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PROSITE entry PS00238


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00238
Entry name [info] OPSIN
Accession [info] PS00238
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00211

Name and characterization of the entry

Description [info] Visual pigments (opsins) retinal binding site.
Pattern [info] 
[LIVMFWAC]-[PSGAC]-x-{G}-x-[SAC]-K-[STALIMR]-[GSACPNV]-[STACP]-x(2)-
[DENF]-[AP]-x(2)-[IY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 231 in 230 different sequences
Number of true positive hits 219 in 218 different sequences
Number of 'unknown' hits 0
Number of false positive hits 12 in 12 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 94.81 %
Recall (true positives / (true positives + false negatives)) 99.10 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Site [info] retinal at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 218 sequences 

OP1S1_DANRE (Q9W6A9), OP1S2_DANRE (Q9W6A8), OPN3_HUMAN  (Q9H1Y3), 

OPN3_MOUSE  (Q9WUK7), OPN4A_DANRE (Q2KNE5), OPN4A_GADMO (Q804X9), 
OPN4B_GADMO (Q804Q2), OPN4B_XENLA (O57422), OPN4L_DANRE (Q1JPS6), 
OPN4_FELCA  (Q5YKK9), OPN4_HUMAN  (Q9UHM6), OPN4_MOUSE  (Q9QXZ9), 
OPN4_PHOSU  (Q5XXP2), OPN4_PODSI  (Q4U4D2), OPN4_RAT(Q8R456), 
OPN4_RUTRU  (Q6XL69), OPN5_HUMAN  (Q6U736), OPN5_MOUSE  (Q6VZZ7), 
OPS1_CALVI  (P22269), OPS1_DROME  (P06002), OPS1_DROPS  (P28678), 
OPS1_MANSE  (O02464), OPS1_SCHGR  (Q94741), OPS2_DROME  (P08099), 
OPS2_DROPS  (P28679), OPS2_SCHGR  (Q26495), OPS3_DROME  (P04950), 
OPS3_DROPS  (P28680), OPS4_DROME  (P08255), OPS4_DROPS  (P29404), 
OPS4_DROVI  (P17646), OPS5_DROME  (P91657), OPS6_DROME  (O01668), 
OPSB_ANOCA  (P51471), OPSB_APIME  (P90680), OPSB_BOVIN  (P51490), 
OPSB_CARAU  (P32310), OPSB_CHICK  (P28682), OPSB_CONCO  (O13227), 
OPSB_GEKGE  (P35357), OPSB_HUMAN  (P03999), OPSB_MOUSE  (P51491), 
OPSB_ORYLA  (P87365), OPSB_PANPA  (P60573), OPSB_PANTR  (P60015), 
OPSB_PSAFA  (P51472), OPSB_RAT(Q63652), OPSB_SAIBB  (O13092), 
OPSC1_HEMSA (Q25157), OPSC2_HEMSA (Q25158), OPSCE_BOMMO (Q95YI3), 
OPSD1_ANGAN (Q90214), OPSD1_MIZYE (O15973), OPSD2_ANGAN (Q90215), 
OPSD2_MIZYE (O15974), OPSD_ABYKO  (O42294), OPSD_ALLMI  (P52202), 
OPSD_ALLSU  (Q17094), OPSD_AMBTI  (Q90245), OPSD_ANOCA  (P41591), 
OPSD_APIME  (Q17053), OPSD_AQUCT  (P51470), OPSD_ATHBO  (Q9YGZ1), 
OPSD_BATMU  (O42300), OPSD_BATNI  (O42301), OPSD_BOVIN  (P02699), 
OPSD_BUFBU  (P56514), OPSD_CALPD  (Q6W3E1), OPSD_CAMAT  (Q17292), 
OPSD_CAMHU  (O18312), OPSD_CAMMA  (O18315), OPSD_CAMSC  (O16018), 
OPSD_CANLF  (P32308), OPSD_CARAU  (P32309), OPSD_CATBO  (Q17296), 
OPSD_CHEAU  (Q9YGZ6), OPSD_CHELB  (Q9YGZ8), OPSD_CHESA  (Q9YGZ7), 
OPSD_CHICK  (P22328), OPSD_COMDY  (O42327), OPSD_CORAU  (Q90305), 
OPSD_COTBO  (O42307), OPSD_COTGR  (O42328), OPSD_COTIN  (O42330), 
OPSD_CRIGR  (P28681), OPSD_CYPCA  (P51488), OPSD_DANRE  (P35359), 
OPSD_DELDE  (O62791), OPSD_DICLA  (Q9YGZ4), OPSD_DIPAN  (Q9YH05), 
OPSD_DIPVU  (Q9YH04), OPSD_ENTDO  (P09241), OPSD_FAXVI  (O16019), 
OPSD_FELCA  (Q95KU1), OPSD_GALML  (O93441), OPSD_GAMAF  (P79756), 
OPSD_GLOME  (O62792), OPSD_GOBNI  (Q9YGZ2), OPSD_HUMAN  (P08100), 
OPSD_ICTPU  (O42268), OPSD_LACLU  (O16017), OPSD_LEOKE  (Q90373), 
OPSD_LETCA  (P22671), OPSD_LEUER  (P79863), OPSD_LIMBE  (O42427), 
OPSD_LIMPA  (O42431), OPSD_LITMO  (Q9YH00), OPSD_LITPI  (P31355), 
OPSD_LOLFO  (P24603), OPSD_LOXAF  (Q68J47), OPSD_MACFA  (Q28886), 
OPSD_MESBI  (O62793), OPSD_MOUSE  (P15409), OPSD_MUGCE  (Q9YGZ9), 
OPSD_MULSU  (Q9YH01), OPSD_MYRBE  (P79798), OPSD_MYRVI  (P79807), 
OPSD_NEOAR  (P79808), OPSD_NEOAU  (P79809), OPSD_NEOSA  (P79812), 
OPSD_ORCAU  (O18481), OPSD_ORYLA  (P87369), OPSD_OTOCR  (Q769E8), 
OPSD_PAGGO  (O62795), OPSD_PARKN  (O42452), OPSD_PETMA  (Q98980), 
OPSD_PHOVI  (O62794), OPSD_PIG(O18766), OPSD_POERE  (P79848), 
OPSD_POMMI  (P35403), OPSD_PROCL  (P35356), OPSD_PROJE  (O42451), 
OPSD_PROML  (O16020), OPSD_PROOR  (O18485), OPSD_PROSE  (O18486), 
OPSD_PSAFA  (P41590), OPSD_RABIT  (P49912), OPSD_RANTE  (P56516), 
OPSD_RAT(P51489), OPSD_RHIMB  (P56515), OPSD_SALPV  (Q9YGZ3), 
OPSD_SARDI  (P79898), OPSD_SARMI  (P79901), OPSD_SARPI  (Q9YGZ0), 
OPSD_SARPU  (P79902), OPSD_SARSL  (Q9YH03), OPSD_SARSP  (P79903), 
OPSD_SARTI  (P79911), OPSD_SARXA  (P79914), OPSD_SCYCA  (O93459), 
OPSD_SEPOF  (O16005), OPSD_SHEEP  (P02700), OPSD_SMICR  (Q8HY69), 
OPSD_SOLSO  (Q9YGZ5), OPSD_SPAAU  (Q9YH02), OPSD_SPHSP  (P35362), 
OPSD_TAUBU  (O42466), OPSD_TETNG  (Q9DGG4), OPSD_TODPA  (P31356), 
OPSD_TRIMA  (O62796), OPSD_TURTR  (O62798), OPSD_XENLA  (P29403), 
OPSD_ZEUFA  (O42604), OPSD_ZOSOP  (Q9YGY9), OPSG1_CARAU (P32311), 
OPSG1_DANRE (Q9W6A5), OPSG1_PSAFA (P22330), OPSG2_CARAU (P32312), 
OPSG2_DANRE (Q8AYM8), OPSG2_HUMAN (P0DN77), OPSG2_PSAFA (P22331), 
OPSG3_DANRE (Q8AYM7), OPSG3_HUMAN (P0DN78), OPSG3_PSAFA (P51474), 
OPSG4_DANRE (Q9W6A6), OPSG_CAVPO  (Q9R024), OPSG_CHICK  (P28683), 
OPSG_GEKGE  (P35358), OPSG_HUMAN  (P04001), OPSG_MOUSE  (O35599), 
OPSG_ORYLA  (P87366), OPSG_RABIT  (O18910), OPSG_RAT(O35476), 
OPSG_SCICA  (O35478), OPSL_CALJA  (P34989), OPSL_LIMPO  (P35360), 
OPSO_LIMPO  (P35361), OPSO_RUTRU  (Q7T3Q7), OPSO_SALSA  (O13018), 
OPSP_CHICK  (P51475), OPSP_COLLI  (P51476), OPSP_ICTPU  (O42266), 
OPSP_PETMA  (O42490), OPSR1_DANRE (Q9W6A7), OPSR2_DANRE (Q8AYN0), 
OPSR_ANOCA  (P41592), OPSR_BOVIN  (Q9BGI7), OPSR_CANLF  (O18914), 
OPSR_CAPHI  (Q95170), OPSR_CARAU  (P32313), OPSR_CHICK  (P22329), 
OPSR_FELCA  (O18913), OPSR_HORSE  (O18912), OPSR_HUMAN  (P04000), 
OPSR_ORYLA  (P87367), OPSR_PSAFA  (P22332), OPSR_XENLA  (O12948), 
OPSUV_APIME (O61303), OPSUV_CARAU (Q90309), OPSUV_MELUD (O57605), 
OPSV_CHICK  (P28684), OPSV_ORYLA  (P87368), OPSV_XENLA  (P51473), 
OPSX_HUMAN  (O14718), OPSX_MOUSE  (O35214), REIS_TODPA  (P23820), 
RGR_BOVIN   (P47803), RGR_HUMAN   (P47804)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

OPN4_BRABE  (Q4R1I4), RGR_MOUSE   (Q9Z2B3)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			2 sequences
			


			
OPS3_DROVI  (P17645), OPSG_ODOVI  (O18911)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			12 sequences
			


			
EFTS_ACISJ  (A1W917), GPRL1_HUMAN (Q6UWM5), ICMS_LEGPH  (Q5ZYD0), 

			
OADB_PASMU  (Q9CL24), POLSF_CHIKS (P0DOK1), POLS_CHIKN  (Q5WQY5), 
POLS_CHIKS  (Q8JUX5), POLS_ONNVG  (P22056), POLS_ONNVI  (O90371), 
POLS_ONNVS  (O90369), POL_HTL1L   (P0C211), RBP17_MOUSE (Q99NF8)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			75 PDB
			


			1F88; 1GZM; 1HZX; 1JFP; 1L9H; 1LN6; 1U19; 2G87; 2HPY; 2I35; 2I36; 2I37; 
			
				2J4Y; 2PED; 2X72; 2Z73; 2ZIY; 3AYM; 3AYN; 3C9L; 3C9M; 3CAP; 3DQB; 3OAX; 
				3PQR; 3PXO; 4A4M; 4BEY; 4BEZ; 4J4Q; 4PXF; 4WW3; 4X1H; 4ZWJ; 5DGY; 5DYS; 
				5EN0; 5TE3; 5TE5; 5W0P; 5WKT; 6CMO; 6FK6; 6FK7; 6FK8; 6FK9; 6FKA; 6FKB; 
				6FKC; 6FKD; 6FUF; 6NWE; 6OFJ; 6OY9; 6OYA; 6PEL; 6PGS; 6PH7; 6QNO; 7MT8; 
				7MT9; 7MTA; 7MTB; 7ZBC; 7ZBE; 8A6C; 8A6D; 8A6E; 8FCZ; 8FD0; 8FD1; 8IU2; 
				8P12; 8P13; 8P15
			
			

			» more