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PROSITE entry PS00166


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00166
Entry name [info] ENOYL_COA_HYDRATASE
Accession [info] PS00166
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00150

Name and characterization of the entry

Description [info] Enoyl-CoA hydratase/isomerase signature.
Pattern [info] 
[LIVM]-[STAG]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-[LIVMST]-x-[CSTA]-
[DQHP]-[LIVMFYA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 245 in 245 different sequences
Number of true positive hits 223 in 223 different sequences
Number of 'unknown' hits 0
Number of false positive hits 22 in 22 different sequences
Number of false negative sequences 159
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 91.02 %
Recall (true positives / (true positives + false negatives)) 58.38 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 223 sequences 

AIM1_ARATH  (Q9ZPI6), AUHM_DICDI  (Q54HG7), AUHM_HUMAN  (Q13825), 

AUHM_MOUSE  (Q9JLZ3), AUHM_RAT(F1LU71), BAMA_GEOMG  (Q39TV7), 
BBSH_THAAR  (Q9KJE7), CAID_CITK8  (A8ALR7), CAID_ECO57  (Q8XA35), 
CAID_ECOL5  (Q0TLV3), CAID_ECOL6  (Q8FLA6), CAID_ECOLC  (B1IRE0), 
CAID_ECOLI  (P31551), CAID_ECOSM  (B1LFW9), CAID_PROMH  (B4EY26), 
CAID_PROSL  (Q8GB17), CAID_SALA4  (B5F749), CAID_SALAR  (A9MR28), 
CAID_SALCH  (Q57TJ1), CAID_SALDC  (B5FHG4), CAID_SALEP  (B5R1Q9), 
CAID_SALG2  (B5RGA4), CAID_SALHS  (B4TIG9), CAID_SALNS  (B4T6J5), 
CAID_SALPA  (Q5PIL1), CAID_SALPB  (A9MYJ5), CAID_SALPC  (C0Q4L2), 
CAID_SALPK  (B5BL54), CAID_SALSV  (B4TWR3), CAID_SALTI  (Q8Z9L5), 
CAID_SALTY  (Q8ZRX5), CAID_SHIFL  (P59395), CBAD1_ARTSP (O85078), 
CBAD2_ARTSP (Q9LCU3), CBADH_PSEUC (A5JTM5), CLAC_PENCR  (A0A481WNM8), 
CRCH_SYNWW  (Q0AVM1), CRTL_DICDI  (Q869N6), CRT_CLOAB   (P52046), 
DCI1_ARATH  (Q9FHR8), DMDD_RUEPO  (Q5LLW6), DPGD_AMYOR  (G4V4T7), 
ECH12_MYCBO (Q7U004), ECH12_MYCLE (P53526), ECH12_MYCTO (P9WNN6), 
ECH12_MYCTU (P9WNN7), ECH14_MYCBO (P64019), ECH14_MYCTO (P9WNN4), 
ECH14_MYCTU (P9WNN5), ECH1_DICDI  (Q54SS0), ECH1_HUMAN  (Q13011), 
ECH1_MOUSE  (O35459), ECH1_PONAB  (Q5RFG0), ECH1_RAT(Q62651), 
ECH2M_ARATH (F4JML5), ECHA6_MYCBO (P64015), ECHA6_MYCLE (Q50130), 
ECHA6_MYCTO (P9WNP0), ECHA6_MYCTU (P9WNP1), ECHA8_MYCBO (P64017), 
ECHA8_MYCLE (O07137), ECHA8_MYCTO (P9WNN8), ECHA8_MYCTU (P9WNN9), 
ECHA_HUMAN  (P40939), ECHA_MOUSE  (Q8BMS1), ECHA_PIG(Q29554), 
ECHA_RAT(Q64428), ECHD1_BOVIN (Q2HJD5), ECHD1_CHICK (F1NB38), 
ECHD1_DANRE (F1R6N4), ECHD1_HUMAN (Q9NTX5), ECHD1_MOUSE (Q9D9V3), 
ECHD1_PONAB (Q5R4W0), ECHD1_RAT   (Q6AYG5), ECHD1_XENLA (Q5HZQ8), 
ECHD1_XENTR (Q28C91), ECHD2_BOVIN (Q2TBT3), ECHD2_HUMAN (Q86YB7), 
ECHD2_MOUSE (Q3TLP5), ECHH_RHIME  (Q52995), ECHH_RHOCB  (P24162), 
ECHM_BOVIN  (Q58DM8), ECHM_CAEEL  (P34559), ECHM_DICDI  (Q1ZXF1), 
ECHM_HUMAN  (P30084), ECHM_MOUSE  (Q8BH95), ECHM_PONAB  (Q5R646), 
ECHM_RAT(P14604), ECHP_CAVPO  (P55100), ECHP_DANRE  (Q6NYL3), 
ECHP_HUMAN  (Q08426), ECHP_MOUSE  (Q9DBM2), ECHP_PONAB  (Q5R5M8), 
ECHP_RAT(P07896), ECH_THET8   (Q5SKU3), ECI1_HUMAN  (P42126), 
ECI1_MOUSE  (P42125), ECI1_RAT(P23965), FADB_ACIAD  (Q6FF68), 
FADB_ACIB3  (B7H1I0), FADB_ACIB5  (B7I3P1), FADB_ACIBC  (B2I2J9), 
FADB_ACIBS  (B0VLX4), FADB_ACIBY  (B0VE45), FADB_ALIF1  (Q5E8X6), 
FADB_ALIFM  (B5FEW8), FADB_ALISL  (B6EGU2), FADB_BACSU  (P94549), 
FADB_CITK8  (A8ACZ4), FADB_COLP3  (Q489W3), FADB_ECO24  (A7ZU51), 
FADB_ECO27  (B7UNH4), FADB_ECO45  (B7MHD1), FADB_ECO55  (B7L9A7), 
FADB_ECO57  (Q8X8I2), FADB_ECO5E  (B5YY93), FADB_ECO7I  (B7NV20), 
FADB_ECO81  (B7N2F2), FADB_ECO8A  (B7M649), FADB_ECOBW  (C5A020), 
FADB_ECODH  (B1XAK8), FADB_ECOHS  (A8A6V1), FADB_ECOL5  (Q0TAL0), 
FADB_ECOL6  (Q8FBI2), FADB_ECOLC  (B1IW61), FADB_ECOLI  (P21177), 
FADB_ECOLU  (B7NFE7), FADB_ECOSM  (B1LM32), FADB_ECOUT  (Q1R466), 
FADB_ECTOL  (Q93Q12), FADB_ENT38  (A4WFX4), FADB_ENTCL  (Q9F0Y7), 
FADB_ESCF3  (B7LTY9), FADB_IDILO  (Q5QXH7), FADB_KLEP3  (B5XYH0), 
FADB_KLEP7  (A6TGM4), FADB_PHOLL  (Q7MZ92), FADB_PHOPR  (Q6LW06), 
FADB_PSEA7  (A6V382), FADB_PSEA8  (B7UYR6), FADB_PSEAB  (Q02PH8), 
FADB_PSEAE  (Q9HZJ2), FADB_PSEE4  (Q1I7D4), FADB_PSEF5  (Q4KFC4), 
FADB_PSEFR  (P28793), FADB_PSEFS  (C3K613), FADB_PSEP1  (A5W6H0), 
FADB_PSEPF  (Q3K9D8), FADB_PSEPG  (B0KH74), FADB_PSEPK  (Q88L02), 
FADB_PSEPU  (Q9AHY3), FADB_PSEPW  (B1J5A5), FADB_SALA4  (B5EZW0), 
FADB_SALCH  (Q57HM6), FADB_SALEP  (B5QW85), FADB_SALG2  (B5RFL6), 
FADB_SALNS  (B4SZ85), FADB_SALPA  (Q5PKQ2), FADB_SALPB  (A9MYB0), 
FADB_SALPK  (B5BIZ0), FADB_SALSV  (B4TNZ1), FADB_SALTI  (Q8Z3C6), 
FADB_SALTY  (Q9L6L5), FADB_SERP5  (A8G8D1), FADB_SHEHH  (B0TLB9), 
FADB_SHEPA  (A8GYG0), FADB_SHEPW  (B8CH91), FADB_SHESH  (A8FP63), 
FADB_SHEWM  (B1KCZ3), FADB_SHIB3  (B2TVJ5), FADB_SHIDS  (Q32A21), 
FADB_SHIF8  (Q0SZ36), FADB_SHIFL  (Q83PG1), FADB_SHISS  (Q3YVC1), 
FADB_VIBA3  (B7VGL4), FADB_YERE8  (A1JIG4), FADB_YERP3  (A7FDF2), 
FADB_YERPA  (Q1C2C4), FADB_YERPB  (B2K0Z6), FADB_YERPE  (Q8ZAN0), 
FADB_YERPG  (A9R754), FADB_YERPN  (Q1CN99), FADB_YERPP  (A4TR27), 
FADB_YERPS  (Q66FR8), FADB_YERPY  (B1JP63), FADJ_ALIF1  (Q5E3U1), 
FADJ_IDILO  (Q5QXM1), FADJ_PECAS  (Q6D2L7), FADJ_PECCP  (C6DAL7), 
FADJ_SHEFN  (Q07ZP8), FADJ_VIBC1  (A7MS61), FADJ_VIBC3  (A5F2P2), 
FADJ_VIBCH  (Q9KT58), FADJ_VIBPA  (Q87MM3), FADJ_VIBVU  (Q8DB47), 
FADJ_VIBVY  (Q7MIS5), FER4_MYCMD  (Q4PEN0), HCHL_PSEFL  (O69762), 
HIBCH_NEUCR (Q1K7A4), HIBCH_YEAST (P28817), HPCD_METS5  (A4YI89), 
MENB_ARATH  (Q8GYN9), MENB_BACSU  (P23966), MENB_CYACA  (Q9TM10), 
MENB_ECOL6  (P0ABU1), MENB_ECOLI  (P0ABU0), MENB_HAEIN  (P44960), 
MENB_PASMU  (Q9CLV5), MENB_SALTY  (Q7CQ56), MENB_STAEQ  (Q5HQC3), 
MENB_STAES  (Q8CPQ4), MENB_STAHJ  (Q4L549), MENB_STAS1  (Q49WG8), 
MFP2_ARATH  (Q9ZPI5), MFPA_BRANA  (O49809), MFPA_CUCSA  (Q39659), 
MFP_ORYSJ   (Q8W1L6), PAAF_ECOLI  (P76082), PKSH_BACSU  (P40805), 
PKSI_BACSU  (P40802), SCPB_ECOLI  (P52045), SIDH_BEAB2  (J4KLY0), 
YNGF_BACSU  (O34893)
» more

UniProtKB/Swiss-Prot
False negative sequences		 159 sequences 

CARB_PECCC  (Q9XB60), DCH_THAAR   (O87873), DPGB_AMYOR  (G4V4T5), 

ECH13_MYCTU (P95279), ECH17_MYCA1 (A0QJH8), ECH17_MYCBO (Q7TXE1), 
ECH17_MYCBP (A1KN36), ECH17_MYCPA (Q73VC7), ECH17_MYCTA (A5U753), 
ECH17_MYCTO (P9WNN2), ECH17_MYCTU (P9WNN3), ECH1P_ARATH (Q6NL24), 
ECH20_MYCTU (I6Y3U6), ECH20_RHOJR (Q0S7P8), ECHD3_DANRE (A0PJR5), 
ECHD3_HUMAN (Q96DC8), ECHD3_MOUSE (Q9D7J9), ECHD3_RAT   (Q3MIE0), 
ECHD3_XENLA (A9JS71), ECI1_YEAST  (Q05871), FABM_STRMU  (Q8DSN0), 
FABM_STRR6  (Q8DR19), FAD3_RICFE  (Q4UL32), FAD3_RICPR  (Q9ZCZ1), 
FAD3_RICTY  (Q68WH7), FADB_AERHH  (A0KEL1), FADB_AERS4  (A4STF2), 
FADB_CROS8  (A7MQP0), FADB_ECOSE  (B6I4I6), FADB_ECTM1  (A4XSM8), 
FADB_PECAS  (Q6DAP5), FADB_PSE14  (Q48GW3), FADB_PSESM  (Q87ZB2), 
FADB_PSEU2  (Q4ZRA0), FADB_PSYA2  (Q4FQC6), FADB_PSYCK  (Q1Q8J9), 
FADB_PSYWF  (A5WH99), FADB_SHEAM  (A1S1I8), FADB_SHEB2  (B8E3R3), 
FADB_SHEB5  (A3CYJ4), FADB_SHEB8  (A6WHA0), FADB_SHEB9  (A9KU91), 
FADB_SHEFN  (Q08A39), FADB_SHELP  (A3Q8U4), FADB_SHEON  (Q8EKR9), 
FADB_SHEPC  (A4Y1B6), FADB_SHESA  (A0KR50), FADB_SHESM  (Q0HPB7), 
FADB_SHESR  (Q0I0T3), FADB_SHESW  (A1RDW6), FADB_STUS1  (A4VKA3), 
FADB_VIBC1  (A7N1D2), FADB_VIBC3  (A5F465), FADB_VIBCH  (Q9KNI1), 
FADB_VIBCM  (C3LSI3), FADB_VIBPA  (Q87TN9), FADB_VIBVU  (Q8DDK6), 
FADB_VIBVY  (Q7MQH9), FADJ_CITK8  (A8ADP2), FADJ_CROS8  (A7MH81), 
FADJ_ECO24  (A7ZPF8), FADJ_ECO27  (B7UFZ8), FADJ_ECO45  (B7MGV7), 
FADJ_ECO55  (B7LBJ5), FADJ_ECO57  (Q8XCP2), FADJ_ECO5E  (B5YXY4), 
FADJ_ECO7I  (B7NP24), FADJ_ECO81  (B7MY16), FADJ_ECO8A  (B7M6M2), 
FADJ_ECOBW  (C4ZVN2), FADJ_ECODH  (B1X9L4), FADJ_ECOHS  (A8A2L0), 
FADJ_ECOK1  (A1ADI8), FADJ_ECOL5  (Q0TFA6), FADJ_ECOL6  (Q8FFG4), 
FADJ_ECOLC  (B1IXA5), FADJ_ECOLI  (P77399), FADJ_ECOLU  (B7N5V2), 
FADJ_ECOSE  (B6I6Q4), FADJ_ECOSM  (B1LME7), FADJ_ECOUT  (Q1R972), 
FADJ_ENT38  (A4WCW6), FADJ_ESCF3  (B7LLD0), FADJ_KLEP3  (B5XVW2), 
FADJ_KLEP7  (A6TC19), FADJ_PHOLL  (Q7N288), FADJ_PHOPR  (Q6LTK3), 
FADJ_SALA4  (B5EZR9), FADJ_SALCH  (Q57LW6), FADJ_SALDC  (B5FPN1), 
FADJ_SALEP  (B5R3R9), FADJ_SALG2  (B5RCL3), FADJ_SALHS  (B4TCA8), 
FADJ_SALNS  (B4SZR0), FADJ_SALPA  (Q5PCX6), FADJ_SALPB  (A9N453), 
FADJ_SALPK  (B5BBA1), FADJ_SALSV  (B4TQC2), FADJ_SALTI  (Q8Z4Z0), 
FADJ_SALTY  (Q8ZNA7), FADJ_SERP5  (A8GH86), FADJ_SHEAM  (A1S7L6), 
FADJ_SHEB5  (A3D684), FADJ_SHEB8  (A6WQ25), FADJ_SHEHH  (B0TL21), 
FADJ_SHELP  (A3QFP3), FADJ_SHEON  (Q8ECP7), FADJ_SHEPC  (A4Y897), 
FADJ_SHESA  (A0KV76), FADJ_SHESM  (Q0HKD1), FADJ_SHESR  (Q0HWN3), 
FADJ_SHESW  (A1RI92), FADJ_SHIB3  (B2TWV4), FADJ_SHIBS  (Q31YB7), 
FADJ_SHIDS  (Q32DJ4), FADJ_SHIF8  (Q0T2E6), FADJ_SHIFL  (Q83QQ0), 
FADJ_SHISS  (Q3YZM2), FADJ_YERE8  (A1JK30), FADJ_YERP3  (A7FGK1), 
FADJ_YERPA  (Q1C660), FADJ_YERPE  (Q8ZD45), FADJ_YERPN  (Q1CHK2), 
FADJ_YERPP  (A4TM82), FADJ_YERPS  (Q668V1), HIBC1_ARATH (Q9LKJ1), 
HIBC2_ARATH (Q1PEY5), HIBC3_ARATH (Q6NMB0), HIBC4_ARATH (Q5XF59), 
HIBC5_ARATH (Q8RXN4), HIBC6_ARATH (Q9T0K7), HIBC7_ARATH (Q9LK08), 
HIBC8_ARATH (Q9SHJ8), HIBCH_BOVIN (Q2HJ73), HIBCH_CHICK (Q5ZJ60), 
HIBCH_DANRE (Q58EB4), HIBCH_DICDI (Q55GS6), HIBCH_HUMAN (Q6NVY1), 
HIBCH_MOUSE (Q8QZS1), HIBCH_RAT   (Q5XIE6), HIBCH_SCHPO (O74802), 
HIBCH_XENLA (A2VDC2), HIBCH_XENTR (Q28FR6), HTDX_MYCTU  (O53664), 
HTDY_MYCTU  (I6YBZ8), HTDZ_MYCBO  (Q7U2S5), HTDZ_MYCTO  (P9WNP2), 
HTDZ_MYCTU  (P9WNP3), MENB_MYCS2  (A0QRD3), MENB_MYCTO  (P9WNP4), 
MENB_MYCTU  (P9WNP5), MENB_STAAC  (Q5HH38), MENB_STAAM  (Q99V48), 
MENB_STAAN  (Q7A6A9), MENB_STAAR  (Q6GI37), MENB_STAAS  (Q6GAG7), 
MENB_STAAW  (Q8NXA0), PAAG_ECOLI  (P77467), YHAR_BACSU  (O07533)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

CRT_CLODI   (P45361), CRT_CLOPA   (P81357)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			22 sequences
			


			
LKA11_MANHA (P55118), LKA13_MANHA (Q9EV31), LKA14_MANHA (Q9EV33), 

			
LKA16_MANHA (Q9EV32), LKA1A_MANHA (P16535), LKA1B_MANHA (Q7BHI8), 
LKA2A_MANHA (Q9EV30), LKA2B_MANHA (P0C081), LKA2C_MANHA (P0C082), 
LKA2D_MANHA (Q9EV29), LKA2E_MANHA (Q9EV27), LKA7A_MANHA (P0C084), 
LKA7B_MANHA (P0C085), LKTA6_MANHA (P0C083), LKTA8_MANHA (Q9EV34), 
LKTA_BIBTR  (P55117), LKTA_MANGL  (Q9ETX2), LKTA_PASSP  (P55123), 
NRT23_ORYSJ (Q94JG1), NRT25_ARATH (Q9LPV5), RFIP5_HUMAN (Q9BXF6), 
SYE1_ROSDO  (Q16AX5)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			90 PDB
			


			1DCI; 1DUB; 1EF8; 1EF9; 1EY3; 1HZD; 1JXZ; 1MJ3; 1NZY; 1SG4; 1UIY; 1WDK; 
			
				1WDL; 1WDM; 1XX4; 2D3T; 2DUB; 2HW5; 2J5I; 2VRE; 2VSS; 2VSU; 2WTB; 2X58; 
				2ZQQ; 2ZQR; 3H02; 3H81; 3HE2; 3HP0; 3PZK; 3Q0G; 3Q0J; 3T88; 3T89; 3ZW8; 
				3ZW9; 3ZWA; 3ZWB; 3ZWC; 4ELS; 4ELW; 4ELX; 4FJW; 4FZW; 4I42; 4IZB; 4IZC; 
				4IZD; 4Q1G; 4Q1H; 4Q1I; 4Q1J; 4Q1K; 5DTP; 5DTW; 5DU4; 5DU6; 5DU8; 5DUC; 
				5DUF; 5MGB; 5MRC; 5MRE; 5MRF; 5OMO; 5Z7R; 5ZAI; 5ZQZ; 5ZRV; 6DV2; 6N92; 
				6N93; 6N94; 6N95; 6N96; 6N97; 6TNM; 6YW5; 6YWX; 6Z5F; 6Z5O; 6Z5V; 6ZIB; 
				6ZIC; 8D8L; 8OM2; 8OM3; 8OM4; 8SK6
			
			

			» more