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PROSITE entry PS00183


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PURL: https://purl.expasy.org/prosite/signature/PS00183

Direct ScanProsite submission
General information about the entry

Entry name [info] UBC_1
Accession [info] PS00183
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00163
Associated ProRule [info] PRU10133

Name and characterization of the entry

Description [info] Ubiquitin-conjugating (UBC) active site signature.
Pattern [info] 
[FYWLSP]-H-[PC]-[NHL]-[LIV]-x(3,4)-G-x-[LIVP]-C-[LIV]-x(1,2)-[LIVR].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_03 which contains 575'748 sequence entries.


Total number of hits 244 in 244 different sequences
Number of true positive hits 244 in 244 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 81
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 75.08 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 10
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 244 sequences 

PEX4_ARATH  (Q8LGF7), PEX4_DICDI  (Q86IZ3), PEX4_KOMPG  (C4R826), 

PEX4_PICAN  (O60015), PEX4_PICPA  (P49428), PEX4_TRYB2  (Q57YD9), 
PEX4_YEAST  (P29340), RAD6_BEAB2  (J4KQN3), RCE1_ARATH  (Q9SDY5), 
SCE1_ARATH  (Q42551), U2D2B_MOUSE (Q6ZWY6), U2D2B_RAT   (P70711), 
UB12L_ARATH (Q9ZU75), UB2D1_BOVIN (Q2TA10), UB2D1_HUMAN (P51668), 
UB2D1_MOUSE (P61080), UB2D1_RAT   (D3ZDK2), UB2D2_BOVIN (Q1RMX2), 
UB2D2_HUMAN (P62837), UB2D2_MOUSE (P62838), UB2D2_PIG   (Q06AA9), 
UB2D2_RAT   (P62839), UB2D2_XENLA (P62840), UB2D3_HUMAN (P61077), 
UB2D3_MACFA (Q4R5N4), UB2D3_MOUSE (P61079), UB2D3_PONAB (Q5R4V7), 
UB2D3_RAT   (P61078), UB2D4_HUMAN (Q9Y2X8), UB2D4_XENLA (A5PKP9), 
UB2E1_HUMAN (P51965), UB2E1_MOUSE (P52482), UB2E2_HUMAN (Q96LR5), 
UB2E2_MOUSE (Q91W82), UB2E3_BOVIN (Q2T9X7), UB2E3_HUMAN (Q969T4), 
UB2E3_MOUSE (P52483), UB2FA_MOUSE (Q9CY34), UB2FB_MOUSE (Q3UWQ3), 
UB2G1_HUMAN (P62253), UB2G1_MACFA (Q4R5Y8), UB2G1_MOUSE (P62254), 
UB2G1_RAT   (P62255), UB2G2_BOVIN (Q17QG5), UB2G2_HUMAN (P60604), 
UB2G2_MOUSE (P60605), UB2G2_PONAB (Q5RF84), UB2L3_BOVIN (Q3MHP1), 
UB2L3_HUMAN (P68036), UB2L3_MOUSE (P68037), UB2L3_PONAB (Q5R5I4), 
UB2L5_HUMAN (A0A1B0GUS4), UB2L6_BOVIN (A5PJC4), UB2L6_HUMAN (O14933), 
UB2L6_MOUSE (Q9QZU9), UB2L6_RAT   (Q4V8J2), UB2R1_HUMAN (P49427), 
UB2R1_MOUSE (Q8CFI2), UB2R2_HUMAN (Q712K3), UB2R2_MOUSE (Q6ZWZ2), 
UB2R2_RABIT (Q29503), UB2SA_XENLA (A1L3K1), UB2SB_XENLA (Q8AVU2), 
UB2SC_XENLA (Q76EZ2), UBC10_ARATH (P35133), UBC10_DROME (Q7K738), 
UBC11_ARATH (P35134), UBC11_SCHPO (O00103), UBC11_YEAST (P52492), 
UBC12_ARATH (Q9C9Y7), UBC12_BOVIN (A3KN22), UBC12_CAEEL (Q9XVK5), 
UBC12_CANGA (Q6FVQ8), UBC12_DICDI (Q54TI6), UBC12_EREGS (Q75AF2), 
UBC12_HUMAN (P61081), UBC12_KLULA (Q6CSW8), UBC12_MOUSE (P61082), 
UBC12_SCHPO (O74549), UBC12_XENLA (Q6DCZ9), UBC12_XENTR (Q6P8D9), 
UBC12_YARLI (Q6C9W0), UBC12_YEAST (P52491), UBC13_ARATH (Q42541), 
UBC13_CAEEL (Q95XX0), UBC13_SCHPO (O13685), UBC13_YEAST (P52490), 
UBC14_ARATH (P42747), UBC15_ARATH (P42743), UBC15_SCHPO (Q9Y818), 
UBC16_ARATH (Q9FWT2), UBC17_ARATH (O23239), UBC18_ARATH (Q9FMM0), 
UBC19_ARATH (Q9LJZ5), UBC1_ARATH  (P25865), UBC1_CAEEL  (P52478), 
UBC1_COLGL  (O74196), UBC1_PYRO7  (Q9UVR2), UBC1_SCHPO  (O74810), 
UBC1_YEAST  (P21734), UBC20_ARATH (Q8L7T3), UBC21_CAEEL (P52484), 
UBC22_ARATH (Q9FF66), UBC27_ARATH (Q9FI61), UBC28_ARATH (Q94F47), 
UBC29_ARATH (Q9SLE4), UBC2M_DROME (Q9VSF3), UBC2_ARATH  (P42745), 
UBC2_ASPFU  (Q4WLA7), UBC2_CAEEL  (P35129), UBC2_CANAL  (O74201), 
UBC2_CANGA  (Q6FR76), UBC2_CRYD1  (P0CS16), UBC2_CRYD3  (P0CS17), 
UBC2_DEBHA  (Q6BU36), UBC2_DICDI  (Q553F3), UBC2_EMENI  (Q96UP5), 
UBC2_EREGS  (Q75EB8), UBC2_FUSSL  (P78717), UBC2_KLULA  (Q6CUD9), 
UBC2_MEDSA  (P35130), UBC2_MYCMD  (Q4PFA5), UBC2_NEUCR  (P52493), 
UBC2_SCHPO  (P23566), UBC2_TRIHA  (Q58FS2), UBC2_WHEAT  (P25866), 
UBC2_YARLI  (Q6C093), UBC2_YEAST  (P06104), UBC30_ARATH (Q9FKT3), 
UBC35_ARATH (Q94A97), UBC36_ARATH (Q9FZ48), UBC37_ARATH (Q941B6), 
UBC3_ARATH  (P42746), UBC3_YEAST  (P14682), UBC4_ARATH  (P42748), 
UBC4_CANAX  (P43102), UBC4_SCHPO  (P46595), UBC4_SOLLC  (P35135), 
UBC4_WHEAT  (P16577), UBC4_YEAST  (P15731), UBC5A_ORYSJ (Q8S920), 
UBC5B_ORYSJ (Q8S919), UBC5_ARATH  (P42749), UBC5_YEAST  (P15732), 
UBC6_ARATH  (P42750), UBC7_ARATH  (Q42540), UBC7_CAEEL  (P34477), 
UBC7_SCHPO  (O00102), UBC7_WHEAT  (P25868), UBC7_YEAST  (Q02159), 
UBC84_DROME (P52487), UBC8_ARATH  (P35131), UBC8_SCHPO  (Q9P7R4), 
UBC8_YEAST  (P28263), UBC9A_DANRE (Q9W6H5), UBC9B_DANRE (Q9DDJ0), 
UBC9_ARATH  (P35132), UBC9_CAEEL  (Q95017), UBC9_CHICK  (P63283), 
UBC9_DICDI  (Q9NGP4), UBC9_HUMAN  (P63279), UBC9_ICTTR  (Q2EF73), 
UBC9_MESAU  (O09181), UBC9_MOUSE  (P63280), UBC9_PAGMA  (Q6Y1Z4), 
UBC9_RAT(P63281), UBC9_SCHPO  (P40984), UBC9_XENLA  (P63282), 
UBC9_XENTR  (Q28CQ4), UBC9_YEAST  (P50623), UBCD1_DROME (P25867), 
UBCD2_DROME (P52485), UBCD4_DROME (P52486), UBCD6_DROME (P25153), 
UBC_ASFB7   (P27949), UBC_ASFK5   (P0C8G3), UBC_ASFM2   (P25869), 
UBC_ASFP4   (P0C8G4), UBC_ASFWA   (P0C8G5), UBE2A_HUMAN (P49459), 
UBE2A_MOUSE (Q9Z255), UBE2B_BOVIN (Q32P99), UBE2B_HUMAN (P63146), 
UBE2B_MOUSE (P63147), UBE2B_RABIT (P63148), UBE2B_RAT   (P63149), 
UBE2C_BOVIN (Q32PA5), UBE2C_DICDI (Q54XS6), UBE2C_DROME (Q9VTY6), 
UBE2C_HUMAN (O00762), UBE2C_MACFA (Q4R9D1), UBE2C_MOUSE (Q9D1C1), 
UBE2C_SPISO (Q95044), UBE2C_XENLA (P56616), UBE2F_BOVIN (Q1RMW1), 
UBE2F_CHICK (Q5ZKX6), UBE2F_DANRE (Q6NY82), UBE2F_HUMAN (Q969M7), 
UBE2F_RAT   (Q5U203), UBE2F_XENLA (Q6IRC7), UBE2F_XENTR (Q5M8Y2), 
UBE2H_BOVIN (Q32LN1), UBE2H_HUMAN (P62256), UBE2H_MOUSE (P62257), 
UBE2K_BOVIN (P61085), UBE2K_HUMAN (P61086), UBE2K_MOUSE (P61087), 
UBE2N_BOVIN (Q0P5K3), UBE2N_DICDI (Q86K32), UBE2N_DROME (P35128), 
UBE2N_HUMAN (P61088), UBE2N_MACFA (Q4R4I1), UBE2N_MOUSE (P61089), 
UBE2N_PONAB (Q5R7J6), UBE2N_RAT   (Q9EQX9), UBE2S_AQUCT (C1C3R6), 
UBE2S_BOVIN (Q1RML1), UBE2S_BRAFL (C3Z724), UBE2S_DANRE (Q4V908), 
UBE2S_DICDI (Q54I43), UBE2S_DROAN (B3MQV3), UBE2S_DROER (B3NWW9), 
UBE2S_DROGR (B4JKB7), UBE2S_DROME (Q9VX25), UBE2S_DROMO (B4L7V4), 
UBE2S_DROPE (B4H9W2), UBE2S_DROPS (B5DKM4), UBE2S_DROSE (B4IF39), 
UBE2S_DROSI (B4R6G1), UBE2S_DROVI (B4MA02), UBE2S_DROWI (B4N208), 
UBE2S_DROYA (B4Q2J2), UBE2S_HUMAN (Q16763), UBE2S_MOUSE (Q921J4), 
UBE2S_NEMVE (A7SE05), UBE2S_RAT   (B5DFI8), UBE2S_XENTR (Q28F89), 
UBE2T_BOVIN (Q32LD2), UBE2T_DANRE (Q08BH7), UBE2T_HUMAN (Q9NPD8), 
UBE2T_MOUSE (Q9CQ37), UBE2T_XENLA (Q7ZY08), UBE2U_HUMAN (Q5VVX9), 
UBE2U_MACFA (Q95LM1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 81 sequences 

BIRC6_HUMAN (Q9NR09), BIRC6_MOUSE (O88738), COP10_ARATH (Q9LJD7), 

MMS2_SCHPO  (O74983), MMS2_YEAST  (P53152), PEX4_SCHPO  (Q9P6I1), 
U2D2L_HUMAN (Q8IWF7), U2QL1_DROME (Q9VM35), U2QL1_HUMAN (A1L167), 
U2QL1_MOUSE (A0PJN4), UB2J1_HUMAN (Q9Y385), UB2J1_MOUSE (Q9JJZ4), 
UB2J2_BOVIN (Q2TA03), UB2J2_DICDI (Q54LP7), UB2J2_HUMAN (Q8N2K1), 
UB2J2_MOUSE (Q6P073), UB2JL_DICDI (Q54AK6), UB2Q1_HUMAN (Q7Z7E8), 
UB2Q1_MOUSE (Q7TSS2), UB2Q2_BOVIN (Q32L27), UB2Q2_HUMAN (Q8WVN8), 
UB2Q2_MOUSE (Q8K2Z8), UB2Q2_RABIT (Q7YQJ9), UB2V1_BOVIN (Q3SZ52), 
UB2V1_CHICK (Q90879), UB2V1_HUMAN (Q13404), UB2V1_MOUSE (Q9CZY3), 
UB2V1_PONAB (Q5R4Z6), UB2V2_BOVIN (Q3SZ43), UB2V2_CHICK (Q5F3Z3), 
UB2V2_DANRE (Q6PEH5), UB2V2_HUMAN (Q15819), UB2V2_MOUSE (Q9D2M8), 
UB2V2_PONAB (Q5R6C9), UB2V2_RAT   (Q7M767), UB2V2_XENLA (Q7ZYP0), 
UB2WA_DANRE (Q4VBH4), UBC14_SCHPO (Q9UTN8), UBC17_CAEEL (Q11076), 
UBC18_CAEEL (Q21633), UBC1_MIMIV  (Q5UQC9), UBC23_ARATH (Q9ZVX1), 
UBC24_ARATH (Q8VY10), UBC25_ARATH (Q9LUQ5), UBC25_CAEEL (Q93571), 
UBC26_ARATH (Q8GY87), UBC31_ARATH (Q9C8X7), UBC32_ARATH (Q9LSP7), 
UBC33_ARATH (Q9FK29), UBC34_ARATH (Q9SHI7), UBC38_ARATH (Q9C918), 
UBC39_ARATH (F4HPP7), UBC3_MIMIV  (Q5UQ88), UBC4_MIMIV  (Q5UQ40), 
UBC6_CANGA  (Q6FQK7), UBC6_DEBHA  (Q6BYG4), UBC6_EREGS  (Q74Z34), 
UBC6_KLULA  (Q6CMG6), UBC6_SCHPO  (O42646), UBC6_YEAST  (P33296), 
UBCB_DICDI  (Q94490), UBE2O_HUMAN (Q9C0C9), UBE2O_MOUSE (Q6ZPJ3), 
UBE2V_DICDI (Q54D06), UBE2W_BOVIN (A6H795), UBE2W_CAEEL (Q9XWF6), 
UBE2W_HUMAN (Q96B02), UBE2W_MOUSE (Q8VDW4), UBE2W_RAT   (B5DEI4), 
UBE2Z_DANRE (Q6DG60), UBE2Z_HUMAN (Q9H832), UBE2Z_MOUSE (Q3UE37), 
UBE2Z_RAT   (Q3B7D1), UBE2Z_XENLA (Q6PCF7), UBE2Z_XENTR (Q66KB0), 
UE2NL_HUMAN (Q5JXB2), UEV1A_ARATH (Q93YP0), UEV1B_ARATH (Q9CAB6), 
UEV1C_ARATH (Q9SJ44), UEV1D_ARATH (Q9SVD7), Y1A1_ENCCU  (Q8SSK3)
» more

PDB
[Detailed view]		 321 PDB

pdb_00001a3s; pdb_00001ayz; pdb_00001c4z; pdb_00001fbv; pdb_00001fxt; pdb_00001fzy; pdb_00001j7d; pdb_00001jas; pdb_00001jat; pdb_00001jbb; pdb_00001kps; pdb_00001pzv; pdb_00001q34; pdb_00001qcq; pdb_00001tte; pdb_00001u9a; pdb_00001u9b; pdb_00001ur6; pdb_00001w4u; pdb_00001wzv; pdb_00001wzw; pdb_00001x23; pdb_00001y6l; pdb_00001y8x; pdb_00001yh2; pdb_00001yla; pdb_00001yrv; pdb_00001z2u; pdb_00001z3d; pdb_00001z5s; pdb_00001zdn; pdb_00002aak; pdb_00002awf; pdb_00002bep; pdb_00002bf8; pdb_00002c2v; pdb_00002c4p; pdb_00002clw; pdb_00002cyx; pdb_00002e2c; pdb_00002edi; pdb_00002eke; pdb_00002esk; pdb_00002eso; pdb_00002esp; pdb_00002esq; pdb_00002fuh; pdb_00002gjd; pdb_00002grn; pdb_00002grp; pdb_00002grq; pdb_00002grr; pdb_00002kjh; pdb_00002kly; pdb_00002lxp; pdb_00002o25; pdb_00002ob4; pdb_00002pe6; pdb_00002px9; pdb_00002ucz; pdb_00002vrr; pdb_00002xwu; pdb_00002y4w; pdb_00002y9m; pdb_00002y9p; pdb_00002yb6; pdb_00002ybf; pdb_00002yho; pdb_00002z5d; pdb_00003a4s; pdb_00003bzh; pdb_00003e46; pdb_00003eb6; pdb_00003f92; pdb_00003fn1; pdb_00003fsh; pdb_00003h8k; pdb_00003hct; pdb_00003hcu; pdb_00003k9o; pdb_00003k9p; pdb_00003l1y; pdb_00003l1z; pdb_00003o2u; pdb_00003oj4; pdb_00003ong; pdb_00003ptf; pdb_00003rcz; pdb_00003rpg; pdb_00003rz3; pdb_00003sqv; pdb_00003sy2; pdb_00003tgd; pdb_00003uin; pdb_00003uio; pdb_00003uip; pdb_00003von; pdb_00003w31; pdb_00004a49; pdb_00004a4b; pdb_00004a4c; pdb_00004ccg; pdb_00004dhi; pdb_00004dhj; pdb_00004dhz; pdb_00004ii2; pdb_00004ip3; pdb_00004jqu; pdb_00004lad; pdb_00004mdk; pdb_00004nr3; pdb_00004nrg; pdb_00004nri; pdb_00004onl; pdb_00004onm; pdb_00004onn; pdb_00004orh; pdb_00004q5e; pdb_00004q5h; pdb_00004qpl; pdb_00004r8p; pdb_00004s3o; pdb_00004tkp; pdb_00004w5v; pdb_00004x57; pdb_00004y1l; pdb_00004yii; pdb_00005a31; pdb_00005aie; pdb_00005bnb; pdb_00005d1k; pdb_00005d1l; pdb_00005d1m; pdb_00005d2m; pdb_00005egg; pdb_00005f6d; pdb_00005f6e; pdb_00005f6u; pdb_00005f6v; pdb_00005f6w; pdb_00005f6x; pdb_00005f6y; pdb_00005fq2; pdb_00005hpt; pdb_00005ifr; pdb_00005jne; pdb_00005khr; pdb_00005knl; pdb_00005l9t; pdb_00005l9u; pdb_00005lbn; pdb_00005ngz; pdb_00005nkz; pdb_00005nl8; pdb_00005ojj; pdb_00005ojw; pdb_00005ywr; pdb_00006cyo; pdb_00006cyr; pdb_00006d4p; pdb_00006d68; pdb_00006d6i; pdb_00006fga; pdb_00006gum; pdb_00006gv3; pdb_00006if1; pdb_00006jky; pdb_00006kfp; pdb_00006kg6; pdb_00006kl4; pdb_00006lp2; pdb_00006m2c; pdb_00006nya; pdb_00006nyd; pdb_00006op8; pdb_00006p5b; pdb_00006q83; pdb_00006qh3; pdb_00006qhk; pdb_00006r75; pdb_00006s96; pdb_00006s98; pdb_00006syf; pdb_00006t7f; pdb_00006ttu; pdb_00006ulh; pdb_00006ump; pdb_00006ums; pdb_00006w7z; pdb_00006w9a; pdb_00006xod; pdb_00006xxu; pdb_00006zhs; pdb_00006zht; pdb_00006zhu; pdb_00007ahf; pdb_00007b5l; pdb_00007b5n; pdb_00007bol; pdb_00007bxg; pdb_00007k5j; pdb_00007kzr; pdb_00007kzs; pdb_00007kzt; pdb_00007kzv; pdb_00007lew; pdb_00007lyb; pdb_00007m2k; pdb_00007mex; pdb_00007mey; pdb_00007myh; pdb_00007oik; pdb_00007p47; pdb_00007uv8; pdb_00007uvc; pdb_00007v8f; pdb_00007w75; pdb_00007w76; pdb_00008b3i; pdb_00008grm; pdb_00008grq; pdb_00008ieg; pdb_00008iej; pdb_00008iya; pdb_00008j1r; pdb_00008juc; pdb_00008jvd; pdb_00008jve; pdb_00008jvl; pdb_00008odr; pdb_00008oif; pdb_00008pql; pdb_00008q7r; pdb_00008r5h; pdb_00008rx0; pdb_00008se9; pdb_00008sea; pdb_00008seb; pdb_00008smw; pdb_00008smx; pdb_00008smy; pdb_00008smz; pdb_00008sn0; pdb_00008sn1; pdb_00008sn2; pdb_00008sn3; pdb_00008sn4; pdb_00008sn5; pdb_00008sn6; pdb_00008sn7; pdb_00008sn8; pdb_00008sn9; pdb_00008sna; pdb_00008sv8; pdb_00008tar; pdb_00008tau; pdb_00008u14; pdb_00008upf; pdb_00008uq8; pdb_00008uq9; pdb_00008v0d; pdb_00008vk8; pdb_00008vk9; pdb_00008x7i; pdb_00008x7j; pdb_00008x7k; pdb_00009b55; pdb_00009b56; pdb_00009b57; pdb_00009b58; pdb_00009b59; pdb_00009b5a; pdb_00009b5b; pdb_00009b5c; pdb_00009b5d; pdb_00009b5e; pdb_00009b5f; pdb_00009b5g; pdb_00009b5h; pdb_00009b5i; pdb_00009b5j; pdb_00009b5k; pdb_00009b5l; pdb_00009b5m; pdb_00009b5n; pdb_00009b5o; pdb_00009b5p; pdb_00009b5q; pdb_00009b5r; pdb_00009b5s; pdb_00009b5t; pdb_00009b5u; pdb_00009b5v; pdb_00009b5w; pdb_00009b5x; pdb_00009b62; pdb_00009biv; pdb_00009bjz; pdb_00009dns; pdb_00009dqb; pdb_00009drj; pdb_00009i1j; pdb_00009ipu; pdb_00009jtc; pdb_00009khs; pdb_00009kht; pdb_00009kqo; pdb_00009lhj; pdb_00009lpk; pdb_00009lto; pdb_00009ltr; pdb_00009lul; pdb_00009m0y; pdb_00009m7o; pdb_00009n9r; pdb_00009n9s; pdb_00009sfp; pdb_00009uv6; pdb_00009w2m; pdb_00009w90; pdb_00009xrl
» more