    ), KPYK1_YEAST (P00549    ), KPYK2_AGRVI (Q44473    ), 
KPYK2_CANGA (Q6FV12    ), KPYK2_ECOLI (P21599    ), KPYK2_SALTY (Q8ZNW0    ), 
KPYK2_SYNY3 (P73534    ), KPYK2_TRYBB (P30616    ), KPYK2_YEAST (P52489    ), 
KPYK_AGABI  (O94122    ), KPYK_ASHGO  (Q759A9    ), KPYK_ASPNG  (Q12669    ), 
KPYK_BACLI  (P51181    ), KPYK_BACSU  (P80885    ), KPYK_BORBU  (O51323    ), 
KPYK_BUCAI  (P57404    ), KPYK_BUCAP  (Q8K9M3    ), KPYK_BUCBP  (Q89AI8    ), 
KPYK_CANAL  (P46614    ), KPYK_CLOPE  (Q46289    ), KPYK_COREF  (Q8FP04    ), 
KPYK_CORGL  (Q46078    ), KPYK_DEBHA  (Q6BS75    ), KPYK_DICDI  (Q54RF5    ), 
KPYK_DROME  (O62619    ), KPYK_EIMTE  (O44006    ), KPYK_EMENI  (P22360    ), 
KPYK_GEOSE  (Q02499    ), KPYK_HAEIN  (P43924    ), KPYK_HYPJE  (P31865    ), 
KPYK_KLULA  (Q875M9    ), KPYK_LACK1  (Q875S4    ), KPYK_LACLA  (Q07637    ), 
KPYK_LEIME  (Q27686    ), KPYK_METEA  (O05118    ), KPYK_METJA  (Q57572    ), 
KPYK_MYCGE  (P47458    ), KPYK_MYCIT  (P94939    ), KPYK_MYCPN  (P78031    ), 
KPYK_MYCTO  (P9WKE4    ), KPYK_MYCTU  (P9WKE5    ), KPYK_NAUCC  (Q875Z9    ), 
KPYK_NEUCR  (Q7RVA8    ), KPYK_SCHPO  (Q10208    ), KPYK_SPOPS  (P51182    ), 
KPYK_STAS1  (Q49YC7    ), KPYK_THELN  (Q56301    ), KPYK_TRYBO  (Q27788    ), 
KPYK_YARLI  (P30614    ), KPYM_CHICK  (P00548    ), KPYM_FELCA  (P11979    ), 
KPYM_HUMAN  (P14618    ), KPYM_MOUSE  (P52480    ), KPYM_PONAB  (Q5NVN0    ), 
KPYM_RABIT  (P11974    ), KPYM_RAT    (P11980    ), KPYM_XENLA  (Q92122    ), 
KPYR_CANLF  (Q29536    ), KPYR_HUMAN  (P30613    ), KPYR_MOUSE  (P53657    ), 
KPYR_RAT    (P12928    ), PKP1_ARATH  (Q9LIK0    ), PKP2_ARATH  (Q9FLW9    ), 
PKP3_ARATH  (Q93Z53    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

KPYK_AERPE  (Q9YEU2    ), KPYK_CHLMU  (Q9PK61    ), KPYK_CHLPN  (Q9Z984    ), 

KPYK_CHLT2  (B0B7Q0    ), KPYK_CHLTR  (P0CE21    ), KPYK_CLOAB  (O08309    ), 
KPYK_LACDE  (P34038    ), KPYK_PYRAE  (Q8ZYE0    ), KPYK_STAA3  (Q2FG40    ), 
KPYK_STAA8  (Q2FXM9    ), KPYK_STAAB  (Q2YTE3    ), KPYK_STAAC  (Q5HF76    ), 
KPYK_STAAM  (Q99TG5    ), KPYK_STAAN  (Q7A559    ), KPYK_STAAR  (Q6GG09    ), 
KPYK_STAAS  (Q6G8M9    ), KPYK_STAAW  (Q7A0N4    ), KPYK_STAEQ  (Q5HNK7    ), 
KPYK_STAES  (Q8CS69    ), KPYK_STAHJ  (Q4L739    ), KPYK_THEAC  (P32044    ), 
KPYK_THEMA  (Q9WY51    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 4 sequences 

KPYK1_PHOLE (O30853    ), KPYK_CLOPA  (P81344    ), KPYK_LEIBR  (Q04668    ), 

KPYK_SPICI  (P19680    )
» more

UniProtKB/Swiss-Prot
False positive sequences		 5 sequences 

ABITM_DROME (Q9VFR1    ), AROB_BRUA2  (Q2YR43    ), AROB_BRUAB  (Q57AM9    ), 

DNAB_HAEIN  (P45256    ), MQO_CAMJE   (P56954    )
» more

PDB
[Detailed view]		 104 PDB

1A3W; 1A3X; 1A49; 1A5U; 1AQF; 1E0T; 1E0U; 1F3W; 1F3X; 1PKL; 1PKM; 1PKN; 1PKY; 1T5A; 1ZJH; 2E28; 2G50; 2VGB; 2VGF; 2VGG; 2VGI; 3BJF; 3BJT; 3E0V; 3E0W; 3G2G; 3GQY; 3GR4; 3H6O; 3HQN; 3HQO; 3HQP; 3HQQ; 3IS4; 3KTX; 3ME3; 3N25; 3PP7; 3QV6; 3QV7; 3QV8; 3SRD; 3SRF; 3SRH; 3SRK; 3U2Z; 4B2D; 4FXF; 4FXJ; 4G1N; 4HYV; 4HYW; 4IMA; 4IP7; 4JPG; 4KCT; 4KCU; 4KCV; 4KCW; 4QG6; 4QG8; 4QG9; 4QGC; 4RPP; 4WJ8; 4YJ5; 4YNG; 5WRP; 5WS8; 5WS9; 5WSA; 5WSB; 5WSC; 5X0I; 5X1V; 5X1W; 6B6U; 6ECH; 6ECK; 6GG3; 6GG4; 6GG5; 6GG6; 6ITO; 6JFB; 6K0K; 6NN4; 6NN5; 6NN7; 6NN8; 6NU1; 6NU5; 6NUB; 6TTF; 6TTH; 6TTI; 6TTQ; 6V74; 6V75; 6V76; 6WP3; 6WP4; 6WP5; 6WP6
» more

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