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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00226


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PURL: https://purl.expasy.org/prosite/signature/PS00226

Direct ScanProsite submission
General information about the entry

Entry name [info] IF_ROD_1
Accession [info] PS00226
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00198

Name and characterization of the entry

Description [info] Intermediate filament (IF) rod domain signature.
Pattern [info] 
[IV]-{K}-[TACI]-Y-[RKH]-{E}-[LM]-L-[DE].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 313 in 313 different sequences
Number of true positive hits 292 in 292 different sequences
Number of 'unknown' hits 0
Number of false positive hits 21 in 21 different sequences
Number of false negative sequences 55
Number of 'partial' sequences 9
Precision (true positives / (true positives + false positives)) 93.29 %
Recall (true positives / (true positives + false negatives)) 84.15 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 292 sequences 

AINX_BOVIN  (Q08DH7), AINX_HUMAN  (Q16352), AINX_MOUSE  (P46660), 

AINX_RAT(P23565), AV71_ACAVI  (Q17107), DESM_BOVIN  (O62654), 
DESM_CANLF  (Q5XFN2), DESM_CHICK  (P02542), DESM_HUMAN  (P17661), 
DESM_MESAU  (P02541), DESM_MOUSE  (P31001), DESM_PIG(P02540), 
DESM_RAT(P48675), DESM_XENLA  (P23239), GFAP_BOVIN  (Q28115), 
GFAP_CARAU  (P48677), GFAP_DANRE  (Q58EE9), GFAP_HUMAN  (P14136), 
GFAP_MOUSE  (P03995), GFAP_PONAB  (Q5RA72), GFAP_RAT(P47819), 
IF3T_TETCF  (P23729), IFA1_CAEEL  (P90901), IFA4_CAEEL  (P90900), 
IFB1_CAEEL  (Q19289), IFEA_ASCSU  (P23730), IFEA_CORAP  (P22488), 
IFEA_HELPO  (P16274), IFEB_ASCSU  (P23731), IFEB_HELPO  (P16275), 
IFE_BRALA   (Q04948), ION3_CARAU  (P18520), K118A_POLSE (A1KQY9), 
K118A_XENLA (P08802), K118B_XENLA (Q7SY65), K1C0_XENLA  (P02537), 
K1C10_BOVIN (P06394), K1C10_CANLF (Q6EIZ0), K1C10_HUMAN (P13645), 
K1C10_MOUSE (P02535), K1C10_RAT   (Q6IFW6), K1C11_LAMFL (Q8AWA7), 
K1C11_PROAT (Q5K2P6), K1C12_HUMAN (Q99456), K1C12_MOUSE (Q64291), 
K1C12_RABIT (Q28706), K1C12_RAT   (Q6IFW5), K1C13_HUMAN (P13646), 
K1C13_MOUSE (P08730), K1C13_PROAT (Q5K2P4), K1C13_RAT   (Q6IFV4), 
K1C14_BOVIN (P05785), K1C14_CHICK (Q6PVZ1), K1C14_HUMAN (P02533), 
K1C14_MOUSE (Q61781), K1C14_RAT   (Q6IFV1), K1C15_HUMAN (P19012), 
K1C15_MOUSE (Q61414), K1C15_PROAT (Q5K2P2), K1C15_RAT   (Q6IFV3), 
K1C15_SHEEP (O77727), K1C16_HUMAN (P08779), K1C16_MOUSE (Q9Z2K1), 
K1C17_BOVIN (A1L595), K1C17_HUMAN (Q04695), K1C17_MOUSE (Q9QWL7), 
K1C17_PANTR (A5A6M0), K1C17_RAT   (Q6IFU8), K1C18_ACIBE (Q7SYF8), 
K1C18_CARAU (Q07427), K1C18_DANRE (Q7ZTS4), K1C18_HUMAN (P05783), 
K1C18_MOUSE (P05784), K1C18_ONCMY (O57607), K1C18_RAT   (Q5BJY9), 
K1C18_SCYST (O57611), K1C18_XENTR (Q6P864), K1C19_BOVIN (P08728), 
K1C19_CHICK (O93256), K1C19_HUMAN (P08727), K1C19_MOUSE (P19001), 
K1C19_PONAB (Q5R8S9), K1C19_POTTR (P51856), K1C19_RAT   (Q63279), 
K1C1_XENLA  (P08777), K1C20_BOVIN (A6QQQ9), K1C20_HUMAN (P35900), 
K1C20_MOUSE (Q9D312), K1C20_RAT   (P25030), K1C23_HUMAN (Q9C075), 
K1C23_MOUSE (Q99PS0), K1C24_HUMAN (Q2M2I5), K1C39_HUMAN (Q6A163), 
K1C39_MOUSE (Q6IFX4), K1C39_RAT   (Q6IFW3), K1C40_MOUSE (Q6IFX3), 
K1C40_RAT   (Q6IFW2), K1C42_MOUSE (Q6IFX2), K1C42_RAT   (Q6IFU7), 
K1C4_XENLA  (P05781), K1C5_XENLA  (P08778), K1C9_HUMAN  (P35527), 
K1C9_RAT(Q8CIS9), K1H1_HUMAN  (Q15323), K1H1_MOUSE  (Q61765), 
K1H1_PANTR  (A5A6M5), K1H2_HUMAN  (Q14532), K1H2_MOUSE  (Q62168), 
K1M1_SHEEP  (P02534), K1M2_SHEEP  (P25690), K22E_CANLF  (Q6EIZ1), 
K22E_HUMAN  (P35908), K22E_MOUSE  (Q3TTY5), K22E_RAT(Q6IG02), 
K22O_HUMAN  (Q01546), K22O_MOUSE  (Q3UV17), K2C1B_HUMAN (Q7Z794), 
K2C1B_MOUSE (Q6IFZ6), K2C1_CANLF  (Q6EIY9), K2C1_HUMAN  (P04264), 
K2C1_MOUSE  (P04104), K2C1_PANTR  (A5A6M6), K2C1_RAT(Q6IMF3), 
K2C1_XENLA  (P04266), K2C2_XENLA  (P04265), K2C3_BOVIN  (P04261), 
K2C3_HUMAN  (P12035), K2C3_RABIT  (Q29426), K2C4_BOVIN  (P04260), 
K2C4_HUMAN  (P19013), K2C4_MOUSE  (P07744), K2C4_RAT(Q6IG00), 
K2C5_BOVIN  (Q5XQN5), K2C5_HUMAN  (P13647), K2C5_MOUSE  (Q922U2), 
K2C5_PANTR  (A5A6M8), K2C5_RAT(Q6P6Q2), K2C6A_HUMAN (P02538), 
K2C6A_MOUSE (P50446), K2C6A_RAT   (Q4FZU2), K2C6B_HUMAN (P04259), 
K2C6B_MOUSE (Q9Z331), K2C6C_HUMAN (P48668), K2C71_BOVIN (Q148H5), 
K2C71_FELCA (E1AB55), K2C71_HUMAN (Q3SY84), K2C71_MOUSE (Q9R0H5), 
K2C72_BOVIN (Q148H8), K2C72_HUMAN (Q14CN4), K2C72_MOUSE (Q6IME9), 
K2C72_RAT   (Q6IG04), K2C73_BOVIN (A7YWK3), K2C73_HUMAN (Q86Y46), 
K2C73_MOUSE (Q6NXH9), K2C73_RAT   (Q6IG03), K2C74_HUMAN (Q7RTS7), 
K2C74_MOUSE (Q6IFZ9), K2C75_BOVIN (Q08D91), K2C75_HUMAN (O95678), 
K2C75_MOUSE (Q8BGZ7), K2C75_RAT   (Q6IG05), K2C78_BOVIN (A6QNX5), 
K2C78_HUMAN (Q8N1N4), K2C79_BOVIN (Q148H7), K2C79_HUMAN (Q5XKE5), 
K2C79_MOUSE (Q8VED5), K2C7_BOVIN  (Q29S21), K2C7_HUMAN  (P08729), 
K2C7_MOUSE  (Q9DCV7), K2C7_PANTR  (A5A6N0), K2C7_POTTR  (Q8HZR5), 
K2C7_RAT(Q6IG12), K2C7_XENLA  (P16878), K2C8_BOVIN  (P05786), 
K2C8_DANRE  (Q6NWF6), K2C8_HUMAN  (P05787), K2C8_MOUSE  (P11679), 
K2C8_PROAT  (Q5K2N3), K2C8_RAT(Q10758), K2C8_XENLA  (P08776), 
K2CA_BOVIN  (P04263), K2CB_BOVIN  (P04262), K2CO_CHICK  (O93532), 
K2M2_SHEEP  (P15241), K2M3_SHEEP  (P25691), KRT34_HUMAN (O76011), 
KRT34_MOUSE (Q9D646), KRT35_BOVIN (Q0P5J7), KRT35_HUMAN (Q92764), 
KRT35_MOUSE (Q497I4), KRT35_SHEEP (B0LKP1), KRT36_HUMAN (O76013), 
KRT36_MOUSE (B1AQ75), KRT37_HUMAN (O76014), KRT38_HUMAN (O76015), 
KRT81_BOVIN (Q148H4), KRT81_HUMAN (Q14533), KRT81_MOUSE (Q9ERE2), 
KRT82_HUMAN (Q9NSB4), KRT82_MOUSE (Q99M74), KRT83_BOVIN (A4FUZ0), 
KRT83_HUMAN (P78385), KRT84_HUMAN (Q9NSB2), KRT84_MOUSE (Q99M73), 
KRT85_HUMAN (P78386), KRT85_MOUSE (Q9Z2T6), KRT86_HUMAN (O43790), 
KRT86_MOUSE (P97861), KRT87_MOUSE (Q6IMF0), KT222_BOVIN (Q2KI75), 
KT222_HUMAN (Q8N1A0), KT222_MOUSE (Q8CCX5), KT33A_HUMAN (O76009), 
KT33A_MOUSE (Q8K0Y2), KT33A_PANTR (A5A6P3), KT33B_HUMAN (Q14525), 
KT33B_MOUSE (Q61897), LMNA_CHICK  (P13648), LMNA_HUMAN  (P02545), 
LMNA_MOUSE  (P48678), LMNA_PIG(Q3ZD69), LMNA_RAT(P48679), 
LMNA_XENLA  (P11048), LMNB1_CHICK (P14731), LMNB1_HUMAN (P20700), 
LMNB1_MOUSE (P14733), LMNB1_RAT   (P70615), LMNB1_XENLA (P09010), 
LMNB2_CHICK (P14732), LMNB2_HUMAN (Q03252), LMNB2_MOUSE (P21619), 
LMNB2_XENLA (P21910), LMNB3_XENLA (P10999), NEST_DANRE  (P86839), 
NEST_HUMAN  (P48681), NEST_MESAU  (Q9Z1Q1), NEST_MOUSE  (Q6P5H2), 
NEST_RAT(P21263), NF60_DORPE  (Q01240), NF70_DORPE  (Q01241), 
NFH_HUMAN   (P12036), NFH_MOUSE   (P19246), NFH_RAT (P16884), 
NFL_BOVIN   (P02548), NFL_COTJA   (Q02916), NFL_HUMAN   (P07196), 
NFL_MOUSE   (P08551), NFL_PIG (P02547), NFL_PONAB   (Q5R408), 
NFL_RAT (P19527), NFL_XENLA   (P35616), NFL_XENTR   (B4F721), 
NFM_BOVIN   (O77788), NFM_CHICK   (P16053), NFM_HUMAN   (P07197), 
NFM_MOUSE   (P08553), NFM_PIG (P08552), NFM_RABIT   (P54938), 
NFM_RAT (P12839), OV71_ONCVO  (P31732), PERI_BOVIN  (A6QQJ3), 
PERI_HUMAN  (P41219), PERI_MOUSE  (P15331), PERI_RAT(P21807), 
PERI_XENLA  (P48676), PLST_CARAU  (P31393), RGP51_LYMST (Q6QUW1), 
SYNEM_HUMAN (O15061), SYNEM_MOUSE (Q70IV5), TANA_XENLA  (Q01550), 
TBFA_EPTST  (Q90501), TBFG_EPTST  (Q90502), VIM1_CARAU  (P48671), 
VIM1_XENLA  (P24789), VIM2_CARAU  (P48672), VIM4_XENLA  (P24790), 
VIMB_CARAU  (P48673), VIME_BOVIN  (P48616), VIME_CANLF  (A0A8C0N8E3), 
VIME_CHICK  (P09654), VIME_CHLAE  (P84198), VIME_CRIGR  (P48670), 
VIME_CYPCA  (Q92155), VIME_HUMAN  (P08670), VIME_MACFA  (Q4R4X4), 
VIME_MESAU  (P02544), VIME_MOUSE  (P20152), VIME_ONCMY  (P48674), 
VIME_PANTR  (Q5R1W8), VIME_PIG(P02543), VIME_RAT(P31000), 
XNIF_XENLA  (P35617)
» more

UniProtKB/Swiss-Prot
False negative sequences		 55 sequences 

BFSP1_BOVIN (Q06002), BFSP1_CHICK (Q06637), BFSP1_HUMAN (Q12934), 

BFSP1_MOUSE (A2AMT1), BFSP1_RAT   (Q02435), BFSP2_BOVIN (Q28177), 
BFSP2_HUMAN (Q13515), BFSP2_MOUSE (Q6NVD9), IFA2_CAEEL  (O02365), 
IFA3_CAEEL  (Q21065), IFB2_CAEEL  (Q19286), IFC1_CAEEL  (O45168), 
IFC2_CAEBR  (Q5WN60), IFC2_CAEEL  (Q21067), IFD1_CAEEL  (Q86DC6), 
IFD2_CAEEL  (Q19782), IFP1_CAEEL  (Q09501), K1C13_ONCMY (Q8JFQ6), 
K1C1_CARAU  (Q90303), K1C24_MOUSE (A1L317), K1C24_RAT   (Q6IFX1), 
K1C25_BOVIN (Q0P5J4), K1C25_CAPHI (Q6R650), K1C25_HUMAN (Q7Z3Z0), 
K1C25_MOUSE (Q8VCW2), K1C25_PANTR (A5A6N2), K1C25_RAT   (Q6IFX0), 
K1C25_SHEEP (Q9BGM5), K1C26_BOVIN (A6H712), K1C26_HUMAN (Q7Z3Y9), 
K1C26_MOUSE (Q3TRJ4), K1C27_BOVIN (Q0P5J6), K1C27_CAPHI (Q6R649), 
K1C27_HUMAN (Q7Z3Y8), K1C27_MOUSE (Q9Z320), K1C27_RAT   (Q6IFW8), 
K1C28_BOVIN (Q148H6), K1C28_HUMAN (Q7Z3Y7), K1C28_MOUSE (A6BLY7), 
K1C40_BOVIN (A7YWM2), K1C40_HUMAN (Q6A162), K1C9_CANLF  (O18740), 
K1C9_MOUSE  (Q6RHW0), K2C1B_RAT   (Q6IG01), K2C74_BOVIN (A3KN27), 
K2C80_BOVIN (A0JND2), K2C80_HUMAN (Q6KB66), K2C80_MOUSE (Q0VBK2), 
K2C80_RAT   (Q6IMF1), KR87P_HUMAN (A6NCN2), LAM0_DROME  (P08928), 
LAMC_DROME  (Q03427), LMN1_CAEEL  (Q21443), SYNCI_HUMAN (Q9H7C4), 
SYNCI_MOUSE (Q9EPM5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 9 sequences 

K1C19_MESAU (P86246), K1C20_PIG   (Q29218), K1C3_XENLA  (P05782), 

K2C8_MESAU  (P86247), K2C8_POTTR  (Q28810), K2M1_SHEEP  (P02539), 
KRT_CEREL   (P86498), NFH_PIG (P12037), VIME_SHEEP  (Q9MZA9)
» more

UniProtKB/Swiss-Prot
False positive sequences		 21 sequences 

ADDB_DESRM  (A4J4E2), AIM6_CANGA  (Q6FWH9), ATPG_NITV2  (Q72E03), 

BAH_STRHY   (Q01109), CEMA_TUPAK  (Q3ZJ15), FAB1D_ARATH (Q9XID0), 
GLYL3_HUMAN (Q5SZD4), LIX1_CHICK  (Q8UVV7), LIX1_HUMAN  (Q8N485), 
LIX1_MOUSE  (Q6P566), LPH_RABIT   (P09849), LPH_SHEEP   (W5PLZ6), 
MEND_NOCSJ  (A1SE17), NCED2_ORYSJ (Q5MBR6), OGRL1_XENTR (A2VCV0), 
PPR36_ARATH (Q0WKV3), RFBF_BACSU  (O06486), RS10_NOVAD  (Q2G8Y1), 
RS10_SACD2  (Q21M58), TTC27_CAEEL (P41842), TYSY_SYMTH  (Q67JQ1)
» more

PDB
[Detailed view]		 14 PDB

pdb_00001gk4; pdb_00001gk6; pdb_00001x8y; pdb_00002xv5; pdb_00003tnu; pdb_00003tyy; pdb_00003v4q; pdb_00003v4w; pdb_00003v5b; pdb_00004zry; pdb_00006jfv; pdb_00006uui; pdb_00006yjd; pdb_00008rve
» more