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PROSITE entry PS00126


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PURL: https://purl.expasy.org/prosite/signature/PS00126

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General information about the entry

Entry name [info] PDEASE_I_1
Accession [info] PS00126
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUL-1998 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00116

Name and characterization of the entry

Description [info] 3'5'-cyclic nucleotide phosphodiesterase domain signature.
Pattern [info] 
H-D-[LIVMFY]-x-H-x-[AG]-x(2)-[NQ]-x-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 102 in 102 different sequences
Number of true positive hits 101 in 101 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.02 %
Recall (true positives / (true positives + false negatives)) 98.06 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 101 sequences 

PDE10_HUMAN (Q9Y233), PDE10_MOUSE (Q8CA95), PDE10_RAT   (Q9QYJ6), 

PDE11_DROME (Q9VJ79), PDE11_HUMAN (Q9HCR9), PDE11_MOUSE (P0C1Q2), 
PDE11_RAT   (Q8VID6), PDE11_TAKRU (Q1KKS3), PDE1A_BOVIN (P14100), 
PDE1A_HUMAN (P54750), PDE1A_MOUSE (Q61481), PDE1B_BOVIN (Q01061), 
PDE1B_CRIGR (Q64395), PDE1B_HUMAN (Q01064), PDE1B_MOUSE (Q01065), 
PDE1B_RAT   (Q01066), PDE1C_HUMAN (Q14123), PDE1C_MOUSE (Q64338), 
PDE1C_RAT   (Q63421), PDE1_CAEEL  (O18696), PDE1_DROME  (B7YZV4), 
PDE2A_BOVIN (P14099), PDE2A_HUMAN (O00408), PDE2A_MOUSE (Q922S4), 
PDE2A_RAT   (Q01062), PDE2_CAEEL  (P30645), PDE2_DICDI  (Q23917), 
PDE2_YEAST  (P06776), PDE3A_HUMAN (Q14432), PDE3A_MOUSE (Q9Z0X4), 
PDE3A_RAT   (Q62865), PDE3B_HUMAN (Q13370), PDE3B_MOUSE (Q61409), 
PDE3B_RAT   (Q63085), PDE3_CAEEL  (Q8I0P7), PDE3_DICDI  (B0G0Y8), 
PDE4A_DROME (Q9W4T4), PDE4A_HUMAN (P27815), PDE4A_MOUSE (O89084), 
PDE4A_RAT   (P54748), PDE4B_DROME (P12252), PDE4B_HUMAN (Q07343), 
PDE4B_RAT   (P14646), PDE4C_DROME (Q9W4S9), PDE4C_HUMAN (Q08493), 
PDE4C_MOUSE (Q3UEI1), PDE4C_RAT   (P14644), PDE4D_HUMAN (Q08499), 
PDE4D_MOUSE (Q01063), PDE4D_RAT   (P14270), PDE4E_DROME (Q8IRU4), 
PDE4_CAEEL  (Q22000), PDE4_DICDI  (Q86H13), PDE5A_BOVIN (Q28156), 
PDE5A_CANLF (O77746), PDE5A_HUMAN (O76074), PDE5A_MOUSE (Q8CG03), 
PDE5A_RAT   (O54735), PDE5_CAEEL  (P91119), PDE6A_BOVIN (P11541), 
PDE6A_CANLF (Q28263), PDE6A_HUMAN (P16499), PDE6A_MOUSE (P27664), 
PDE6B_BOVIN (P23439), PDE6B_CANLF (P33726), PDE6B_HUMAN (P35913), 
PDE6B_MOUSE (P23440), PDE6C_BOVIN (P16586), PDE6C_CHICK (P52731), 
PDE6C_HUMAN (P51160), PDE6C_MOUSE (Q91ZQ1), PDE6_CAEEL  (Q9N2V9), 
PDE6_DROAN  (B3LVW5), PDE6_DROER  (B3P3K2), PDE6_DROGR  (B4JXX2), 
PDE6_DROME  (Q9VFI9), PDE6_DROMO  (B4K9L4), PDE6_DROPE  (B4G4E5), 
PDE6_DROPS  (Q298P4), PDE6_DROSE  (B4HEM4), PDE6_DROSI  (B4QZU1), 
PDE6_DROVI  (B4LVU6), PDE6_DROWI  (B4NAL6), PDE6_DROYA  (B4PSS5), 
PDE7A_HUMAN (Q13946), PDE7A_MOUSE (P70453), PDE7A_RAT   (O08593), 
PDE7B_HUMAN (Q9NP56), PDE7B_MOUSE (Q9QXQ1), PDE8A_HUMAN (O60658), 
PDE8A_MOUSE (O88502), PDE8B_HUMAN (O95263), PDE8B_MOUSE (E9Q4S1), 
PDE9A_DROME (Q9I7S6), PDE9A_HUMAN (O76083), PDE9A_MOUSE (O70628), 
PDE9A_PANTR (H2QL32), PDE9A_RAT   (Q8QZV1), PDEB_PLAF7  (Q8I6Z7), 
PDED_PLAF7  (Q8IKD3), PDEG_PLAYE  (A0A077YBL0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

PDE8_DROME  (Q6NNF2), PDEA_PLAF7  (Q8I5V4)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
PDE4A_CAVPO (O89085)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
DNAE2_BRADU (Q89QU8)


				
	

	

		PDB
[Detailed view]		
		
			679 PDB
			


			pdb_00001f0j; pdb_00001mkd; pdb_00001oyn; pdb_00001ptw; pdb_00001q9m; pdb_00001rkp; pdb_00001ro6; pdb_00001ro9; pdb_00001ror; pdb_00001so2; pdb_00001soj; pdb_00001t9r; 
			
				pdb_00001t9s; pdb_00001taz; pdb_00001tb5; pdb_00001tb7; pdb_00001tbb; pdb_00001tbf; pdb_00001udt; pdb_00001udu; pdb_00001uho; pdb_00001xlx; pdb_00001xlz; pdb_00001xm4; 
				pdb_00001xm6; pdb_00001xmu; pdb_00001xmy; pdb_00001xn0; pdb_00001xom; pdb_00001xon; pdb_00001xoq; pdb_00001xor; pdb_00001xos; pdb_00001xot; pdb_00001xoz; pdb_00001xp0; 
				pdb_00001y2b; pdb_00001y2c; pdb_00001y2d; pdb_00001y2e; pdb_00001y2h; pdb_00001y2j; pdb_00001y2k; pdb_00001z1l; pdb_00001zkl; pdb_00001zkn; pdb_00002chm; pdb_00002fm0; 
				pdb_00002fm5; pdb_00002h40; pdb_00002h42; pdb_00002h44; pdb_00002hd1; pdb_00002o8h; pdb_00002oun; pdb_00002oup; pdb_00002ouq; pdb_00002our; pdb_00002ous; pdb_00002ouu; 
				pdb_00002ovv; pdb_00002ovy; pdb_00002qyk; pdb_00002qyl; pdb_00002qym; pdb_00002qyn; pdb_00002wey; pdb_00002y0j; pdb_00002yy2; pdb_00003b2r; pdb_00003bjc; pdb_00003d3p; 
				pdb_00003dy8; pdb_00003dyl; pdb_00003dyn; pdb_00003dyq; pdb_00003dys; pdb_00003ecm; pdb_00003ecn; pdb_00003frg; pdb_00003g3n; pdb_00003g45; pdb_00003g4g; pdb_00003g4i; 
				pdb_00003g4k; pdb_00003g4l; pdb_00003g58; pdb_00003gwt; pdb_00003hc8; pdb_00003hdz; pdb_00003hmv; pdb_00003hqw; pdb_00003hqy; pdb_00003hqz; pdb_00003hr1; pdb_00003i8v; 
				pdb_00003iad; pdb_00003iak; pdb_00003ibj; pdb_00003itm; pdb_00003itu; pdb_00003jab; pdb_00003jbq; pdb_00003jsi; pdb_00003jsw; pdb_00003jwq; pdb_00003jwr; pdb_00003k3e; 
				pdb_00003k3h; pdb_00003k4s; pdb_00003kkt; pdb_00003lxg; pdb_00003ly2; pdb_00003n3z; pdb_00003o0j; pdb_00003o56; pdb_00003o57; pdb_00003qi3; pdb_00003qi4; pdb_00003qpn; 
				pdb_00003qpo; pdb_00003qpp; pdb_00003shy; pdb_00003shz; pdb_00003sie; pdb_00003sl3; pdb_00003sl4; pdb_00003sl5; pdb_00003sl6; pdb_00003sl8; pdb_00003sn7; pdb_00003sni; 
				pdb_00003snl; pdb_00003tge; pdb_00003tgg; pdb_00003tvx; pdb_00003ui7; pdb_00003uuo; pdb_00003v9b; pdb_00003w5e; pdb_00003wd9; pdb_00003wi2; pdb_00003ws8; pdb_00003ws9; 
				pdb_00003wyk; pdb_00003wyl; pdb_00003wym; pdb_00004ael; pdb_00004ajd; pdb_00004ajf; pdb_00004ajg; pdb_00004ajm; pdb_00004bbx; pdb_00004c1i; pdb_00004d08; pdb_00004d09; 
				pdb_00004ddl; pdb_00004dff; pdb_00004e90; pdb_00004fcb; pdb_00004fcd; pdb_00004g2j; pdb_00004g2l; pdb_00004g2w; pdb_00004g2y; pdb_00004gh6; pdb_00004heu; pdb_00004hf4; 
				pdb_00004htx; pdb_00004htz; pdb_00004i9z; pdb_00004ia0; pdb_00004jib; pdb_00004kp6; pdb_00004lkq; pdb_00004llj; pdb_00004llk; pdb_00004llp; pdb_00004llx; pdb_00004lm0; 
				pdb_00004lm1; pdb_00004lm2; pdb_00004lm3; pdb_00004lm4; pdb_00004md6; pdb_00004mrw; pdb_00004mrz; pdb_00004ms0; pdb_00004msa; pdb_00004msc; pdb_00004mse; pdb_00004msh; 
				pdb_00004msn; pdb_00004muw; pdb_00004mvh; pdb_00004myq; pdb_00004npv; pdb_00004npw; pdb_00004nw7; pdb_00004oew; pdb_00004oex; pdb_00004ogb; pdb_00004p0n; pdb_00004p1r; 
				pdb_00004phw; pdb_00004pm0; pdb_00004qge; pdb_00004tpm; pdb_00004tpp; pdb_00004w1o; pdb_00004wcu; pdb_00004wn1; pdb_00004wzi; pdb_00004x0f; pdb_00004xy2; pdb_00004y2b; 
				pdb_00004y86; pdb_00004y87; pdb_00004y8c; pdb_00004yqh; pdb_00004ys7; pdb_00004zo5; pdb_00005axp; pdb_00005axq; pdb_00005b25; pdb_00005b4k; pdb_00005b4l; pdb_00005c1w; 
				pdb_00005c28; pdb_00005c29; pdb_00005c2a; pdb_00005c2e; pdb_00005c2h; pdb_00005dh4; pdb_00005dh5; pdb_00005ede; pdb_00005edg; pdb_00005edh; pdb_00005edi; pdb_00005i2r; 
				pdb_00005jo3; pdb_00005k1i; pdb_00005k32; pdb_00005k6j; pdb_00005k9r; pdb_00005laq; pdb_00005lbo; pdb_00005ohj; pdb_00005sdu; pdb_00005sdv; pdb_00005sdw; pdb_00005sdx; 
				pdb_00005sdy; pdb_00005sdz; pdb_00005se0; pdb_00005se1; pdb_00005se2; pdb_00005se3; pdb_00005se4; pdb_00005se5; pdb_00005se6; pdb_00005se7; pdb_00005se8; pdb_00005se9; 
				pdb_00005sea; pdb_00005seb; pdb_00005sec; pdb_00005sed; pdb_00005see; pdb_00005sef; pdb_00005seg; pdb_00005seh; pdb_00005sei; pdb_00005sej; pdb_00005sek; pdb_00005sel; 
				pdb_00005sem; pdb_00005sen; pdb_00005seo; pdb_00005sep; pdb_00005seq; pdb_00005ser; pdb_00005ses; pdb_00005set; pdb_00005seu; pdb_00005sev; pdb_00005sew; pdb_00005sex; 
				pdb_00005sey; pdb_00005sez; pdb_00005sf0; pdb_00005sf1; pdb_00005sf2; pdb_00005sf3; pdb_00005sf4; pdb_00005sf5; pdb_00005sf6; pdb_00005sf7; pdb_00005sf8; pdb_00005sf9; 
				pdb_00005sfa; pdb_00005sfb; pdb_00005sfc; pdb_00005sfd; pdb_00005sfe; pdb_00005sff; pdb_00005sfg; pdb_00005sfh; pdb_00005sfi; pdb_00005sfj; pdb_00005sfk; pdb_00005sfl; 
				pdb_00005sfm; pdb_00005sfn; pdb_00005sfo; pdb_00005sfp; pdb_00005sfq; pdb_00005sfr; pdb_00005sfs; pdb_00005sft; pdb_00005sfu; pdb_00005sfv; pdb_00005sfw; pdb_00005sfx; 
				pdb_00005sfy; pdb_00005sfz; pdb_00005sg0; pdb_00005sg1; pdb_00005sg2; pdb_00005sg3; pdb_00005sg4; pdb_00005sg5; pdb_00005sg6; pdb_00005sg7; pdb_00005sg8; pdb_00005sg9; 
				pdb_00005sgb; pdb_00005sgc; pdb_00005sgd; pdb_00005sge; pdb_00005sgf; pdb_00005sgg; pdb_00005sgh; pdb_00005sgi; pdb_00005sgj; pdb_00005sgk; pdb_00005sgl; pdb_00005sgm; 
				pdb_00005sgn; pdb_00005sgo; pdb_00005sgp; pdb_00005sgq; pdb_00005sgr; pdb_00005sgs; pdb_00005sgt; pdb_00005sgu; pdb_00005sgv; pdb_00005sgw; pdb_00005sgx; pdb_00005sgy; 
				pdb_00005sgz; pdb_00005sh0; pdb_00005sh1; pdb_00005sh2; pdb_00005sh3; pdb_00005sh4; pdb_00005sh5; pdb_00005sh6; pdb_00005sh7; pdb_00005sh8; pdb_00005sh9; pdb_00005sha; 
				pdb_00005shb; pdb_00005shc; pdb_00005shd; pdb_00005she; pdb_00005shf; pdb_00005shg; pdb_00005shh; pdb_00005shi; pdb_00005shj; pdb_00005shk; pdb_00005shl; pdb_00005shm; 
				pdb_00005shn; pdb_00005sho; pdb_00005shp; pdb_00005shq; pdb_00005shr; pdb_00005shs; pdb_00005sht; pdb_00005shu; pdb_00005shv; pdb_00005shw; pdb_00005shx; pdb_00005shy; 
				pdb_00005shz; pdb_00005si0; pdb_00005si1; pdb_00005si2; pdb_00005si3; pdb_00005si4; pdb_00005si5; pdb_00005si6; pdb_00005si7; pdb_00005si8; pdb_00005si9; pdb_00005sia; 
				pdb_00005sib; pdb_00005sid; pdb_00005sie; pdb_00005sif; pdb_00005sig; pdb_00005sih; pdb_00005sii; pdb_00005sij; pdb_00005sik; pdb_00005sil; pdb_00005sim; pdb_00005sin; 
				pdb_00005sio; pdb_00005sip; pdb_00005siq; pdb_00005sir; pdb_00005sis; pdb_00005sit; pdb_00005siu; pdb_00005siv; pdb_00005siw; pdb_00005six; pdb_00005siy; pdb_00005siz; 
				pdb_00005sj0; pdb_00005sj1; pdb_00005sj2; pdb_00005sj3; pdb_00005sj4; pdb_00005sj5; pdb_00005sj6; pdb_00005sj7; pdb_00005sj8; pdb_00005sj9; pdb_00005sja; pdb_00005sjb; 
				pdb_00005sjc; pdb_00005sjd; pdb_00005sje; pdb_00005sjf; pdb_00005sjg; pdb_00005sjh; pdb_00005sji; pdb_00005sjj; pdb_00005sjk; pdb_00005sjl; pdb_00005sjm; pdb_00005sjn; 
				pdb_00005sjo; pdb_00005sjp; pdb_00005sjq; pdb_00005sjr; pdb_00005sjs; pdb_00005sjt; pdb_00005sju; pdb_00005sjv; pdb_00005sjw; pdb_00005sjx; pdb_00005sjy; pdb_00005sjz; 
				pdb_00005sk0; pdb_00005sk1; pdb_00005sk2; pdb_00005sk3; pdb_00005sk4; pdb_00005sk5; pdb_00005sk6; pdb_00005sk7; pdb_00005sk8; pdb_00005sk9; pdb_00005ska; pdb_00005skb; 
				pdb_00005skc; pdb_00005skd; pdb_00005ske; pdb_00005skf; pdb_00005skg; pdb_00005skh; pdb_00005ski; pdb_00005skj; pdb_00005skk; pdb_00005skl; pdb_00005skm; pdb_00005skn; 
				pdb_00005sko; pdb_00005skp; pdb_00005skq; pdb_00005skr; pdb_00005sks; pdb_00005skt; pdb_00005sku; pdb_00005skv; pdb_00005tkb; pdb_00005tz3; pdb_00005tza; pdb_00005tzc; 
				pdb_00005tzh; pdb_00005tzw; pdb_00005tzx; pdb_00005tzz; pdb_00005u00; pdb_00005u7d; pdb_00005u7i; pdb_00005u7j; pdb_00005u7k; pdb_00005u7l; pdb_00005uoy; pdb_00005up0; 
				pdb_00005uwf; pdb_00005vp0; pdb_00005vp1; pdb_00005w6e; pdb_00005wh5; pdb_00005wh6; pdb_00005wqa; pdb_00005xkm; pdb_00005xui; pdb_00005xuj; pdb_00005znl; pdb_00005zz2; 
				pdb_00006a3n; pdb_00006acb; pdb_00006akr; pdb_00006b96; pdb_00006b97; pdb_00006b98; pdb_00006blf; pdb_00006boj; pdb_00006c7d; pdb_00006c7e; pdb_00006c7f; pdb_00006c7g; 
				pdb_00006c7i; pdb_00006c7j; pdb_00006cyb; pdb_00006cyc; pdb_00006cyd; pdb_00006f6u; pdb_00006f8r; pdb_00006f8t; pdb_00006f8u; pdb_00006f8v; pdb_00006f8w; pdb_00006f8x; 
				pdb_00006fdc; pdb_00006fdi; pdb_00006fe7; pdb_00006feb; pdb_00006fet; pdb_00006ft0; pdb_00006fta; pdb_00006ftw; pdb_00006fw3; pdb_00006hwo; pdb_00006iag; pdb_00006ibf; 
				pdb_00006ijh; pdb_00006iji; pdb_00006im6; pdb_00006imb; pdb_00006imd; pdb_00006imi; pdb_00006imo; pdb_00006imr; pdb_00006imt; pdb_00006ind; pdb_00006ink; pdb_00006inm; 
				pdb_00006iwi; pdb_00006k9u; pdb_00006kdx; pdb_00006kdz; pdb_00006ke0; pdb_00006kjz; pdb_00006kk0; pdb_00006ko0; pdb_00006ko1; pdb_00006kze; pdb_00006l6e; pdb_00006lrm; 
				pdb_00006lzz; pdb_00006msa; pdb_00006msc; pdb_00006mzb; pdb_00006njh; pdb_00006nji; pdb_00006njj; pdb_00006rcw; pdb_00006vbi; pdb_00006x88; pdb_00006zba; pdb_00006znd; 
				pdb_00006zqz; pdb_00007a8q; pdb_00007a9v; pdb_00007aag; pdb_00007ab9; pdb_00007abd; pdb_00007abe; pdb_00007abj; pdb_00007ay6; pdb_00007b9h; pdb_00007bpi; pdb_00007cbj; 
				pdb_00007cbq; pdb_00007cwa; pdb_00007cwf; pdb_00007cwg; pdb_00007eg0; pdb_00007eg1; pdb_00007eg4; pdb_00007f0i; pdb_00007f2k; pdb_00007f2l; pdb_00007f2m; pdb_00007faq; 
				pdb_00007far; pdb_00007jsn; pdb_00007kwe; pdb_00007l27; pdb_00007l28; pdb_00007l29; pdb_00007lrc; pdb_00007lrd; pdb_00007qpf; pdb_00007qpm; pdb_00007qpq; pdb_00007qpv; 
				pdb_00007qq4; pdb_00007vsl; pdb_00007vtv; pdb_00007vtw; pdb_00007vtx; pdb_00007w4x; pdb_00007w4y; pdb_00007xaa; pdb_00007xab; pdb_00007xbb; pdb_00007yqf; pdb_00007ysx; 
				pdb_00008bpy; pdb_00008di4; pdb_00008k4c; pdb_00008k4h; pdb_00008oeg; pdb_00008syc; pdb_00008ufi; pdb_00008ugb; pdb_00008ugs; pdb_00008ulg; pdb_00008w4q; pdb_00008w4r; 
				pdb_00008w4s; pdb_00008w4t; pdb_00008wdn; pdb_00008wdo; pdb_00008wkf; pdb_00008wkg; pdb_00008xv3; pdb_00008xww; pdb_00008xxs; pdb_00008ylc; pdb_00008zq1; pdb_00008zq2; 
				pdb_00008zqu; pdb_00008zqw; pdb_00009cxg; pdb_00009cxh; pdb_00009cxi; pdb_00009cxj; pdb_00009ja8
			
			

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