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PROSITE entry PS00126


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PURL: https://purl.expasy.org/prosite/signature/PS00126

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General information about the entry

Entry name [info] PDEASE_I_1
Accession [info] PS00126
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUL-1998 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00116

Name and characterization of the entry

Description [info] 3'5'-cyclic nucleotide phosphodiesterase domain signature.
Pattern [info] 
H-D-[LIVMFY]-x-H-x-[AG]-x(2)-[NQ]-x-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 102 in 102 different sequences
Number of true positive hits 101 in 101 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.02 %
Recall (true positives / (true positives + false negatives)) 98.06 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 101 sequences 

PDE10_HUMAN (Q9Y233), PDE10_MOUSE (Q8CA95), PDE10_RAT   (Q9QYJ6), 

PDE11_DROME (Q9VJ79), PDE11_HUMAN (Q9HCR9), PDE11_MOUSE (P0C1Q2), 
PDE11_RAT   (Q8VID6), PDE11_TAKRU (Q1KKS3), PDE1A_BOVIN (P14100), 
PDE1A_HUMAN (P54750), PDE1A_MOUSE (Q61481), PDE1B_BOVIN (Q01061), 
PDE1B_CRIGR (Q64395), PDE1B_HUMAN (Q01064), PDE1B_MOUSE (Q01065), 
PDE1B_RAT   (Q01066), PDE1C_HUMAN (Q14123), PDE1C_MOUSE (Q64338), 
PDE1C_RAT   (Q63421), PDE1_CAEEL  (O18696), PDE1_DROME  (B7YZV4), 
PDE2A_BOVIN (P14099), PDE2A_HUMAN (O00408), PDE2A_MOUSE (Q922S4), 
PDE2A_RAT   (Q01062), PDE2_CAEEL  (P30645), PDE2_DICDI  (Q23917), 
PDE2_YEAST  (P06776), PDE3A_HUMAN (Q14432), PDE3A_MOUSE (Q9Z0X4), 
PDE3A_RAT   (Q62865), PDE3B_HUMAN (Q13370), PDE3B_MOUSE (Q61409), 
PDE3B_RAT   (Q63085), PDE3_CAEEL  (Q8I0P7), PDE3_DICDI  (B0G0Y8), 
PDE4A_DROME (Q9W4T4), PDE4A_HUMAN (P27815), PDE4A_MOUSE (O89084), 
PDE4A_RAT   (P54748), PDE4B_DROME (P12252), PDE4B_HUMAN (Q07343), 
PDE4B_RAT   (P14646), PDE4C_DROME (Q9W4S9), PDE4C_HUMAN (Q08493), 
PDE4C_MOUSE (Q3UEI1), PDE4C_RAT   (P14644), PDE4D_HUMAN (Q08499), 
PDE4D_MOUSE (Q01063), PDE4D_RAT   (P14270), PDE4E_DROME (Q8IRU4), 
PDE4_CAEEL  (Q22000), PDE4_DICDI  (Q86H13), PDE5A_BOVIN (Q28156), 
PDE5A_CANLF (O77746), PDE5A_HUMAN (O76074), PDE5A_MOUSE (Q8CG03), 
PDE5A_RAT   (O54735), PDE5_CAEEL  (P91119), PDE6A_BOVIN (P11541), 
PDE6A_CANLF (Q28263), PDE6A_HUMAN (P16499), PDE6A_MOUSE (P27664), 
PDE6B_BOVIN (P23439), PDE6B_CANLF (P33726), PDE6B_HUMAN (P35913), 
PDE6B_MOUSE (P23440), PDE6C_BOVIN (P16586), PDE6C_CHICK (P52731), 
PDE6C_HUMAN (P51160), PDE6C_MOUSE (Q91ZQ1), PDE6_CAEEL  (Q9N2V9), 
PDE6_DROAN  (B3LVW5), PDE6_DROER  (B3P3K2), PDE6_DROGR  (B4JXX2), 
PDE6_DROME  (Q9VFI9), PDE6_DROMO  (B4K9L4), PDE6_DROPE  (B4G4E5), 
PDE6_DROPS  (Q298P4), PDE6_DROSE  (B4HEM4), PDE6_DROSI  (B4QZU1), 
PDE6_DROVI  (B4LVU6), PDE6_DROWI  (B4NAL6), PDE6_DROYA  (B4PSS5), 
PDE7A_HUMAN (Q13946), PDE7A_MOUSE (P70453), PDE7A_RAT   (O08593), 
PDE7B_HUMAN (Q9NP56), PDE7B_MOUSE (Q9QXQ1), PDE8A_HUMAN (O60658), 
PDE8A_MOUSE (O88502), PDE8B_HUMAN (O95263), PDE8B_MOUSE (E9Q4S1), 
PDE9A_DROME (Q9I7S6), PDE9A_HUMAN (O76083), PDE9A_MOUSE (O70628), 
PDE9A_PANTR (H2QL32), PDE9A_RAT   (Q8QZV1), PDEB_PLAF7  (Q8I6Z7), 
PDED_PLAF7  (Q8IKD3), PDEG_PLAYE  (A0A077YBL0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

PDE8_DROME  (Q6NNF2), PDEA_PLAF7  (Q8I5V4)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
PDE4A_CAVPO (O89085)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
DNAE2_BRADU (Q89QU8)


				
	

	

		PDB
[Detailed view]		
		
			679 PDB
			


			1F0J; 1MKD; 1OYN; 1PTW; 1Q9M; 1RKP; 1RO6; 1RO9; 1ROR; 1SO2; 1SOJ; 1T9R; 
			
				1T9S; 1TAZ; 1TB5; 1TB7; 1TBB; 1TBF; 1UDT; 1UDU; 1UHO; 1XLX; 1XLZ; 1XM4; 
				1XM6; 1XMU; 1XMY; 1XN0; 1XOM; 1XON; 1XOQ; 1XOR; 1XOS; 1XOT; 1XOZ; 1XP0; 
				1Y2B; 1Y2C; 1Y2D; 1Y2E; 1Y2H; 1Y2J; 1Y2K; 1Z1L; 1ZKL; 1ZKN; 2CHM; 2FM0; 
				2FM5; 2H40; 2H42; 2H44; 2HD1; 2O8H; 2OUN; 2OUP; 2OUQ; 2OUR; 2OUS; 2OUU; 
				2OVV; 2OVY; 2QYK; 2QYL; 2QYM; 2QYN; 2WEY; 2Y0J; 2YY2; 3B2R; 3BJC; 3D3P; 
				3DY8; 3DYL; 3DYN; 3DYQ; 3DYS; 3ECM; 3ECN; 3FRG; 3G3N; 3G45; 3G4G; 3G4I; 
				3G4K; 3G4L; 3G58; 3GWT; 3HC8; 3HDZ; 3HMV; 3HQW; 3HQY; 3HQZ; 3HR1; 3I8V; 
				3IAD; 3IAK; 3IBJ; 3ITM; 3ITU; 3JAB; 3JBQ; 3JSI; 3JSW; 3JWQ; 3JWR; 3K3E; 
				3K3H; 3K4S; 3KKT; 3LXG; 3LY2; 3N3Z; 3O0J; 3O56; 3O57; 3QI3; 3QI4; 3QPN; 
				3QPO; 3QPP; 3SHY; 3SHZ; 3SIE; 3SL3; 3SL4; 3SL5; 3SL6; 3SL8; 3SN7; 3SNI; 
				3SNL; 3TGE; 3TGG; 3TVX; 3UI7; 3UUO; 3V9B; 3W5E; 3WD9; 3WI2; 3WS8; 3WS9; 
				3WYK; 3WYL; 3WYM; 4AEL; 4AJD; 4AJF; 4AJG; 4AJM; 4BBX; 4C1I; 4D08; 4D09; 
				4DDL; 4DFF; 4E90; 4FCB; 4FCD; 4G2J; 4G2L; 4G2W; 4G2Y; 4GH6; 4HEU; 4HF4; 
				4HTX; 4HTZ; 4I9Z; 4IA0; 4JIB; 4KP6; 4LKQ; 4LLJ; 4LLK; 4LLP; 4LLX; 4LM0; 
				4LM1; 4LM2; 4LM3; 4LM4; 4MD6; 4MRW; 4MRZ; 4MS0; 4MSA; 4MSC; 4MSE; 4MSH; 
				4MSN; 4MUW; 4MVH; 4MYQ; 4NPV; 4NPW; 4NW7; 4OEW; 4OEX; 4OGB; 4P0N; 4P1R; 
				4PHW; 4PM0; 4QGE; 4TPM; 4TPP; 4W1O; 4WCU; 4WN1; 4WZI; 4X0F; 4XY2; 4Y2B; 
				4Y86; 4Y87; 4Y8C; 4YQH; 4YS7; 4ZO5; 5AXP; 5AXQ; 5B25; 5B4K; 5B4L; 5C1W; 
				5C28; 5C29; 5C2A; 5C2E; 5C2H; 5DH4; 5DH5; 5EDE; 5EDG; 5EDH; 5EDI; 5I2R; 
				5JO3; 5K1I; 5K32; 5K6J; 5K9R; 5LAQ; 5LBO; 5OHJ; 5SDU; 5SDV; 5SDW; 5SDX; 
				5SDY; 5SDZ; 5SE0; 5SE1; 5SE2; 5SE3; 5SE4; 5SE5; 5SE6; 5SE7; 5SE8; 5SE9; 
				5SEA; 5SEB; 5SEC; 5SED; 5SEE; 5SEF; 5SEG; 5SEH; 5SEI; 5SEJ; 5SEK; 5SEL; 
				5SEM; 5SEN; 5SEO; 5SEP; 5SEQ; 5SER; 5SES; 5SET; 5SEU; 5SEV; 5SEW; 5SEX; 
				5SEY; 5SEZ; 5SF0; 5SF1; 5SF2; 5SF3; 5SF4; 5SF5; 5SF6; 5SF7; 5SF8; 5SF9; 
				5SFA; 5SFB; 5SFC; 5SFD; 5SFE; 5SFF; 5SFG; 5SFH; 5SFI; 5SFJ; 5SFK; 5SFL; 
				5SFM; 5SFN; 5SFO; 5SFP; 5SFQ; 5SFR; 5SFS; 5SFT; 5SFU; 5SFV; 5SFW; 5SFX; 
				5SFY; 5SFZ; 5SG0; 5SG1; 5SG2; 5SG3; 5SG4; 5SG5; 5SG6; 5SG7; 5SG8; 5SG9; 
				5SGB; 5SGC; 5SGD; 5SGE; 5SGF; 5SGG; 5SGH; 5SGI; 5SGJ; 5SGK; 5SGL; 5SGM; 
				5SGN; 5SGO; 5SGP; 5SGQ; 5SGR; 5SGS; 5SGT; 5SGU; 5SGV; 5SGW; 5SGX; 5SGY; 
				5SGZ; 5SH0; 5SH1; 5SH2; 5SH3; 5SH4; 5SH5; 5SH6; 5SH7; 5SH8; 5SH9; 5SHA; 
				5SHB; 5SHC; 5SHD; 5SHE; 5SHF; 5SHG; 5SHH; 5SHI; 5SHJ; 5SHK; 5SHL; 5SHM; 
				5SHN; 5SHO; 5SHP; 5SHQ; 5SHR; 5SHS; 5SHT; 5SHU; 5SHV; 5SHW; 5SHX; 5SHY; 
				5SHZ; 5SI0; 5SI1; 5SI2; 5SI3; 5SI4; 5SI5; 5SI6; 5SI7; 5SI8; 5SI9; 5SIA; 
				5SIB; 5SID; 5SIE; 5SIF; 5SIG; 5SIH; 5SII; 5SIJ; 5SIK; 5SIL; 5SIM; 5SIN; 
				5SIO; 5SIP; 5SIQ; 5SIR; 5SIS; 5SIT; 5SIU; 5SIV; 5SIW; 5SIX; 5SIY; 5SIZ; 
				5SJ0; 5SJ1; 5SJ2; 5SJ3; 5SJ4; 5SJ5; 5SJ6; 5SJ7; 5SJ8; 5SJ9; 5SJA; 5SJB; 
				5SJC; 5SJD; 5SJE; 5SJF; 5SJG; 5SJH; 5SJI; 5SJJ; 5SJK; 5SJL; 5SJM; 5SJN; 
				5SJO; 5SJP; 5SJQ; 5SJR; 5SJS; 5SJT; 5SJU; 5SJV; 5SJW; 5SJX; 5SJY; 5SJZ; 
				5SK0; 5SK1; 5SK2; 5SK3; 5SK4; 5SK5; 5SK6; 5SK7; 5SK8; 5SK9; 5SKA; 5SKB; 
				5SKC; 5SKD; 5SKE; 5SKF; 5SKG; 5SKH; 5SKI; 5SKJ; 5SKK; 5SKL; 5SKM; 5SKN; 
				5SKO; 5SKP; 5SKQ; 5SKR; 5SKS; 5SKT; 5SKU; 5SKV; 5TKB; 5TZ3; 5TZA; 5TZC; 
				5TZH; 5TZW; 5TZX; 5TZZ; 5U00; 5U7D; 5U7I; 5U7J; 5U7K; 5U7L; 5UOY; 5UP0; 
				5UWF; 5VP0; 5VP1; 5W6E; 5WH5; 5WH6; 5WQA; 5XKM; 5XUI; 5XUJ; 5ZNL; 5ZZ2; 
				6A3N; 6ACB; 6AKR; 6B96; 6B97; 6B98; 6BLF; 6BOJ; 6C7D; 6C7E; 6C7F; 6C7G; 
				6C7I; 6C7J; 6CYB; 6CYC; 6CYD; 6F6U; 6F8R; 6F8T; 6F8U; 6F8V; 6F8W; 6F8X; 
				6FDC; 6FDI; 6FE7; 6FEB; 6FET; 6FT0; 6FTA; 6FTW; 6FW3; 6HWO; 6IAG; 6IBF; 
				6IJH; 6IJI; 6IM6; 6IMB; 6IMD; 6IMI; 6IMO; 6IMR; 6IMT; 6IND; 6INK; 6INM; 
				6IWI; 6K9U; 6KDX; 6KDZ; 6KE0; 6KJZ; 6KK0; 6KO0; 6KO1; 6KZE; 6L6E; 6LRM; 
				6LZZ; 6MSA; 6MSC; 6MZB; 6NJH; 6NJI; 6NJJ; 6RCW; 6VBI; 6X88; 6ZBA; 6ZND; 
				6ZQZ; 7A8Q; 7A9V; 7AAG; 7AB9; 7ABD; 7ABE; 7ABJ; 7AY6; 7B9H; 7BPI; 7CBJ; 
				7CBQ; 7CWA; 7CWF; 7CWG; 7EG0; 7EG1; 7EG4; 7F0I; 7F2K; 7F2L; 7F2M; 7FAQ; 
				7FAR; 7JSN; 7KWE; 7L27; 7L28; 7L29; 7LRC; 7LRD; 7QPF; 7QPM; 7QPQ; 7QPV; 
				7QQ4; 7VSL; 7VTV; 7VTW; 7VTX; 7W4X; 7W4Y; 7XAA; 7XAB; 7XBB; 7YQF; 7YSX; 
				8BPY; 8DI4; 8K4C; 8K4H; 8OEG; 8SYC; 8UFI; 8UGB; 8UGS; 8ULG; 8W4Q; 8W4R; 
				8W4S; 8W4T; 8WDN; 8WDO; 8WKF; 8WKG; 8XV3; 8XWW; 8XXS; 8YLC; 8ZQ1; 8ZQ2; 
				8ZQU; 8ZQW; 9CXG; 9CXH; 9CXI; 9CXJ; 9JA8
			
			

			» more