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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00248


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PURL: https://purl.expasy.org/prosite/signature/PS00248

Direct ScanProsite submission
General information about the entry

Entry name [info] NGF_1
Accession [info] PS00248
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00221

Name and characterization of the entry

Description [info] Nerve growth factor family signature.
Pattern [info] 
[GSRE]-C-[KRL]-G-[LIVT]-[DE]-x(3)-[YW]-x-S-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 117 in 117 different sequences
Number of true positive hits 117 in 117 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 27
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.15 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 2
Site [info] disulfide at position 12
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 117 sequences 

BDNF_ACRDU  (Q1X706), BDNF_ACRJA  (Q1X702), BDNF_AILFU  (O97759), 

BDNF_AILME  (Q6LCI5), BDNF_ANISC  (Q1X700), BDNF_ASPME  (Q1HN40), 
BDNF_BOACO  (Q1X708), BDNF_BOVIN  (Q95106), BDNF_CALRI  (Q1X6Z7), 
BDNF_CANCA  (Q1X707), BDNF_CANLF  (Q7YRB4), BDNF_CAVPO  (O70183), 
BDNF_CHABO  (Q1X6Z6), BDNF_CHICK  (P25429), BDNF_CHISR  (Q1HN42), 
BDNF_CORCI  (Q1X711), BDNF_CYLRU  (Q1X701), BDNF_CYPCA  (Q90322), 
BDNF_EPICE  (Q1X710), BDNF_ERYCC  (Q1HN34), BDNF_ERYCN  (Q1X6Z8), 
BDNF_ERYJO  (Q1HN32), BDNF_ERYJY  (Q1HN36), BDNF_EUNNO  (Q1X709), 
BDNF_EXIPL  (Q1X704), BDNF_FELCA  (Q9TST3), BDNF_HELMA  (O18753), 
BDNF_HORSE  (Q0EAB7), BDNF_HUMAN  (P23560), BDNF_LICTR  (Q1HN31), 
BDNF_LIPVE  (Q49M28), BDNF_LOXBI  (Q1HN33), BDNF_MACLB  (P25431), 
BDNF_MACMU  (Q06225), BDNF_MORSI  (Q1X703), BDNF_MOUSE  (P21237), 
BDNF_PANTR  (Q5IS78), BDNF_PIG(P14082), BDNF_PROLO  (O18755), 
BDNF_PTYMJ  (Q8QG74), BDNF_RAJCL  (P25430), BDNF_RAMSP  (Q1X6Z5), 
BDNF_RAT(P23363), BDNF_SANME  (Q1X705), BDNF_SPECI  (Q4L0Y3), 
BDNF_TROHA  (Q1X6Z9), BDNF_URSAR  (O18752), BDNF_URSTH  (Q3SAT7), 
BDNF_XENLA  (P25432), BDNF_XENUN  (Q1HN38), BDNF_XIPMA  (Q02193), 
NGFV1_AZEFE (Q2XXL6), NGFV1_DEMVE (A6MFL5), NGFV1_HOPST (Q3HXY0), 
NGFV1_NAJSP (Q5YF90), NGFV1_NOTSC (Q3HXY7), NGFV1_OXYMI (Q3HXZ1), 
NGFV1_PSEAU (Q3HXY3), NGFV1_PSETE (Q3HXY9), NGFV1_TROCA (Q3HXX8), 
NGFV2_DEMVE (A6MFL6), NGFV2_HOPST (Q3HXX9), NGFV2_NAJSP (Q5YF89), 
NGFV2_OXYMI (Q3HXZ0), NGFV2_PSEAU (Q3HXY2), NGFV2_PSETE (Q3HXY8), 
NGFV2_TROCA (Q3HXX7), NGFV3_DEMVE (A6MFL7), NGFV3_NOTSC (Q3HXY5), 
NGFV3_PSEAU (Q3HXY1), NGFV3_TROCA (Q3HXX6), NGFV4_TROCA (Q3HXX5), 
NGFV5_TROCA (Q3HXX4), NGFV_AGKCO  (B8QCG6), NGFV_BOTJR  (Q90W38), 
NGFV_BUNMU  (P34128), NGFV_CRODU  (Q9DEZ9), NGFV_CRYNI  (Q1W7Q6), 
NGFV_DABRR  (P30894), NGFV_DRYCN  (F8RKW5), NGFV_MACLB  (P25428), 
NGFV_NAJAT  (P61898), NGFV_NAJKA  (P61899), NGFV_NAJNA  (P01140), 
NGFV_OXYSC  (Q3I5F4), NGFV_PSEPO  (Q3HXY4), NGF_BOVIN   (P13600), 
NGF_CAVPO   (P19093), NGF_CHICK   (P05200), NGF_DANRE   (Q6YBR5), 
NGF_GORGO   (Q9N2F0), NGF_HUMAN   (P01138), NGF_MASNA   (P20675), 
NGF_MOUSE   (P01139), NGF_PANTR   (Q9N2F1), NGF_PIG (Q29074), 
NGF_PONPY   (Q9N2E9), NGF_RAT (P25427), NGF_SAIBB   (Q5ISB0), 
NGF_XENLA   (P21617), NGF_XIPMA   (P34129), NTF3_BOVIN  (Q08DT3), 
NTF3_CHICK  (P25433), NTF3_FELCA  (Q9TST2), NTF3_HUMAN  (P20783), 
NTF3_MOUSE  (P20181), NTF3_PIG(Q06AV0), NTF3_RAJCL  (P25434), 
NTF3_RAT(P18280), NTF3_XENLA  (P25435), NTF4_HUMAN  (P34130), 
NTF4_MACLB  (P25436), NTF4_MOUSE  (Q80VU4), NTF4_RAT(P34131), 
NTF4_XENLA  (P24727), NTF7_CYPCA  (O93474), NTF7_DANRE  (O73797)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

NGFV2_NOTSC (Q3HXY6)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			27 sequences
			


			
NGFV_BOTCO  (P0DMG7), NGFV_ECHOC  (P0DMD1), NTF3_ACRDU  (Q1X6Y9), 

			
NTF3_ACRJA  (Q1X6Y5), NTF3_ANISC  (Q1X6Y3), NTF3_ASPME  (Q1KN21), 
NTF3_BOACO  (Q1X6Z1), NTF3_CALRI  (Q1X6Y0), NTF3_CANCA  (Q1X6Z0), 
NTF3_CEREL  (Q95150), NTF3_CHABO  (Q1X6X9), NTF3_CHISR  (Q1KN23), 
NTF3_CORCI  (Q1X6Z4), NTF3_CYLRU  (Q1X6Y4), NTF3_EPICE  (Q1X6Z3), 
NTF3_ERYCC  (Q1KN16), NTF3_ERYCN  (Q1X6Y1), NTF3_ERYJO  (Q1KN12), 
NTF3_EUNNO  (Q1X6Z2), NTF3_EXIPL  (Q1X6Y7), NTF3_LICTR  (Q1KN10), 
NTF3_LOXBI  (Q1KN14), NTF3_MORSI  (Q1X6Y6), NTF3_RAMSP  (Q1X6X8), 
NTF3_SANME  (Q1X6Y8), NTF3_TROHA  (Q1X6Y2), NTF3_XENUN  (Q1KN19)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			24 PDB
			


			pdb_00001b8k; pdb_00001b8m; pdb_00001b98; pdb_00001bet; pdb_00001bnd; pdb_00001btg; pdb_00001hcf; pdb_00001nt3; pdb_00001sg1; pdb_00001sgf; pdb_00001www; pdb_00002ifg; 
			
				pdb_00003buk; pdb_00003ij2; pdb_00004eax; pdb_00004ec7; pdb_00004edw; pdb_00004edx; pdb_00004xpj; pdb_00004zbn; pdb_00005jz7; pdb_00005lsd; pdb_00006ffy; pdb_00006yw8
			
			

			» more