PROSITE entry PS00251
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General information about the entry
| Entry name [info] | TNF_1 |
| Accession [info] | PS00251 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE; 13-SEP-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00224 |
Name and characterization of the entry
| Description [info] | TNF family signature. |
| Pattern [info] |
[LV]-x-[LIVM]-{V}-x-{L}-G-[LIVMF]-Y-[LIVMFY](2)-x(2)-[QEKHL]-[LIVMGT]-x-
[LIVMFY].
|
Numerical results [info]
| Total number of hits | 93 in 93 different sequences |
| Number of true positive hits | 88 in 88 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 5 in 5 different sequences |
| Number of false negative sequences | 16 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 94.62 % |
| Recall (true positives / (true positives + false negatives)) | 84.62 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
88 sequences
CD40L_AOTTR (Q9BDM3), CD40L_BOVIN (P51749), CD40L_CALJA (Q9BDN3), CD40L_CANLF (O97626), CD40L_CERAT (P63305), CD40L_CHICK (Q9I8D8), CD40L_FELCA (O97605), CD40L_HUMAN (P29965), CD40L_MACMU (P63304), CD40L_MACNE (Q9BDM7), CD40L_MOUSE (P27548), CD40L_PIG (Q95MQ5), CD40L_RAT (Q9Z2V2), CD70_HUMAN (P32970), EIGER_DROME (Q8MUJ1), TNF10_HUMAN (P50591), TNF10_MOUSE (P50592), TNF13_HUMAN (O75888), TNF13_MOUSE (Q9D777), TNFA_BOSIN (P59684), TNFA_BOSTR (Q1G1A2), TNFA_BOVIN (Q06599), TNFA_BUBBU (P59693), TNFA_BUBCA (Q2MH05), TNFA_CALJA (Q19LH4), TNFA_CAMBA (Q75N23), TNFA_CANLF (P51742), TNFA_CAPHI (P13296), TNFA_CAVPO (P51435), TNFA_CEREL (P51743), TNFA_DASNO (Q1WM27), TNFA_DELLE (Q8WNR1), TNFA_FELCA (P19101), TNFA_HORSE (P29553), TNFA_HUMAN (P01375), TNFA_LAMGL (P59694), TNFA_MACFA (P79337), TNFA_MACMU (P48094), TNFA_MARMO (O35734), TNFA_MOUSE (P06804), TNFA_NOTEU (O77764), TNFA_PANTR (Q8HZD9), TNFA_PAPAN (P59695), TNFA_PAPHU (O77510), TNFA_PAPSP (P33620), TNFA_PERLE (P36939), TNFA_PIG(P23563), TNFA_RABIT (P04924), TNFA_RAT(P16599), TNFA_SAISC (Q8MKG8), TNFA_SHEEP (P23383), TNFA_TRIVU (P79374), TNFA_TUPTA (Q539C2), TNFA_TURTR (Q9BEA1), TNFB_BOVIN (Q06600), TNFB_CANLF (Q5WR07), TNFB_HUMAN (P01374), TNFB_MACMU (Q5TM20), TNFB_MARMO (Q9JM09), TNFB_MOUSE (P09225), TNFB_NOTEU (Q9XT48), TNFB_PANTR (P61125), TNFB_PIG(P26445), TNFB_RABIT (P10154), TNFB_RAT(Q06332), TNFC_HUMAN (Q06643), TNFC_MACMU (Q5TM22), TNFC_MOUSE (P41155), TNFC_NOTEU (Q9XT47), TNFC_PANTR (Q862Z7), TNFC_PIG(Q9TSV8), TNFL4_HUMAN (P23510), TNFL4_MOUSE (P43488), TNFL4_RABIT (O02765), TNFL4_RAT (Q9Z2P3), TNFL6_CERAT (Q9BDN1), TNFL6_FELCA (Q861W5), TNFL6_HUMAN (P48023), TNFL6_MACFA (P63308), TNFL6_MACMU (P63307), TNFL6_MACNE (P63306), TNFL6_MOUSE (P41047), TNFL6_PIG (Q9BEA8), TNFL6_RAT (P36940), TNFL8_HUMAN (P32971), TNFL8_MOUSE (P32972), TNFL9_HUMAN (P41273), TNFL9_MOUSE (P41274)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
16 sequences
EDA_BOVIN (Q9BEG5), EDA_HUMAN (Q92838), EDA_MOUSE (O54693), TN13B_HUMAN (Q9Y275), TN13B_MOUSE (Q9WU72), TNF11_HUMAN (O14788), TNF11_MOUSE (O35235), TNF11_RAT (Q9ESE2), TNF12_HUMAN (O43508), TNF12_MOUSE (O54907), TNF14_HUMAN (O43557), TNF14_MOUSE (Q9QYH9), TNF18_HUMAN (Q9UNG2), TNF18_MOUSE (Q7TS55), TNFA_SPAAU (Q8JFG3), TNFC_MARMO (Q9JM10)» more |
| UniProtKB/Swiss-Prot False positive sequences |
5 sequences
ATP6_VANPO (A6H4Q8), LIVH_METJA (Q58665), LNT2_LEPIC (Q72MD8), LNT2_LEPIN (Q8EYY4), PCID2_DROME (Q9VTL1)» more |
| PDB [Detailed view] |
81 PDB
1A8M; 1ALY; 1D0G; 1D2Q; 1D4V; 1DG6; 1DU3; 1I9R; 1TNF; 1TNR; 1U5X; 1U5Y; 1U5Z; 1XU1; 1XU2; 2AZ5; 2E7A; 2HEV; 2HEW; 2HEY; 2TNF; 2TUN; 2X29; 2ZJC; 2ZPX; 3ALQ; 3IT8; 3K48; 3L9J; 3LKJ; 3QD6; 3WD5; 4G3Y; 4MSV; 4MXV; 4MXW; 4N90; 4TWT; 4ZCH; 5CIR; 5L19; 5L36; 5M2I; 5M2J; 5M2M; 5MU8; 5UUI; 5WUX; 5YOY; 6A3V; 6BRB; 6BWV; 6CPR; 6CU0; 6D3N; 6FIB; 6MGE; 6MGP; 6MKB; 6MKZ; 6OOY; 6OOZ; 6OP0; 6RMJ; 6W9G; 6X81; 6X82; 6X83; 6X85; 6X86; 6ZT0; 7JRA; 7KP7; 7KP8; 7KP9; 7KPA; 7KPB; 7KX0; 7SGM; 7TA3; 7TA6 » more |