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PROSITE entry PS00122


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00122
Entry name [info] CARBOXYLESTERASE_B_1
Accession [info] PS00122
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00112
Associated ProRule [info] PRU10039

Name and characterization of the entry

Description [info] Carboxylesterases type-B serine active site.
Pattern [info] 
F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 133 in 133 different sequences
Number of true positive hits 131 in 131 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 14
Precision (true positives / (true positives + false positives)) 98.50 %
Recall (true positives / (true positives + false negatives)) 97.04 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 131 sequences 

ACE1_CAEBR  (Q27459), ACE1_CAEEL  (P38433), ACE4_CAEBR  (Q9NDG8), 

ACES_ANOGA  (Q869C3), ACES_ANOST  (P56161), ACES_BOMIG  (A0A8B0RBM2), 
ACES_BOVIN  (P23795), ACES_BUNFA  (Q92035), ACES_CHICK  (P36196), 
ACES_CULPI  (Q86GC8), ACES_DANRE  (Q9DDE3), ACES_DROME  (P07140), 
ACES_ELEEL  (O42275), ACES_FELCA  (O62763), ACES_HUMAN  (P22303), 
ACES_LEPDE  (Q27677), ACES_MOUSE  (P21836), ACES_MYXGL  (Q92081), 
ACES_RABIT  (Q29499), ACES_RAT(P37136), ACES_TETCF  (P04058), 
ACES_TORMA  (P07692), AQDA2_RHOER (A0A0E4AET8), CEL_BOVIN   (P30122), 
CEL_HUMAN   (P19835), CEL_MOUSE   (Q64285), CEL_RAT (P07882), 
CHLE1_BRALA (Q95000), CHLE2_BRALA (Q95001), CHLE_ASPNG  (A7YN26), 
CHLE_BOVIN  (P32749), CHLE_CANLF  (P32750), CHLE_FELCA  (O62760), 
CHLE_HORSE  (P81908), CHLE_HUMAN  (P06276), CHLE_MACMU  (P32751), 
CHLE_MIMIV  (Q5UR02), CHLE_MOUSE  (Q03311), CHLE_MYCMD  (A0A060S684), 
CHLE_PANTT  (O62761), CHLE_PIG(P32752), CHLE_RABIT  (P21927), 
CHLE_SHEEP  (P32753), CRYS_DICDI  (P21837), D2_DICDI(P18142), 
EST1C_MOUSE (P23953), EST1C_RAT   (P10959), EST1D_MOUSE (Q8VCT4), 
EST1D_RAT   (P16303), EST1E_MOUSE (Q64176), EST1E_RAT   (Q63108), 
EST1F_MOUSE (Q91WU0), EST1F_RAT   (Q64573), EST1_CAEBR  (Q04456), 
EST1_CAEEL  (Q04457), EST1_CULPI  (P16854), EST1_HUMAN  (P23141), 
EST1_MACFA  (O46421), EST1_MESAU  (Q64419), EST1_MOUSE  (Q8VCC2), 
EST1_PIG(Q29550), EST1_RABIT  (P12337), EST1_THEFU  (P86325), 
EST1_THEFY  (Q47M62), EST2A_MOUSE (Q8QZR3), EST2A_RAT   (Q8K3R0), 
EST2C_MOUSE (Q91WG0), EST2C_RAT   (O70631), EST2E_MOUSE (Q8BK48), 
EST2E_RAT   (G3V7J5), EST2_CAEEL  (Q07085), EST2_HUMAN  (O00748), 
EST2_RABIT  (P14943), EST3A_MOUSE (Q63880), EST3B_MOUSE (Q8VCU1), 
EST3_HUMAN  (Q6UWW8), EST3_PONAB  (Q5RCL7), EST4A_BOVIN (P0C6R3), 
EST4A_HUMAN (Q5XG92), EST4A_MOUSE (Q8R0W5), EST5A_CANLF (Q6AW47), 
EST5A_DROMI (O16168), EST5A_DROPE (O16173), EST5A_DROPS (P25727), 
EST5A_FELCA (Q8I034), EST5A_HUMAN (Q6NT32), EST5A_MOUSE (Q6AW46), 
EST5A_RAT   (Q5GRG2), EST5A_SHEEP (Q3T930), EST5B_DROMI (O16170), 
EST5B_DROPE (O16172), EST5B_DROPS (P25726), EST5C_DROMI (O16169), 
EST5C_DROPE (O16171), EST5C_DROPS (P25725), EST5_RAT(Q63010), 
EST6_APIME  (B2D0J5), EST6_DROMA  (P47982), EST6_DROME  (P08171), 
EST6_DROSI  (Q08662), ESTE_MYZPE  (P35501), ESTF_MYZPE  (P35502), 
ESTJ_HELVI  (P12992), ESTJ_TRICA  (D6WMZ8), ESTP_DROME  (P18167), 
ESTS_DROVI  (Q05487), FDB34_GIBM7 (W7MSI0), FGL4_GIBZE  (I1RHF8), 
FGL5_GIBZE  (I1RIF1), FUMD_SPHMC  (D2D3B6), LIP1_ARTBC  (D4ASH1), 
LIP1_BOTFB  (Q5XTQ4), LIP1_DIPFE  (P79066), LIP1_DIURU  (P20261), 
LIP1_GEOCN  (P17573), LIP1_GIBZE  (I1RDA9), LIP1_YARLI  (Q99156), 
LIP2_DIURU  (P32946), LIP2_GEOCN  (P22394), LIP3_ARTBC  (D4B1N9), 
LIP3_DIURU  (P32947), LIP3_YARLI  (Q96VC9), LIP4_DIURU  (P32948), 
LIP5_DIURU  (P32949), LIPC_MYCTU  (P96402), PATB_ASPCL  (A1CFK9), 
PATB_PENEN  (A0A075TXZ3), PCD_PSEOX   (Q01470), PNBA_BACSU  (P37967), 
SASB_ANAPL  (Q04791), YC7C_SCHPO  (O94493)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

ACES_TRILK  (W4VSJ0), CES1P_HUMAN (Q9UKY3), ESTE_HVAVE  (A4KX74), 

ESTE_SFAVA  (Q0E588)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 14 sequences 

ACES_CULPP  (Q867X3), ACES_CULQU  (Q867X2), ACES_CULTO  (Q86GC9), 

ACES_NAJOX  (Q7LZG1), EST1_SCHGA  (P81429), EST2_CULPI  (P21370), 
EST4_DROMO  (P10094), EST5_DROMO  (P10095), ESTA_SCHGA  (P81012), 
ESTB_SCHGA  (P81011), ESTJ_MANSE  (P19985), JHEA_TRINI  (P30809), 
JHEB_TRINI  (P30810), PMCH_RAT(P80250)
» more

UniProtKB/Swiss-Prot
False positive sequences		 2 sequences 

ICME_ARATH  (Q94AS5), ICML2_ARATH (Q1PET6)


				
	

	

		PDB
[Detailed view]		
		
			431 PDB
			


			1ACJ; 1ACL; 1AKN; 1AMN; 1AQL; 1AX9; 1B41; 1C2B; 1C2O; 1C7I; 1C7J; 1CFJ; 
			
				1CLE; 1CRL; 1DX6; 1E3Q; 1E66; 1EA5; 1EEA; 1EVE; 1F6W; 1F8U; 1FSS; 1GPK; 
				1GPN; 1GQR; 1GQS; 1GZ7; 1H22; 1H23; 1HBJ; 1J06; 1J07; 1JJB; 1JMY; 1K4Y; 
				1KU6; 1LLF; 1LPM; 1LPN; 1LPO; 1LPP; 1LPS; 1MAA; 1MAH; 1MX1; 1MX5; 1MX9; 
				1N5M; 1N5R; 1OCE; 1ODC; 1P0I; 1P0M; 1P0P; 1P0Q; 1Q83; 1Q84; 1QE3; 1QID; 
				1QIE; 1QIF; 1QIG; 1QIH; 1QII; 1QIJ; 1QIK; 1QIM; 1QTI; 1SOM; 1THG; 1TRH; 
				1U65; 1UT6; 1VOT; 1VXO; 1VXR; 1W4L; 1W6R; 1W75; 1W76; 1XLU; 1XLV; 1XLW; 
				1YA4; 1YA8; 1YAH; 1YAJ; 1ZGB; 1ZGC; 2ACE; 2ACK; 2BAG; 2BCE; 2C0P; 2C0Q; 
				2C4H; 2C58; 2C5F; 2C5G; 2CEK; 2CKM; 2CMF; 2DFP; 2DQY; 2DQZ; 2DR0; 2GYU; 
				2GYV; 2GYW; 2H7C; 2H9Y; 2HA0; 2HA2; 2HA3; 2HRQ; 2HRR; 2J3D; 2J3Q; 2J4C; 
				2J4F; 2JEY; 2JEZ; 2JF0; 2JGF; 2JGI; 2JGJ; 2JGK; 2JGM; 2PM8; 2V96; 2V97; 
				2V98; 2VA9; 2VJA; 2VJB; 2VJC; 2VJD; 2VQ6; 2VT6; 2VT7; 2W6C; 2WFZ; 2WG0; 
				2WG1; 2WG2; 2WHP; 2WHR; 2WID; 2WIF; 2WIG; 2WIJ; 2WIK; 2WIL; 2WLS; 2WSL; 
				2WU3; 2WU4; 2X8B; 2XI4; 2XMB; 2XMC; 2XMD; 2XMG; 2XQF; 2XQG; 2XQI; 2XQJ; 
				2XQK; 2XUD; 2XUF; 2XUG; 2XUH; 2XUI; 2XUJ; 2XUK; 2XUO; 2XUP; 2XUQ; 2Y1K; 
				2Y2U; 2Y2V; 3DJY; 3DKK; 3DL4; 3DL7; 3I6M; 3I6Z; 3K9B; 3LII; 3M3D; 3O9M; 
				3RAR; 3ZLT; 3ZLU; 3ZLV; 3ZV7; 4A16; 4A23; 4AB1; 4AQD; 4ARA; 4ARB; 4B7Z; 
				4B80; 4B81; 4B82; 4B83; 4B84; 4B85; 4BBZ; 4BC0; 4BC1; 4BDS; 4BDT; 4BTL; 
				4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE; 4QWW; 4TPK; 4TVK; 4W63; 
				4X3C; 4XII; 5A7F; 5A7H; 5BWB; 5BWC; 5DLP; 5DTI; 5DTJ; 5DYT; 5DYW; 5DYY; 
				5E2I; 5E4J; 5E4T; 5EHN; 5EHQ; 5EHX; 5EHZ; 5EI5; 5EIA; 5EIE; 5EIH; 5FKJ; 
				5FOQ; 5FPP; 5FPQ; 5FUM; 5FV4; 5HCU; 5HF5; 5HF6; 5HF8; 5HF9; 5HFA; 5HQ3; 
				5IH7; 5K5E; 5LKR; 5NAP; 5NAU; 5NN0; 5NUU; 5OV9; 5THM; 5X61; 5YDH; 5YDI; 
				5YDJ; 6ARX; 6ARY; 6CQT; 6CQU; 6CQV; 6CQW; 6CQX; 6CQY; 6CQZ; 6EMI; 6EP4; 
				6EQP; 6EQQ; 6ESJ; 6ESY; 6EUC; 6EUE; 6EWK; 6EYF; 6EZ2; 6EZG; 6EZH; 6F25; 
				6F7Q; 6FLD; 6FQN; 6FSD; 6FSE; 6G17; 6G1U; 6G1V; 6G1W; 6G4M; 6G4N; 6G4O; 
				6G4P; 6H0T; 6H0V; 6H12; 6H13; 6H14; 6H18; 6H19; 6H1A; 6I0B; 6I0C; 6I2T; 
				6NEA; 6NTG; 6NTH; 6NTK; 6NTL; 6NTM; 6NTN; 6NTO; 6O4W; 6O4X; 6O50; 6O52; 
				6O5R; 6O5S; 6O5V; 6O66; 6O69; 6QAA; 6QAB; 6QAC; 6QAD; 6QAE; 6R6V; 6R6W; 
				6RUA; 6SAM; 6T9P; 6T9S; 6TD2; 6TT0; 6U34; 6U37; 6U3P; 6WUV; 6WUY; 6WUZ; 
				6WV1; 6WVC; 6WVO; 6WVP; 6WVQ; 6XTA; 6XYS; 6XYU; 6XYY; 6ZWE; 6ZWI; 7AIS; 
				7AIT; 7AIU; 7AIV; 7AIW; 7AIX; 7AIY; 7AMZ; 7AWG; 7AWH; 7AWI; 7B2W; 7B38; 
				7B8E; 7BGC; 7BO3; 7BO4; 7D9O; 7D9P; 7D9Q; 7E3D; 7E3H; 7Q1M; 7Q1N; 7Q1O; 
				7Q1P; 7QAK; 7QB4; 7QBQ; 7QBR; 7QHD; 7QHE; 7QYN; 7R02; 7R0A; 7R2F; 7R3C; 
				7R4E; 7RB5; 7RB6; 7RB7; 7W1I; 7W1J; 7W1K; 7W1L; 7XN1; 7ZPB; 8AEN; 8AM1; 
				8AM2; 8AXC; 8CGO; 8DT2; 8DT4; 8DT5; 8DT7; 8EOR; 8ORC; 8QTW; 8QTX
			
			

			» more