PROSITE entry PS00251

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PURL: https://purl.expasy.org/prosite/signature/PS00251

Direct ScanProsite submission

General information about the entry

Entry name [info]	THD_1
Accession [info]	PS00251
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00224

Name and characterization of the entry

Description [info]	Tumor necrosis factor (TNF) homology domain (THD) signature.
Pattern [info]	[LV]-x-[LIVM]-{V}-x-{L}-G-[LIVMF]-Y-[LIVMFY](2)-x(2)-[QEKHL]-[LIVMGT]-x- [LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	93 in 93 different sequences
Number of true positive hits	88 in 88 different sequences
Number of 'unknown' hits	0
Number of false positive hits	5 in 5 different sequences
Number of false negative sequences	21
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	94.62 %
Recall (true positives / (true positives + false negatives))	80.73 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	88 sequences CD40L_AOTTR (Q9BDM3), CD40L_BOVIN (P51749), CD40L_CALJA (Q9BDN3), CD40L_CANLF (O97626), CD40L_CERAT (P63305), CD40L_CHICK (Q9I8D8), CD40L_FELCA (O97605), CD40L_HUMAN (P29965), CD40L_MACMU (P63304), CD40L_MACNE (Q9BDM7), CD40L_MOUSE (P27548), CD40L_PIG (Q95MQ5), CD40L_RAT (Q9Z2V2), CD70_HUMAN (P32970), EIGER_DROME (Q8MUJ1), TNF10_HUMAN (P50591), TNF10_MOUSE (P50592), TNF13_HUMAN (O75888), TNF13_MOUSE (Q9D777), TNFA_BOSIN (P59684), TNFA_BOSTR (Q1G1A2), TNFA_BOVIN (Q06599), TNFA_BUBBU (P59693), TNFA_BUBCA (Q2MH05), TNFA_CALJA (Q19LH4), TNFA_CAMBA (Q75N23), TNFA_CANLF (P51742), TNFA_CAPHI (P13296), TNFA_CAVPO (P51435), TNFA_CEREL (P51743), TNFA_DASNO (Q1WM27), TNFA_DELLE (Q8WNR1), TNFA_FELCA (P19101), TNFA_HORSE (P29553), TNFA_HUMAN (P01375), TNFA_LAMGL (P59694), TNFA_MACFA (P79337), TNFA_MACMU (P48094), TNFA_MARMO (O35734), TNFA_MOUSE (P06804), TNFA_NOTEU (O77764), TNFA_PANTR (Q8HZD9), TNFA_PAPAN (P59695), TNFA_PAPHU (O77510), TNFA_PAPSP (P33620), TNFA_PERLE (P36939), TNFA_PIG(P23563), TNFA_RABIT (P04924), TNFA_RAT(P16599), TNFA_SAISC (Q8MKG8), TNFA_SHEEP (P23383), TNFA_TRIVU (P79374), TNFA_TUPTA (Q539C2), TNFA_TURTR (Q9BEA1), TNFB_BOVIN (Q06600), TNFB_CANLF (Q5WR07), TNFB_HUMAN (P01374), TNFB_MACMU (Q5TM20), TNFB_MARMO (Q9JM09), TNFB_MOUSE (P09225), TNFB_NOTEU (Q9XT48), TNFB_PANTR (P61125), TNFB_PIG(P26445), TNFB_RABIT (P10154), TNFB_RAT(Q06332), TNFC_HUMAN (Q06643), TNFC_MACMU (Q5TM22), TNFC_MOUSE (P41155), TNFC_NOTEU (Q9XT47), TNFC_PANTR (Q862Z7), TNFC_PIG(Q9TSV8), TNFL4_HUMAN (P23510), TNFL4_MOUSE (P43488), TNFL4_RABIT (O02765), TNFL4_RAT (Q9Z2P3), TNFL6_CERAT (Q9BDN1), TNFL6_FELCA (Q861W5), TNFL6_HUMAN (P48023), TNFL6_MACFA (P63308), TNFL6_MACMU (P63307), TNFL6_MACNE (P63306), TNFL6_MOUSE (P41047), TNFL6_PIG (Q9BEA8), TNFL6_RAT (P36940), TNFL8_HUMAN (P32971), TNFL8_MOUSE (P32972), TNFL9_HUMAN (P41273), TNFL9_MOUSE (P41274) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	21 sequences CD70_MOUSE (O55237), CD70_PIG(Q3ZDR4), EDA_BOVIN (Q9BEG5), EDA_HUMAN (Q92838), EDA_MOUSE (O54693), TN13B_HUMAN (Q9Y275), TN13B_MOUSE (Q9WU72), TNF11_HUMAN (O14788), TNF11_MOUSE (O35235), TNF11_RAT (Q9ESE2), TNF12_HUMAN (O43508), TNF12_MOUSE (O54907), TNF14_HUMAN (O43557), TNF14_MOUSE (Q9QYH9), TNF15_HUMAN (O95150), TNF15_MOUSE (Q5UBV8), TNF15_RAT (Q8K3Y7), TNF18_HUMAN (Q9UNG2), TNF18_MOUSE (Q7TS55), TNFA_SPAAU (Q8JFG3), TNFC_MARMO (Q9JM10) » more
UniProtKB/Swiss-Prot False positive sequences	5 sequences ATP6_VANPO (A6H4Q8), LIVH_METJA (Q58665), LNT2_LEPIC (Q72MD8), LNT2_LEPIN (Q8EYY4), PCID2_DROME (Q9VTL1) » more
PDB [Detailed view]	84 PDB pdb_00001a8m; pdb_00001aly; pdb_00001d0g; pdb_00001d2q; pdb_00001d4v; pdb_00001dg6; pdb_00001du3; pdb_00001i9r; pdb_00001tnf; pdb_00001tnr; pdb_00001u5x; pdb_00001u5y; pdb_00001u5z; pdb_00001xu1; pdb_00001xu2; pdb_00002az5; pdb_00002e7a; pdb_00002hev; pdb_00002hew; pdb_00002hey; pdb_00002tnf; pdb_00002tun; pdb_00002x29; pdb_00002zjc; pdb_00002zpx; pdb_00003alq; pdb_00003it8; pdb_00003k48; pdb_00003l9j; pdb_00003lkj; pdb_00003qd6; pdb_00003wd5; pdb_00004g3y; pdb_00004msv; pdb_00004mxv; pdb_00004mxw; pdb_00004n90; pdb_00004twt; pdb_00004zch; pdb_00005cir; pdb_00005l19; pdb_00005l36; pdb_00005m2i; pdb_00005m2j; pdb_00005m2m; pdb_00005mu8; pdb_00005uui; pdb_00005wux; pdb_00005yoy; pdb_00006a3v; pdb_00006brb; pdb_00006bwv; pdb_00006cpr; pdb_00006cu0; pdb_00006d3n; pdb_00006fib; pdb_00006mge; pdb_00006mgp; pdb_00006mkb; pdb_00006mkz; pdb_00006ooy; pdb_00006ooz; pdb_00006op0; pdb_00006rmj; pdb_00006w9g; pdb_00006x81; pdb_00006x82; pdb_00006x83; pdb_00006x85; pdb_00006x86; pdb_00006zt0; pdb_00007jra; pdb_00007kp7; pdb_00007kp8; pdb_00007kp9; pdb_00007kpa; pdb_00007kpb; pdb_00007kx0; pdb_00007sgm; pdb_00007ta3; pdb_00007ta6; pdb_00008kb6; pdb_00008slr; pdb_00008z8m » more