PROSITE entry PS00246

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00246
Entry name [info]	WNT1
Accession [info]	PS00246
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00219

Name and characterization of the entry

Description [info]	Wnt-1 family signature.
Pattern [info]	C-[KR]-C-H-G-[LIVMT]-S-G-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	135 in 135 different sequences
Number of true positive hits	135 in 135 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	59

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

135 sequences

LIN44_CAEBR (A8XEH1), LIN44_CAEEL (Q27886), MOM2_CAEEL  (Q10459),

W11B1_XENTR (Q66II0), W11B2_XENTR (Q28J82), WN10A_DANRE (P43446), 
WN10A_HUMAN (Q9GZT5), WN10A_MOUSE (P70701), WN10B_DANRE (Q801F7), 
WN10B_HUMAN (O00744), WN10B_MOUSE (P48614), WN11B_XENLA (P49893), 
WN2BA_XENLA (P87387), WNT10_XENLA (P31292), WNT11_CHICK (P49339), 
WNT11_COTJA (P51891), WNT11_DANRE (O73864), WNT11_HUMAN (O96014), 
WNT11_MOUSE (P48615), WNT11_XENLA (Q670P5), WNT11_XENTR (B2GUT4), 
WNT16_BOVIN (Q5E9U6), WNT16_HUMAN (Q9UBV4), WNT16_MOUSE (Q9QYS1), 
WNT1_AMBME  (P21551), WNT1_BOMMO  (P49340), WNT1_CAEEL  (P34888), 
WNT1_CHICK  (Q91029), WNT1_DANRE  (P24257), WNT1_HUMAN  (P04628), 
WNT1_MOUSE  (P04426), WNT1_STRPU  (P28094), WNT1_XENLA  (P10108), 
WNT2B_CHICK (Q98SN7), WNT2B_HUMAN (Q93097), WNT2B_MOUSE (O70283), 
WNT2_AOTNA  (Q07DV4), WNT2_ATEGE  (Q09YK7), WNT2_BOVIN  (A4D7S0), 
WNT2_CAEEL  (P34889), WNT2_CALJA  (Q2QLG1), WNT2_CARPS  (Q2QLC7), 
WNT2_CHLAE  (Q2IBB0), WNT2_COLGU  (Q07DY7), WNT2_DANRE  (Q92048), 
WNT2_DASNO  (Q07E44), WNT2_DIDVI  (Q2QL76), WNT2_DROME  (P28465), 
WNT2_ECHTE  (A1X153), WNT2_EULMM  (Q2IBG1), WNT2_FELCA  (A0M8T2), 
WNT2_GORGO  (Q2IBF4), WNT2_HORSE  (Q2QLA5), WNT2_HUMAN  (P09544), 
WNT2_LOXAF  (Q108U2), WNT2_MICMU  (Q2QL85), WNT2_MONDO  (Q2QL96), 
WNT2_MOUSE  (P21552), WNT2_MUNMU  (Q09YJ6), WNT2_MUNRE  (Q07DW8), 
WNT2_MUSPF  (Q07E18), WNT2_NEONE  (Q07E31), WNT2_NOMLE  (Q07DX7), 
WNT2_ORNAN  (Q07DZ8), WNT2_OTOGA  (Q2QLH2), WNT2_PANTR  (Q2QLE7), 
WNT2_PAPAN  (A0M8S1), WNT2_PLEMO  (Q2QLB6), WNT2_PONAB  (Q2IBE2), 
WNT2_RABIT  (Q09YN1), WNT2_RHIFE  (Q2IBB5), WNT2_SHEEP  (Q09YI4), 
WNT3A_CHICK (Q2LMP1), WNT3A_HUMAN (P56704), WNT3A_MOUSE (P27467), 
WNT3A_XENLA (P31285), WNT3_HUMAN  (P56703), WNT3_MOUSE  (P17553), 
WNT3_XENLA  (P31284), WNT4A_DANRE (P47793), WNT4_CHICK  (P49337), 
WNT4_DROME  (P40589), WNT4_HUMAN  (P56705), WNT4_MOUSE  (P22724), 
WNT4_RAT(Q9QXQ5), WNT4_XENLA  (P49338), WNT5A_AMBME (Q06442), 
WNT5A_HUMAN (P41221), WNT5A_MOUSE (P22725), WNT5A_PLEWA (O13267), 
WNT5A_RABIT (Q27Q52), WNT5A_RAT   (Q9QXQ7), WNT5A_XENLA (P31286), 
WNT5B_AMBME (Q06443), WNT5B_DANRE (Q92050), WNT5B_HUMAN (Q9H1J7), 
WNT5B_MOUSE (P22726), WNT5B_ORYLA (O42122), WNT5B_PONAB (Q5NVK2), 
WNT5B_XENLA (P33945), WNT5_DROME  (P28466), WNT5_HALRO  (O15978), 
WNT6_HUMAN  (Q9Y6F9), WNT6_MOUSE  (P22727), WNT6_XENLA  (P31287), 
WNT7A_AOTTR (Q1KYK4), WNT7A_CALJA (Q1KYK6), WNT7A_CHLAE (Q1KYL3), 
WNT7A_GORGO (Q1KYK7), WNT7A_HUMAN (O00755), WNT7A_MACFA (Q1KYK9), 
WNT7A_MOUSE (P24383), WNT7A_PANTR (Q1KYL1), WNT7A_PONPY (Q1KYK5), 
WNT7A_XENLA (P31288), WNT7B_CHICK (Q3L254), WNT7B_HUMAN (P56706), 
WNT7B_MOUSE (P28047), WNT7B_XENLA (P31289), WNT7C_XENLA (P31290), 
WNT8A_DANRE (P51028), WNT8A_HUMAN (Q9H1J5), WNT8A_MOUSE (Q64527), 
WNT8B_DANRE (P51029), WNT8B_HUMAN (Q93098), WNT8B_MOUSE (Q9WUD6), 
WNT8B_XENLA (P31291), WNT8C_CHICK (P51030), WNT8_XENLA  (P28026), 
WNT9A_CHICK (O42280), WNT9A_HUMAN (O14904), WNT9A_MOUSE (Q8R5M2), 
WNT9B_HUMAN (O14905), WNT9B_MOUSE (O35468), WNTG_DROME  (P09615)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
'Partial' sequences

59 sequences

WN10A_ALOVU (P28099), WN10A_PLEJO (P28131), WN10B_PLEJO (P28132),

WN2BB_XENLA (P31283), WNT10_EPTST (P28112), WNT1_ALOVU  (P28100), 
WNT1_EVATR  (P28089), WNT1_PITME  (P28139), WNT1_PLESK  (P28113), 
WNT1_SCEOC  (P28141), WNT2_STRPU  (P28095), WNT3A_ALOVU (P28101), 
WNT3A_MELGA (P28125), WNT3A_PITME (P28140), WNT3A_PLEJO (P28133), 
WNT3A_SCEOC (P28142), WNT3B_ALOVU (P28102), WNT3B_MELGA (P28126), 
WNT3B_PLEJO (P28134), WNT3_EPTST  (P28114), WNT3_EVATR  (P28090), 
WNT4_ANSCE  (P28108), WNT4_EPTST  (P28115), WNT4_MELGA  (P28127), 
WNT4_PLEJO  (P28135), WNT4_PLESK  (P28116), WNT4_SCEOC  (P28143), 
WNT4_STRPU  (P28096), WNT51_EPTST (P28119), WNT52_EPTST (P28120), 
WNT53_EPTST (P28121), WNT5A_ALOVU (P28103), WNT5A_ANSCE (P28109), 
WNT5A_MELGA (P28128), WNT5A_PLESK (P28117), WNT5B_ALOVU (P28104), 
WNT5B_PLEJO (P28136), WNT5B_PLESK (P28118), WNT6_EVATR  (P28091), 
WNT6_PLEJO  (P28137), WNT6_STRPU  (P28097), WNT6_THUTH  (P28145), 
WNT71_EPTST (P28122), WNT72_EPTST (P28123), WNT7A_ALOVU (P28105), 
WNT7A_ANSCE (P28110), WNT7A_MELGA (P28129), WNT7A_PLEJO (P28138), 
WNT7B_ALOVU (P28106), WNT7B_ANSCE (P28111), WNT7B_MELGA (P28130), 
WNT7B_SCEOC (P28144), WNT7_EVATR  (P28092), WNT7_STRPU  (P28098), 
WNT8_EVATR  (P28093), WNT8_THUTH  (P28146), WNT9_ALOVU  (P28107), 
WNT9_EPTST  (P28124), WNTG_MANSE  (Q25533)

» more

PDB
[Detailed view]

9 PDB

4F0A; 6AHY; 7DRT; 7KC4; 7URD; 8CTG; 8TZO; 8TZP; 8TZR