We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS00114

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00114

Direct ScanProsite submission

General information about the entry

Entry name [info]	PRPP_SYNTHASE
Accession [info]	PS00114
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00105

Name and characterization of the entry

Description [info]	Phosphoribosyl pyrophosphate synthase signature.
Pattern [info]	D-[LIM]-H-[SANDT]-x-[QS]-[IMSTAVF]-[QMLPH]-[GA]-[FY]-F-x(2)-P- [LIVMFCT]-D.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	172 in 172 different sequences
Number of true positive hits	172 in 172 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	32
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	84.31 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	magnesium(?) at position 1
Site [info]	magnesium(?) at position 3
Site [info]	magnesium(?) at position 15
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

172 sequences

KPR1_CANAX  (P46585), KPR1_SCHPO  (P41831), KPR1_YEAST  (P32895),

KPR2_SCHPO  (O94413), KPR2_YEAST  (P38620), KPR3_YEAST  (P38689), 
KPR4_YEAST  (P38063), KPR5_SCHPO  (P87171), KPR5_YEAST  (Q12265), 
KPRS1_ARATH (Q42581), KPRS1_ENTFA (Q832Z5), KPRS1_LACLA (Q9CHB8), 
KPRS1_LACPL (Q88Z84), KPRS1_LISIN (Q92F68), KPRS1_LISMF (Q724L4), 
KPRS1_LISMO (Q48793), KPRS1_ORYSJ (Q6Z2L5), KPRS1_SPIOL (Q9XG98), 
KPRS1_STRA3 (Q8E7X8), KPRS1_STRA5 (Q8E2H0), KPRS1_STRMU (Q8DWM2), 
KPRS1_STRP1 (P65243), KPRS1_STRP3 (P0DB98), KPRS1_STRP6 (Q5XEL0), 
KPRS1_STRP8 (P65245), KPRS1_STRPN (P65239), KPRS1_STRPQ (P0DB99), 
KPRS1_STRR6 (P65240), KPRS2_ARATH (Q42583), KPRS2_ENTFA (Q82ZA5), 
KPRS2_LACLA (Q9CEI4), KPRS2_LACPL (Q88VA5), KPRS2_LISIN (Q92EF1), 
KPRS2_LISMF (Q723E1), KPRS2_LISMO (Q8Y9L8), KPRS2_ORYSJ (Q69XQ6), 
KPRS2_SPIOL (Q9XG99), KPRS2_STRA3 (Q8E568), KPRS2_STRA5 (Q8DZK4), 
KPRS2_STRMU (Q8DU94), KPRS2_STRP1 (Q99ZR0), KPRS2_STRP3 (P0DC00), 
KPRS2_STRP6 (Q5XC85), KPRS2_STRP8 (Q8P137), KPRS2_STRPN (P65241), 
KPRS2_STRPQ (P0DC01), KPRS2_STRR6 (P65242), KPRS5_ARATH (O64888), 
KPRS_AGRFC  (Q8UDA9), KPRS_BACAN  (Q81VZ0), KPRS_BACCL  (P42816), 
KPRS_BACCR  (Q81J97), KPRS_BACSU  (P14193), KPRS_BAUCH  (Q1LTH2), 
KPRS_BIFLO  (Q8G5P2), KPRS_BLOFL  (Q7VR76), KPRS_BORBR  (Q7WNY4), 
KPRS_BORPA  (Q7W181), KPRS_BORPE  (Q7VUH1), KPRS_BRADU  (Q89DJ1), 
KPRS_BRUME  (Q8YIG1), KPRS_BRUSU  (Q8FZF0), KPRS_BUCAI  (P57266), 
KPRS_BUCAP  (Q8K9X2), KPRS_BUCBP  (P59512), KPRS_BURPS  (Q63XL8), 
KPRS_CALS4  (Q8R753), KPRS_CAMJE  (Q9PP15), KPRS_CAUVC  (Q9AAV6), 
KPRS_CAUVN  (B8GZV1), KPRS_CERSK  (B9KPJ0), KPRS_CHLTE  (Q8KCQ2), 
KPRS_CHRVO  (Q7NQS9), KPRS_CLOAB  (Q97E93), KPRS_CLOPE  (Q8XHJ4), 
KPRS_CLOTE  (Q899I8), KPRS_CORAM  (O33924), KPRS_COREF  (Q8FQV2), 
KPRS_CORGL  (Q8NRU9), KPRS_COXBU  (Q83AQ1), KPRS_DESPS  (Q6AJL7), 
KPRS_ECO57  (P0A719), KPRS_ECOL6  (P0A718), KPRS_ECOLI  (P0A717), 
KPRS_FUSNN  (Q8RHM2), KPRS_GLOVI  (Q7NM67), KPRS_GRABC  (Q0BPP0), 
KPRS_HAEDU  (Q7VL55), KPRS_HAEIN  (P44328), KPRS_HALH5  (Q9KGJ5), 
KPRS_HELHP  (Q7VFY9), KPRS_HELPJ  (Q9ZLA1), KPRS_HELPY  (P56184), 
KPRS_HYPNA  (Q0C5A1), KPRS_LEPIC  (Q72V73), KPRS_LEPIN  (Q8EZN0), 
KPRS_LISIV  (Q83YI7), KPRS_LISWE  (Q83TK1), KPRS_MARMM  (Q0ARN5), 
KPRS_MARMS  (A6W1C7), KPRS_MYCBO  (P65233), KPRS_MYCGE  (P47304), 
KPRS_MYCLE  (Q9CD45), KPRS_MYCPN  (P75044), KPRS_MYCPU  (Q98R83), 
KPRS_MYCTO  (P9WKE2), KPRS_MYCTU  (P9WKE3), KPRS_NEIMA  (P65234), 
KPRS_NEIMB  (P65235), KPRS_NITEU  (Q82TQ4), KPRS_NOSS1  (Q8YN97), 
KPRS_OCEIH  (Q8EU34), KPRS_PARMW  (Q7U7L5), KPRS_PASMU  (Q9CP22), 
KPRS_PHOLL  (Q7N590), KPRS_PORGI  (Q7MT83), KPRS_PROMA  (Q7VBH4), 
KPRS_PROMM  (Q7V6S2), KPRS_PROMP  (Q7V111), KPRS_PSEAE  (Q9HVC5), 
KPRS_PSEPK  (Q88PX6), KPRS_PSESM  (Q888C6), KPRS_RALN1  (Q8Y2E1), 
KPRS_RHILO  (Q98HW3), KPRS_RHIME  (Q92N73), KPRS_RHOBA  (Q7UPM4), 
KPRS_SALTI  (P0A1V7), KPRS_SALTY  (P0A1V6), KPRS_SHEON  (Q8EAQ9), 
KPRS_STAAC  (Q5HIH5), KPRS_STAAM  (P65236), KPRS_STAAN  (P65237), 
KPRS_STAAR  (Q6GJH1), KPRS_STAAS  (Q6GBY8), KPRS_STAAW  (P65238), 
KPRS_STAEQ  (Q5HRQ5), KPRS_STAES  (Q8CQU7), KPRS_STAHJ  (Q4L3F7), 
KPRS_STAS1  (Q49V09), KPRS_STRAW  (Q82HE7), KPRS_STRCO  (Q9K3U0), 
KPRS_SYNE7  (Q59988), KPRS_SYNY3  (Q55848), KPRS_THEAB  (B7IFM5), 
KPRS_THEMA  (Q9X1W3), KPRS_UREPA  (Q9PQV0), KPRS_VIBCH  (Q9KQ22), 
KPRS_VIBPA  (Q87RN8), KPRS_VIBVU  (Q8DFF5), KPRS_VIBVY  (Q7MMZ1), 
KPRS_WOLSU  (Q7M8J0), KPRS_XANAC  (Q8PNU0), KPRS_XANCP  (Q8PC63), 
KPRS_XYLFA  (Q9PA76), KPRS_XYLFT  (Q87A22), KPRS_YERPE  (Q8ZEY2), 
PRPS1_BOVIN (Q2HJ58), PRPS1_HUMAN (P60891), PRPS1_MACFA (Q4R4U3), 
PRPS1_MOUSE (Q9D7G0), PRPS1_PONAB (Q5RFJ7), PRPS1_RAT   (P60892), 
PRPS2_CHICK (Q5ZI49), PRPS2_HUMAN (P11908), PRPS2_MACFA (Q4R4R7), 
PRPS2_MOUSE (Q9CS42), PRPS2_PONAB (Q5R8F8), PRPS2_RAT   (P09330), 
PRPS2_XENLA (Q7ZXC9), PRPS2_XENTR (Q5XGI0), PRPS3_HUMAN (P21108), 
PRPSA_DICDI (Q54PA9)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

32 sequences

KPRH_STRCO  (Q9EWS0), KPRS1_ARCFU (O29666), KPRS2_ARCFU (O28853),

KPRS3_ARATH (Q93Z66), KPRS3_ORYSJ (Q8S2E5), KPRS3_SPIOL (Q9XGA0), 
KPRS4_ARATH (Q680A5), KPRS4_ORYSJ (Q6ZFT5), KPRS4_SPIOL (Q9XGA1), 
KPRS_AERPE  (Q9YAW0), KPRS_AQUAE  (O67556), KPRS_DEIRA  (Q9RUD2), 
KPRS_HALS3  (B0R7B4), KPRS_HALSA  (Q9HN88), KPRS_METAC  (Q8TRK8), 
KPRS_METJA  (Q58761), KPRS_METKA  (Q8TUT6), KPRS_METMA  (Q8PUX3), 
KPRS_METS3  (A5UNK4), KPRS_METTH  (O26877), KPRS_PYRAB  (Q9UY08), 
KPRS_PYRAE  (Q8ZU24), KPRS_PYRFU  (Q8U458), KPRS_PYRHO  (O59586), 
KPRS_SACS2  (Q97Z86), KPRS_SULAC  (Q4J9A6), KPRS_SULTO  (Q973F3), 
KPRS_THEAC  (Q9HLV6), KPRS_THEKO  (O52958), KPRS_THEVO  (Q97CA5), 
PRPSB_DICDI (Q75JN8), PRPSC_DICDI (Q54QU9)

» more

PDB
[Detailed view]

35 PDB

pdb_00001dkr; pdb_00001dku; pdb_00001ibs; pdb_00002h06; pdb_00002h07; pdb_00002h08; pdb_00002hcr; pdb_00003dah; pdb_00003efh; pdb_00003s5j; pdb_00004f8e; pdb_00004lyg; pdb_00004lzn; pdb_00004lzo; pdb_00004m0p; pdb_00004s2u; pdb_00006asv; pdb_00007xmu; pdb_00007xmv; pdb_00007xn3; pdb_00007yk1; pdb_00008dbc; pdb_00008dbd; pdb_00008dbe; pdb_00008dbf; pdb_00008dbg; pdb_00008dbh; pdb_00008dbi; pdb_00008dbj; pdb_00008dbk; pdb_00008dbl; pdb_00008dbm; pdb_00008dbn; pdb_00008dbo; pdb_00008yi9
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