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PROSITE entry PS00146


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General information about the entry

Entry name [info] BETA_LACTAMASE_A
Accession [info] PS00146
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00134
Associated ProRule [info] PRU10101

Name and characterization of the entry

Description [info] Beta-lactamase class-A active site.
Pattern [info] 
[FY]-x-[LIVMFY]-{E}-S-[TV]-x-K-x(3)-{T}-[AGLM]-{D}-{KA}-[LC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 105 in 105 different sequences
Number of true positive hits 82 in 82 different sequences
Number of 'unknown' hits 2 in 2 different sequences
Number of false positive hits 21 in 21 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 79.61 %
Recall (true positives / (true positives + false negatives)) 93.18 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 82 sequences 

BLA13_KLEPN (Q9S424), BLA1_ACTPL  (P67920), BLA1_AERHY  (Q44056), 

BLA1_BACCE  (P10424), BLA1_BACMY  (P28018), BLA1_ECOLX  (P0AD63), 
BLA1_ENTCL  (P18251), BLA1_HAEIF  (P67918), BLA1_KLEPN  (P0AD64), 
BLA1_MANHA  (P67919), BLA1_STRCI  (Q03680), BLA24_ECOLX (Q9S169), 
BLA29_KLEPN (Q9AHN9), BLA2_ECOLX  (P0A9Z7), BLA2_KLEPN  (P0A9Z8), 
BLA2_KLEPO  (P0A9Z9), BLA2_SALTM  (P0AA00), BLA2_STEMA  (P96465), 
BLA2_STRCI  (P14560), BLA34_ECOLX (Q93LM8), BLA3_BACCE  (P06548), 
BLA3_KLEPN  (P30896), BLA46_KLEOX (Q848S4), BLA4_KLEPN  (P37323), 
BLA5_KLEPN  (P0A3M1), BLA5_PSEAI  (P0A3M2), BLA6_KLEPN  (P96348), 
BLA8_ECOLX  (O08337), BLAB_PROVU  (P52664), BLAC_AMYLA  (Q06316), 
BLAC_BACAM  (Q44674), BLAC_BACCE  (P00809), BLAC_BACLI  (P00808), 
BLAC_BACSU  (P39824), BLAC_BACTU  (Q45726), BLAC_BACUN  (P30898), 
BLAC_CITKO  (P22390), BLAC_KITAU  (P10509), BLAC_KLEPN  (P05192), 
BLAC_MYCBO  (P0A5I7), BLAC_MYCTA  (A5U493), BLAC_MYCTO  (P9WKD2), 
BLAC_MYCTU  (P9WKD3), BLAC_NOCAS  (Q9EZQ7), BLAC_NOCFA  (Q5YXD6), 
BLAC_PHOVU  (P30899), BLAC_PROMI  (P30897), BLAC_PROVU  (P80298), 
BLAC_RHOCA  (P14171), BLAC_STAAU  (P00807), BLAC_STRAL  (P14559), 
BLAC_STRBA  (P35391), BLAC_STRCE  (Q06650), BLAC_STRLA  (P35393), 
BLAC_YEREN  (Q01166), BLAF_MYCFO  (Q59517), BLAT_ECOLX  (P62593), 
BLAT_KLEOX  (Q48406), BLAT_SALTI  (P62594), BLC14_ECOLX (A0A649V088), 
BLC15_ECO25 (A0A5R8T042), BLC1_ECOLX  (P28585), BLC25_ECOLX (Q8KSA6), 
BLC2_SALTM  (P74841), BLC3_PSEAI  (P37322), BLC4_PSEAI  (Q51355), 
BLC4_SALTM  (O33807), BLC5_SALTM  (O65975), BLC6_SALTM  (O65976), 
BLC6_VIBCL  (P81781), BLC8_CITAM  (Q9RMT4), BLC97_ECOLX (E1ANH6), 
BLE1_PSEAI  (P37321), BLML_ARTBC  (D4AXL1), BLO1_KLEOX  (P22391), 
BLO2_KLEOX  (P23954), BLP1_PSEAI  (Q03170), BLP4_PSEAI  (P16897), 
BLT1_ECOLX  (Q47066), BLT2_ECOLX  (O69395), ESTB_BURGA  (Q9KX40), 
FTSI_CAUVN  (B8H0A0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

BLAC_SERFO  (P80545), BLAC_STRFR  (P35392), BLAN_ENTCL  (P52663), 

BLAN_SERMA  (P52682), BLKPC_KLEOX (Q848S6), BLKPC_KLEPN (Q9F663)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

BLAC_STRGR  (P81173)


				
	

	

		UniProtKB/Swiss-Prot
'Unknown' sequences		
		
			2 sequences
			


			
FIMDD_DICNO (P17420), FIMDH_DICNO (P17421)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			21 sequences
			


			
GLSA2_YERPE (Q9ZC49), GLSA_SYNY3  (P73903), MYO7B_MOUSE (Q99MZ6), 

			
NRT25_ARATH (Q9LPV5), PCRK1_ARATH (Q9SF86), PCRK2_ARATH (Q9LZF8), 
PH11A_MOUSE (Q8BVM9), PH11L_RAT   (Q5I0J8), PHF11_MOUSE (A6H5X4), 
PHF11_RAT   (Q5I0E2), PHF1_ARATH  (Q8GYE0), PORA_PHOPM  (B5CY96), 
PP244_ARATH (Q9LT48), PP448_ARATH (Q9FJY9), PPR83_ARATH (Q9FXA9), 
RR2_EUGGR   (P30389), RSMH_MESFL  (Q6F170), SRP72_DICDI (Q54EP7), 
UTP17_SCHPO (O13878), Y0701_DICDI (Q559T8), Y2899_ARATH (O81069)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			272 PDB
			


			1ALQ; 1AXB; 1BLC; 1BLH; 1BLP; 1BSG; 1BT5; 1BTL; 1BZA; 1CI8; 1CI9; 1CK3; 
			
				1E25; 1ERM; 1ERO; 1ERQ; 1ESU; 1FQG; 1G68; 1G6A; 1GHI; 1GHM; 1GHP; 1HZO; 
				1I2S; 1I2W; 1IYO; 1IYP; 1IYQ; 1IYS; 1JTD; 1JTG; 1JVJ; 1JWP; 1JWV; 1JWZ; 
				1KGE; 1KGF; 1KGG; 1LHY; 1LI0; 1LI9; 1M40; 1MBL; 1N9B; 1NXY; 1NY0; 1NYM; 
				1NYY; 1OME; 1ONG; 1PIO; 1PZO; 1PZP; 1Q2P; 1RCJ; 1S0W; 1SHV; 1TDG; 1TDL; 
				1TEM; 1VM1; 1W7F; 1WE4; 1XPB; 1XXM; 1YT4; 1ZG4; 2A3U; 2A49; 2B5R; 2BLM; 
				2CC1; 2G2U; 2G2W; 2GDN; 2H0T; 2H0Y; 2H10; 2H5S; 2V1Z; 2V20; 2WK0; 2WYX; 
				2XQZ; 2XR0; 2Y91; 2ZD8; 2ZQ7; 2ZQ8; 2ZQ9; 2ZQA; 2ZQC; 2ZQD; 3B3X; 3BLM; 
				3BYD; 3C4O; 3C4P; 3C7U; 3C7V; 3CG5; 3CMZ; 3D4F; 3DTM; 3DWZ; 3IQA; 3JYI; 
				3LY3; 3LY4; 3M2J; 3M2K; 3M6B; 3M6H; 3MKE; 3MKF; 3MXR; 3MXS; 3N4I; 3N6I; 
				3N7W; 3N8L; 3N8R; 3N8S; 3NBL; 3NC8; 3NCK; 3NDE; 3NDG; 3OPH; 3OPL; 3OPP; 
				3OPR; 3SH7; 3SH8; 3SH9; 3SOI; 3TOI; 3V50; 3V5M; 3VFF; 3VFH; 3ZHH; 4BD0; 
				4BD1; 4BLM; 4C3Q; 4DF6; 4DXB; 4DXC; 4EBL; 4EBN; 4EBP; 4FCF; 4FH4; 4GD6; 
				4GD8; 4GDB; 4GKU; 4HBT; 4HBU; 4IBR; 4IBX; 4ID4; 4JLF; 4JPM; 4M3K; 4MBF; 
				4MBH; 4MBK; 4MEZ; 4N1H; 4N92; 4N9K; 4N9L; 4Q8I; 4QHC; 4QY5; 4QY6; 4R3B; 
				4R4R; 4R4S; 4RVA; 4RX2; 4X69; 4X6T; 4ZAM; 4ZJ1; 5A90; 5A91; 5A92; 5A93; 
				5EE8; 5FA7; 5FAO; 5FAP; 5G18; 5GHX; 5GHY; 5GHZ; 5HVI; 5HW1; 5HW5; 5I52; 
				5I63; 5IQ8; 5KKF; 5KMW; 5KPU; 5KSC; 5LWF; 5NJ2; 5NPO; 5OYO; 5ZFL; 5ZFT; 
				5ZG6; 6APA; 6AYK; 6B2N; 6B5X; 6B5Y; 6B68; 6B69; 6B6A; 6B6B; 6B6C; 6B6D; 
				6B6E; 6B6F; 6N14; 6U58; 6W2Z; 6WGR; 7A5T; 7A5U; 7A5W; 7A6Z; 7A71; 7A72; 
				7A74; 7K8E; 7K8F; 7K8H; 7K8K; 7K8L; 7QLP; 7QNK; 7QOR; 7U48; 7U49; 7U4B; 
				7U57; 8BTU; 8BTV; 8BTW; 8BV4; 8DDZ; 8DE0; 8DE1; 8DE2; 8EBI; 8EBR; 8EC4; 
				8ECF; 8GCS; 8IWV; 8IX8; 8IXX; 8IY4; 8OE1; 8OE5
			
			

			» more