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PROSITE entry PS00124


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General information about the entry

Entry name [info] FBPASE
Accession [info] PS00124
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00114
Associated ProRule [info] PRU10043

Name and characterization of the entry

Description [info] Fructose-1-6-bisphosphatase active site.
Pattern [info] 
[AG]-[RK]-[LI]-x(1,2)-[LIV]-[FY]-E-x(2)-P-[LIVM]-[GSA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 225 in 225 different sequences
Number of true positive hits 222 in 222 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 182
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.67 %
Recall (true positives / (true positives + false negatives)) 54.95 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 2
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 222 sequences 

F16A1_ACAM1 (B0CAD9), F16A1_ALBFT (Q21YM7), F16A1_BRASB (A5E987), 

F16A1_CERS1 (A3PNY0), F16A1_CERS4 (Q3IYB9), F16A1_CERS5 (A4WW38), 
F16A1_CERSP (P27994), F16A1_CHRFK (A0M0J2), F16A1_METPP (A2SFV4), 
F16A1_NITHX (Q1QH19), F16A1_XANP2 (A7IGL7), F16A2_ACAM1 (B0C7G7), 
F16A2_BRASB (A5EQ67), F16A2_CERS1 (A3PRW1), F16A2_CERS4 (Q3IX60), 
F16A2_CERS5 (A4WZQ4), F16A2_CERSP (P22780), F16A2_CUPMC (Q1LN82), 
F16A2_CUPNH (P19911), F16A2_CUPTR (B3RBL3), F16A2_DECAR (Q479X4), 
F16A2_LEPCP (B1Y5W3), F16A2_NITHX (Q1QGD7), F16A2_PARXL (Q13QU8), 
F16A2_POLNA (A1VNR3), F16A2_PSET1 (Q3IH61), F16A2_XANP2 (A7IL64), 
F16A3_CUPNH (P19912), F16A3_METPP (A2SJK3), F16A3_PSET1 (Q3ICJ5), 
F16P1_ARATH (P25851), F16P1_BOVIN (Q3SZB7), F16P1_BRANA (Q07204), 
F16P1_HUMAN (P09467), F16P1_MOUSE (Q9QXD6), F16P1_ORYSI (A2XEX2), 
F16P1_ORYSJ (O64422), F16P1_PEA   (P46275), F16P1_PIG   (P00636), 
F16P1_RABIT (P00637), F16P1_RAT   (P19112), F16P1_SHEEP (P09199), 
F16P1_SPIOL (P22418), F16P1_WHEAT (P09195), F16P2_ARATH (Q9MA79), 
F16P2_BETVU (Q42649), F16P2_BOVIN (Q2KJJ9), F16P2_BRANA (P46267), 
F16P2_HUMAN (O00757), F16P2_MOUSE (P70695), F16P2_MUSAC (Q9XF47), 
F16P2_ORYCO (Q9SDL8), F16P2_ORYSI (A2WXB2), F16P2_ORYSJ (Q0JHF8), 
F16P2_PEA   (Q8RW99), F16P2_RABIT (Q9N0J6), F16P2_RAT   (Q9Z1N1), 
F16P2_SACHY (Q43139), F16P2_SOLTU (P46276), F16P2_SPIOL (P14766), 
F16PA_ACICJ (A5FWQ8), F16PA_ACIF5 (B5ELA6), F16PA_ACTP2 (A3N298), 
F16PA_ACTP7 (B3H282), F16PA_ACTPJ (B0BQZ1), F16PA_ACTSZ (A6VN92), 
F16PA_AERHH (A0KJT2), F16PA_AERS4 (A4SM33), F16PA_ALIF1 (Q5E887), 
F16PA_ALIFM (B5FGE3), F16PA_ALISL (B6EPV3), F16PA_ALKEH (Q0A5B1), 
F16PA_ALTMD (B4S2E8), F16PA_AZOC5 (A8I541), F16PA_BRASO (A4YNQ7), 
F16PA_BRUA1 (B2SAG4), F16PA_BRUA2 (Q2YIQ9), F16PA_BRUA4 (A6X307), 
F16PA_BRUAB (Q578Z3), F16PA_BRUC2 (A9MCF4), F16PA_BRUMB (C0RM19), 
F16PA_BRUME (Q8YCV6), F16PA_BRUO2 (A5VVE8), F16PA_BRUSI (A9WZF8), 
F16PA_BRUSU (Q8FVG9), F16PA_CAUSK (B0T0R1), F16PA_CELJU (B3PGC8), 
F16PA_CITBB (B5EFV5), F16PA_CITK8 (A8AMG4), F16PA_CROS5 (B1WX40), 
F16PA_CROS8 (A7MM48), F16PA_ECO24 (A7ZVB0), F16PA_ECO57 (Q8XCF0), 
F16PA_ECO5E (B5Z3I7), F16PA_ECODH (B1XEL4), F16PA_ECOHS (A8A7Y7), 
F16PA_ECOK1 (A1AJD7), F16PA_ECOL5 (Q0T9F7), F16PA_ECOL6 (P0A994), 
F16PA_ECOLC (B1ISX3), F16PA_ECOLI (P0A993), F16PA_ECOSM (B1LRB5), 
F16PA_ECOUT (Q1R324), F16PA_ENT38 (A4W5X6), F16PA_ERWT9 (B2VCY1), 
F16PA_FLAJ1 (A5FMJ5), F16PA_FLAPJ (A6GWD9), F16PA_GEOSL (Q74CM2), 
F16PA_GEOUR (A5G439), F16PA_GLOVI (Q7NGN9), F16PA_HAEDU (Q7VN74), 
F16PA_HAEI8 (Q4QL80), F16PA_HAEIE (A5UCP1), F16PA_HAEIN (P45292), 
F16PA_HAHCH (Q2S8D3), F16PA_HISS1 (Q0I4Y5), F16PA_HISS2 (B0USR6), 
F16PA_HYDTE (Q9LBE7), F16PA_KLEP3 (B5Y2X3), F16PA_KLEP7 (A6THE3), 
F16PA_LEPBA (B0SHG0), F16PA_LEPBJ (Q04T19), F16PA_LEPBL (Q051E1), 
F16PA_LEPBP (B0SQL1), F16PA_LEPIC (Q72RN8), F16PA_LEPIN (Q8F421), 
F16PA_MANSM (Q65S38), F16PA_METB6 (A7I8R6), F16PA_METC4 (B7L270), 
F16PA_METEP (A9W1C8), F16PA_METFK (Q1H3T1), F16PA_METI4 (B3DWS5), 
F16PA_METLZ (A2ST39), F16PA_METPB (B1Z939), F16PA_METRJ (B1LUU9), 
F16PA_MICAN (B0JH56), F16PA_NATPD (Q3ISJ9), F16PA_NITVU (P37099), 
F16PA_NITWN (Q3SP44), F16PA_NOSP7 (P48847), F16PA_NOSS1 (P48991), 
F16PA_PARDP (A1B2P8), F16PA_PASMU (Q9CMA4), F16PA_PECAS (Q6D074), 
F16PA_PELPD (A1APW8), F16PA_PERMH (C0QTP7), F16PA_PHOLL (Q7MYW6), 
F16PA_PHOPR (Q6LV59), F16PA_PICP2 (B1XNG1), F16PA_PROMH (B4F298), 
F16PA_PSEA6 (Q15ZB4), F16PA_PSYIN (A1T0H3), F16PA_RHIME (Q9EXV4), 
F16PA_RHOCB (O34011), F16PA_RHOP2 (Q2J1K3), F16PA_RHOP5 (Q07N65), 
F16PA_RHOPA (Q6N0W5), F16PA_RHOPB (Q213I9), F16PA_RHOPS (Q13CA1), 
F16PA_RHOPT (B3QB72), F16PA_RHORT (Q2RRP2), F16PA_SACD2 (Q21L89), 
F16PA_SALA4 (B5F3E2), F16PA_SALAR (A9MEY3), F16PA_SALCH (Q57GG7), 
F16PA_SALDC (B5FSC7), F16PA_SALEP (B5R0U4), F16PA_SALG2 (B5R9H4), 
F16PA_SALHS (B4TFG0), F16PA_SALNS (B4T3H9), F16PA_SALPA (Q5PJ74), 
F16PA_SALPB (A9N548), F16PA_SALPK (B5BKN5), F16PA_SALSV (B4TT57), 
F16PA_SALTI (Q8Z146), F16PA_SALTY (Q8ZK67), F16PA_SERP5 (A8G8Y2), 
F16PA_SHIB3 (B2TZ12), F16PA_SHIBS (Q31TG8), F16PA_SHIDS (Q328V4), 
F16PA_SHIF8 (Q0SXH4), F16PA_SHIFL (P0A995), F16PA_SHISS (Q3YUB9), 
F16PA_SINMW (P56886), F16PA_SULSY (B2V6E2), F16PA_SYNC1 (Q3A5T0), 
F16PA_SYNE7 (Q59943), F16PA_SYNP6 (Q5N163), F16PA_SYNY3 (P74324), 
F16PA_TERTT (C5BMI0), F16PA_THEVB (Q8DLF2), F16PA_TRIEI (Q118F5), 
F16PA_TRIL1 (B3E2M3), F16PA_TRIV2 (Q3MCI4), F16PA_VEREI (A1WH14), 
F16PA_VIBA3 (B7VKW7), F16PA_VIBC1 (A7MWE4), F16PA_VIBC3 (A5F599), 
F16PA_VIBCH (Q9KP35), F16PA_VIBCM (C3LRK7), F16PA_VIBPA (Q87SW0), 
F16PA_VIBVU (Q8DE90), F16PA_VIBVY (Q7MPD0), F16PA_XANFL (P23014), 
F16PA_YERE8 (A1JIU6), F16PA_YERP3 (A7FMU7), F16PA_YERPA (Q1CBY3), 
F16PA_YERPB (B2K2N1), F16PA_YERPE (Q0WBC9), F16PA_YERPG (A9R579), 
F16PA_YERPN (Q1CEI9), F16PA_YERPP (A4TRK7), F16PA_YERPS (Q66F84), 
F16PA_YERPY (B1JMK6), F16P_DICDI  (Q6RYT0), F16P_KLULA  (Q05079), 
F16P_SCHPO  (P09202), F16P_YEAST  (P09201), S17P_ARATH  (P46283), 
S17P_CHLRE  (P46284), S17P_SPIOL  (O20252), S17P_WHEAT  (P46285)
» more

UniProtKB/Swiss-Prot
False negative sequences		 182 sequences 

F16A1_CUPMC (Q1LQ15), F16A1_CUPNH (Q0KCY0), F16A1_CUPTR (B3R3R6), 

F16A1_DECAR (Q47A13), F16A1_HALMA (Q5V3Z1), F16A1_LEPCP (B1XZ11), 
F16A1_PARP8 (B2JEJ7), F16A1_PARXL (Q13V64), F16A1_POLNA (A1VL56), 
F16A1_PSET1 (Q3IFQ5), F16A1_SALRD (Q2S2I3), F16A2_ALBFT (Q21UY4), 
F16A2_CHRFK (A0M764), F16A2_HALMA (Q5V311), F16A2_METPP (A2SJJ0), 
F16A2_PARP8 (B2JVN8), F16A2_SALRD (Q2S1G3), F16A3_PARP8 (B2JX47), 
F16P1_SOYBN (Q42796), F16PA_ACIAD (Q6F982), F16PA_ACIBC (B2HWU2), 
F16PA_ACIBS (B0VT80), F16PA_ACIBT (A3M7W9), F16PA_ACIBY (B0VDK0), 
F16PA_ACISJ (A1W9H6), F16PA_ALIB4 (A8EU55), F16PA_AMOA5 (B3ERE1), 
F16PA_AROAE (Q5P7F8), F16PA_AZOSB (A1K430), F16PA_AZOVD (C1DHU3), 
F16PA_BORA1 (Q2KZ46), F16PA_BORBR (Q7WL20), F16PA_BORPA (Q7W7N2), 
F16PA_BORPD (A9IQQ8), F16PA_BORPE (Q7VZM9), F16PA_BRADU (Q8GKS1), 
F16PA_BURA4 (B1YUZ7), F16PA_BURCH (A0K5J0), F16PA_BURCJ (B4EB94), 
F16PA_BURCM (Q0BHD7), F16PA_BURL3 (Q39IJ4), F16PA_BURM1 (A9AEN5), 
F16PA_BURM7 (A3MHJ7), F16PA_BURM9 (A2S4W0), F16PA_BURMA (Q62LZ0), 
F16PA_BURMS (A1V6R5), F16PA_BURO0 (B1JXN8), F16PA_BURO1 (Q1BY59), 
F16PA_BURP0 (A3NY10), F16PA_BURP1 (Q3JPU4), F16PA_BURP6 (A3NC72), 
F16PA_BURPS (Q63RX4), F16PA_BURTA (Q2SY57), F16PA_BURVG (A4JCE2), 
F16PA_CAMC1 (A7ZCB2), F16PA_CAMC5 (A7GXH6), F16PA_CAMFF (A0RP36), 
F16PA_CAMHC (A7I1B8), F16PA_CAMJ8 (A8FLP9), F16PA_CAMJD (A7H3L9), 
F16PA_CAMJE (Q0PA50), F16PA_CAMJJ (A1VZI4), F16PA_CAMJR (Q5HUV6), 
F16PA_CAUVC (Q9A8G9), F16PA_CHLCH (Q3AT00), F16PA_CHLL2 (B3EGL2), 
F16PA_CHLL3 (Q3B5N2), F16PA_CHLP8 (B3QQ73), F16PA_CHLPB (B3ELC6), 
F16PA_CHLPD (A1BEB4), F16PA_CHLPM (A4SDH2), F16PA_CHLT3 (B3QWF5), 
F16PA_CHLTE (Q8KFG8), F16PA_CHRVO (Q7NVB6), F16PA_COLP3 (Q47VB1), 
F16PA_CUPPJ (Q46YH7), F16PA_CYTH3 (Q11R22), F16PA_DELAS (A9BW85), 
F16PA_DICNV (A5EVS5), F16PA_GEOMG (Q39UC4), F16PA_HALHL (A1WZH0), 
F16PA_HALS3 (B0R3Y1), F16PA_HALSA (Q9HRI1), F16PA_HALWD (Q18J03), 
F16PA_HELAH (Q17V54), F16PA_HELHP (Q7VGH7), F16PA_HELPG (B5Z9G5), 
F16PA_HELPH (Q1CR72), F16PA_HELPJ (Q9ZJ74), F16PA_HELPS (B2UVU9), 
F16PA_HELPY (O25936), F16PA_HERAR (A4G2P0), F16PA_HERSE (A2RQ29), 
F16PA_HYDCU (Q31FI6), F16PA_IDILO (Q5QVR9), F16PA_JANMA (A6SVE7), 
F16PA_LAWIP (Q1MRF1), F16PA_MARMS (A6W2V5), F16PA_MARSD (C6BTU7), 
F16PA_METHJ (Q2FM20), F16PA_METS4 (B0UEK2), F16PA_NEIG1 (Q5F8C3), 
F16PA_NEIG2 (B4RLD4), F16PA_NEIM0 (A9LYX9), F16PA_NEIMA (A1IRQ3), 
F16PA_NEIMB (Q9JZH1), F16PA_NEIMF (A1KTU6), F16PA_NITEC (Q0AGV1), 
F16PA_NITEU (Q82WY3), F16PA_NITOC (Q3JF33), F16PA_NITSB (A6Q349), 
F16PA_NITV2 (Q72AZ9), F16PA_NITV4 (A1VD23), F16PA_OLEA2 (Q30ZN0), 
F16PA_PARC0 (A1TN89), F16PA_PARL1 (A7HYA5), F16PA_PARM1 (Q2W3W0), 
F16PA_PARPJ (B2T699), F16PA_PELPB (B4SDN7), F16PA_POLAQ (A4SWM3), 
F16PA_POLNS (B1XVF7), F16PA_POLSJ (Q12D67), F16PA_PROA2 (B4S3F3), 
F16PA_PSE14 (Q48PL3), F16PA_PSEA7 (A6VDM7), F16PA_PSEA8 (B7V3K3), 
F16PA_PSEAB (Q02EQ6), F16PA_PSEAE (Q9HU73), F16PA_PSEE4 (Q1I3Q0), 
F16PA_PSEF5 (Q4KJP6), F16PA_PSEFS (C3K7D6), F16PA_PSEMY (A4XPL2), 
F16PA_PSEP1 (A5WA74), F16PA_PSEPF (Q3KJG0), F16PA_PSEPG (B0KM65), 
F16PA_PSEPK (Q88CY9), F16PA_PSEPW (B1J2P7), F16PA_PSESM (Q87UX4), 
F16PA_PSEU2 (Q4ZZI0), F16PA_PSYA2 (Q4FUA6), F16PA_PSYCK (Q1QDE0), 
F16PA_PSYWF (A5WGK6), F16PA_RALN1 (Q8XXI7), F16PA_RALPJ (B2U8C4), 
F16PA_SHEAM (A1S351), F16PA_SHEB5 (A3D0P6), F16PA_SHEB8 (A6WSQ6), 
F16PA_SHEB9 (A9L375), F16PA_SHEDO (Q12JW2), F16PA_SHEFN (Q088C3), 
F16PA_SHEHH (B0TTL6), F16PA_SHELP (A3QAZ7), F16PA_SHEON (Q8EAB6), 
F16PA_SHEPA (A8H0H1), F16PA_SHEPC (A4Y373), F16PA_SHESA (A0KSW7), 
F16PA_SHESH (A8FRF1), F16PA_SHESM (Q0HMI8), F16PA_SHESR (Q0HRA0), 
F16PA_SHESW (A1RNR2), F16PA_SHEWM (B1KEL4), F16PA_SODGM (Q2NW44), 
F16PA_SORC5 (A9G6T8), F16PA_STRM5 (B4SR24), F16PA_STRMK (B2FU10), 
F16PA_STUS1 (A4VGC9), F16PA_SULDN (Q30RP0), F16PA_SULNB (A6Q9C9), 
F16PA_SYNAS (Q2LUC0), F16PA_SYNJA (Q2JTX5), F16PA_SYNJB (Q2JK61), 
F16PA_THIDA (Q3SFS6), F16PA_WIGBR (Q8D275), F16PA_WOLSU (Q7MAI9), 
F16PA_XANAC (Q8PR42), F16PA_XANC8 (Q4V0I4), F16PA_XANCB (B0RLK6), 
F16PA_XANCP (Q8PE85), F16PA_XANE5 (Q3BZI4), F16PA_XANOM (Q2P9K6), 
F16PA_XANOP (B2SUX7), F16PA_XANOR (Q5H701)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

WDR81_HUMAN (Q562E7), WDR81_MOUSE (Q5ND34), WDR81_RAT   (D4A929)


				
	

	

		PDB
[Detailed view]		
		
			141 PDB
			


			1BK4; 1CNQ; 1D9Q; 1DBZ; 1DCU; 1EYI; 1EYJ; 1EYK; 1FBC; 1FBD; 1FBE; 1FBF; 
			
				1FBG; 1FBH; 1FBP; 1FJ6; 1FJ9; 1FPB; 1FPD; 1FPE; 1FPF; 1FPG; 1FPI; 1FPJ; 
				1FPK; 1FPL; 1FRP; 1FSA; 1FTA; 1KZ8; 1LEV; 1NUW; 1NUX; 1NUY; 1NUZ; 1NV0; 
				1NV1; 1NV2; 1NV3; 1NV4; 1NV5; 1NV6; 1NV7; 1Q9D; 1RDX; 1RDY; 1RDZ; 1SPI; 
				1YXI; 1YYZ; 1YZ0; 2F3B; 2F3D; 2FBP; 2FHY; 2FIE; 2FIX; 2GQ1; 2JJK; 2OWZ; 
				2OX3; 2Q8M; 2QVR; 2QVU; 2QVV; 2VT5; 2WBB; 2WBD; 2Y5K; 2Y5L; 3A29; 3FBP; 
				3IFA; 3IFC; 3KBZ; 3KC0; 3KC1; 4FBP; 4GBV; 4GBW; 4GWS; 4GWU; 4GWW; 4GWX; 
				4GWY; 4GWZ; 4GX3; 4GX4; 4GX6; 4H45; 4H46; 4HE0; 4HE1; 4HE2; 4KXP; 4MJO; 
				5ET5; 5ET6; 5ET7; 5ET8; 5FBP; 5K54; 5K55; 5K56; 5L0A; 5LDZ; 5PZQ; 5PZR; 
				5PZS; 5PZT; 5PZU; 5PZV; 5PZW; 5PZX; 5PZY; 5PZZ; 5Q00; 5Q01; 5Q02; 5Q03; 
				5Q04; 5Q05; 5Q06; 5Q07; 5Q08; 5Q09; 5Q0A; 5Q0B; 5Q0C; 6LS5; 6LW2; 7C9Q; 
				7CVH; 7CVN; 7CWE; 7EZF; 7EZP; 7EZR; 7NS5; 7WJV; 7WVB
			
			

			» more