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PROSITE entry PS00250


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General information about the entry

Entry name [info] TGF_BETA_1
Accession [info] PS00250
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-1990 DATA UPDATE;
13-SEP-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00223

Name and characterization of the entry

Description [info] TGF-beta family signature.
Pattern [info] 
[LIVM]-x(2)-P-x(2)-[FY]-x(4)-C-x-G-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_04 which contains 570'157 sequence entries.


Total number of hits 205 in 205 different sequences
Number of true positive hits 203 in 203 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 23
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.02 %
Recall (true positives / (true positives + false negatives)) 89.82 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 7
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 203 sequences 

60A_DROME   (P27091), 60A_DROVI   (Q24735), BMP10_HUMAN (O95393), 

BMP10_MOUSE (Q9R229), BMP10_RAT   (Q4AEG6), BMP15_BOVIN (Q6PX77), 
BMP15_HUMAN (O95972), BMP15_MOUSE (Q9Z0L4), BMP15_SHEEP (Q9MZE2), 
BMP2A_XENLA (P25703), BMP2B_XENLA (P30884), BMP2_CHICK  (Q90751), 
BMP2_DAMDA  (O19006), BMP2_HUMAN  (P12643), BMP2_MOUSE  (P21274), 
BMP2_RABIT  (O46564), BMP2_RAT(P49001), BMP2_TETNG  (Q804S2), 
BMP3_BOVIN  (P22444), BMP3_HUMAN  (P12645), BMP3_MOUSE  (Q8BHE5), 
BMP3_RAT(P49002), BMP3_XENLA  (Q7T2X7), BMP4_BOVIN  (Q2KJH1), 
BMP4_CHICK  (Q90752), BMP4_DAMDA  (Q29607), BMP4_HUMAN  (P12644), 
BMP4_MOUSE  (P21275), BMP4_RABIT  (O46576), BMP4_RAT(Q06826), 
BMP4_SUNMU  (Q8MJV5), BMP4_XENLA  (P30885), BMP5_HUMAN  (P22003), 
BMP5_MOUSE  (P49003), BMP6_HUMAN  (P22004), BMP6_MOUSE  (P20722), 
BMP6_RAT(Q04906), BMP7_HUMAN  (P18075), BMP7_MOUSE  (P23359), 
BMP7_XENLA  (P30886), BMP8A_HUMAN (Q7Z5Y6), BMP8A_MOUSE (P34821), 
BMP8B_HUMAN (P34820), BMP8B_MOUSE (P55105), DAF7_CAEEL  (P92172), 
DBL1_CAEEL  (G5EEL5), DECA_DROME  (P07713), DECA_DROPS  (P91699), 
DECA_DROSI  (P91706), DECA_TRICA  (Q26974), DERR_XENTR  (Q66KL4), 
DSL1_CHICK  (P34822), DVR1_DANRE  (P35621), DVR1_STRPU  (P48969), 
DVR1_XENLA  (P09534), GDF10_BOVIN (Q08DX6), GDF10_HUMAN (P55107), 
GDF10_MOUSE (P97737), GDF10_RAT   (P55108), GDF10_XENLA (Q7T2X6), 
GDF11_HUMAN (O95390), GDF11_MOUSE (Q9Z1W4), GDF11_RAT   (Q9Z217), 
GDF1_HUMAN  (P27539), GDF1_MOUSE  (P20863), GDF2_DANRE  (F1QWZ4), 
GDF2_HUMAN  (Q9UK05), GDF2_MOUSE  (Q9WV56), GDF3_HUMAN  (Q9NR23), 
GDF3_MOUSE  (Q07104), GDF3_XENLA  (Q9YGV1), GDF5_HUMAN  (P43026), 
GDF5_MOUSE  (P43027), GDF6A_DANRE (P85857), GDF6B_DANRE (A8E7N9), 
GDF6_BOVIN  (P55106), GDF6_HUMAN  (Q6KF10), GDF6_MOUSE  (P43028), 
GDF6_RAT(Q6HA10), GDF7_CHLAE  (Q9BDW8), GDF7_HUMAN  (Q7Z4P5), 
GDF7_MOUSE  (P43029), GDF8_AEPME  (Q5USV7), GDF8_ANSAN  (Q8UWD9), 
GDF8_ANTAM  (Q5USV5), GDF8_BOSGA  (Q5USW1), GDF8_BOSIN  (Q5RZV4), 
GDF8_BOVIN  (O18836), GDF8_BUBBU  (Q6X5V1), GDF8_CANLF  (Q6UKZ8), 
GDF8_CAPHI  (Q6T5B8), GDF8_CAPIB  (Q5USV9), GDF8_CHICK  (O42220), 
GDF8_COLLI  (Q8UWD8), GDF8_COTCO  (Q8AVB2), GDF8_DANRE  (O42222), 
GDF8_EPICO  (Q5I3Q2), GDF8_EXCCH  (Q8UWD7), GDF8_GORGO  (A1C2V5), 
GDF8_HEMJE  (Q5USV8), GDF8_HORSE  (Q9GM97), GDF8_HUMAN  (O14793), 
GDF8_LEPCA  (Q8HY52), GDF8_MACFA  (Q95J86), GDF8_MACMU  (A1C2U6), 
GDF8_MELGA  (O42221), GDF8_MOUSE  (O08689), GDF8_OREMO  (Q98TB4), 
GDF8_PANPA  (A1C2U7), GDF8_PANTR  (A1C2V0), GDF8_PAPHA  (O18828), 
GDF8_PIG(O18831), GDF8_PONPY  (A1C2U3), GDF8_RAT(O35312), 
GDF8_SHEEP  (O18830), GDF8_SYLGR  (Q5USV6), GDF8_TAUDE  (Q5USW0), 
GDF8_VULLA  (Q6J1J2), GDF8_VULVU  (Q6DTL9), GDF9_BOVIN  (Q9GK68), 
GDF9_CAPHI  (Q66NC0), GDF9_HUMAN  (O60383), GDF9_MOUSE  (Q07105), 
GDF9_PAPAN  (A9CB18), GDF9_SHEEP  (O77681), INHA_BOVIN  (P07994), 
INHA_CHICK  (P43031), INHA_HORSE  (P55101), INHA_HUMAN  (P05111), 
INHA_MOUSE  (Q04997), INHA_PIG(P04087), INHA_RAT(P17490), 
INHA_SHEEP  (P38440), INHA_TRIVU  (O77755), INHBA_BOVIN (P07995), 
INHBA_FELCA (Q6X2S4), INHBA_HORSE (P55102), INHBA_HUMAN (P08476), 
INHBA_MOUSE (Q04998), INHBA_PIG   (P03970), INHBA_RAT   (P18331), 
INHBA_SHEEP (P43032), INHBB_BOVIN (P42917), INHBB_CHICK (P27093), 
INHBB_HUMAN (P09529), INHBB_MOUSE (Q04999), INHBB_PIG   (P04088), 
INHBB_RAT   (P17491), INHBC_HUMAN (P55103), INHBC_MOUSE (P55104), 
INHBC_RAT   (Q9WUK5), INHBE_HUMAN (P58166), INHBE_MOUSE (O08717), 
INHBE_RAT   (O88959), INHB_DROME  (O61643), LFTY1_HUMAN (O75610), 
LFTY1_MOUSE (Q64280), LFTY2_HUMAN (O00292), LFTY2_MOUSE (P57785), 
MIS_BOVIN   (P03972), MIS_HUMAN   (P03971), MIS_MOUSE   (P27106), 
MIS_PIG (P79295), MIS_RAT (P49000), NOD2A_XENLA (Q91620), 
NOD2B_XENLA (Q90XB7), NOD4A_XENLA (O13048), NOD4B_XENLA (Q90XB8), 
NODAL_HUMAN (Q96S42), NODAL_MOUSE (P43021), NODAL_XENLA (Q91619), 
NODAL_XENTR (Q28GB8), SCW_DROME   (P54631), TGFB1_BOVIN (P18341), 
TGFB1_CANLF (P54831), TGFB1_CAVPO (Q9Z1Y6), TGFB1_CHICK (P09531), 
TGFB1_CHLAE (P09533), TGFB1_CYPCA (Q9PTQ2), TGFB1_HORSE (O19011), 
TGFB1_HUMAN (P01137), TGFB1_MOUSE (P04202), TGFB1_MUSPF (Q38HS2), 
TGFB1_ONCMY (O93449), TGFB1_PIG   (P07200), TGFB1_RAT   (P17246), 
TGFB1_SHEEP (P50414), TGFB1_XENLA (P16176), TGFB2_BOVIN (P21214), 
TGFB2_CHICK (P30371), TGFB2_CHLAE (P61811), TGFB2_HUMAN (P61812), 
TGFB2_MOUSE (P27090), TGFB2_MUSPF (Q38L25), TGFB2_PIG   (P09858), 
TGFB2_RAT   (Q07257), TGFB2_XENLA (P17247), TGFB3_CHICK (P16047), 
TGFB3_HUMAN (P10600), TGFB3_MOUSE (P17125), TGFB3_PIG   (P15203), 
TGFB3_RAT   (Q07258), UNIV_STRPU  (P48970)
» more

UniProtKB/Swiss-Prot
False negative sequences		 23 sequences 

ARTN_HUMAN  (Q5T4W7), ARTN_MOUSE  (Q9Z0L2), ARTN_RAT(Q6AYE8), 

GDF15_HUMAN (Q99988), GDF15_MOUSE (Q9Z0J7), GDF15_RAT   (Q9Z0J6), 
GDF8_ANAPL  (Q8UWE0), GDNF_DANRE  (Q98TU0), GDNF_HUMAN  (P39905), 
GDNF_MOUSE  (P48540), GDNF_RAT(Q07731), GDNF_XENLA  (Q06PM8), 
INHBA_CHICK (P27092), NOD3A_XENLA (Q91609), NOD3A_XENTR (Q800C0), 
NOD3B_XENLA (Q91621), NOD3B_XENTR (Q800B9), NOD3C_XENTR (Q800B8), 
NRTN_HUMAN  (Q99748), NRTN_MOUSE  (P97463), PSPN_HUMAN  (O60542), 
PSPN_MOUSE  (O70300), PSPN_RAT(O70301)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

BMP7_CANLF  (P34819)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			2 sequences
			


			
ACOXL_MOUSE (Q9DBS4), CLPX_MYXXA  (Q9X5N1)


				
	

	

		PDB
[Detailed view]		
		
			109 PDB
			


			1BMP; 1ES7; 1KLA; 1KLC; 1KLD; 1KTZ; 1LX5; 1LXI; 1M4U; 1NYS; 1NYU; 1REU; 
			
				1REW; 1S4Y; 1TFG; 1TGJ; 1TGK; 1WAQ; 1ZKZ; 2ARP; 2ARV; 2B0U; 2BHK; 2GOO; 
				2H62; 2H64; 2P6A; 2PJY; 2QCQ; 2QCW; 2QJ9; 2QJA; 2QJB; 2R52; 2R53; 2TGI; 
				3B4V; 3BK3; 3BMP; 3EO1; 3EVS; 3HH2; 3KFD; 3QB4; 3RJR; 3SEK; 4FAO; 4KV5; 
				4KXZ; 4MID; 4MPL; 4N1D; 4UHY; 4UHZ; 4UI0; 4UI1; 4UI2; 4YCG; 4YCI; 5E4G; 
				5F3B; 5F3H; 5FFO; 5HK5; 5HLY; 5HLZ; 5HZW; 5I05; 5JHW; 5JI1; 5NTU; 5NXS; 
				5TX2; 5TX4; 5TX6; 5TY4; 5UHM; 5VQF; 5VQP; 6I9J; 6MAC; 6OMN; 6OMO; 6SF1; 
				6SF3; 6UJA; 6UMX; 6XM2; 6Y6N; 6Y6O; 6Z3G; 6Z3H; 6Z3J; 6Z3L; 6Z3M; 7AG0; 
				7L0J; 7MRZ; 7OLY; 7PPA; 7PPB; 7PPC; 7RCO; 7U5O; 7U5P; 7Y1R; 7Y1T; 7ZJF; 
				8E3G
			
			

			» more