PROSITE logo

PROSITE entry PS00122


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] CARBOXYLESTERASE_B_1
Accession [info] PS00122
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00112
Associated ProRule [info] PRU10039

Name and characterization of the entry

Description [info] Carboxylesterases type-B serine active site.
Pattern [info] 
F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 133 in 133 different sequences
Number of true positive hits 131 in 131 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 14
Precision (true positives / (true positives + false positives)) 98.50 %
Recall (true positives / (true positives + false negatives)) 97.04 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 131 sequences 

ACE1_CAEBR  (Q27459), ACE1_CAEEL  (P38433), ACE4_CAEBR  (Q9NDG8), 

ACES_ANOGA  (Q869C3), ACES_ANOST  (P56161), ACES_BOMIG  (A0A8B0RBM2), 
ACES_BOVIN  (P23795), ACES_BUNFA  (Q92035), ACES_CHICK  (P36196), 
ACES_CULPI  (Q86GC8), ACES_DANRE  (Q9DDE3), ACES_DROME  (P07140), 
ACES_ELEEL  (O42275), ACES_FELCA  (O62763), ACES_HUMAN  (P22303), 
ACES_LEPDE  (Q27677), ACES_MOUSE  (P21836), ACES_MYXGL  (Q92081), 
ACES_RABIT  (Q29499), ACES_RAT(P37136), ACES_TETCF  (P04058), 
ACES_TORMA  (P07692), AQDA2_RHOER (A0A0E4AET8), CEL_BOVIN   (P30122), 
CEL_HUMAN   (P19835), CEL_MOUSE   (Q64285), CEL_RAT (P07882), 
CHLE1_BRALA (Q95000), CHLE2_BRALA (Q95001), CHLE_ASPNG  (A7YN26), 
CHLE_BOVIN  (P32749), CHLE_CANLF  (P32750), CHLE_FELCA  (O62760), 
CHLE_HORSE  (P81908), CHLE_HUMAN  (P06276), CHLE_MACMU  (P32751), 
CHLE_MIMIV  (Q5UR02), CHLE_MOUSE  (Q03311), CHLE_PANTT  (O62761), 
CHLE_PIG(P32752), CHLE_RABIT  (P21927), CHLE_SHEEP  (P32753), 
CHLE_USTMD  (A0A060S684), CRYS_DICDI  (P21837), D2_DICDI(P18142), 
EST1C_MOUSE (P23953), EST1C_RAT   (P10959), EST1D_MOUSE (Q8VCT4), 
EST1D_RAT   (P16303), EST1E_MOUSE (Q64176), EST1E_RAT   (Q63108), 
EST1F_MOUSE (Q91WU0), EST1F_RAT   (Q64573), EST1_CAEBR  (Q04456), 
EST1_CAEEL  (Q04457), EST1_CULPI  (P16854), EST1_HUMAN  (P23141), 
EST1_MACFA  (O46421), EST1_MESAU  (Q64419), EST1_MOUSE  (Q8VCC2), 
EST1_PIG(Q29550), EST1_RABIT  (P12337), EST1_THEFU  (P86325), 
EST1_THEFY  (Q47M62), EST2A_MOUSE (Q8QZR3), EST2A_RAT   (Q8K3R0), 
EST2C_MOUSE (Q91WG0), EST2C_RAT   (O70631), EST2E_MOUSE (Q8BK48), 
EST2E_RAT   (G3V7J5), EST2_CAEEL  (Q07085), EST2_HUMAN  (O00748), 
EST2_RABIT  (P14943), EST3A_MOUSE (Q63880), EST3B_MOUSE (Q8VCU1), 
EST3_HUMAN  (Q6UWW8), EST3_PONAB  (Q5RCL7), EST4A_BOVIN (P0C6R3), 
EST4A_HUMAN (Q5XG92), EST4A_MOUSE (Q8R0W5), EST5A_CANLF (Q6AW47), 
EST5A_DROMI (O16168), EST5A_DROPE (O16173), EST5A_DROPS (P25727), 
EST5A_FELCA (Q8I034), EST5A_HUMAN (Q6NT32), EST5A_MOUSE (Q6AW46), 
EST5A_RAT   (Q5GRG2), EST5A_SHEEP (Q3T930), EST5B_DROMI (O16170), 
EST5B_DROPE (O16172), EST5B_DROPS (P25726), EST5C_DROMI (O16169), 
EST5C_DROPE (O16171), EST5C_DROPS (P25725), EST5_RAT(Q63010), 
EST6_APIME  (B2D0J5), EST6_DROMA  (P47982), EST6_DROME  (P08171), 
EST6_DROSI  (Q08662), ESTE_MYZPE  (P35501), ESTF_MYZPE  (P35502), 
ESTJ_HELVI  (P12992), ESTJ_TRICA  (D6WMZ8), ESTP_DROME  (P18167), 
ESTS_DROVI  (Q05487), FDB34_GIBM7 (W7MSI0), FGL4_GIBZE  (I1RHF8), 
FGL5_GIBZE  (I1RIF1), FUMD_SPHMC  (D2D3B6), LIP1_ARTBC  (D4ASH1), 
LIP1_BOTFB  (Q5XTQ4), LIP1_DIPFE  (P79066), LIP1_DIURU  (P20261), 
LIP1_GEOCN  (P17573), LIP1_GIBZE  (I1RDA9), LIP1_YARLI  (Q99156), 
LIP2_DIURU  (P32946), LIP2_GEOCN  (P22394), LIP3_ARTBC  (D4B1N9), 
LIP3_DIURU  (P32947), LIP3_YARLI  (Q96VC9), LIP4_DIURU  (P32948), 
LIP5_DIURU  (P32949), LIPC_MYCTU  (P96402), PATB_ASPCL  (A1CFK9), 
PATB_PENEN  (A0A075TXZ3), PCD_PSEOX   (Q01470), PNBA_BACSU  (P37967), 
SASB_ANAPL  (Q04791), YC7C_SCHPO  (O94493)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

ACES_TRILK  (W4VSJ0), CES1P_HUMAN (Q9UKY3), ESTE_HVAVE  (A4KX74), 

ESTE_SFAVA  (Q0E588)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 14 sequences 

ACES_CULPP  (Q867X3), ACES_CULQU  (Q867X2), ACES_CULTO  (Q86GC9), 

ACES_NAJOX  (Q7LZG1), EST1_SCHGA  (P81429), EST2_CULPI  (P21370), 
EST4_DROMO  (P10094), EST5_DROMO  (P10095), ESTA_SCHGA  (P81012), 
ESTB_SCHGA  (P81011), ESTJ_MANSE  (P19985), JHEA_TRINI  (P30809), 
JHEB_TRINI  (P30810), PMCH_RAT(P80250)
» more

UniProtKB/Swiss-Prot
False positive sequences		 2 sequences 

ICME_ARATH  (Q94AS5), ICML2_ARATH (Q1PET6)


				
	

	

		PDB
[Detailed view]		
		
			429 PDB
			


			1ACJ; 1ACL; 1AKN; 1AMN; 1AQL; 1AX9; 1B41; 1C2B; 1C2O; 1C7I; 1C7J; 1CFJ; 
			
				1CLE; 1CRL; 1DX6; 1E3Q; 1E66; 1EA5; 1EEA; 1EVE; 1F6W; 1F8U; 1FSS; 1GPK; 
				1GPN; 1GQR; 1GQS; 1GZ7; 1H22; 1H23; 1HBJ; 1J06; 1J07; 1JJB; 1JMY; 1K4Y; 
				1KU6; 1LLF; 1LPM; 1LPN; 1LPO; 1LPP; 1LPS; 1MAA; 1MAH; 1MX1; 1MX5; 1MX9; 
				1N5M; 1N5R; 1OCE; 1ODC; 1P0I; 1P0M; 1P0P; 1P0Q; 1Q83; 1Q84; 1QE3; 1QID; 
				1QIE; 1QIF; 1QIG; 1QIH; 1QII; 1QIJ; 1QIK; 1QIM; 1QTI; 1SOM; 1THG; 1TRH; 
				1U65; 1UT6; 1VOT; 1VXO; 1VXR; 1W4L; 1W6R; 1W75; 1W76; 1XLU; 1XLV; 1XLW; 
				1YA4; 1YA8; 1YAH; 1YAJ; 1ZGB; 1ZGC; 2ACE; 2ACK; 2BAG; 2BCE; 2C0P; 2C0Q; 
				2C4H; 2C58; 2C5F; 2C5G; 2CEK; 2CKM; 2CMF; 2DFP; 2DQY; 2DQZ; 2DR0; 2GYU; 
				2GYV; 2GYW; 2H7C; 2H9Y; 2HA0; 2HA2; 2HA3; 2HRQ; 2HRR; 2J3D; 2J3Q; 2J4C; 
				2J4F; 2JEY; 2JEZ; 2JF0; 2JGF; 2JGI; 2JGJ; 2JGK; 2JGM; 2PM8; 2V96; 2V97; 
				2V98; 2VA9; 2VJA; 2VJB; 2VJC; 2VJD; 2VQ6; 2VT6; 2VT7; 2W6C; 2WFZ; 2WG0; 
				2WG1; 2WG2; 2WHP; 2WHR; 2WID; 2WIF; 2WIG; 2WIJ; 2WIK; 2WIL; 2WLS; 2WSL; 
				2WU3; 2WU4; 2X8B; 2XI4; 2XMB; 2XMC; 2XMD; 2XMG; 2XQF; 2XQG; 2XQI; 2XQJ; 
				2XQK; 2XUD; 2XUF; 2XUG; 2XUH; 2XUI; 2XUJ; 2XUK; 2XUO; 2XUP; 2XUQ; 2Y1K; 
				2Y2U; 2Y2V; 3DJY; 3DKK; 3DL4; 3DL7; 3I6M; 3I6Z; 3K9B; 3LII; 3M3D; 3O9M; 
				3RAR; 3ZLT; 3ZLU; 3ZLV; 3ZV7; 4A16; 4A23; 4AB1; 4AQD; 4ARA; 4ARB; 4B7Z; 
				4B80; 4B81; 4B82; 4B83; 4B84; 4B85; 4BBZ; 4BC0; 4BC1; 4BDS; 4BDT; 4BTL; 
				4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE; 4QWW; 4TPK; 4TVK; 4W63; 
				4X3C; 4XII; 5A7F; 5A7H; 5BWB; 5BWC; 5DLP; 5DTI; 5DTJ; 5DYT; 5DYW; 5DYY; 
				5E2I; 5E4J; 5E4T; 5EHN; 5EHQ; 5EHX; 5EHZ; 5EI5; 5EIA; 5EIE; 5EIH; 5FKJ; 
				5FOQ; 5FPP; 5FPQ; 5FUM; 5FV4; 5HCU; 5HF5; 5HF6; 5HF8; 5HF9; 5HFA; 5HQ3; 
				5IH7; 5K5E; 5LKR; 5NAP; 5NAU; 5NN0; 5NUU; 5OV9; 5THM; 5X61; 5YDH; 5YDI; 
				5YDJ; 6ARX; 6ARY; 6CQT; 6CQU; 6CQV; 6CQW; 6CQX; 6CQY; 6CQZ; 6EMI; 6EP4; 
				6EQP; 6EQQ; 6ESJ; 6ESY; 6EUC; 6EUE; 6EWK; 6EYF; 6EZ2; 6EZG; 6EZH; 6F25; 
				6F7Q; 6FLD; 6FQN; 6FSD; 6FSE; 6G17; 6G1U; 6G1V; 6G1W; 6G4M; 6G4N; 6G4O; 
				6G4P; 6H0T; 6H0V; 6H12; 6H13; 6H14; 6H18; 6H19; 6H1A; 6I0B; 6I0C; 6I2T; 
				6NEA; 6NTG; 6NTH; 6NTK; 6NTL; 6NTM; 6NTN; 6NTO; 6O4W; 6O4X; 6O50; 6O52; 
				6O5R; 6O5S; 6O5V; 6O66; 6O69; 6QAA; 6QAB; 6QAC; 6QAD; 6QAE; 6R6V; 6R6W; 
				6RUA; 6SAM; 6T9P; 6T9S; 6TD2; 6TT0; 6U34; 6U37; 6U3P; 6WUV; 6WUY; 6WUZ; 
				6WV1; 6WVC; 6WVO; 6WVP; 6WVQ; 6XTA; 6XYS; 6XYU; 6XYY; 6ZWE; 6ZWI; 7AIS; 
				7AIT; 7AIU; 7AIV; 7AIW; 7AIX; 7AIY; 7AMZ; 7AWG; 7AWH; 7AWI; 7B2W; 7B38; 
				7B8E; 7BGC; 7BO3; 7BO4; 7D9O; 7D9P; 7D9Q; 7E3D; 7E3H; 7Q1M; 7Q1N; 7Q1O; 
				7Q1P; 7QAK; 7QB4; 7QBQ; 7QBR; 7QHD; 7QHE; 7QYN; 7R02; 7R0A; 7R2F; 7R3C; 
				7R4E; 7RB5; 7RB6; 7RB7; 7W1I; 7W1J; 7W1K; 7W1L; 7XN1; 7ZPB; 8AEN; 8AM1; 
				8AM2; 8AXC; 8CGO; 8DT2; 8DT4; 8DT5; 8DT7; 8EOR; 8ORC
			
			

			» more