PROSITE logo

PROSITE entry PS00124


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] FBPASE
Accession [info] PS00124
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00114
Associated ProRule [info] PRU10043

Name and characterization of the entry

Description [info] Fructose-1-6-bisphosphatase active site.
Pattern [info]
[AG]-[RK]-[LI]-x(1,2)-[LIV]-[FY]-E-x(2)-P-[LIVM]-[GSA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 225 in 225 different sequences
Number of true positive hits 222 in 222 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 182
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.67 %
Recall (true positives / (true positives + false negatives)) 54.95 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 2
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
222 sequences

F16A1_ACAM1 (B0CAD9), F16A1_ALBFT (Q21YM7), F16A1_BRASB (A5E987), 
F16A1_CERS1 (A3PNY0), F16A1_CERS4 (Q3IYB9), F16A1_CERS5 (A4WW38), 
F16A1_CERSP (P27994), F16A1_CHRFK (A0M0J2), F16A1_METPP (A2SFV4), 
F16A1_NITHX (Q1QH19), F16A1_XANP2 (A7IGL7), F16A2_ACAM1 (B0C7G7), 
F16A2_BRASB (A5EQ67), F16A2_CERS1 (A3PRW1), F16A2_CERS4 (Q3IX60), 
F16A2_CERS5 (A4WZQ4), F16A2_CERSP (P22780), F16A2_CUPMC (Q1LN82), 
F16A2_CUPNH (P19911), F16A2_CUPTR (B3RBL3), F16A2_DECAR (Q479X4), 
F16A2_LEPCP (B1Y5W3), F16A2_NITHX (Q1QGD7), F16A2_PARXL (Q13QU8), 
F16A2_POLNA (A1VNR3), F16A2_PSET1 (Q3IH61), F16A2_XANP2 (A7IL64), 
F16A3_CUPNH (P19912), F16A3_METPP (A2SJK3), F16A3_PSET1 (Q3ICJ5), 
F16P1_ARATH (P25851), F16P1_BOVIN (Q3SZB7), F16P1_BRANA (Q07204), 
F16P1_HUMAN (P09467), F16P1_MOUSE (Q9QXD6), F16P1_ORYSI (A2XEX2), 
F16P1_ORYSJ (O64422), F16P1_PEA   (P46275), F16P1_PIG   (P00636), 
F16P1_RABIT (P00637), F16P1_RAT   (P19112), F16P1_SHEEP (P09199), 
F16P1_SPIOL (P22418), F16P1_WHEAT (P09195), F16P2_ARATH (Q9MA79), 
F16P2_BETVU (Q42649), F16P2_BOVIN (Q2KJJ9), F16P2_BRANA (P46267), 
F16P2_HUMAN (O00757), F16P2_MOUSE (P70695), F16P2_MUSAC (Q9XF47), 
F16P2_ORYCO (Q9SDL8), F16P2_ORYSI (A2WXB2), F16P2_ORYSJ (Q0JHF8), 
F16P2_PEA   (Q8RW99), F16P2_RABIT (Q9N0J6), F16P2_RAT   (Q9Z1N1), 
F16P2_SACHY (Q43139), F16P2_SOLTU (P46276), F16P2_SPIOL (P14766), 
F16PA_ACICJ (A5FWQ8), F16PA_ACIF5 (B5ELA6), F16PA_ACTP2 (A3N298), 
F16PA_ACTP7 (B3H282), F16PA_ACTPJ (B0BQZ1), F16PA_ACTSZ (A6VN92), 
F16PA_AERHH (A0KJT2), F16PA_AERS4 (A4SM33), F16PA_ALIF1 (Q5E887), 
F16PA_ALIFM (B5FGE3), F16PA_ALISL (B6EPV3), F16PA_ALKEH (Q0A5B1), 
F16PA_ALTMD (B4S2E8), F16PA_AZOC5 (A8I541), F16PA_BRASO (A4YNQ7), 
F16PA_BRUA1 (B2SAG4), F16PA_BRUA2 (Q2YIQ9), F16PA_BRUA4 (A6X307), 
F16PA_BRUAB (Q578Z3), F16PA_BRUC2 (A9MCF4), F16PA_BRUMB (C0RM19), 
F16PA_BRUME (Q8YCV6), F16PA_BRUO2 (A5VVE8), F16PA_BRUSI (A9WZF8), 
F16PA_BRUSU (Q8FVG9), F16PA_CAUSK (B0T0R1), F16PA_CELJU (B3PGC8), 
F16PA_CITBB (B5EFV5), F16PA_CITK8 (A8AMG4), F16PA_CROS5 (B1WX40), 
F16PA_CROS8 (A7MM48), F16PA_ECO24 (A7ZVB0), F16PA_ECO57 (Q8XCF0), 
F16PA_ECO5E (B5Z3I7), F16PA_ECODH (B1XEL4), F16PA_ECOHS (A8A7Y7), 
F16PA_ECOK1 (A1AJD7), F16PA_ECOL5 (Q0T9F7), F16PA_ECOL6 (P0A994), 
F16PA_ECOLC (B1ISX3), F16PA_ECOLI (P0A993), F16PA_ECOSM (B1LRB5), 
F16PA_ECOUT (Q1R324), F16PA_ENT38 (A4W5X6), F16PA_ERWT9 (B2VCY1), 
F16PA_FLAJ1 (A5FMJ5), F16PA_FLAPJ (A6GWD9), F16PA_GEOSL (Q74CM2), 
F16PA_GEOUR (A5G439), F16PA_GLOVI (Q7NGN9), F16PA_HAEDU (Q7VN74), 
F16PA_HAEI8 (Q4QL80), F16PA_HAEIE (A5UCP1), F16PA_HAEIN (P45292), 
F16PA_HAHCH (Q2S8D3), F16PA_HISS1 (Q0I4Y5), F16PA_HISS2 (B0USR6), 
F16PA_HYDTE (Q9LBE7), F16PA_KLEP3 (B5Y2X3), F16PA_KLEP7 (A6THE3), 
F16PA_LEPBA (B0SHG0), F16PA_LEPBJ (Q04T19), F16PA_LEPBL (Q051E1), 
F16PA_LEPBP (B0SQL1), F16PA_LEPIC (Q72RN8), F16PA_LEPIN (Q8F421), 
F16PA_MANSM (Q65S38), F16PA_METB6 (A7I8R6), F16PA_METC4 (B7L270), 
F16PA_METEP (A9W1C8), F16PA_METFK (Q1H3T1), F16PA_METI4 (B3DWS5), 
F16PA_METLZ (A2ST39), F16PA_METPB (B1Z939), F16PA_METRJ (B1LUU9), 
F16PA_MICAN (B0JH56), F16PA_NATPD (Q3ISJ9), F16PA_NITVU (P37099), 
F16PA_NITWN (Q3SP44), F16PA_NOSP7 (P48847), F16PA_NOSS1 (P48991), 
F16PA_PARDP (A1B2P8), F16PA_PASMU (Q9CMA4), F16PA_PECAS (Q6D074), 
F16PA_PELPD (A1APW8), F16PA_PERMH (C0QTP7), F16PA_PHOLL (Q7MYW6), 
F16PA_PHOPR (Q6LV59), F16PA_PICP2 (B1XNG1), F16PA_PROMH (B4F298), 
F16PA_PSEA6 (Q15ZB4), F16PA_PSYIN (A1T0H3), F16PA_RHIME (Q9EXV4), 
F16PA_RHOCB (O34011), F16PA_RHOP2 (Q2J1K3), F16PA_RHOP5 (Q07N65), 
F16PA_RHOPA (Q6N0W5), F16PA_RHOPB (Q213I9), F16PA_RHOPS (Q13CA1), 
F16PA_RHOPT (B3QB72), F16PA_RHORT (Q2RRP2), F16PA_SACD2 (Q21L89), 
F16PA_SALA4 (B5F3E2), F16PA_SALAR (A9MEY3), F16PA_SALCH (Q57GG7), 
F16PA_SALDC (B5FSC7), F16PA_SALEP (B5R0U4), F16PA_SALG2 (B5R9H4), 
F16PA_SALHS (B4TFG0), F16PA_SALNS (B4T3H9), F16PA_SALPA (Q5PJ74), 
F16PA_SALPB (A9N548), F16PA_SALPK (B5BKN5), F16PA_SALSV (B4TT57), 
F16PA_SALTI (Q8Z146), F16PA_SALTY (Q8ZK67), F16PA_SERP5 (A8G8Y2), 
F16PA_SHIB3 (B2TZ12), F16PA_SHIBS (Q31TG8), F16PA_SHIDS (Q328V4), 
F16PA_SHIF8 (Q0SXH4), F16PA_SHIFL (P0A995), F16PA_SHISS (Q3YUB9), 
F16PA_SINMW (P56886), F16PA_SULSY (B2V6E2), F16PA_SYNC1 (Q3A5T0), 
F16PA_SYNE7 (Q59943), F16PA_SYNP6 (Q5N163), F16PA_SYNY3 (P74324), 
F16PA_TERTT (C5BMI0), F16PA_THEVB (Q8DLF2), F16PA_TRIEI (Q118F5), 
F16PA_TRIL1 (B3E2M3), F16PA_TRIV2 (Q3MCI4), F16PA_VEREI (A1WH14), 
F16PA_VIBA3 (B7VKW7), F16PA_VIBC1 (A7MWE4), F16PA_VIBC3 (A5F599), 
F16PA_VIBCH (Q9KP35), F16PA_VIBCM (C3LRK7), F16PA_VIBPA (Q87SW0), 
F16PA_VIBVU (Q8DE90), F16PA_VIBVY (Q7MPD0), F16PA_XANFL (P23014), 
F16PA_YERE8 (A1JIU6), F16PA_YERP3 (A7FMU7), F16PA_YERPA (Q1CBY3), 
F16PA_YERPB (B2K2N1), F16PA_YERPE (Q0WBC9), F16PA_YERPG (A9R579), 
F16PA_YERPN (Q1CEI9), F16PA_YERPP (A4TRK7), F16PA_YERPS (Q66F84), 
F16PA_YERPY (B1JMK6), F16P_DICDI  (Q6RYT0), F16P_KLULA  (Q05079), 
F16P_SCHPO  (P09202), F16P_YEAST  (P09201), S17P_ARATH  (P46283), 
S17P_CHLRE  (P46284), S17P_SPIOL  (O20252), S17P_WHEAT  (P46285)
» more

UniProtKB/Swiss-Prot
False negative sequences
182 sequences

F16A1_CUPMC (Q1LQ15), F16A1_CUPNH (Q0KCY0), F16A1_CUPTR (B3R3R6), 
F16A1_DECAR (Q47A13), F16A1_HALMA (Q5V3Z1), F16A1_LEPCP (B1XZ11), 
F16A1_PARP8 (B2JEJ7), F16A1_PARXL (Q13V64), F16A1_POLNA (A1VL56), 
F16A1_PSET1 (Q3IFQ5), F16A1_SALRD (Q2S2I3), F16A2_ALBFT (Q21UY4), 
F16A2_CHRFK (A0M764), F16A2_HALMA (Q5V311), F16A2_METPP (A2SJJ0), 
F16A2_PARP8 (B2JVN8), F16A2_SALRD (Q2S1G3), F16A3_PARP8 (B2JX47), 
F16P1_SOYBN (Q42796), F16PA_ACIAD (Q6F982), F16PA_ACIBC (B2HWU2), 
F16PA_ACIBS (B0VT80), F16PA_ACIBT (A3M7W9), F16PA_ACIBY (B0VDK0), 
F16PA_ACISJ (A1W9H6), F16PA_ALIB4 (A8EU55), F16PA_AMOA5 (B3ERE1), 
F16PA_AROAE (Q5P7F8), F16PA_AZOSB (A1K430), F16PA_AZOVD (C1DHU3), 
F16PA_BORA1 (Q2KZ46), F16PA_BORBR (Q7WL20), F16PA_BORPA (Q7W7N2), 
F16PA_BORPD (A9IQQ8), F16PA_BORPE (Q7VZM9), F16PA_BRADU (Q8GKS1), 
F16PA_BURA4 (B1YUZ7), F16PA_BURCH (A0K5J0), F16PA_BURCJ (B4EB94), 
F16PA_BURCM (Q0BHD7), F16PA_BURL3 (Q39IJ4), F16PA_BURM1 (A9AEN5), 
F16PA_BURM7 (A3MHJ7), F16PA_BURM9 (A2S4W0), F16PA_BURMA (Q62LZ0), 
F16PA_BURMS (A1V6R5), F16PA_BURO0 (B1JXN8), F16PA_BURO1 (Q1BY59), 
F16PA_BURP0 (A3NY10), F16PA_BURP1 (Q3JPU4), F16PA_BURP6 (A3NC72), 
F16PA_BURPS (Q63RX4), F16PA_BURTA (Q2SY57), F16PA_BURVG (A4JCE2), 
F16PA_CAMC1 (A7ZCB2), F16PA_CAMC5 (A7GXH6), F16PA_CAMFF (A0RP36), 
F16PA_CAMHC (A7I1B8), F16PA_CAMJ8 (A8FLP9), F16PA_CAMJD (A7H3L9), 
F16PA_CAMJE (Q0PA50), F16PA_CAMJJ (A1VZI4), F16PA_CAMJR (Q5HUV6), 
F16PA_CAUVC (Q9A8G9), F16PA_CHLCH (Q3AT00), F16PA_CHLL2 (B3EGL2), 
F16PA_CHLL3 (Q3B5N2), F16PA_CHLP8 (B3QQ73), F16PA_CHLPB (B3ELC6), 
F16PA_CHLPD (A1BEB4), F16PA_CHLPM (A4SDH2), F16PA_CHLT3 (B3QWF5), 
F16PA_CHLTE (Q8KFG8), F16PA_CHRVO (Q7NVB6), F16PA_COLP3 (Q47VB1), 
F16PA_CUPPJ (Q46YH7), F16PA_CYTH3 (Q11R22), F16PA_DELAS (A9BW85), 
F16PA_DICNV (A5EVS5), F16PA_GEOMG (Q39UC4), F16PA_HALHL (A1WZH0), 
F16PA_HALS3 (B0R3Y1), F16PA_HALSA (Q9HRI1), F16PA_HALWD (Q18J03), 
F16PA_HELAH (Q17V54), F16PA_HELHP (Q7VGH7), F16PA_HELPG (B5Z9G5), 
F16PA_HELPH (Q1CR72), F16PA_HELPJ (Q9ZJ74), F16PA_HELPS (B2UVU9), 
F16PA_HELPY (O25936), F16PA_HERAR (A4G2P0), F16PA_HERSE (A2RQ29), 
F16PA_HYDCU (Q31FI6), F16PA_IDILO (Q5QVR9), F16PA_JANMA (A6SVE7), 
F16PA_LAWIP (Q1MRF1), F16PA_MARMS (A6W2V5), F16PA_MARSD (C6BTU7), 
F16PA_METHJ (Q2FM20), F16PA_METS4 (B0UEK2), F16PA_NEIG1 (Q5F8C3), 
F16PA_NEIG2 (B4RLD4), F16PA_NEIM0 (A9LYX9), F16PA_NEIMA (A1IRQ3), 
F16PA_NEIMB (Q9JZH1), F16PA_NEIMF (A1KTU6), F16PA_NITEC (Q0AGV1), 
F16PA_NITEU (Q82WY3), F16PA_NITOC (Q3JF33), F16PA_NITSB (A6Q349), 
F16PA_NITV2 (Q72AZ9), F16PA_NITV4 (A1VD23), F16PA_OLEA2 (Q30ZN0), 
F16PA_PARC0 (A1TN89), F16PA_PARL1 (A7HYA5), F16PA_PARM1 (Q2W3W0), 
F16PA_PARPJ (B2T699), F16PA_PELPB (B4SDN7), F16PA_POLAQ (A4SWM3), 
F16PA_POLNS (B1XVF7), F16PA_POLSJ (Q12D67), F16PA_PROA2 (B4S3F3), 
F16PA_PSE14 (Q48PL3), F16PA_PSEA7 (A6VDM7), F16PA_PSEA8 (B7V3K3), 
F16PA_PSEAB (Q02EQ6), F16PA_PSEAE (Q9HU73), F16PA_PSEE4 (Q1I3Q0), 
F16PA_PSEF5 (Q4KJP6), F16PA_PSEFS (C3K7D6), F16PA_PSEMY (A4XPL2), 
F16PA_PSEP1 (A5WA74), F16PA_PSEPF (Q3KJG0), F16PA_PSEPG (B0KM65), 
F16PA_PSEPK (Q88CY9), F16PA_PSEPW (B1J2P7), F16PA_PSESM (Q87UX4), 
F16PA_PSEU2 (Q4ZZI0), F16PA_PSYA2 (Q4FUA6), F16PA_PSYCK (Q1QDE0), 
F16PA_PSYWF (A5WGK6), F16PA_RALN1 (Q8XXI7), F16PA_RALPJ (B2U8C4), 
F16PA_SHEAM (A1S351), F16PA_SHEB5 (A3D0P6), F16PA_SHEB8 (A6WSQ6), 
F16PA_SHEB9 (A9L375), F16PA_SHEDO (Q12JW2), F16PA_SHEFN (Q088C3), 
F16PA_SHEHH (B0TTL6), F16PA_SHELP (A3QAZ7), F16PA_SHEON (Q8EAB6), 
F16PA_SHEPA (A8H0H1), F16PA_SHEPC (A4Y373), F16PA_SHESA (A0KSW7), 
F16PA_SHESH (A8FRF1), F16PA_SHESM (Q0HMI8), F16PA_SHESR (Q0HRA0), 
F16PA_SHESW (A1RNR2), F16PA_SHEWM (B1KEL4), F16PA_SODGM (Q2NW44), 
F16PA_SORC5 (A9G6T8), F16PA_STRM5 (B4SR24), F16PA_STRMK (B2FU10), 
F16PA_STUS1 (A4VGC9), F16PA_SULDN (Q30RP0), F16PA_SULNB (A6Q9C9), 
F16PA_SYNAS (Q2LUC0), F16PA_SYNJA (Q2JTX5), F16PA_SYNJB (Q2JK61), 
F16PA_THIDA (Q3SFS6), F16PA_WIGBR (Q8D275), F16PA_WOLSU (Q7MAI9), 
F16PA_XANAC (Q8PR42), F16PA_XANC8 (Q4V0I4), F16PA_XANCB (B0RLK6), 
F16PA_XANCP (Q8PE85), F16PA_XANE5 (Q3BZI4), F16PA_XANOM (Q2P9K6), 
F16PA_XANOP (B2SUX7), F16PA_XANOR (Q5H701)
» more

UniProtKB/Swiss-Prot
False positive sequences
3 sequences

WDR81_HUMAN (Q562E7), WDR81_MOUSE (Q5ND34), WDR81_RAT   (D4A929)

		
PDB
[Detailed view]
141 PDB

1BK4; 1CNQ; 1D9Q; 1DBZ; 1DCU; 1EYI; 1EYJ; 1EYK; 1FBC; 1FBD; 1FBE; 1FBF; 1FBG; 1FBH; 1FBP; 1FJ6; 1FJ9; 1FPB; 1FPD; 1FPE; 1FPF; 1FPG; 1FPI; 1FPJ; 1FPK; 1FPL; 1FRP; 1FSA; 1FTA; 1KZ8; 1LEV; 1NUW; 1NUX; 1NUY; 1NUZ; 1NV0; 1NV1; 1NV2; 1NV3; 1NV4; 1NV5; 1NV6; 1NV7; 1Q9D; 1RDX; 1RDY; 1RDZ; 1SPI; 1YXI; 1YYZ; 1YZ0; 2F3B; 2F3D; 2FBP; 2FHY; 2FIE; 2FIX; 2GQ1; 2JJK; 2OWZ; 2OX3; 2Q8M; 2QVR; 2QVU; 2QVV; 2VT5; 2WBB; 2WBD; 2Y5K; 2Y5L; 3A29; 3FBP; 3IFA; 3IFC; 3KBZ; 3KC0; 3KC1; 4FBP; 4GBV; 4GBW; 4GWS; 4GWU; 4GWW; 4GWX; 4GWY; 4GWZ; 4GX3; 4GX4; 4GX6; 4H45; 4H46; 4HE0; 4HE1; 4HE2; 4KXP; 4MJO; 5ET5; 5ET6; 5ET7; 5ET8; 5FBP; 5K54; 5K55; 5K56; 5L0A; 5LDZ; 5PZQ; 5PZR; 5PZS; 5PZT; 5PZU; 5PZV; 5PZW; 5PZX; 5PZY; 5PZZ; 5Q00; 5Q01; 5Q02; 5Q03; 5Q04; 5Q05; 5Q06; 5Q07; 5Q08; 5Q09; 5Q0A; 5Q0B; 5Q0C; 6LS5; 6LW2; 7C9Q; 7CVH; 7CVN; 7CWE; 7EZF; 7EZP; 7EZR; 7NS5; 7WJV; 7WVB
» more