PROSITE entry PS00123

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00123
Entry name [info]	ALKALINE_PHOSPHATASE
Accession [info]	PS00123
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-OCT-1993 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00113
Associated ProRule [info]	PRU10042

Name and characterization of the entry

Description [info]	Alkaline phosphatase active site.
Pattern [info]	[IV]-x-D-S-[GAS]-[GASC]-[GAST]-[GA]-T.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	36 in 36 different sequences
Number of true positive hits	27 in 27 different sequences
Number of 'unknown' hits	0
Number of false positive hits	9 in 9 different sequences
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	75.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 4
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

27 sequences

APH4_DROME  (Q24238), PPB1_HUMAN  (P05187), PPB3_BACSU  (P19405),

PPB4_BACSU  (P19406), PPBH_PSEAB  (Q02QC9), PPBH_PSEAE  (P35483), 
PPBI1_RAT   (P15693), PPBI2_RAT   (P51740), PPBI_BOVIN  (P19111), 
PPBI_HUMAN  (P09923), PPBI_MOUSE  (P24822), PPBN_HUMAN  (P10696), 
PPBN_MOUSE  (P24823), PPBT_BOVIN  (P09487), PPBT_CHICK  (Q92058), 
PPBT_FELCA  (Q29486), PPBT_HUMAN  (P05186), PPBT_MOUSE  (P09242), 
PPBT_RAT(P08289), PPB_BOMMO   (P29523), PPB_ECOLI   (P00634), 
PPB_ESCF3   (P21948), PPB_GADMO   (P83456), PPB_SCHPO   (O60109), 
PPB_SERMA   (P19147), PPB_YEAST   (P11491), STRK_STRGR  (P09401)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False positive sequences

9 sequences

CIAO1_ASPCL (A1CQL6), FBID2_RHOJR (Q0RVJ9), INF2_HUMAN  (Q27J81),

INF2_MOUSE  (Q0GNC1), RBP10_BOVIN (A3KMV8), RDUF2_ARATH (Q940T5), 
SLAP_CAUVC  (P35828), TRPC_BUCAP  (P42393), ZAP1_YEAST  (P47043)

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PDB
[Detailed view]

54 PDB

1AJA; 1AJB; 1AJC; 1AJD; 1ALH; 1ALI; 1ALJ; 1ALK; 1ANI; 1ANJ; 1B8J; 1ED8; 1ED9; 1EW2; 1EW8; 1EW9; 1HJK; 1HQA; 1KH4; 1KH5; 1KH7; 1KH9; 1KHJ; 1KHK; 1KHL; 1KHN; 1URA; 1URB; 1Y6V; 1Y7A; 1ZEB; 1ZED; 1ZEF; 2ANH; 2GLQ; 2MLY; 3BDF; 3BDG; 3BDH; 3CMR; 3DYC; 3MK0; 3MK1; 3MK2; 3TG0; 4KJD; 4KJG; 5C66; 5JTL; 5JTN; 6PSI; 7YIV; 7YIW; 7YIX
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