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PROSITE entry PS00221


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00221
Entry name [info] MIP
Accession [info] PS00221
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00193

Name and characterization of the entry

Description [info] MIP family signature.
Pattern [info] 
[HNQA]-{D}-N-P-[STA]-[LIVMF]-[ST]-[LIVMF]-[GSTAFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 287 in 287 different sequences
Number of true positive hits 266 in 266 different sequences
Number of 'unknown' hits 0
Number of false positive hits 21 in 21 different sequences
Number of false negative sequences 49
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 92.68 %
Recall (true positives / (true positives + false negatives)) 84.44 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 266 sequences 

AQP10_HUMAN (Q96PS8), AQP10_MILTA (G5CTG7), AQP1_BOVIN  (P47865), 

AQP1_CANLF  (Q9N2J4), AQP1_HUMAN  (P29972), AQP1_MOUSE  (Q02013), 
AQP1_PIG(Q6PQZ1), AQP1_PONAB  (Q5R819), AQP1_RAT(P29975), 
AQP1_RHIO9  (I1CR68), AQP1_SHEEP  (P56401), AQP1_TRYBB  (Q6ZXT4), 
AQP2_AMBHO  (O77697), AQP2_BOVIN  (P79099), AQP2_CANLF  (P79144), 
AQP2_DASNO  (P79164), AQP2_DUGDU  (O77714), AQP2_ELEMA  (P79168), 
AQP2_ERIEU  (O77722), AQP2_GIBZE  (I1RHJ1), AQP2_HORSE  (P79165), 
AQP2_HUMAN  (P41181), AQP2_LACBS  (B0D4K0), AQP2_MACPR  (P79803), 
AQP2_MOUSE  (P56402), AQP2_ORYAF  (P79200), AQP2_PROHA  (P79229), 
AQP2_RABIT  (P79213), AQP2_RAT(P34080), AQP2_RHIIR  (I3W9F7), 
AQP2_RHIO9  (I1CS06), AQP2_SHEEP  (O62735), AQP2_TALEU  (O77740), 
AQP3_BOVIN  (Q08DE6), AQP3_HUMAN  (Q92482), AQP3_MOUSE  (Q8R2N1), 
AQP3_PIG(A9Y006), AQP3_RAT(P47862), AQP3_TRYBB  (Q6ZXT2), 
AQP4_BOVIN  (O77750), AQP4_DIPME  (Q923J4), AQP4_GIBZE  (I1RIY3), 
AQP4_HUMAN  (P55087), AQP4_MOUSE  (P55088), AQP4_NOTAL  (Q5I4F9), 
AQP4_RAT(P47863), AQP5_HUMAN  (P55064), AQP5_LACBI  (I1Z8E7), 
AQP5_LACBS  (B0D4E4), AQP5_MILTA  (G5CTG2), AQP5_MOUSE  (Q9WTY4), 
AQP5_PIG(A8W649), AQP5_RAT(P47864), AQP5_SHEEP  (Q866S3), 
AQP6_HUMAN  (Q13520), AQP6_LACBI  (I1Z8E8), AQP6_LACBS  (B0DLE4), 
AQP6_MOUSE  (Q8C4A0), AQP6_RAT(Q9WTY0), AQP71_LACBI (I1Z8E9), 
AQP72_LACBI (I1Z8F0), AQP7_LACBS  (B0D4J9), AQP7_MILTA  (G5CTG4), 
AQP8_BOTFB  (A0A384JP03), AQP8_HUMAN  (O94778), AQP8_MOUSE  (P56404), 
AQP8_NOTAL  (Q5I4F8), AQP8_RAT(P56405), AQP9_BOTFB  (A0A384JSZ0), 
AQP9_HUMAN  (O43315), AQP9_MOUSE  (Q9JJJ3), AQP9_RAT(P56627), 
AQPA_DICDI  (Q9U8P7), AQPA_PELLE  (P50501), AQPB_DICDI  (Q54WT8), 
AQPC_DICDI  (Q54V53), AQPM_ARCFU  (O28846), AQPM_METTH  (O26206), 
AQPM_METTM  (Q9C4Z5), AQPZ1_AGRFC (Q8UI24), AQPZ1_RHIME (Q92NM3), 
AQPZ2_AGRFC (Q8UJW4), AQPZ2_RHIME (Q92ZW9), AQPZ_BORBR  (Q7WKG2), 
AQPZ_BORPA  (Q7W917), AQPZ_BRADU  (Q89EG9), AQPZ_BRUA2  (Q2YR68), 
AQPZ_BRUAB  (P0C112), AQPZ_BRUME  (Q9L772), AQPZ_BRUSU  (Q8FY85), 
AQPZ_CHRVO  (Q7NU39), AQPZ_ECO57  (Q8X6K6), AQPZ_ECOL6  (P60845), 
AQPZ_ECOLI  (P60844), AQPZ_FLAJO  (Q7WVD3), AQPZ_GLOVI  (Q7NNP3), 
AQPZ_PHOLL  (Q7N5C1), AQPZ_PSEAE  (Q9HWZ3), AQPZ_PSEPK  (Q88F17), 
AQPZ_RHOPA  (P60925), AQPZ_SHEON  (Q8EHC1), AQPZ_SHIFL  (O68874), 
AQPZ_SYNY3  (P73809), AQPZ_VIBPA  (Q87MQ5), AQPZ_VIBVU  (Q8DB17), 
AQPZ_VIBVY  (Q7MIV9), AQP_AEDAE   (Q9NHW7), AQP_ANOGA   (Q7PWV1), 
AQP_DROME   (Q9V5Z7), AQP_ENCCU   (Q8SRK2), AQP_ENCHE   (Q1M1A0), 
AQP_ENCIN   (Q1M2P4), AQP_ENTBH   (B7XIC4), AQP_HAEIX   (Q25074), 
AQP_VAIC1   (C4VBN2), AQY1_YEAS7  (A6ZX66), AQY1_YEAS8  (C8ZJM1), 
AQY1_YEAST  (P0CD91), AQY1_YEASX  (P0CD92), AQY2_YEASX  (P0CD89), 
AQY3_YEAST  (P43549), BIB_DROME   (P23645), FPS1_YEAST  (P23900), 
GLA_LACLA   (Q9CE02), GLA_LACLC   (P22094), GLPF2_LACPL (F9USY3), 
GLPF3_LACPL (F9UTW9), GLPF5_LACPL (F9UUB3), GLPF_BACSU  (P18156), 
GLPF_BUCAI  (P57392), GLPF_BUCAP  (Q8K9M9), GLPF_ECO57  (P0AER2), 
GLPF_ECOL6  (P0AER1), GLPF_ECOLI  (P0AER0), GLPF_HAEIN  (P44826), 
GLPF_MYCGA  (P52280), GLPF_MYCGE  (P47279), GLPF_MYCPN  (P75071), 
GLPF_PSEAE  (Q51389), GLPF_SHIFL  (P31140), GLPF_STRCO  (P19255), 
GLPF_STRR6  (P0A3Q8), GLPF_THEMA  (Q9X1E3), HOG1_KLULA  (Q6CJA8), 
MIP_BOVIN   (P06624), MIP_CANLF   (A2IBY8), MIP_CAVPO   (Q6RZ07), 
MIP_CHICK   (P28238), MIP_HUMAN   (P30301), MIP_LITPI   (Q06019), 
MIP_MOUSE   (P51180), MIP_RABIT   (A4L9J0), MIP_RAT (P09011), 
MIP_SHEEP   (Q6J8I9), NIP11_ARATH (Q8VZW1), NIP11_MAIZE (Q9ATN4), 
NIP11_ORYSJ (Q40746), NIP12_ARATH (Q8LFP7), NIP12_ORYSJ (Q0JPT5), 
NIP13_ORYSJ (Q0DK16), NIP14_ORYSJ (Q5Z9E2), NIP1_NICAL  (P49173), 
NIP21_ARATH (Q8W037), NIP21_MAIZE (Q19KC1), NIP21_ORYSJ (Q6Z2T3), 
NIP22_MAIZE (Q9ATN2), NIP22_ORYSJ (Q67WJ8), NIP23_MAIZE (Q9AT74), 
NIP31_ARATH (Q9C6T0), NIP31_MAIZE (Q9ATN1), NIP31_ORYSJ (Q0IWF3), 
NIP32_ORYSJ (Q7EYH7), NIP33_ORYSJ (Q84S07), NIP41_ARATH (Q9FIZ9), 
NIP41_ORYSJ (Q9ASI1), NIP42_ARATH (Q8W036), NIP51_ARATH (Q9SV84), 
NIP61_ARATH (Q9SAI4), NIP71_ARATH (Q8LAI1), NO26_SOYBN  (P08995), 
PDUF_CITFR  (B1VB61), PDUF_SALTY  (P37451), PIP11_ARATH (P61837), 
PIP11_MAIZE (Q41870), PIP11_MUSAC (S5ZH89), PIP11_ORYSJ (Q6EU94), 
PIP11_VICFA (P61838), PIP12_ARATH (Q06611), PIP12_MAIZE (Q9XF59), 
PIP12_MUSAC (P0DO53), PIP12_MUSAM (A0A804KTT0), PIP12_ORYSJ (Q7XSQ9), 
PIP13_ARATH (Q08733), PIP13_MAIZE (Q9AQU5), PIP13_ORYSJ (Q9SXF8), 
PIP14_ARATH (Q39196), PIP15_ARATH (Q8LAA6), PIP15_MAIZE (Q9AR14), 
PIP16_MAIZE (Q9ATN0), PIP1_ATRCA  (P42767), PIP1_SOLLC  (Q08451), 
PIP21_ARATH (P43286), PIP21_MAIZE (Q84RL7), PIP21_ORYSJ (Q8H5N9), 
PIP22_ARATH (P43287), PIP22_MAIZE (Q9ATM8), PIP22_ORYSJ (Q6K215), 
PIP23_ARATH (P30302), PIP23_MAIZE (Q9ATM7), PIP23_ORYSJ (Q7XUA6), 
PIP24_ARATH (Q9FF53), PIP24_MAIZE (Q9ATM6), PIP24_ORYSJ (Q8GRT8), 
PIP25_ARATH (Q9SV31), PIP25_MAIZE (Q9XF58), PIP25_ORYSJ (Q8GRI8), 
PIP26_ARATH (Q9ZV07), PIP26_MAIZE (Q9ATM5), PIP26_ORYSJ (Q7XLR1), 
PIP27_ARATH (P93004), PIP27_MAIZE (Q9ATM4), PIP27_MUSAC (A0A6M3QG69), 
PIP27_ORYSJ (Q651D5), PIP28_ARATH (Q9ZVX8), PIP28_ORYSJ (Q7Y1E6), 
PIP2_PEA(P25794), TIP11_ARATH (P25818), TIP11_MAIZE (O64964), 
TIP11_ORYSJ (P50156), TIP12_ARATH (Q41963), TIP12_MAIZE (Q9ATM0), 
TIP12_MUSAC (P0DO54), TIP12_ORYSJ (Q94CS9), TIP13_ARATH (O82598), 
TIP1_MEDTR  (Q9FY14), TIP1_TOBAC  (P21653), TIP21_ARATH (Q41951), 
TIP21_MAIZE (Q9ATL9), TIP21_ORYSJ (Q7XA61), TIP22_ARATH (Q41975), 
TIP22_MAIZE (Q9ATL8), TIP22_ORYSJ (Q5Z6F0), TIP23_ARATH (Q9FGL2), 
TIP23_MAIZE (Q84RL6), TIP2_TOBAC  (P24422), TIP31_ARATH (P26587), 
TIP31_MAIZE (Q9ATL7), TIP31_ORYSJ (Q9FWV6), TIP32_ARATH (O22588), 
TIP32_MAIZE (Q9AT75), TIP32_ORYSJ (Q7XKI5), TIP41_ARATH (O82316), 
TIP41_MAIZE (Q9ATL6), TIP41_ORYSJ (Q75GA5), TIP42_MAIZE (Q9ATL5), 
TIP42_ORYSJ (Q9LWR0), TIP43_MAIZE (Q9ATL4), TIP43_ORYSJ (Q9LWR2), 
TIP44_MAIZE (Q9ATL3), TIP51_ARATH (Q9STX9), TIP51_MAIZE (Q9ATL2), 
TIP51_ORYSJ (Q7XU31), TIPA_PHAVU  (P23958), TIP_ANTMA   (P33560), 
Y9877_DICDI (Q54QI2), YI7H_SCHPO  (Q9P7T9)
» more

UniProtKB/Swiss-Prot
False negative sequences		 49 sequences 

AQ12A_HUMAN (Q8IXF9), AQ12B_HUMAN (A6NM10), AQP10_CAEEL (Q09369), 

AQP11_HUMAN (Q8NBQ7), AQP11_MOUSE (Q8BHH1), AQP11_RAT   (Q8CHM1), 
AQP12_MOUSE (Q8CHJ2), AQP1_BOTFB  (A0A384JL97), AQP1_GIBZE  (V6QVS3), 
AQP1_LACBI  (I1Z8E5), AQP1_LACBS  (B0DMR6), AQP1_PLABA  (A0A509APT1), 
AQP1_PLAF7  (Q8II36), AQP1_RHIIR  (I3W9F6), AQP2_BOTFB  (A0A384J441), 
AQP2_PLABA  (A0A509AUY5), AQP2_PLAFO  (W7KGE5), AQP2_TRYBB  (Q6ZXT3), 
AQP3_GIBZE  (V6R6F0), AQP3_LACBI  (I1Z8E6), AQP3_LACBS  (B0DPL3), 
AQP4_BOTFB  (A0A384JPP3), AQP4_LACBS  (B0DAC6), AQP5_BOTFB  (A0A384J983), 
AQP5_GIBZE  (V6RVB4), AQP6_BOTFB  (A0A384JGJ4), AQP7_BOTFB  (A0A384J409), 
AQP7_HUMAN  (O14520), AQP7_MACFA  (Q4R691), AQP7_MOUSE  (O54794), 
AQP7_RAT(P56403), AQPS_RHIME  (Q92R43), AQP_CICVR   (Q23808), 
AQP_TOXGM   (A0A125YZH9), AQY2_YEAST  (P0CD90), GLPF4_LACPL (F9UMX3), 
GLPF6_LACPL (F9UUD2), GLPF_STRPN  (P0A3Q7), LARD_LACPL  (F9UST3), 
SIP11_ARATH (Q9M8W5), SIP11_MAIZE (Q9ATM3), SIP11_ORYSJ (Q5VR89), 
SIP12_ARATH (Q9FK43), SIP12_MAIZE (Q9ATM2), SIP21_ARATH (Q9M1K3), 
SIP21_MAIZE (Q9ATM1), TIP1_MEDSA  (P42067), Y1017_HAEIN (O86231), 
YLL53_YEAST (P0CD98)
» more

UniProtKB/Swiss-Prot
False positive sequences		 21 sequences 

AMPP2_TRIVH (D4D6B8), DPP4_ASPFN  (B8N970), DPP4_ASPOR  (Q2UH35), 

DPPD_BACSU  (P26905), DTX_DROME   (Q23985), EAF1_YARLI  (Q6C7K8), 
GRS12_ARATH (Q8LBS4), IDD4_ARATH  (Q8GYC1), IDD6_ARATH  (Q8RWX7), 
LST2_MOUSE  (Q6ZPK7), MENE_HAEIN  (P44565), MODD_RHOCA  (Q08384), 
MYCP1_HUMAN (P12525), POLG_POWVL  (Q04538), RDF_BPPHC   (Q9T216), 
SC24B_HUMAN (O95487), SEC24_DICDI (Q54U61), SWAHB_HUMAN (A6NEL2), 
THI1_ORYSJ  (Q7XXS4), XB34_ORYSJ  (Q7XI08), YEA8_SCHPO  (O14073)
» more

PDB
[Detailed view]		 59 PDB

1FQY; 1FX8; 1H6I; 1IH5; 1J4N; 1LDA; 1LDF; 1LDI; 1RC2; 1SOR; 1YMG; 2ABM; 2B6O; 2B6P; 2C32; 2D57; 2EVU; 2F2B; 2O9D; 2O9E; 2O9F; 2O9G; 2ZZ9; 3D9S; 3GD8; 3IYZ; 3J41; 3LLQ; 3M9I; 3NE2; 3NK5; 3NKA; 3NKC; 4CSK; 4NEF; 4OJ2; 5C5X; 5DYE; 5I32; 6F7H; 6POJ; 6QF5; 6QIM; 7CJS; 7NL4; 7STC; 7UZE; 8CT2; 8CTE; 8GCL; 8GHJ; 8H1D; 8OEE; 8SJX; 8SJY; 8UY6; 8V8S; 8V91; 8V9D
» more