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PROSITE entry PS00191


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00191
Entry name [info] CYTOCHROME_B5_1
Accession [info] PS00191
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00170

Name and characterization of the entry

Description [info] Cytochrome b5 family, heme-binding domain signature.
Pattern [info] 
[FY]-[LIVMK]-{I}-{Q}-H-P-[GA]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 126 in 126 different sequences
Number of true positive hits 105 in 105 different sequences
Number of 'unknown' hits 0
Number of false positive hits 21 in 21 different sequences
Number of false negative sequences 80
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 83.33 %
Recall (true positives / (true positives + false negatives)) 56.76 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] heme_iron at position 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 105 sequences 

ACO1_AJECA  (Q12618), ACO1_YEAST  (P21147), CYB2_TALSN  (B8MKR3),
» more

UniProtKB/Swiss-Prot
False negative sequences		 80 sequences 

ACET6_CERPU (Q9LEN0), ACO1_SCHPO  (O94523), APF12_GIBF5 (S0DLN7),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

NIA2_MAIZE  (P39871), NIA_LOTTE   (P39882)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			21 sequences
			


			
CCD32_MOUSE (Q8BS39), CCD32_RAT   (Q561K4), CDK14_CALJA (B0VXE8), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			70 PDB
			


			1AQA; 1AW3; 1AWP; 1AXX; 1B5A; 1B5B; 1B5M; 1BFX; 1BLV; 1CYO; 1DO9; 1EHB; 
			
			

			» more