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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00238


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PURL: https://purl.expasy.org/prosite/signature/PS00238

Direct ScanProsite submission
General information about the entry

Entry name [info] OPSIN
Accession [info] PS00238
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00211

Name and characterization of the entry

Description [info] Visual pigments (opsins) retinal binding site.
Pattern [info] 
[LIVMFWAC]-[PSGAC]-x-{G}-x-[SAC]-K-[STALIMR]-[GSACPNV]-[STACP]-x(2)-
[DENF]-[AP]-x(2)-[IY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 231 in 230 different sequences
Number of true positive hits 219 in 218 different sequences
Number of 'unknown' hits 0
Number of false positive hits 12 in 12 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 94.81 %
Recall (true positives / (true positives + false negatives)) 99.10 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Site [info] retinal at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 218 sequences 

OP1S1_DANRE (Q9W6A9), OP1S2_DANRE (Q9W6A8), OPN3_HUMAN  (Q9H1Y3), 

OPN3_MOUSE  (Q9WUK7), OPN4A_DANRE (Q2KNE5), OPN4A_GADMO (Q804X9), 
OPN4B_GADMO (Q804Q2), OPN4B_XENLA (O57422), OPN4L_DANRE (Q1JPS6), 
OPN4_FELCA  (Q5YKK9), OPN4_HUMAN  (Q9UHM6), OPN4_MOUSE  (Q9QXZ9), 
OPN4_PHOSU  (Q5XXP2), OPN4_PODSI  (Q4U4D2), OPN4_RAT(Q8R456), 
OPN4_RUTRU  (Q6XL69), OPN5_HUMAN  (Q6U736), OPN5_MOUSE  (Q6VZZ7), 
OPS1_CALVI  (P22269), OPS1_DROME  (P06002), OPS1_DROPS  (P28678), 
OPS1_MANSE  (O02464), OPS1_SCHGR  (Q94741), OPS2_DROME  (P08099), 
OPS2_DROPS  (P28679), OPS2_SCHGR  (Q26495), OPS3_DROME  (P04950), 
OPS3_DROPS  (P28680), OPS4_DROME  (P08255), OPS4_DROPS  (P29404), 
OPS4_DROVI  (P17646), OPS5_DROME  (P91657), OPS6_DROME  (O01668), 
OPSB_ANOCA  (P51471), OPSB_APIME  (P90680), OPSB_BOVIN  (P51490), 
OPSB_CARAU  (P32310), OPSB_CHICK  (P28682), OPSB_CONCO  (O13227), 
OPSB_GEKGE  (P35357), OPSB_HUMAN  (P03999), OPSB_MOUSE  (P51491), 
OPSB_ORYLA  (P87365), OPSB_PANPA  (P60573), OPSB_PANTR  (P60015), 
OPSB_PSAFA  (P51472), OPSB_RAT(Q63652), OPSB_SAIBB  (O13092), 
OPSC1_HEMSA (Q25157), OPSC2_HEMSA (Q25158), OPSCE_BOMMO (Q95YI3), 
OPSD1_ANGAN (Q90214), OPSD1_MIZYE (O15973), OPSD2_ANGAN (Q90215), 
OPSD2_MIZYE (O15974), OPSD_ABYKO  (O42294), OPSD_ALLMI  (P52202), 
OPSD_ALLSU  (Q17094), OPSD_AMBTI  (Q90245), OPSD_ANOCA  (P41591), 
OPSD_APIME  (Q17053), OPSD_AQUCT  (P51470), OPSD_ATHBO  (Q9YGZ1), 
OPSD_BATMU  (O42300), OPSD_BATNI  (O42301), OPSD_BOVIN  (P02699), 
OPSD_BUFBU  (P56514), OPSD_CALPD  (Q6W3E1), OPSD_CAMAT  (Q17292), 
OPSD_CAMHU  (O18312), OPSD_CAMMA  (O18315), OPSD_CAMSC  (O16018), 
OPSD_CANLF  (P32308), OPSD_CARAU  (P32309), OPSD_CATBO  (Q17296), 
OPSD_CHEAU  (Q9YGZ6), OPSD_CHELB  (Q9YGZ8), OPSD_CHESA  (Q9YGZ7), 
OPSD_CHICK  (P22328), OPSD_COMDY  (O42327), OPSD_CORAU  (Q90305), 
OPSD_COTBO  (O42307), OPSD_COTGR  (O42328), OPSD_COTIN  (O42330), 
OPSD_CRIGR  (P28681), OPSD_CYPCA  (P51488), OPSD_DANRE  (P35359), 
OPSD_DELDE  (O62791), OPSD_DICLA  (Q9YGZ4), OPSD_DIPAN  (Q9YH05), 
OPSD_DIPVU  (Q9YH04), OPSD_ENTDO  (P09241), OPSD_FAXVI  (O16019), 
OPSD_FELCA  (Q95KU1), OPSD_GALML  (O93441), OPSD_GAMAF  (P79756), 
OPSD_GLOME  (O62792), OPSD_GOBNI  (Q9YGZ2), OPSD_HUMAN  (P08100), 
OPSD_ICTPU  (O42268), OPSD_LACLU  (O16017), OPSD_LEOKE  (Q90373), 
OPSD_LETCA  (P22671), OPSD_LEUER  (P79863), OPSD_LIMBE  (O42427), 
OPSD_LIMPA  (O42431), OPSD_LITMO  (Q9YH00), OPSD_LITPI  (P31355), 
OPSD_LOLFO  (P24603), OPSD_LOXAF  (Q68J47), OPSD_MACFA  (Q28886), 
OPSD_MESBI  (O62793), OPSD_MOUSE  (P15409), OPSD_MUGCE  (Q9YGZ9), 
OPSD_MULSU  (Q9YH01), OPSD_MYRBE  (P79798), OPSD_MYRVI  (P79807), 
OPSD_NEOAR  (P79808), OPSD_NEOAU  (P79809), OPSD_NEOSA  (P79812), 
OPSD_ORCAU  (O18481), OPSD_ORYLA  (P87369), OPSD_OTOCR  (Q769E8), 
OPSD_PAGGO  (O62795), OPSD_PARKN  (O42452), OPSD_PETMA  (Q98980), 
OPSD_PHOVI  (O62794), OPSD_PIG(O18766), OPSD_POERE  (P79848), 
OPSD_POMMI  (P35403), OPSD_PROCL  (P35356), OPSD_PROJE  (O42451), 
OPSD_PROML  (O16020), OPSD_PROOR  (O18485), OPSD_PROSE  (O18486), 
OPSD_PSAFA  (P41590), OPSD_RABIT  (P49912), OPSD_RANTE  (P56516), 
OPSD_RAT(P51489), OPSD_RHIMB  (P56515), OPSD_SALPV  (Q9YGZ3), 
OPSD_SARDI  (P79898), OPSD_SARMI  (P79901), OPSD_SARPI  (Q9YGZ0), 
OPSD_SARPU  (P79902), OPSD_SARSL  (Q9YH03), OPSD_SARSP  (P79903), 
OPSD_SARTI  (P79911), OPSD_SARXA  (P79914), OPSD_SCYCA  (O93459), 
OPSD_SEPOF  (O16005), OPSD_SHEEP  (P02700), OPSD_SMICR  (Q8HY69), 
OPSD_SOLSO  (Q9YGZ5), OPSD_SPAAU  (Q9YH02), OPSD_SPHSP  (P35362), 
OPSD_TAUBU  (O42466), OPSD_TETNG  (Q9DGG4), OPSD_TODPA  (P31356), 
OPSD_TRIMA  (O62796), OPSD_TURTR  (O62798), OPSD_XENLA  (P29403), 
OPSD_ZEUFA  (O42604), OPSD_ZOSOP  (Q9YGY9), OPSG1_CARAU (P32311), 
OPSG1_DANRE (Q9W6A5), OPSG1_PSAFA (P22330), OPSG2_CARAU (P32312), 
OPSG2_DANRE (Q8AYM8), OPSG2_HUMAN (P0DN77), OPSG2_PSAFA (P22331), 
OPSG3_DANRE (Q8AYM7), OPSG3_HUMAN (P0DN78), OPSG3_PSAFA (P51474), 
OPSG4_DANRE (Q9W6A6), OPSG_CAVPO  (Q9R024), OPSG_CHICK  (P28683), 
OPSG_GEKGE  (P35358), OPSG_HUMAN  (P04001), OPSG_MOUSE  (O35599), 
OPSG_ORYLA  (P87366), OPSG_RABIT  (O18910), OPSG_RAT(O35476), 
OPSG_SCICA  (O35478), OPSL_CALJA  (P34989), OPSL_LIMPO  (P35360), 
OPSO_LIMPO  (P35361), OPSO_RUTRU  (Q7T3Q7), OPSO_SALSA  (O13018), 
OPSP_CHICK  (P51475), OPSP_COLLI  (P51476), OPSP_ICTPU  (O42266), 
OPSP_PETMA  (O42490), OPSR1_DANRE (Q9W6A7), OPSR2_DANRE (Q8AYN0), 
OPSR_ANOCA  (P41592), OPSR_BOVIN  (Q9BGI7), OPSR_CANLF  (O18914), 
OPSR_CAPHI  (Q95170), OPSR_CARAU  (P32313), OPSR_CHICK  (P22329), 
OPSR_FELCA  (O18913), OPSR_HORSE  (O18912), OPSR_HUMAN  (P04000), 
OPSR_ORYLA  (P87367), OPSR_PSAFA  (P22332), OPSR_XENLA  (O12948), 
OPSUV_APIME (O61303), OPSUV_CARAU (Q90309), OPSUV_MELUD (O57605), 
OPSV_CHICK  (P28684), OPSV_ORYLA  (P87368), OPSV_XENLA  (P51473), 
OPSX_HUMAN  (O14718), OPSX_MOUSE  (O35214), REIS_TODPA  (P23820), 
RGR_BOVIN   (P47803), RGR_HUMAN   (P47804)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

OPN4_BRABE  (Q4R1I4), RGR_MOUSE   (Q9Z2B3)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			2 sequences
			


			
OPS3_DROVI  (P17645), OPSG_ODOVI  (O18911)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			12 sequences
			


			
EFTS_ACISJ  (A1W917), GPRL1_HUMAN (Q6UWM5), ICMS_LEGPH  (Q5ZYD0), 

			
OADB_PASMU  (Q9CL24), POLSF_CHIKS (P0DOK1), POLS_CHIKN  (Q5WQY5), 
POLS_CHIKS  (Q8JUX5), POLS_ONNVG  (P22056), POLS_ONNVI  (O90371), 
POLS_ONNVS  (O90369), POL_HTL1L   (P0C211), RBP17_MOUSE (Q99NF8)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			76 PDB
			


			pdb_00001f88; pdb_00001gzm; pdb_00001hzx; pdb_00001jfp; pdb_00001l9h; pdb_00001ln6; pdb_00001u19; pdb_00002g87; pdb_00002hpy; pdb_00002i35; pdb_00002i36; pdb_00002i37; 
			
				pdb_00002j4y; pdb_00002ped; pdb_00002x72; pdb_00002z73; pdb_00002ziy; pdb_00003aym; pdb_00003ayn; pdb_00003c9l; pdb_00003c9m; pdb_00003cap; pdb_00003dqb; pdb_00003oax; 
				pdb_00003pqr; pdb_00003pxo; pdb_00004a4m; pdb_00004bey; pdb_00004bez; pdb_00004j4q; pdb_00004pxf; pdb_00004ww3; pdb_00004x1h; pdb_00004zwj; pdb_00005dgy; pdb_00005dys; 
				pdb_00005en0; pdb_00005te3; pdb_00005te5; pdb_00005w0p; pdb_00005wkt; pdb_00006cmo; pdb_00006fk6; pdb_00006fk7; pdb_00006fk8; pdb_00006fk9; pdb_00006fka; pdb_00006fkb; 
				pdb_00006fkc; pdb_00006fkd; pdb_00006fuf; pdb_00006nwe; pdb_00006ofj; pdb_00006oy9; pdb_00006oya; pdb_00006pel; pdb_00006pgs; pdb_00006ph7; pdb_00006qno; pdb_00007mt8; 
				pdb_00007mt9; pdb_00007mta; pdb_00007mtb; pdb_00007zbc; pdb_00007zbe; pdb_00008a6c; pdb_00008a6d; pdb_00008a6e; pdb_00008fcz; pdb_00008fd0; pdb_00008fd1; pdb_00008iu2; 
				pdb_00008p12; pdb_00008p13; pdb_00008p15; pdb_00008y01
			
			

			» more