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PROSITE entry PS00161


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PURL: https://purl.expasy.org/prosite/signature/PS00161

Direct ScanProsite submission
General information about the entry

Entry name [info] ISOCITRATE_LYASE
Accession [info] PS00161
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00145
Associated ProRule [info] PRU10119

Name and characterization of the entry

Description [info] Isocitrate lyase signature.
Pattern [info] 
K-[KR]-C-G-H-[LMQR].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 71 in 71 different sequences
Number of true positive hits 68 in 68 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 9
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 95.77 %
Recall (true positives / (true positives + false negatives)) 88.31 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site(?) at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 68 sequences 

ACEA1_MYCBO (P0A5H4), ACEA1_MYCTE (H8EVV4), ACEA1_MYCTO (P9WKK6), 

ACEA1_SOYBN (P45456), ACEA2_MYCBO (Q7TZA8), ACEA2_MYCTE (H8F3R6), 
ACEA2_MYCTO (Q8VJU4), ACEA2_SOYBN (P45457), ACEAA_MYCTU (O07718), 
ACEA_ARATH  (P28297), ACEA_ASPFU  (Q6T267), ACEA_BRANA  (P25248), 
ACEA_CANAX  (Q9P8Q7), ACEA_CANGA  (Q6FPK7), ACEA_CANTR  (P20014), 
ACEA_COCIM  (Q96TP5), ACEA_COPC7  (A8NR45), ACEA_COPCI  (O13439), 
ACEA_COREF  (Q8RQN6), ACEA_CORGL  (P42449), ACEA_CUCMA  (P93110), 
ACEA_CUCSA  (P49296), ACEA_CYBJA  (Q9HFN2), ACEA_DEBHA  (Q6BRY4), 
ACEA_DENCR  (Q9SE26), ACEA_ECOL6  (P0A9G7), ACEA_ECOLI  (P0A9G6), 
ACEA_EMENI  (P28298), ACEA_EREGS  (O94198), ACEA_GIBZE  (Q4HYR2), 
ACEA_GOSHI  (P17069), ACEA_HALH5  (Q9K9H0), ACEA_KLULA  (Q8NJ72), 
ACEA_LEPMC  (Q86ZF1), ACEA_MYCLE  (P46831), ACEA_MYCTU  (P9WKK7), 
ACEA_NEUCR  (P28299), ACEA_ORYSJ  (Q6Z6M4), ACEA_PICPA  (Q9C124), 
ACEA_PINTA  (Q43097), ACEA_PYRO3  (L7HUY5), ACEA_PYRO7  (P0CT06), 
ACEA_RHOFA  (P41554), ACEA_RICCO  (P15479), ACEA_SALTY  (P51066), 
ACEA_SOLLC  (P49297), ACEA_TALMA  (Q96WZ5), ACEA_YARLI  (P41555), 
ACEA_YEAST  (P28240), ACEB_EMENI  (C8V9Y5), ACEB_HYPAI  (G9NNY7), 
ACEB_YARLI  (Q6BZP5), ACEB_YEAST  (Q12031), CPPM_ARATH  (O49290), 
CPPM_STRHY  (P11435), DML_EUBBA   (Q0QLE4), GCP_CAEEL   (Q10663), 
MMGF_BACSU  (P54528), MMGF_HALH5  (Q9Z9T7), PDP_DIACA   (Q05957), 
PRPB1_CORGL (Q8NSH8), PRPB2_CORGL (Q8NSL2), PRPB_AERPE  (Q9YFM7), 
PRPB_CUPNE  (Q937P0), PRPB_ECOLI  (P77541), PRPB_SALTY  (Q56062), 
PRPB_SHEON  (Q8EJW1), PRPB_VIBCH  (Q9KSC2)
» more

UniProtKB/Swiss-Prot
False negative sequences		 9 sequences 

ACEA_PSEAE  (Q9I0K4), ACEB_SCHPO  (Q9P6J1), FOM1_STRWE  (P96074), 

PEPM_MYTED  (P56839), PEPM_STRHY  (P29247), PEPM_STRR3  (Q0ZQ45), 
PEPM_STRVT  (O86937), PEPM_TETPY  (P33182), PPHA_VARSP  (Q84G06)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

ACEA_ACICA  (P28467), ACEA_HELAN  (P20699)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			3 sequences
			


			
KLKB1_BOVIN (Q2KJ63), RING2_CAEEL (H2KYH3), SYL_ANAMM   (Q5PB38)


				
	

	

		PDB
[Detailed view]		
		
			24 PDB
			


			pdb_00001dqu; pdb_00001f61; pdb_00001f8m; pdb_00001igw; pdb_00001mum; pdb_00001o5q; pdb_00001oqf; pdb_00001ujq; pdb_00001zlp; pdb_00005dql; pdb_00005e9f; pdb_00005e9g; 
			
				pdb_00005e9h; pdb_00006edw; pdb_00006edz; pdb_00006ee1; pdb_00006vb9; pdb_00006wsi; pdb_00006xpp; pdb_00007cp1; pdb_00007ebc; pdb_00007ebe; pdb_00007ebf; pdb_00007rb1
			
			

			» more