PROSITE logo

PROSITE entry PS00251


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] THD_1
Accession [info] PS00251
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00224

Name and characterization of the entry

Description [info] Tumor necrosis factor (TNF) homology domain (THD) signature.
Pattern [info] 
[LV]-x-[LIVM]-{V}-x-{L}-G-[LIVMF]-Y-[LIVMFY](2)-x(2)-[QEKHL]-[LIVMGT]-x-
[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 88 in 88 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 21
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 94.62 %
Recall (true positives / (true positives + false negatives)) 80.73 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 88 sequences 

CD40L_AOTTR (Q9BDM3), CD40L_BOVIN (P51749), CD40L_CALJA (Q9BDN3), 

CD40L_CANLF (O97626), CD40L_CERAT (P63305), CD40L_CHICK (Q9I8D8), 
CD40L_FELCA (O97605), CD40L_HUMAN (P29965), CD40L_MACMU (P63304), 
CD40L_MACNE (Q9BDM7), CD40L_MOUSE (P27548), CD40L_PIG   (Q95MQ5), 
CD40L_RAT   (Q9Z2V2), CD70_HUMAN  (P32970), EIGER_DROME (Q8MUJ1), 
TNF10_HUMAN (P50591), TNF10_MOUSE (P50592), TNF13_HUMAN (O75888), 
TNF13_MOUSE (Q9D777), TNFA_BOSIN  (P59684), TNFA_BOSTR  (Q1G1A2), 
TNFA_BOVIN  (Q06599), TNFA_BUBBU  (P59693), TNFA_BUBCA  (Q2MH05), 
TNFA_CALJA  (Q19LH4), TNFA_CAMBA  (Q75N23), TNFA_CANLF  (P51742), 
TNFA_CAPHI  (P13296), TNFA_CAVPO  (P51435), TNFA_CEREL  (P51743), 
TNFA_DASNO  (Q1WM27), TNFA_DELLE  (Q8WNR1), TNFA_FELCA  (P19101), 
TNFA_HORSE  (P29553), TNFA_HUMAN  (P01375), TNFA_LAMGL  (P59694), 
TNFA_MACFA  (P79337), TNFA_MACMU  (P48094), TNFA_MARMO  (O35734), 
TNFA_MOUSE  (P06804), TNFA_NOTEU  (O77764), TNFA_PANTR  (Q8HZD9), 
TNFA_PAPAN  (P59695), TNFA_PAPHU  (O77510), TNFA_PAPSP  (P33620), 
TNFA_PERLE  (P36939), TNFA_PIG(P23563), TNFA_RABIT  (P04924), 
TNFA_RAT(P16599), TNFA_SAISC  (Q8MKG8), TNFA_SHEEP  (P23383), 
TNFA_TRIVU  (P79374), TNFA_TUPTA  (Q539C2), TNFA_TURTR  (Q9BEA1), 
TNFB_BOVIN  (Q06600), TNFB_CANLF  (Q5WR07), TNFB_HUMAN  (P01374), 
TNFB_MACMU  (Q5TM20), TNFB_MARMO  (Q9JM09), TNFB_MOUSE  (P09225), 
TNFB_NOTEU  (Q9XT48), TNFB_PANTR  (P61125), TNFB_PIG(P26445), 
TNFB_RABIT  (P10154), TNFB_RAT(Q06332), TNFC_HUMAN  (Q06643), 
TNFC_MACMU  (Q5TM22), TNFC_MOUSE  (P41155), TNFC_NOTEU  (Q9XT47), 
TNFC_PANTR  (Q862Z7), TNFC_PIG(Q9TSV8), TNFL4_HUMAN (P23510), 
TNFL4_MOUSE (P43488), TNFL4_RABIT (O02765), TNFL4_RAT   (Q9Z2P3), 
TNFL6_CERAT (Q9BDN1), TNFL6_FELCA (Q861W5), TNFL6_HUMAN (P48023), 
TNFL6_MACFA (P63308), TNFL6_MACMU (P63307), TNFL6_MACNE (P63306), 
TNFL6_MOUSE (P41047), TNFL6_PIG   (Q9BEA8), TNFL6_RAT   (P36940), 
TNFL8_HUMAN (P32971), TNFL8_MOUSE (P32972), TNFL9_HUMAN (P41273), 
TNFL9_MOUSE (P41274)
» more

UniProtKB/Swiss-Prot
False negative sequences		 21 sequences 

CD70_MOUSE  (O55237), CD70_PIG(Q3ZDR4), EDA_BOVIN   (Q9BEG5), 

EDA_HUMAN   (Q92838), EDA_MOUSE   (O54693), TN13B_HUMAN (Q9Y275), 
TN13B_MOUSE (Q9WU72), TNF11_HUMAN (O14788), TNF11_MOUSE (O35235), 
TNF11_RAT   (Q9ESE2), TNF12_HUMAN (O43508), TNF12_MOUSE (O54907), 
TNF14_HUMAN (O43557), TNF14_MOUSE (Q9QYH9), TNF15_HUMAN (O95150), 
TNF15_MOUSE (Q5UBV8), TNF15_RAT   (Q8K3Y7), TNF18_HUMAN (Q9UNG2), 
TNF18_MOUSE (Q7TS55), TNFA_SPAAU  (Q8JFG3), TNFC_MARMO  (Q9JM10)
» more

UniProtKB/Swiss-Prot
False positive sequences		 5 sequences 

ATP6_VANPO  (A6H4Q8), LIVH_METJA  (Q58665), LNT2_LEPIC  (Q72MD8), 

LNT2_LEPIN  (Q8EYY4), PCID2_DROME (Q9VTL1)
» more

PDB
[Detailed view]		 83 PDB

1A8M; 1ALY; 1D0G; 1D2Q; 1D4V; 1DG6; 1DU3; 1I9R; 1TNF; 1TNR; 1U5X; 1U5Y; 1U5Z; 1XU1; 1XU2; 2AZ5; 2E7A; 2HEV; 2HEW; 2HEY; 2TNF; 2TUN; 2X29; 2ZJC; 2ZPX; 3ALQ; 3IT8; 3K48; 3L9J; 3LKJ; 3QD6; 3WD5; 4G3Y; 4MSV; 4MXV; 4MXW; 4N90; 4TWT; 4ZCH; 5CIR; 5L19; 5L36; 5M2I; 5M2J; 5M2M; 5MU8; 5UUI; 5WUX; 5YOY; 6A3V; 6BRB; 6BWV; 6CPR; 6CU0; 6D3N; 6FIB; 6MGE; 6MGP; 6MKB; 6MKZ; 6OOY; 6OOZ; 6OP0; 6RMJ; 6W9G; 6X81; 6X82; 6X83; 6X85; 6X86; 6ZT0; 7JRA; 7KP7; 7KP8; 7KP9; 7KPA; 7KPB; 7KX0; 7SGM; 7TA3; 7TA6; 8KB6; 8SLR
» more