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PROSITE entry PS00185


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00185
Entry name [info] IPNS_1
Accession [info] PS00185
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-1990 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00165

Name and characterization of the entry

Description [info] Isopenicillin N synthase signature 1.
Pattern [info] 
[RK]-x-[STA]-x(2)-S-x-C-Y-[SL].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 22 in 22 different sequences
Number of true positive hits 13 in 13 different sequences
Number of 'unknown' hits 0
Number of false positive hits 9 in 9 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 59.09 %
Recall (true positives / (true positives + false negatives)) 86.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site(?) at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 13 sequences 

EXPA_HAPCH  (P11935), IPNA_EMENI  (P05326), IPNA_HAPCH  (P05189), 

IPNA_PENCH  (P08703), IPNA_PENRW  (B6HLU0), IPNS_AMYLA  (P27744), 
IPNS_FLASS  (P16020), IPNS_LYSLA  (Q48739), IPNS_STRCL  (P10621), 
IPNS_STRCT  (Q53932), IPNS_STRGR  (Q54243), IPNS_STRJU  (P18286), 
IPNS_STRMI  (P12438)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

CEFE_AMYLA  (Q03047), CEFE_STRCL  (P18548)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			9 sequences
			


			
HYAS1_HUMAN (Q92839), HYAS1_MOUSE (Q61647), LUC8_FUSSX  (A0A6J4B484), 

			
NT56_DROVI  (Q24332), PMIP_MALGO  (A8QB25), RIR1_CHLMU  (Q9PL93), 
RIR1_CHLPN  (Q9Z6S5), RIR1_CHLTR  (O84834), ZHP2_CAEEL  (Q9U3L0)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			84 PDB
			


			1BK0; 1BLZ; 1HB1; 1HB2; 1HB3; 1HB4; 1IPS; 1OBN; 1OC1; 1ODM; 1ODN; 1QIQ; 
			
				1QJE; 1QJF; 1UZW; 1W03; 1W04; 1W05; 1W06; 1W3V; 1W3X; 2BJS; 2BU9; 2IVI; 
				2IVJ; 2JB4; 2VAU; 2VBB; 2VBD; 2VBP; 2VCM; 2VE1; 2WO7; 2Y60; 2Y6F; 3ZKU; 
				3ZKY; 3ZOI; 4BB3; 6Y0O; 6Y0P; 6ZAE; 6ZAF; 6ZAG; 6ZAH; 6ZAI; 6ZAJ; 6ZAK; 
				6ZAL; 6ZAM; 6ZAN; 6ZAO; 6ZAP; 6ZAQ; 6ZW8; 7P3L; 7POY; 7PSW; 7ZOE; 8A4G; 
				8ALI; 8ALJ; 8BB9; 8BBA; 8BBB; 8BBC; 8BBD; 8BSV; 8BSW; 8BSX; 8BSY; 8P46; 
				8P47; 8P48; 8P7O; 8P7P; 8PTV; 8PY5; 8PY6; 8PY7; 8PY8; 8PY9; 8PYA; 8RDB
			
			

			» more