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PROSITE entry PS00177


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General information about the entry

Entry name [info] TOPOISOMERASE_II
Accession [info] PS00177
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00160

Name and characterization of the entry

Description [info] DNA topoisomerase II signature.
Pattern [info] 
[LIVMA]-{R}-E-G-[DN]-S-A-{F}-[STAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 185 in 185 different sequences
Number of true positive hits 170 in 170 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 91.89 %
Recall (true positives / (true positives + false negatives)) 98.27 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 170 sequences 

CIN4_CAEEL  (G5ECQ8), GYRB1_ACILW (Q44088), GYRB2_ACILW (Q44272), 

GYRBM_ARATH (Q94BZ7), GYRBP_ARATH (Q9SS38), GYRBR_STRNV (P50074), 
GYRBS_STRNV (P50075), GYRB_ACIBA  (Q43907), GYRB_ACIBZ  (Q44273), 
GYRB_ACICA  (Q43947), GYRB_ACIG6  (Q44271), GYRB_ACIGI  (Q44274), 
GYRB_ACIHA  (Q44065), GYRB_ACIJO  (Q44081), GYRB_ACIJU  (Q44080), 
GYRB_ACIPI  (Q44270), GYRB_ACIS8  (Q44275), GYRB_ACIS9  (Q44276), 
GYRB_ACIVR  (Q44277), GYRB_BACAN  (Q9X3Y6), GYRB_BACCE  (Q9X3Y3), 
GYRB_BACMY  (Q9X3Y5), GYRB_BACSU  (P05652), GYRB_BORBU  (P33769), 
GYRB_BORHE  (Q9ZFK1), GYRB_BUCAI  (P57126), GYRB_BUCAP  (P29435), 
GYRB_BUCBP  (Q89B37), GYRB_CAMJE  (O87667), GYRB_CAUVC  (P0CAX1), 
GYRB_CAUVN  (B8GXQ0), GYRB_CHIJA  (Q9FAX2), GYRB_CHLMU  (Q9PKK3), 
GYRB_CHLPN  (Q9Z8R3), GYRB_CHLTR  (O84193), GYRB_CLOAB  (P94604), 
GYRB_CYTAU  (Q9LCK0), GYRB_CYTHU  (Q9LCK1), GYRB_ECO57  (P0AES7), 
GYRB_ECOLI  (P0AES6), GYRB_EISEL  (Q9FAX1), GYRB_ENTFA  (Q839Z1), 
GYRB_HAEIN  (P43701), GYRB_HALH5  (O50627), GYRB_HALL2  (P21558), 
GYRB_HALVD  (D4GZ01), GYRB_HELPJ  (Q9ZLX3), GYRB_HELPY  (P55992), 
GYRB_METAT  (Q9ZAQ6), GYRB_METH1  (P43053), GYRB_MICLC  (C5C7X8), 
GYRB_MYCBP  (A0A0G2Q9D6), GYRB_MYCGA  (P47720), GYRB_MYCGE  (P47249), 
GYRB_MYCLE  (Q59533), GYRB_MYCPA  (Q9L7L3), GYRB_MYCPN  (P22447), 
GYRB_MYCS2  (A0QNE0), GYRB_MYCSM  (P0C559), GYRB_MYCTA  (A5TY73), 
GYRB_MYCTO  (P9WG44), GYRB_MYCTU  (P9WG45), GYRB_MYXXA  (O33367), 
GYRB_NEIG1  (Q5F5Z6), GYRB_NEIGO  (P22118), GYRB_NICBE  (Q5YLB4), 
GYRB_ORYSJ  (Q5NBJ3), GYRB_PSEAE  (Q9I7C2), GYRB_PSEPU  (P13364), 
GYRB_RICBR  (Q1RHT8), GYRB_RICCN  (Q92H87), GYRB_RICFE  (Q4UKX5), 
GYRB_RICPR  (Q9ZCX2), GYRB_RICTY  (Q68WF6), GYRB_SALTI  (P0A2I4), 
GYRB_SALTY  (P0A2I3), GYRB_SHIFL  (P0AES8), GYRB_SPICI  (P34031), 
GYRB_STAA3  (Q2FKQ1), GYRB_STAAC  (Q5HJZ1), GYRB_STAAM  (P66936), 
GYRB_STAAN  (P66937), GYRB_STAAR  (Q6GKU0), GYRB_STAAS  (Q6GD85), 
GYRB_STAAU  (P0A0K8), GYRB_STAAW  (P0A0K7), GYRB_STAEQ  (Q5HK03), 
GYRB_STAES  (Q8CQK4), GYRB_STRCO  (P35886), GYRB_STRP1  (Q9A0L0), 
GYRB_STRP3  (P0DG04), GYRB_STRP6  (Q5XD05), GYRB_STRP8  (Q8P1M4), 
GYRB_STRPN  (P0A4L9), GYRB_STRPQ  (P0DG05), GYRB_STRR6  (P0A4M0), 
GYRB_SYNY3  (P77966), GYRB_THEMA  (P77993), GYRB_THET8  (Q5SHZ4), 
GYRB_TREDE  (O87545), GYRB_TREPA  (O08399), GYRB_VIBCH  (Q9KVX3), 
GYRB_VIBPA  (O51859), PARE_BACSU  (Q59192), PARE_BARBK  (P94281), 
PARE_BORBU  (Q59189), PARE_CAUVC  (O54479), PARE_ECOLI  (P20083), 
PARE_ENTFA  (H7C794), PARE_FRATH  (A0A0J9WZF0), PARE_HAEIN  (P43703), 
PARE_MYCCT  (P50028), PARE_MYCGA  (Q59526), PARE_MYCGE  (P47445), 
PARE_MYCPN  (P78016), PARE_PSEAE  (Q9HUJ8), PARE_RICBR  (Q1RK03), 
PARE_RICCN  (Q92IW1), PARE_RICFE  (Q4UKT4), PARE_RICPR  (Q9ZDU7), 
PARE_RICTY  (Q68XE1), PARE_SALTI  (P0A2I6), PARE_SALTY  (P0A2I5), 
PARE_STAA8  (Q2FYS5), PARE_STAAC  (Q5HG65), PARE_STAAM  (P66938), 
PARE_STAAN  (P66939), PARE_STAAR  (Q6GH51), PARE_STAAS  (Q6G9K5), 
PARE_STAAU  (P0C1S7), PARE_STAAW  (P0A0K9), PARE_STAEQ  (Q5HPI6), 
PARE_STAES  (Q8CSN9), PARE_STRPN  (Q59961), TOP2A_CHICK (O42130), 
TOP2A_CRIGR (P41515), TOP2A_HUMAN (P11388), TOP2A_MOUSE (Q01320), 
TOP2A_PIG   (O46374), TOP2A_RAT   (P41516), TOP2B_CHICK (O42131), 
TOP2B_CRILO (Q64399), TOP2B_HUMAN (Q02880), TOP2B_MOUSE (Q64511), 
TOP2M_CAEEL (P34534), TOP2M_DICDI (P90520), TOP2_ARATH  (P30182), 
TOP2_ASFB7  (Q00942), TOP2_ASFK5  (P0C9C2), TOP2_ASFM2  (P34203), 
TOP2_ASFP4  (P0C9C0), TOP2_ASFWA  (P0C9C1), TOP2_BOMMO  (O16140), 
TOP2_CAEEL  (Q23670), TOP2_CANGA  (O93794), TOP2_CRIFA  (P27570), 
TOP2_DICDI  (Q55BP5), TOP2_DROME  (P15348), TOP2_LEICH  (O61078), 
TOP2_MIMIV  (Q5UQE6), TOP2_PEA(O24308), TOP2_PENCH  (Q9Y8G8), 
TOP2_PLAFK  (P41001), TOP2_SCHPO  (P08096), TOP2_TRYBB  (P12531), 
TOP2_TRYCR  (P30190), TOP2_YEAST  (P06786), TOP4B_AQUAE (O67137), 
TOPL_BPT4   (P09176), TOPON_MYCS2 (A0QPN2)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

GYRB_ARCFU  (O29720), TOP2_CANAX  (P87078), TOP2_PICGU  (Q01879)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			2 sequences
			


			
GYRB_PROMI  (P22840), GYRB_RHOCA  (P31860)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			15 sequences
			


			
ASTD_PARXL  (Q141D3), CIPK6_ORYSJ (Q6Z9F4), DDL_CUPNH   (Q0K6M6), 

			
DOM_DROME   (Q9NDJ2), MIC60_DEBHA (Q6BXM9), NACA_DANRE  (Q8JIU7), 
RPOA_METCA  (Q605D7), RTEL1_ORYSJ (A0A0P0V4R0), SECA_HALHL  (A1WYM9), 
SEPT9_MOUSE (Q80UG5), SEPT9_RAT   (Q9QZR6), XTH6_DIOKA  (A0A067XRK9), 
XTH9_ARATH  (Q8LDW9), Y1130_XYLFA (Q9PE98), Y419_XYLFT  (Q87E99)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			101 PDB
			


			1BGW; 1BJT; 2RGR; 2XCO; 2XCQ; 2XCR; 2XCS; 2XCT; 2ZJT; 3FOE; 3FOF; 3IG0; 
			
				3K9F; 3KSA; 3KSB; 3L4J; 3L4K; 3LTN; 3M4I; 3NUH; 3QX3; 3RAD; 3RAE; 3RAF; 
				4BUL; 4FM9; 4G0U; 4G0V; 4G0W; 4GFH; 4I3H; 4J3N; 4JUO; 4KOE; 4KPE; 4KPF; 
				4PLB; 4Z2C; 4Z2D; 4Z2E; 4Z3O; 4Z4Q; 4Z53; 5BS3; 5BS8; 5BTA; 5BTC; 5BTD; 
				5BTF; 5BTG; 5BTI; 5BTL; 5BTN; 5CDM; 5CDN; 5CDO; 5CDP; 5CDQ; 5CDR; 5GWI; 
				5GWJ; 5GWK; 5IWI; 5IWM; 5NPK; 5NPP; 5ZAD; 5ZEN; 5ZQF; 5ZRF; 6FM4; 6FQS; 
				6FQV; 6GAU; 6GAV; 6QTK; 6QTP; 6QX1; 6QX2; 6RKS; 6RKU; 6RKV; 6RKW; 6Z1A; 
				6ZY5; 6ZY6; 6ZY7; 6ZY8; 7FVS; 7FVT; 7MVS; 7UGW; 7YQ8; 7Z9C; 7Z9G; 7Z9K; 
				7Z9M; 8BP2; 8QDX; 8QQS; 8QQU
			
			

			» more