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PROSITE entry PS00251


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General information about the entry

Entry name [info] THD_1
Accession [info] PS00251
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00224

Name and characterization of the entry

Description [info] Tumor necrosis factor (TNF) homology domain (THD) signature.
Pattern [info] 
[LV]-x-[LIVM]-{V}-x-{L}-G-[LIVMF]-Y-[LIVMFY](2)-x(2)-[QEKHL]-[LIVMGT]-x-
[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 88 in 88 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 21
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 94.62 %
Recall (true positives / (true positives + false negatives)) 80.73 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 88 sequences 

CD40L_AOTTR (Q9BDM3), CD40L_BOVIN (P51749), CD40L_CALJA (Q9BDN3), 

CD40L_CANLF (O97626), CD40L_CERAT (P63305), CD40L_CHICK (Q9I8D8), 
CD40L_FELCA (O97605), CD40L_HUMAN (P29965), CD40L_MACMU (P63304), 
CD40L_MACNE (Q9BDM7), CD40L_MOUSE (P27548), CD40L_PIG   (Q95MQ5), 
CD40L_RAT   (Q9Z2V2), CD70_HUMAN  (P32970), EIGER_DROME (Q8MUJ1), 
TNF10_HUMAN (P50591), TNF10_MOUSE (P50592), TNF13_HUMAN (O75888), 
TNF13_MOUSE (Q9D777), TNFA_BOSIN  (P59684), TNFA_BOSTR  (Q1G1A2), 
TNFA_BOVIN  (Q06599), TNFA_BUBBU  (P59693), TNFA_BUBCA  (Q2MH05), 
TNFA_CALJA  (Q19LH4), TNFA_CAMBA  (Q75N23), TNFA_CANLF  (P51742), 
TNFA_CAPHI  (P13296), TNFA_CAVPO  (P51435), TNFA_CEREL  (P51743), 
TNFA_DASNO  (Q1WM27), TNFA_DELLE  (Q8WNR1), TNFA_FELCA  (P19101), 
TNFA_HORSE  (P29553), TNFA_HUMAN  (P01375), TNFA_LAMGL  (P59694), 
TNFA_MACFA  (P79337), TNFA_MACMU  (P48094), TNFA_MARMO  (O35734), 
TNFA_MOUSE  (P06804), TNFA_NOTEU  (O77764), TNFA_PANTR  (Q8HZD9), 
TNFA_PAPAN  (P59695), TNFA_PAPHU  (O77510), TNFA_PAPSP  (P33620), 
TNFA_PERLE  (P36939), TNFA_PIG(P23563), TNFA_RABIT  (P04924), 
TNFA_RAT(P16599), TNFA_SAISC  (Q8MKG8), TNFA_SHEEP  (P23383), 
TNFA_TRIVU  (P79374), TNFA_TUPTA  (Q539C2), TNFA_TURTR  (Q9BEA1), 
TNFB_BOVIN  (Q06600), TNFB_CANLF  (Q5WR07), TNFB_HUMAN  (P01374), 
TNFB_MACMU  (Q5TM20), TNFB_MARMO  (Q9JM09), TNFB_MOUSE  (P09225), 
TNFB_NOTEU  (Q9XT48), TNFB_PANTR  (P61125), TNFB_PIG(P26445), 
TNFB_RABIT  (P10154), TNFB_RAT(Q06332), TNFC_HUMAN  (Q06643), 
TNFC_MACMU  (Q5TM22), TNFC_MOUSE  (P41155), TNFC_NOTEU  (Q9XT47), 
TNFC_PANTR  (Q862Z7), TNFC_PIG(Q9TSV8), TNFL4_HUMAN (P23510), 
TNFL4_MOUSE (P43488), TNFL4_RABIT (O02765), TNFL4_RAT   (Q9Z2P3), 
TNFL6_CERAT (Q9BDN1), TNFL6_FELCA (Q861W5), TNFL6_HUMAN (P48023), 
TNFL6_MACFA (P63308), TNFL6_MACMU (P63307), TNFL6_MACNE (P63306), 
TNFL6_MOUSE (P41047), TNFL6_PIG   (Q9BEA8), TNFL6_RAT   (P36940), 
TNFL8_HUMAN (P32971), TNFL8_MOUSE (P32972), TNFL9_HUMAN (P41273), 
TNFL9_MOUSE (P41274)
» more

UniProtKB/Swiss-Prot
False negative sequences		 21 sequences 

CD70_MOUSE  (O55237), CD70_PIG(Q3ZDR4), EDA_BOVIN   (Q9BEG5), 

EDA_HUMAN   (Q92838), EDA_MOUSE   (O54693), TN13B_HUMAN (Q9Y275), 
TN13B_MOUSE (Q9WU72), TNF11_HUMAN (O14788), TNF11_MOUSE (O35235), 
TNF11_RAT   (Q9ESE2), TNF12_HUMAN (O43508), TNF12_MOUSE (O54907), 
TNF14_HUMAN (O43557), TNF14_MOUSE (Q9QYH9), TNF15_HUMAN (O95150), 
TNF15_MOUSE (Q5UBV8), TNF15_RAT   (Q8K3Y7), TNF18_HUMAN (Q9UNG2), 
TNF18_MOUSE (Q7TS55), TNFA_SPAAU  (Q8JFG3), TNFC_MARMO  (Q9JM10)
» more

UniProtKB/Swiss-Prot
False positive sequences		 5 sequences 

ATP6_VANPO  (A6H4Q8), LIVH_METJA  (Q58665), LNT2_LEPIC  (Q72MD8), 

LNT2_LEPIN  (Q8EYY4), PCID2_DROME (Q9VTL1)
» more

PDB
[Detailed view]		 82 PDB

1A8M; 1ALY; 1D0G; 1D2Q; 1D4V; 1DG6; 1DU3; 1I9R; 1TNF; 1TNR; 1U5X; 1U5Y; 1U5Z; 1XU1; 1XU2; 2AZ5; 2E7A; 2HEV; 2HEW; 2HEY; 2TNF; 2TUN; 2X29; 2ZJC; 2ZPX; 3ALQ; 3IT8; 3K48; 3L9J; 3LKJ; 3QD6; 3WD5; 4G3Y; 4MSV; 4MXV; 4MXW; 4N90; 4TWT; 4ZCH; 5CIR; 5L19; 5L36; 5M2I; 5M2J; 5M2M; 5MU8; 5UUI; 5WUX; 5YOY; 6A3V; 6BRB; 6BWV; 6CPR; 6CU0; 6D3N; 6FIB; 6MGE; 6MGP; 6MKB; 6MKZ; 6OOY; 6OOZ; 6OP0; 6RMJ; 6W9G; 6X81; 6X82; 6X83; 6X85; 6X86; 6ZT0; 7JRA; 7KP7; 7KP8; 7KP9; 7KPA; 7KPB; 7KX0; 7SGM; 7TA3; 7TA6; 8SLR
» more