PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00242


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00242

Direct ScanProsite submission
General information about the entry

Entry name [info] INTEGRIN_ALPHA
Accession [info] PS00242
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUN-1994 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00215

Name and characterization of the entry

Description [info] Integrins alpha chain signature.
Pattern [info] 
[FYWS]-[RK]-x-G-F-F-x-R.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 65 in 65 different sequences
Number of true positive hits 53 in 53 different sequences
Number of 'unknown' hits 0
Number of false positive hits 12 in 12 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 81.54 %
Recall (true positives / (true positives + false negatives)) 94.64 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 53 sequences 

INA1_CAEEL  (Q03600), ITA1_DROME  (Q24247), ITA1_HUMAN  (P56199), 

ITA1_MOUSE  (Q3V3R4), ITA1_RAT(P18614), ITA2B_HUMAN (P08514), 
ITA2B_MOUSE (Q9QUM0), ITA2B_PAPCY (P53711), ITA2_BOVIN  (P53710), 
ITA2_DROME  (P12080), ITA2_HUMAN  (P17301), ITA2_MOUSE  (Q62469), 
ITA3_BOVIN  (F1MMS9), ITA3_CRIGR  (P17852), ITA3_DROME  (O44386), 
ITA3_HUMAN  (P26006), ITA3_MOUSE  (Q62470), ITA4_DROME  (Q9V7A4), 
ITA4_HUMAN  (P13612), ITA4_MOUSE  (Q00651), ITA4_XENLA  (Q91687), 
ITA5_HUMAN  (P08648), ITA5_MOUSE  (P11688), ITA5_XENLA  (Q06274), 
ITA6_CHICK  (P26007), ITA6_HUMAN  (P23229), ITA6_MOUSE  (Q61739), 
ITA7_HUMAN  (Q13683), ITA7_MOUSE  (Q61738), ITA7_RAT(Q63258), 
ITA8_CHICK  (P26009), ITA8_HUMAN  (P53708), ITA8_MOUSE  (A2ARA8), 
ITA9_HUMAN  (Q13797), ITA9_MOUSE  (B8JK39), ITAD_HUMAN  (Q13349), 
ITAD_MOUSE  (Q3V0T4), ITAD_RAT(Q9QYE7), ITAE_HUMAN  (P38570), 
ITAE_MOUSE  (Q60677), ITAL_BOVIN  (P61625), ITAL_HUMAN  (P20701), 
ITAL_MOUSE  (P24063), ITAM_HUMAN  (P11215), ITAM_MOUSE  (P05555), 
ITAV_BOVIN  (P80746), ITAV_CHICK  (P26008), ITAV_HUMAN  (P06756), 
ITAV_MOUSE  (P43406), ITAX_HUMAN  (P20702), ITAX_MOUSE  (Q9QXH4), 
PAT2_CAEBR  (A8X3A7), PAT2_CAEEL  (P34446)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

ITA10_HUMAN (O75578), ITA11_HUMAN (Q9UKX5), ITA11_MOUSE (P61622)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			3 sequences
			


			
ITA1_CHICK  (Q90615), ITA5_BOVIN  (Q27977), ITAM_CAVPO  (P11578)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			12 sequences
			


			
ALT5_ALTAL  (A0A3G9H9H1), GRK1_CAEBR  (Q622Z7), GRK1_CAEEL  (Q09537), 

			
NAAT1_DROAN (B3MRS1), NAAT1_DROER (B3NV41), NAAT1_DROME (Q9W4C5), 
NAAT1_DROSI (B4R4T6), NAAT1_DROYA (B4PZQ4), POM1_SCHPO  (Q09690), 
PUT2H_BORBR (A0A0H3LKV3), UCSM_ACRSP  (A0A411KUQ2), Y736_HAEIN  (P44849)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			35 PDB
			


			pdb_00001kup; pdb_00001kuz; pdb_00002k1a; pdb_00002k9j; pdb_00002knc; pdb_00002l8s; pdb_00002m3e; pdb_00002mtp; pdb_00002n9y; pdb_00006uja; pdb_00006ujb; pdb_00006ujc; 
			
				pdb_00007kn0; pdb_00007la4; pdb_00007nwl; pdb_00007nxd; pdb_00007sc4; pdb_00007sft; pdb_00008gcd; pdb_00008gce; pdb_00008t2u; pdb_00008t2v; pdb_00008xei; pdb_00008xek; 
				pdb_00008xel; pdb_00008xen; pdb_00008xer; pdb_00008xez; pdb_00008xf6; pdb_00008xfg; pdb_00008xfo; pdb_00008zjf; pdb_00009axl; pdb_00009deq; pdb_00009der
			
			

			» more