PROSITE logo

PROSITE entry PS00236


View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] NEUROTR_ION_CHANNEL
Accession [info] PS00236
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00209

Name and characterization of the entry

Description [info] Neurotransmitter-gated ion-channels signature.
Pattern [info] 
C-x-[LIVMFQ]-x-[LIVMF]-x(2)-[FY]-P-x-D-x(3)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 252 in 252 different sequences
Number of true positive hits 252 in 252 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 4
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 98.44 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 12
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 252 sequences 

5HT3A_CAVPO (O70212), 5HT3A_HUMAN (P46098), 5HT3A_MOUSE (P23979), 

5HT3A_RAT   (P35563), 5HT3C_HUMAN (Q8WXA8), 5HT3E_HUMAN (A5X5Y0), 
ACC1_CAEEL  (Q21005), ACC2_CAEEL  (Q18812), ACC3_CAEEL  (G5EDN0), 
ACH10_CHICK (Q9I8C7), ACH10_HUMAN (Q9GZZ6), ACH10_RAT   (Q9JLB5), 
ACH15_CAEEL (O16926), ACH1_CAEBR  (A8WQK3), ACH1_CAEEL  (P48180), 
ACH1_DROME  (P09478), ACH1_MANSE  (P91766), ACH1_SCHGR  (P23414), 
ACH23_CAEEL (G5EG88), ACH2_CAEEL  (P48181), ACH2_DROME  (P17644), 
ACH3_CAEEL  (P54244), ACH3_DROME  (P04755), ACH4_CAEEL  (O76554), 
ACH4_DROME  (P25162), ACH5_CAEEL  (Q23022), ACH6_CAEEL  (Q9N587), 
ACH7_CAEEL  (Q27218), ACH8_CAEBR  (Q60S81), ACH8_CAEEL  (Q9U298), 
ACH91_ONCMY (Q8JFN7), ACH92_ONCMY (Q68RJ7), ACHA2_CHICK (P09480), 
ACHA2_HUMAN (Q15822), ACHA2_MOUSE (Q91X60), ACHA2_PANTR (Q5IS52), 
ACHA2_RAT   (P12389), ACHA3_BOVIN (Q07263), ACHA3_CARAU (P18845), 
ACHA3_CHICK (P09481), ACHA3_HUMAN (P32297), ACHA3_MOUSE (Q8R4G9), 
ACHA3_RAT   (P04757), ACHA4_CHICK (P09482), ACHA4_HUMAN (P43681), 
ACHA4_MOUSE (O70174), ACHA4_MUSPF (Q19AE6), ACHA4_PANTR (Q5IS77), 
ACHA4_RAT   (P09483), ACHA5_BOVIN (Q8SPU7), ACHA5_CHICK (P26152), 
ACHA5_HUMAN (P30532), ACHA5_MOUSE (Q2MKA5), ACHA5_PANTR (Q5IS51), 
ACHA5_RAT   (P20420), ACHA6_CHICK (P49581), ACHA6_HUMAN (Q15825), 
ACHA6_MOUSE (Q9R0W9), ACHA6_PANTR (Q5IS76), ACHA6_RAT   (P43143), 
ACHA7_BOVIN (P54131), ACHA7_CHICK (P22770), ACHA7_HUMAN (P36544), 
ACHA7_MACMU (Q866A2), ACHA7_MOUSE (P49582), ACHA7_RAT   (Q05941), 
ACHA9_CHICK (Q9PTS8), ACHA9_HUMAN (Q9UGM1), ACHA9_RAT   (P43144), 
ACHAA_XENLA (P22456), ACHAB_XENLA (P05377), ACHA_BOVIN  (P02709), 
ACHA_CHICK  (P09479), ACHA_CRORS  (P54248), ACHA_DANRE  (Q98880), 
ACHA_ERICO  (P54249), ACHA_FELCA  (P54250), ACHA_HERIC  (P54251), 
ACHA_HUMAN  (P02708), ACHA_MOUSE  (P04756), ACHA_NAJNA  (P14143), 
ACHA_NATTE  (P14144), ACHA_RAT(P25108), ACHA_TETCF  (P02710), 
ACHA_TORMA  (P02711), ACHB2_CARAU (P19370), ACHB2_CHICK (P09484), 
ACHB2_HUMAN (P17787), ACHB2_MOUSE (Q9ERK7), ACHB2_RAT   (P12390), 
ACHB3_CHICK (P43679), ACHB3_HUMAN (Q05901), ACHB3_MOUSE (Q8BMN3), 
ACHB3_PANTR (Q5IS75), ACHB3_RAT   (P12391), ACHB4_BOVIN (Q8SPU6), 
ACHB4_CHICK (P26153), ACHB4_HUMAN (P30926), ACHB4_MOUSE (Q8R493), 
ACHB4_RAT   (P12392), ACHB_BOVIN  (P04758), ACHB_HUMAN  (P11230), 
ACHB_MOUSE  (P09690), ACHB_RAT(P25109), ACHB_TETCF  (P02712), 
ACHB_XENLA  (P49579), ACHD_BOVIN  (P04759), ACHD_CHICK  (P02717), 
ACHD_HUMAN  (Q07001), ACHD_MOUSE  (P02716), ACHD_RAT(P25110), 
ACHD_TETCF  (P02718), ACHD_XENLA  (P09628), ACHE_BOVIN  (P02715), 
ACHE_HUMAN  (Q04844), ACHE_MOUSE  (P20782), ACHE_RAT(P09660), 
ACHE_XENLA  (P49580), ACHG_BOVIN  (P13536), ACHG_CHICK  (P02713), 
ACHG_HUMAN  (P07510), ACHG_MOUSE  (P04760), ACHG_RAT(P18916), 
ACHG_TETCF  (P02714), ACHG_XENLA  (P05376), ACHN2_CARAU (P13908), 
ACHN3_CARAU (P18257), ACHX_ONCVO  (P54247), ACR2_CAEEL  (P48182), 
ACR3_CAEEL  (Q93149), ACR5_CAEEL  (P54246), ACR7_CAEEL  (P45963), 
ARKA_DICDI  (Q54HC6), CRFM7_HUMAN (Q494W8), CUP4_CAEBR  (A8XF54), 
CUP4_CAEEL  (P34271), GBR1_CAEEL  (G5ECJ0), GBRA1_BOVIN (P08219), 
GBRA1_CHICK (P19150), GBRA1_HUMAN (P14867), GBRA1_MACFA (Q4R534), 
GBRA1_MOUSE (P62812), GBRA1_PONAB (Q5R6B2), GBRA1_RAT   (P62813), 
GBRA2_BOVIN (P10063), GBRA2_HUMAN (P47869), GBRA2_MOUSE (P26048), 
GBRA2_PONAB (Q5RCC5), GBRA2_RAT   (P23576), GBRA3_BOVIN (P10064), 
GBRA3_HUMAN (P34903), GBRA3_MOUSE (P26049), GBRA3_RAT   (P20236), 
GBRA4_BOVIN (P20237), GBRA4_HUMAN (P48169), GBRA4_MOUSE (Q9D6F4), 
GBRA4_RAT   (P28471), GBRA5_BOVIN (Q08E50), GBRA5_HUMAN (P31644), 
GBRA5_MOUSE (Q8BHJ7), GBRA5_RAT   (P19969), GBRA6_CHICK (Q90845), 
GBRA6_HUMAN (Q16445), GBRA6_MOUSE (P16305), GBRA6_RAT   (P30191), 
GBRAL_DROME (Q24352), GBRB1_BOVIN (P08220), GBRB1_HUMAN (P18505), 
GBRB1_MOUSE (P50571), GBRB1_RAT   (P15431), GBRB2_BOVIN (P0C2W5), 
GBRB2_HUMAN (P47870), GBRB2_MACMU (D1LYT2), GBRB2_MOUSE (P63137), 
GBRB2_RAT   (P63138), GBRB3_CHICK (P19019), GBRB3_DROME (Q08832), 
GBRB3_HUMAN (P28472), GBRB3_MOUSE (P63080), GBRB3_RAT   (P63079), 
GBRB4_CHICK (P24045), GBRB_CAEEL  (O18276), GBRB_DROME  (P25123), 
GBRB_DROSI  (Q9BLY8), GBRB_LYMST  (P26714), GBRB_MUSDO  (Q75NA5), 
GBRD_HUMAN  (O14764), GBRD_MOUSE  (P22933), GBRD_RAT(P18506), 
GBRE_HUMAN  (P78334), GBRE_RAT(Q9ES14), GBRG1_HUMAN (Q8N1C3), 
GBRG1_MOUSE (Q9R0Y8), GBRG1_RAT   (P23574), GBRG2_BOVIN (P22300), 
GBRG2_CHICK (P21548), GBRG2_HUMAN (P18507), GBRG2_MOUSE (P22723), 
GBRG2_PONAB (Q5REA1), GBRG2_RAT   (P18508), GBRG3_HUMAN (Q99928), 
GBRG3_MOUSE (P27681), GBRG3_RAT   (P28473), GBRG4_CHICK (P34904), 
GBRP_BOVIN  (Q5EA06), GBRP_HUMAN  (O00591), GBRP_MOUSE  (Q8QZW7), 
GBRP_RAT(O09028), GBRR1_HUMAN (P24046), GBRR1_MOUSE (P56475), 
GBRR1_RAT   (P50572), GBRR2_BOVIN (Q0II76), GBRR2_HUMAN (P28476), 
GBRR2_MOUSE (P56476), GBRR2_RAT   (P47742), GBRR3_HUMAN (A8MPY1), 
GBRR3_RAT   (P50573), GBRT_HUMAN  (Q9UN88), GBRT_MOUSE  (Q9JLF1), 
GLRA1_BOVIN (P57695), GLRA1_DANRE (O93430), GLRA1_HUMAN (P23415), 
GLRA1_MOUSE (Q64018), GLRA1_RAT   (P07727), GLRA2_DANRE (F1R8P4), 
GLRA2_HUMAN (P23416), GLRA2_MOUSE (Q7TNC8), GLRA2_RAT   (P22771), 
GLRA3_HUMAN (O75311), GLRA3_MOUSE (Q91XP5), GLRA3_RAT   (P24524), 
GLRA4_MOUSE (Q61603), GLRB4_CAEEL (Q09453), GLRB_BOVIN  (Q9GJS9), 
GLRB_HUMAN  (P48167), GLRB_MOUSE  (P48168), GLRB_RAT(P20781), 
GLUCB_CAEEL (Q17328), GLUCB_HAECO (P91730), GLUCL_CAEEL (G5EBR3), 
GLUCL_DROME (Q94900), LGC46_CAEEL (Q95Y52), LGC4_CAEBR  (A8XNX8), 
LGC4_CAEEL  (P54245), LGC50_CAEEL (P41849), MOD1_CAEEL  (Q9GQ00), 
PBO5_CAEEL  (G5ECT0), PBO6_CAEEL  (Q19351), PHCL2_ANOGA (A0A1S4H2E2), 
PHCL2_DROME (Q9V9Y4), ZACN_CANLF  (Q866Y9), ZACN_HUMAN  (Q401N2)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

5HT3B_HUMAN (O95264), 5HT3B_MOUSE (Q9JHJ5), 5HT3B_RAT   (Q9JJ16), 

5HT3D_HUMAN (Q70Z44)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

ACHA_ELEEL  (P09688), ACHB_CHICK  (P16005), ACHB_ELEEL  (P09689), 

ACHD_ELEEL  (P09691), ACHG_ELEEL  (P09692)
» more

PDB
[Detailed view]		 154 PDB

2BG9; 2QC1; 3JAD; 3JAE; 3JAF; 3RHW; 3RI5; 3RIA; 3RIF; 4AQ5; 4AQ9; 4BOG; 4BOI; 4BON; 4BOO; 4BOR; 4BOT; 4COF; 4D01; 4PIR; 4TNV; 4TNW; 4UXU; 4UY2; 5BKF; 5BKG; 5CFB; 5FJV; 5HBT; 5HBV; 5KXI; 5O8F; 5OJM; 5TIN; 5TIO; 5VDH; 5VDI; 6A96; 6BE1; 6CNJ; 6CNK; 6D6T; 6D6U; 6DG7; 6DG8; 6DW0; 6DW1; 6HIN; 6HIO; 6HIQ; 6HUG; 6HUJ; 6HUK; 6HUO; 6HUP; 6HY7; 6I53; 6NP0; 6PLO; 6PLP; 6PLQ; 6PLR; 6PLS; 6PLT; 6PLU; 6PLV; 6PLW; 6PLX; 6PLY; 6PLZ; 6PM0; 6PM1; 6PM2; 6PM3; 6PM4; 6PM5; 6PM6; 6PV7; 6PV8; 6PXD; 6QFA; 6UBS; 6UBT; 6UD3; 6UR8; 6USF; 6UWZ; 6VM0; 6VM2; 6VM3; 6W1J; 6W1M; 6W1Y; 6X3S; 6X3T; 6X3U; 6X3V; 6X3W; 6X3X; 6X3Z; 6X40; 6Y1Z; 7EKI; 7EKP; 7EKT; 7KOO; 7KOQ; 7KOX; 7KUY; 7L31; 7M6M; 7M6N; 7M6O; 7M6P; 7M6Q; 7M6R; 7M6S; 7PBD; 7PBZ; 7PC0; 7QKO; 7QL5; 7QL6; 7QN5; 7QN6; 7QN7; 7QN8; 7QN9; 7QNA; 7QNB; 7QNC; 7QND; 7QNE; 7SMM; 7SMQ; 7SMR; 7SMS; 7SMT; 7T0W; 7T0Z; 7TU9; 7TVI; 7U2M; 7U2N; 7U2O; 7Z14; 8A5U; 8DD2; 8DD3; 8ESK; 8F2S; 8F6Y; 8F6Z; 8FE1
» more