PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00250


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00250

Direct ScanProsite submission
General information about the entry

Entry name [info] TGF_BETA_1
Accession [info] PS00250
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-1990 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00223

Name and characterization of the entry

Description [info] TGF-beta family signature.
Pattern [info] 
[LIVM]-x(2)-P-x(2)-[FY]-x(4)-C-x-G-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 205 in 205 different sequences
Number of true positive hits 203 in 203 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 23
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.02 %
Recall (true positives / (true positives + false negatives)) 89.82 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 7
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 203 sequences 

60A_DROME   (P27091), 60A_DROVI   (Q24735), BMP10_HUMAN (O95393), 

BMP10_MOUSE (Q9R229), BMP10_RAT   (Q4AEG6), BMP15_BOVIN (Q6PX77), 
BMP15_HUMAN (O95972), BMP15_MOUSE (Q9Z0L4), BMP15_SHEEP (Q9MZE2), 
BMP2A_XENLA (P25703), BMP2B_XENLA (P30884), BMP2_CHICK  (Q90751), 
BMP2_DAMDA  (O19006), BMP2_HUMAN  (P12643), BMP2_MOUSE  (P21274), 
BMP2_RABIT  (O46564), BMP2_RAT(P49001), BMP2_TETNG  (Q804S2), 
BMP3_BOVIN  (P22444), BMP3_HUMAN  (P12645), BMP3_MOUSE  (Q8BHE5), 
BMP3_RAT(P49002), BMP3_XENLA  (Q7T2X7), BMP4_BOVIN  (Q2KJH1), 
BMP4_CHICK  (Q90752), BMP4_DAMDA  (Q29607), BMP4_HUMAN  (P12644), 
BMP4_MOUSE  (P21275), BMP4_RABIT  (O46576), BMP4_RAT(Q06826), 
BMP4_SUNMU  (Q8MJV5), BMP4_XENLA  (P30885), BMP5_HUMAN  (P22003), 
BMP5_MOUSE  (P49003), BMP6_HUMAN  (P22004), BMP6_MOUSE  (P20722), 
BMP6_RAT(Q04906), BMP7_HUMAN  (P18075), BMP7_MOUSE  (P23359), 
BMP7_XENLA  (P30886), BMP8A_HUMAN (Q7Z5Y6), BMP8A_MOUSE (P34821), 
BMP8B_HUMAN (P34820), BMP8B_MOUSE (P55105), DAF7_CAEEL  (P92172), 
DBL1_CAEEL  (G5EEL5), DECA_DROME  (P07713), DECA_DROPS  (P91699), 
DECA_DROSI  (P91706), DECA_TRICA  (Q26974), DERR_XENTR  (Q66KL4), 
DSL1_CHICK  (P34822), DVR1_DANRE  (P35621), DVR1_STRPU  (P48969), 
DVR1_XENLA  (P09534), GDF10_BOVIN (Q08DX6), GDF10_HUMAN (P55107), 
GDF10_MOUSE (P97737), GDF10_RAT   (P55108), GDF10_XENLA (Q7T2X6), 
GDF11_HUMAN (O95390), GDF11_MOUSE (Q9Z1W4), GDF11_RAT   (Q9Z217), 
GDF1_HUMAN  (P27539), GDF1_MOUSE  (P20863), GDF2_DANRE  (F1QWZ4), 
GDF2_HUMAN  (Q9UK05), GDF2_MOUSE  (Q9WV56), GDF3_HUMAN  (Q9NR23), 
GDF3_MOUSE  (Q07104), GDF3_XENLA  (Q9YGV1), GDF5_HUMAN  (P43026), 
GDF5_MOUSE  (P43027), GDF6A_DANRE (P85857), GDF6B_DANRE (A8E7N9), 
GDF6_BOVIN  (P55106), GDF6_HUMAN  (Q6KF10), GDF6_MOUSE  (P43028), 
GDF6_RAT(Q6HA10), GDF7_CHLAE  (Q9BDW8), GDF7_HUMAN  (Q7Z4P5), 
GDF7_MOUSE  (P43029), GDF8_AEPME  (Q5USV7), GDF8_ANSAN  (Q8UWD9), 
GDF8_ANTAM  (Q5USV5), GDF8_BOSGA  (Q5USW1), GDF8_BOSIN  (Q5RZV4), 
GDF8_BOVIN  (O18836), GDF8_BUBBU  (Q6X5V1), GDF8_CANLF  (Q6UKZ8), 
GDF8_CAPHI  (Q6T5B8), GDF8_CAPIB  (Q5USV9), GDF8_CHICK  (O42220), 
GDF8_COLLI  (Q8UWD8), GDF8_COTCO  (Q8AVB2), GDF8_DANRE  (O42222), 
GDF8_EPICO  (Q5I3Q2), GDF8_EXCCH  (Q8UWD7), GDF8_GORGO  (A1C2V5), 
GDF8_HEMJE  (Q5USV8), GDF8_HORSE  (Q9GM97), GDF8_HUMAN  (O14793), 
GDF8_LEPCA  (Q8HY52), GDF8_MACFA  (Q95J86), GDF8_MACMU  (A1C2U6), 
GDF8_MELGA  (O42221), GDF8_MOUSE  (O08689), GDF8_OREMO  (Q98TB4), 
GDF8_PANPA  (A1C2U7), GDF8_PANTR  (A1C2V0), GDF8_PAPHA  (O18828), 
GDF8_PIG(O18831), GDF8_PONPY  (A1C2U3), GDF8_RAT(O35312), 
GDF8_SHEEP  (O18830), GDF8_SYLGR  (Q5USV6), GDF8_TAUDE  (Q5USW0), 
GDF8_VULLA  (Q6J1J2), GDF8_VULVU  (Q6DTL9), GDF9_BOVIN  (Q9GK68), 
GDF9_CAPHI  (Q66NC0), GDF9_HUMAN  (O60383), GDF9_MOUSE  (Q07105), 
GDF9_PAPAN  (A9CB18), GDF9_SHEEP  (O77681), INHA_BOVIN  (P07994), 
INHA_CHICK  (P43031), INHA_HORSE  (P55101), INHA_HUMAN  (P05111), 
INHA_MOUSE  (Q04997), INHA_PIG(P04087), INHA_RAT(P17490), 
INHA_SHEEP  (P38440), INHA_TRIVU  (O77755), INHBA_BOVIN (P07995), 
INHBA_FELCA (Q6X2S4), INHBA_HORSE (P55102), INHBA_HUMAN (P08476), 
INHBA_MOUSE (Q04998), INHBA_PIG   (P03970), INHBA_RAT   (P18331), 
INHBA_SHEEP (P43032), INHBB_BOVIN (P42917), INHBB_CHICK (P27093), 
INHBB_HUMAN (P09529), INHBB_MOUSE (Q04999), INHBB_PIG   (P04088), 
INHBB_RAT   (P17491), INHBC_HUMAN (P55103), INHBC_MOUSE (P55104), 
INHBC_RAT   (Q9WUK5), INHBE_HUMAN (P58166), INHBE_MOUSE (O08717), 
INHBE_RAT   (O88959), INHB_DROME  (O61643), LFTY1_HUMAN (O75610), 
LFTY1_MOUSE (Q64280), LFTY2_HUMAN (O00292), LFTY2_MOUSE (P57785), 
MIS_BOVIN   (P03972), MIS_HUMAN   (P03971), MIS_MOUSE   (P27106), 
MIS_PIG (P79295), MIS_RAT (P49000), NOD2A_XENLA (Q91620), 
NOD2B_XENLA (Q90XB7), NOD4A_XENLA (O13048), NOD4B_XENLA (Q90XB8), 
NODAL_HUMAN (Q96S42), NODAL_MOUSE (P43021), NODAL_XENLA (Q91619), 
NODAL_XENTR (Q28GB8), SCW_DROME   (P54631), TGFB1_BOVIN (P18341), 
TGFB1_CANLF (P54831), TGFB1_CAVPO (Q9Z1Y6), TGFB1_CHICK (P09531), 
TGFB1_CHLAE (P09533), TGFB1_CYPCA (Q9PTQ2), TGFB1_HORSE (O19011), 
TGFB1_HUMAN (P01137), TGFB1_MOUSE (P04202), TGFB1_MUSPF (Q38HS2), 
TGFB1_ONCMY (O93449), TGFB1_PIG   (P07200), TGFB1_RAT   (P17246), 
TGFB1_SHEEP (P50414), TGFB1_XENLA (P16176), TGFB2_BOVIN (P21214), 
TGFB2_CHICK (P30371), TGFB2_CHLAE (P61811), TGFB2_HUMAN (P61812), 
TGFB2_MOUSE (P27090), TGFB2_MUSPF (Q38L25), TGFB2_PIG   (P09858), 
TGFB2_RAT   (Q07257), TGFB2_XENLA (P17247), TGFB3_CHICK (P16047), 
TGFB3_HUMAN (P10600), TGFB3_MOUSE (P17125), TGFB3_PIG   (P15203), 
TGFB3_RAT   (Q07258), UNIV_STRPU  (P48970)
» more

UniProtKB/Swiss-Prot
False negative sequences		 23 sequences 

ARTN_HUMAN  (Q5T4W7), ARTN_MOUSE  (Q9Z0L2), ARTN_RAT(Q6AYE8), 

GDF15_HUMAN (Q99988), GDF15_MOUSE (Q9Z0J7), GDF15_RAT   (Q9Z0J6), 
GDF8_ANAPL  (Q8UWE0), GDNF_DANRE  (Q98TU0), GDNF_HUMAN  (P39905), 
GDNF_MOUSE  (P48540), GDNF_RAT(Q07731), GDNF_XENLA  (Q06PM8), 
INHBA_CHICK (P27092), NOD3A_XENLA (Q91609), NOD3A_XENTR (Q800C0), 
NOD3B_XENLA (Q91621), NOD3B_XENTR (Q800B9), NOD3C_XENTR (Q800B8), 
NRTN_HUMAN  (Q99748), NRTN_MOUSE  (P97463), PSPN_HUMAN  (O60542), 
PSPN_MOUSE  (O70300), PSPN_RAT(O70301)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

BMP7_CANLF  (P34819)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			2 sequences
			


			
ACOXL_MOUSE (Q9DBS4), CLPX_MYXXA  (Q9X5N1)


				
	

	

		PDB
[Detailed view]		
		
			138 PDB
			


			pdb_00001bmp; pdb_00001es7; pdb_00001kla; pdb_00001klc; pdb_00001kld; pdb_00001ktz; pdb_00001lx5; pdb_00001lxi; pdb_00001m4u; pdb_00001nys; pdb_00001nyu; pdb_00001reu; 
			
				pdb_00001rew; pdb_00001s4y; pdb_00001tfg; pdb_00001tgj; pdb_00001tgk; pdb_00001waq; pdb_00001zkz; pdb_00002arp; pdb_00002arv; pdb_00002b0u; pdb_00002bhk; pdb_00002goo; 
				pdb_00002h62; pdb_00002h64; pdb_00002p6a; pdb_00002pjy; pdb_00002qcq; pdb_00002qcw; pdb_00002qj9; pdb_00002qja; pdb_00002qjb; pdb_00002r52; pdb_00002r53; pdb_00002tgi; 
				pdb_00003b4v; pdb_00003bk3; pdb_00003bmp; pdb_00003eo1; pdb_00003evs; pdb_00003hh2; pdb_00003kfd; pdb_00003qb4; pdb_00003sek; pdb_00004fao; pdb_00004kv5; pdb_00004kxz; 
				pdb_00004mid; pdb_00004mpl; pdb_00004n1d; pdb_00004uhy; pdb_00004uhz; pdb_00004ui0; pdb_00004ui1; pdb_00004ui2; pdb_00004ycg; pdb_00004yci; pdb_00005e4g; pdb_00005f3b; 
				pdb_00005f3h; pdb_00005ffo; pdb_00005hk5; pdb_00005hly; pdb_00005hlz; pdb_00005hzw; pdb_00005i05; pdb_00005jhw; pdb_00005ji1; pdb_00005ntu; pdb_00005nxs; pdb_00005tx2; 
				pdb_00005tx4; pdb_00005tx6; pdb_00005ty4; pdb_00005uhm; pdb_00005vqf; pdb_00005vqp; pdb_00006i9j; pdb_00006mac; pdb_00006omn; pdb_00006omo; pdb_00006sf1; pdb_00006sf3; 
				pdb_00006uja; pdb_00006umx; pdb_00006xm2; pdb_00006y6n; pdb_00006y6o; pdb_00006z3g; pdb_00006z3h; pdb_00006z3j; pdb_00006z3l; pdb_00006z3m; pdb_00007ag0; pdb_00007l0j; 
				pdb_00007mrz; pdb_00007oly; pdb_00007ppa; pdb_00007ppb; pdb_00007ppc; pdb_00007rco; pdb_00007u5o; pdb_00007u5p; pdb_00007y1r; pdb_00007y1t; pdb_00007zjf; pdb_00008bwl; 
				pdb_00008bwm; pdb_00008bwn; pdb_00008dc0; pdb_00008e3g; pdb_00008fxs; pdb_00008fxv; pdb_00008udz; pdb_00008v52; pdb_00008vs6; pdb_00008vsb; pdb_00008vsc; pdb_00008vsd; 
				pdb_00009b9f; pdb_00009dpm; pdb_00009dpn; pdb_00009dpo; pdb_00009dpp; pdb_00009dpq; pdb_00009dpr; pdb_00009dps; pdb_00009dpt; pdb_00009dpu; pdb_00009dpv; pdb_00009dpw; 
				pdb_00009dpx; pdb_00009dpy; pdb_00009fdy; pdb_00009fk5; pdb_00009fkp; pdb_00009i5w
			
			

			» more