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PROSITE entry PS00191


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00191
Entry name [info] CYTOCHROME_B5_1
Accession [info] PS00191
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00170

Name and characterization of the entry

Description [info] Cytochrome b5 family, heme-binding domain signature.
Pattern [info] 
[FY]-[LIVMK]-{I}-{Q}-H-P-[GA]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 126 in 126 different sequences
Number of true positive hits 105 in 105 different sequences
Number of 'unknown' hits 0
Number of false positive hits 21 in 21 different sequences
Number of false negative sequences 80
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 83.33 %
Recall (true positives / (true positives + false negatives)) 56.76 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] heme_iron at position 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 105 sequences 

ACO1_AJECA  (Q12618), ACO1_YEAST  (P21147), CYB2_TALSN  (B8MKR3), 

CYB2_WICAO  (P09437), CYB2_YEAST  (P00175), CYB52_SCHPO (Q9USM6), 
CYB5A_ARATH (Q9FDW8), CYB5B_ARATH (O48845), CYB5B_HUMAN (O43169), 
CYB5B_MOUSE (Q9CQX2), CYB5B_PONAB (Q5RDJ5), CYB5B_RAT   (P04166), 
CYB5C_ARATH (Q9ZNV4), CYB5D_ARATH (Q9ZWT2), CYB5E_ARATH (Q42342), 
CYB5L_MIMIV (Q5UR80), CYB5L_NEUCR (Q8X0J4), CYB5R_DROME (P19967), 
CYB5R_DROVI (P50266), CYB5S_TOBAC (P49099), CYB5_ALOSE  (P00168), 
CYB5_BOROF  (O04354), CYB5_BOVIN  (P00171), CYB5_BRAOB  (P40934), 
CYB5_CANTR  (Q874I5), CYB5_CHICK  (P00174), CYB5_CUSRE  (P49097), 
CYB5_DROME  (Q9V4N3), CYB5_HORSE  (P00170), CYB5_HUMAN  (P00167), 
CYB5_MORAP  (Q9Y706), CYB5_MOUSE  (P56395), CYB5_MUSDO  (P49096), 
CYB5_NEUCR  (Q9P5L0), CYB5_ORYSJ  (P49100), CYB5_PHATC  (B7GCG7), 
CYB5_PIG(P00172), CYB5_RABIT  (P00169), CYB5_RAT(P00173), 
CYB5_RHIST  (Q9HFV1), CYB5_TOBAC  (P49098), CYB5_YEAST  (P40312), 
CYBL_RHOGR  (P32953), CYP5F_ARATH (O22704), D4FAD_CHLRE (I2CYZ4), 
D4FAD_EUGGR (Q6WNG7), D5FAD_MORAP (O74212), D5FAD_REBSA (A4KDP0), 
DESAT_THAPS (Q4G2T3), DES_CHLRE   (Q2HWK7), FA2H_HUMAN  (Q7L5A8), 
FA2H_MACFA  (Q4R4P4), FA2H_MOUSE  (Q5MPP0), FA2H_RAT(Q2LAM0), 
FAD5C_DICDI (Q1ZXQ5), IRC21_YEAST (Q04772), NB5R4_BOVIN (Q32LH7), 
NB5R4_DANRE (Q502I6), NB5R4_HUMAN (Q7L1T6), NB5R4_MOUSE (Q3TDX8), 
NB5R4_RAT   (Q68EJ0), NB5R4_XENTR (Q28CZ9), NIA1_ARATH  (P11832), 
NIA1_BRANA  (P39867), NIA1_HORVU  (P27967), NIA1_MAIZE  (P17571), 
NIA1_ORYSJ  (P16081), NIA1_PHAVU  (P39865), NIA1_SOYBN  (P54233), 
NIA1_TOBAC  (P11605), NIA2_ARATH  (P11035), NIA2_BRANA  (P39868), 
NIA2_HORVU  (P27969), NIA2_PHAVU  (P39866), NIA2_SOYBN  (P39870), 
NIA2_TOBAC  (P08509), NIA3_MAIZE  (P49102), NIA7_HORVU  (P27968), 
NIA_ASPNG   (P36858), NIA_BEABA   (P43100), NIA_BETPN   (P27783), 
NIA_CHLVU   (Q01170), NIA_CICIN   (P43101), NIA_CUCMA   (P17569), 
NIA_EMENI   (P22945), NIA_FUSOX   (P39863), NIA_LEPMC   (P36842), 
NIA_LOTJA   (P39869), NIA_MYCMD   (Q05531), NIA_NEUCR   (P08619), 
NIA_PETHY   (P36859), NIA_PHYIN   (P39864), NIA_PICAN   (P49050), 
NIA_SOLLC   (P17570), NIA_SPIOL   (P23312), NIA_ULVPR   (A0A286R227), 
NIA_VOLCA   (P36841), RLF_ARATH   (Q9LXD1), SCS7_YEAST  (Q03529), 
SUOX_CHICK  (P07850), SUOX_DROME  (Q9VWP4), SUOX_HUMAN  (P51687), 
SUOX_MOUSE  (Q8R086), SUOX_RAT(Q07116), YDAA_SCHPO  (Q10352)
» more

UniProtKB/Swiss-Prot
False negative sequences		 80 sequences 

ACET6_CERPU (Q9LEN0), ACO1_SCHPO  (O94523), APF12_GIBF5 (S0DLN7), 

CB5D1_DANRE (Q567I9), CB5D1_HUMAN (Q6P9G0), CB5D1_MOUSE (Q5NCY3), 
CB5D1_PONAB (Q5R4Q5), CB5D1_XENLA (Q5PPR6), CB5D1_XENTR (Q0IHR1), 
CHS5B_FUSO4 (A0A0J9UR47), CYB5_ECTSH  (P82291), D4FAD_DIALT (Q6VPV2), 
D4FAD_REBSA (A0PJ29), D4FAD_THRSP (Q8S3C0), D5FAD_PHYPA (A9SIZ6), 
D5FAD_THRSP (Q8S3C1), D8FAD_REBSA (A4KDP1), DAP1_SCHPO  (O13995), 
DAP1_YEAST  (Q12091), DES6_CERPU  (Q9LEM9), FAD5A_DICDI (Q9Y1W0), 
FAD5B_DICDI (O96099), FADS1_HUMAN (O60427), FADS1_MOUSE (Q920L1), 
FADS1_PAPAN (A4UVI1), FADS1_RAT   (Q920R3), FADS2_BOVIN (A4FV48), 
FADS2_DANRE (Q9DEX7), FADS2_HUMAN (O95864), FADS2_MACFA (Q4R749), 
FADS2_MOUSE (Q9Z0R9), FADS2_PONAB (Q5REA7), FADS2_RAT   (Q9Z122), 
FADS2_TACFU (A0A0C5PRW9), FADS3_HUMAN (Q9Y5Q0), FADS3_MOUSE (Q9JJE7), 
FADS3_RAT   (Q8K1P9), FAT3_CAEEL  (Q23221), FAT4_CAEEL  (G5EG11), 
HERC2_HUMAN (O95714), HERC2_MOUSE (Q4U2R1), MAPR4_ARATH (Q2HIW2), 
MSBP1_ARATH (Q9XFM6), MSBP1_ORYSJ (Q9FVZ7), MSBP2_ARATH (Q9M2Z4), 
MSBP2_ORYSJ (Q9FVZ9), NENF_BOVIN  (Q1JQA5), NENF_HUMAN  (Q9UMX5), 
NENF_MOUSE  (Q9CQ45), NENF_RAT(Q6IUR5), NEUFC_CAEBR (Q60YT6), 
NEUFC_CAEEL (Q9XXA7), NEUFC_DANRE (A2CES0), NEUFC_DROME (Q9W376), 
NEUFC_DROPS (Q29HF1), NEUFC_HUMAN (Q8WUJ1), NEUFC_MOUSE (Q5SSH8), 
NEUFC_RAT   (Q6AY62), NEUFC_XENTR (Q28FI8), PGRC1_BOVIN (Q17QC0), 
PGRC1_CHICK (Q5ZKN2), PGRC1_HUMAN (O00264), PGRC1_MOUSE (O55022), 
PGRC1_PIG   (Q95250), PGRC1_PONAB (Q5RED0), PGRC1_RAT   (P70580), 
PGRC2_HUMAN (O15173), PGRC2_MOUSE (Q80UU9), PGRC2_RAT   (Q5XIU9), 
SBP3_ARATH  (Q9SK39), SLD1_ARATH  (Q9ZRP7), SLD1_BOROF  (Q9FR82), 
SLD1_EUGGR  (Q9SWQ9), SLD1_HELAN  (Q43469), SLD1_KLULA  (Q6CMK7), 
SLD1_KLULC  (Q8NKG8), SLD1_LACK1  (Q8NKG9), SLD2_ARATH  (Q3EBF7), 
SUOX_MACFA  (Q60HD0), VEM1_CAEEL  (Q7YZW5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

NIA2_MAIZE  (P39871), NIA_LOTTE   (P39882)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			21 sequences
			


			
CCD32_MOUSE (Q8BS39), CCD32_RAT   (Q561K4), CDK14_CALJA (B0VXE8), 

			
CDK14_DASNO (C0RW22), CDK14_HUMAN (O94921), CDK14_MOUSE (O35495), 
CDK14_PLEMO (B0VXL7), CDK14_RABIT (B6A7Q3), CDK14_XENLA (Q6DJM7), 
CDK14_XENTR (A4IIW7), HYAL3_PIG   (Q6RHW2), LAR1B_HUMAN (Q659C4), 
LARP1_HUMAN (Q6PKG0), LARP1_MOUSE (Q6ZQ58), MATK_WOLBI  (Q6JVN2), 
MSRAB_HELPJ (Q9ZMK8), PPCEL_XENLA (Q32N48), SFSA_METS4  (B0ULY8), 
VCLY_TEGPF  (P07447), VILI_BOVIN  (Q3SZP7), VILL_HUMAN  (O15195)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			70 PDB
			


			1AQA; 1AW3; 1AWP; 1AXX; 1B5A; 1B5B; 1B5M; 1BFX; 1BLV; 1CYO; 1DO9; 1EHB; 
			
				1ES1; 1EUE; 1F03; 1F04; 1FCB; 1HKO; 1I5U; 1I87; 1I8C; 1IB7; 1ICC; 1IET; 
				1IEU; 1J0Q; 1JEX; 1KBI; 1LCO; 1LDC; 1LJ0; 1LQX; 1LR6; 1LTD; 1M20; 1M2I; 
				1M2M; 1MJ4; 1MNY; 1NX7; 1SH4; 1SOX; 1SZE; 1SZF; 1SZG; 1U9M; 1U9U; 2AXX; 
				2I89; 2I96; 2IBJ; 2M33; 2OZ0; 3HBG; 3HBP; 3HBQ; 3KS0; 3LF5; 3MUS; 3NER; 
				3OZZ; 3R18; 3R19; 3X32; 3X33; 3X34; 3X35; 4HIL; 4HIN; 4ZR0
			
			

			» more