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PROSITE entry PS00122


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PURL: https://purl.expasy.org/prosite/signature/PS00122

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General information about the entry

Entry name [info] CARBOXYLESTERASE_B_1
Accession [info] PS00122
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00112
Associated ProRule [info] PRU10039

Name and characterization of the entry

Description [info] Carboxylesterases type-B serine active site.
Pattern [info] 
F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 133 in 133 different sequences
Number of true positive hits 131 in 131 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 14
Precision (true positives / (true positives + false positives)) 98.50 %
Recall (true positives / (true positives + false negatives)) 97.04 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 131 sequences 

ACE1_CAEBR  (Q27459), ACE1_CAEEL  (P38433), ACE4_CAEBR  (Q9NDG8), 

ACES_ANOGA  (Q869C3), ACES_ANOST  (P56161), ACES_BOMIG  (A0A8B0RBM2), 
ACES_BOVIN  (P23795), ACES_BUNFA  (Q92035), ACES_CHICK  (P36196), 
ACES_CULPI  (Q86GC8), ACES_DANRE  (Q9DDE3), ACES_DROME  (P07140), 
ACES_ELEEL  (O42275), ACES_FELCA  (O62763), ACES_HUMAN  (P22303), 
ACES_LEPDE  (Q27677), ACES_MOUSE  (P21836), ACES_MYXGL  (Q92081), 
ACES_RABIT  (Q29499), ACES_RAT(P37136), ACES_TETCF  (P04058), 
ACES_TORMA  (P07692), AQDA2_RHOER (A0A0E4AET8), CEL_BOVIN   (P30122), 
CEL_HUMAN   (P19835), CEL_MOUSE   (Q64285), CEL_RAT (P07882), 
CHLE1_BRALA (Q95000), CHLE2_BRALA (Q95001), CHLE_ASPNG  (A7YN26), 
CHLE_BOVIN  (P32749), CHLE_CANLF  (P32750), CHLE_FELCA  (O62760), 
CHLE_HORSE  (P81908), CHLE_HUMAN  (P06276), CHLE_MACMU  (P32751), 
CHLE_MIMIV  (Q5UR02), CHLE_MOUSE  (Q03311), CHLE_MYCMD  (A0A060S684), 
CHLE_PANTT  (O62761), CHLE_PIG(P32752), CHLE_RABIT  (P21927), 
CHLE_SHEEP  (P32753), CRYS_DICDI  (P21837), D2_DICDI(P18142), 
EST1C_MOUSE (P23953), EST1C_RAT   (P10959), EST1D_MOUSE (Q8VCT4), 
EST1D_RAT   (P16303), EST1E_MOUSE (Q64176), EST1E_RAT   (Q63108), 
EST1F_MOUSE (Q91WU0), EST1F_RAT   (Q64573), EST1_CAEBR  (Q04456), 
EST1_CAEEL  (Q04457), EST1_CULPI  (P16854), EST1_HUMAN  (P23141), 
EST1_MACFA  (O46421), EST1_MESAU  (Q64419), EST1_MOUSE  (Q8VCC2), 
EST1_PIG(Q29550), EST1_RABIT  (P12337), EST1_THEFU  (P86325), 
EST1_THEFY  (Q47M62), EST2A_MOUSE (Q8QZR3), EST2A_RAT   (Q8K3R0), 
EST2C_MOUSE (Q91WG0), EST2C_RAT   (O70631), EST2E_MOUSE (Q8BK48), 
EST2E_RAT   (G3V7J5), EST2_CAEEL  (Q07085), EST2_HUMAN  (O00748), 
EST2_RABIT  (P14943), EST3A_MOUSE (Q63880), EST3B_MOUSE (Q8VCU1), 
EST3_HUMAN  (Q6UWW8), EST3_PONAB  (Q5RCL7), EST4A_BOVIN (P0C6R3), 
EST4A_HUMAN (Q5XG92), EST4A_MOUSE (Q8R0W5), EST5A_CANLF (Q6AW47), 
EST5A_DROMI (O16168), EST5A_DROPE (O16173), EST5A_DROPS (P25727), 
EST5A_FELCA (Q8I034), EST5A_HUMAN (Q6NT32), EST5A_MOUSE (Q6AW46), 
EST5A_RAT   (Q5GRG2), EST5A_SHEEP (Q3T930), EST5B_DROMI (O16170), 
EST5B_DROPE (O16172), EST5B_DROPS (P25726), EST5C_DROMI (O16169), 
EST5C_DROPE (O16171), EST5C_DROPS (P25725), EST5_RAT(Q63010), 
EST6_APIME  (B2D0J5), EST6_DROMA  (P47982), EST6_DROME  (P08171), 
EST6_DROSI  (Q08662), ESTE_MYZPE  (P35501), ESTF_MYZPE  (P35502), 
ESTJ_HELVI  (P12992), ESTJ_TRICA  (D6WMZ8), ESTP_DROME  (P18167), 
ESTS_DROVI  (Q05487), FDB34_GIBM7 (W7MSI0), FGL4_GIBZE  (I1RHF8), 
FGL5_GIBZE  (I1RIF1), FUMD_SPHMC  (D2D3B6), LIP1_ARTBC  (D4ASH1), 
LIP1_BOTFB  (Q5XTQ4), LIP1_DIURU  (P20261), LIP1_GEOCN  (P17573), 
LIP1_GEOFM  (P79066), LIP1_GIBZE  (I1RDA9), LIP1_YARLI  (Q99156), 
LIP2_DIURU  (P32946), LIP2_GEOCN  (P22394), LIP3_ARTBC  (D4B1N9), 
LIP3_DIURU  (P32947), LIP3_YARLI  (Q96VC9), LIP4_DIURU  (P32948), 
LIP5_DIURU  (P32949), LIPC_MYCTU  (P96402), PATB_ASPCL  (A1CFK9), 
PATB_PENEN  (A0A075TXZ3), PCD_PSEOX   (Q01470), PNBA_BACSU  (P37967), 
SASB_ANAPL  (Q04791), YC7C_SCHPO  (O94493)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

ACES_TRILK  (W4VSJ0), CES1P_HUMAN (Q9UKY3), ESTE_HVAVE  (A4KX74), 

ESTE_SFAVA  (Q0E588)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 14 sequences 

ACES_CULPP  (Q867X3), ACES_CULQU  (Q867X2), ACES_CULTO  (Q86GC9), 

ACES_NAJOX  (Q7LZG1), EST1_SCHGA  (P81429), EST2_CULPI  (P21370), 
EST4_DROMO  (P10094), EST5_DROMO  (P10095), ESTA_SCHGA  (P81012), 
ESTB_SCHGA  (P81011), ESTJ_MANSE  (P19985), JHEA_TRINI  (P30809), 
JHEB_TRINI  (P30810), PMCH_RAT(P80250)
» more

UniProtKB/Swiss-Prot
False positive sequences		 2 sequences 

ICME_ARATH  (Q94AS5), ICML2_ARATH (Q1PET6)


				
	

	

		PDB
[Detailed view]		
		
			434 PDB
			


			pdb_00001acj; pdb_00001acl; pdb_00001akn; pdb_00001amn; pdb_00001aql; pdb_00001ax9; pdb_00001b41; pdb_00001c2b; pdb_00001c2o; pdb_00001c7i; pdb_00001c7j; pdb_00001cfj; 
			
				pdb_00001cle; pdb_00001crl; pdb_00001dx6; pdb_00001e3q; pdb_00001e66; pdb_00001ea5; pdb_00001eea; pdb_00001eve; pdb_00001f6w; pdb_00001f8u; pdb_00001fss; pdb_00001gpk; 
				pdb_00001gpn; pdb_00001gqr; pdb_00001gqs; pdb_00001gz7; pdb_00001h22; pdb_00001h23; pdb_00001hbj; pdb_00001j06; pdb_00001j07; pdb_00001jjb; pdb_00001jmy; pdb_00001k4y; 
				pdb_00001ku6; pdb_00001llf; pdb_00001lpm; pdb_00001lpn; pdb_00001lpo; pdb_00001lpp; pdb_00001lps; pdb_00001maa; pdb_00001mah; pdb_00001mx1; pdb_00001mx5; pdb_00001mx9; 
				pdb_00001n5m; pdb_00001n5r; pdb_00001oce; pdb_00001odc; pdb_00001p0i; pdb_00001p0m; pdb_00001p0p; pdb_00001p0q; pdb_00001q83; pdb_00001q84; pdb_00001qe3; pdb_00001qid; 
				pdb_00001qie; pdb_00001qif; pdb_00001qig; pdb_00001qih; pdb_00001qii; pdb_00001qij; pdb_00001qik; pdb_00001qim; pdb_00001qti; pdb_00001som; pdb_00001thg; pdb_00001trh; 
				pdb_00001u65; pdb_00001ut6; pdb_00001vot; pdb_00001vxo; pdb_00001vxr; pdb_00001w4l; pdb_00001w6r; pdb_00001w75; pdb_00001w76; pdb_00001xlu; pdb_00001xlv; pdb_00001xlw; 
				pdb_00001ya4; pdb_00001ya8; pdb_00001yah; pdb_00001yaj; pdb_00001zgb; pdb_00001zgc; pdb_00002ace; pdb_00002ack; pdb_00002bag; pdb_00002bce; pdb_00002c0p; pdb_00002c0q; 
				pdb_00002c4h; pdb_00002c58; pdb_00002c5f; pdb_00002c5g; pdb_00002cek; pdb_00002ckm; pdb_00002cmf; pdb_00002dfp; pdb_00002dqy; pdb_00002dqz; pdb_00002dr0; pdb_00002gyu; 
				pdb_00002gyv; pdb_00002gyw; pdb_00002h7c; pdb_00002h9y; pdb_00002ha0; pdb_00002ha2; pdb_00002ha3; pdb_00002hrq; pdb_00002hrr; pdb_00002j3d; pdb_00002j3q; pdb_00002j4c; 
				pdb_00002j4f; pdb_00002jey; pdb_00002jez; pdb_00002jf0; pdb_00002jgf; pdb_00002jgi; pdb_00002jgj; pdb_00002jgk; pdb_00002jgm; pdb_00002pm8; pdb_00002v96; pdb_00002v97; 
				pdb_00002v98; pdb_00002va9; pdb_00002vja; pdb_00002vjb; pdb_00002vjc; pdb_00002vjd; pdb_00002vq6; pdb_00002vt6; pdb_00002vt7; pdb_00002w6c; pdb_00002wfz; pdb_00002wg0; 
				pdb_00002wg1; pdb_00002wg2; pdb_00002whp; pdb_00002whr; pdb_00002wid; pdb_00002wif; pdb_00002wig; pdb_00002wij; pdb_00002wik; pdb_00002wil; pdb_00002wls; pdb_00002wsl; 
				pdb_00002wu3; pdb_00002wu4; pdb_00002x8b; pdb_00002xi4; pdb_00002xmb; pdb_00002xmc; pdb_00002xmd; pdb_00002xmg; pdb_00002xqf; pdb_00002xqg; pdb_00002xqi; pdb_00002xqj; 
				pdb_00002xqk; pdb_00002xud; pdb_00002xuf; pdb_00002xug; pdb_00002xuh; pdb_00002xui; pdb_00002xuj; pdb_00002xuk; pdb_00002xuo; pdb_00002xup; pdb_00002xuq; pdb_00002y1k; 
				pdb_00002y2u; pdb_00002y2v; pdb_00003djy; pdb_00003dkk; pdb_00003dl4; pdb_00003dl7; pdb_00003i6m; pdb_00003i6z; pdb_00003k9b; pdb_00003lii; pdb_00003m3d; pdb_00003o9m; 
				pdb_00003rar; pdb_00003zlt; pdb_00003zlu; pdb_00003zlv; pdb_00003zv7; pdb_00004a16; pdb_00004a23; pdb_00004ab1; pdb_00004aqd; pdb_00004ara; pdb_00004arb; pdb_00004b7z; 
				pdb_00004b80; pdb_00004b81; pdb_00004b82; pdb_00004b83; pdb_00004b84; pdb_00004b85; pdb_00004bbz; pdb_00004bc0; pdb_00004bc1; pdb_00004bds; pdb_00004bdt; pdb_00004btl; 
				pdb_00004ey4; pdb_00004ey5; pdb_00004ey6; pdb_00004ey7; pdb_00004ey8; pdb_00004m0e; pdb_00004m0f; pdb_00004pqe; pdb_00004qww; pdb_00004tpk; pdb_00004tvk; pdb_00004w63; 
				pdb_00004x3c; pdb_00004xii; pdb_00005a7f; pdb_00005a7h; pdb_00005bwb; pdb_00005bwc; pdb_00005dlp; pdb_00005dti; pdb_00005dtj; pdb_00005dyt; pdb_00005dyw; pdb_00005dyy; 
				pdb_00005e2i; pdb_00005e4j; pdb_00005e4t; pdb_00005ehn; pdb_00005ehq; pdb_00005ehx; pdb_00005ehz; pdb_00005ei5; pdb_00005eia; pdb_00005eie; pdb_00005eih; pdb_00005fkj; 
				pdb_00005foq; pdb_00005fpp; pdb_00005fpq; pdb_00005fum; pdb_00005fv4; pdb_00005hcu; pdb_00005hf5; pdb_00005hf6; pdb_00005hf8; pdb_00005hf9; pdb_00005hfa; pdb_00005hq3; 
				pdb_00005ih7; pdb_00005k5e; pdb_00005lkr; pdb_00005nap; pdb_00005nau; pdb_00005nn0; pdb_00005nuu; pdb_00005ov9; pdb_00005thm; pdb_00005x61; pdb_00005ydh; pdb_00005ydi; 
				pdb_00005ydj; pdb_00006arx; pdb_00006ary; pdb_00006cqt; pdb_00006cqu; pdb_00006cqv; pdb_00006cqw; pdb_00006cqx; pdb_00006cqy; pdb_00006cqz; pdb_00006emi; pdb_00006ep4; 
				pdb_00006eqp; pdb_00006eqq; pdb_00006esj; pdb_00006esy; pdb_00006euc; pdb_00006eue; pdb_00006ewk; pdb_00006eyf; pdb_00006ez2; pdb_00006ezg; pdb_00006ezh; pdb_00006f25; 
				pdb_00006f7q; pdb_00006fld; pdb_00006fqn; pdb_00006fsd; pdb_00006fse; pdb_00006g17; pdb_00006g1u; pdb_00006g1v; pdb_00006g1w; pdb_00006g4m; pdb_00006g4n; pdb_00006g4o; 
				pdb_00006g4p; pdb_00006h0t; pdb_00006h0v; pdb_00006h12; pdb_00006h13; pdb_00006h14; pdb_00006h18; pdb_00006h19; pdb_00006h1a; pdb_00006i0b; pdb_00006i0c; pdb_00006i2t; 
				pdb_00006nea; pdb_00006ntg; pdb_00006nth; pdb_00006ntk; pdb_00006ntl; pdb_00006ntm; pdb_00006ntn; pdb_00006nto; pdb_00006o4w; pdb_00006o4x; pdb_00006o50; pdb_00006o52; 
				pdb_00006o5r; pdb_00006o5s; pdb_00006o5v; pdb_00006o66; pdb_00006o69; pdb_00006qaa; pdb_00006qab; pdb_00006qac; pdb_00006qad; pdb_00006qae; pdb_00006r6v; pdb_00006r6w; 
				pdb_00006rua; pdb_00006sam; pdb_00006t9p; pdb_00006t9s; pdb_00006td2; pdb_00006tt0; pdb_00006u34; pdb_00006u37; pdb_00006u3p; pdb_00006wuv; pdb_00006wuy; pdb_00006wuz; 
				pdb_00006wv1; pdb_00006wvc; pdb_00006wvo; pdb_00006wvp; pdb_00006wvq; pdb_00006xta; pdb_00006xys; pdb_00006xyu; pdb_00006xyy; pdb_00006zwe; pdb_00006zwi; pdb_00007ais; 
				pdb_00007ait; pdb_00007aiu; pdb_00007aiv; pdb_00007aiw; pdb_00007aix; pdb_00007aiy; pdb_00007amz; pdb_00007awg; pdb_00007awh; pdb_00007awi; pdb_00007b2w; pdb_00007b38; 
				pdb_00007b8e; pdb_00007bgc; pdb_00007bo3; pdb_00007bo4; pdb_00007d9o; pdb_00007d9p; pdb_00007d9q; pdb_00007e3d; pdb_00007e3h; pdb_00007q1m; pdb_00007q1n; pdb_00007q1o; 
				pdb_00007q1p; pdb_00007qak; pdb_00007qb4; pdb_00007qbq; pdb_00007qbr; pdb_00007qhd; pdb_00007qhe; pdb_00007qyn; pdb_00007r02; pdb_00007r0a; pdb_00007r2f; pdb_00007r3c; 
				pdb_00007r4e; pdb_00007rb5; pdb_00007rb6; pdb_00007rb7; pdb_00007w1i; pdb_00007w1j; pdb_00007w1k; pdb_00007w1l; pdb_00007xn1; pdb_00007zpb; pdb_00008aen; pdb_00008am1; 
				pdb_00008am2; pdb_00008axc; pdb_00008cgo; pdb_00008dt2; pdb_00008dt4; pdb_00008dt5; pdb_00008dt7; pdb_00008eor; pdb_00008orc; pdb_00008qtw; pdb_00008qtx; pdb_00009ewu; 
				pdb_00009kwl; pdb_00009kwm
			
			

			» more