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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00252


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PURL: https://purl.expasy.org/prosite/signature/PS00252

Direct ScanProsite submission
General information about the entry

Entry name [info] INTERFERON_A_B_D
Accession [info] PS00252
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00225

Name and characterization of the entry

Description [info] Interferon alpha, beta and delta family signature.
Pattern [info] 
[FYH]-[FY]-x-[GNRCDS]-[LIVM]-x(2)-[FYL]-L-x(7)-[CY]-[AT]-W.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 82 in 82 different sequences
Number of true positive hits 81 in 81 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.78 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 81 sequences 

IFN10_HUMAN (P01566), IFN14_HUMAN (P01570), IFN16_HUMAN (P05015), 

IFN17_HUMAN (P01571), IFN21_HUMAN (P01568), IFNA1_BOVIN (P07348), 
IFNA1_CANLF (P81255), IFNA1_CHICK (P42165), IFNA1_HORSE (P05003), 
IFNA1_HUMAN (P01562), IFNA1_MOUSE (P01572), IFNA1_PIG   (P49879), 
IFNA1_RAT   (P05011), IFNA2_HORSE (P05004), IFNA2_HUMAN (P01563), 
IFNA2_MOUSE (P01573), IFNA3_CANLF (O97945), IFNA3_CHICK (Q90872), 
IFNA3_HORSE (P05005), IFNA4_HORSE (P05006), IFNA4_HUMAN (P05014), 
IFNA4_MOUSE (P07351), IFNA5_HUMAN (P01569), IFNA5_MOUSE (P07349), 
IFNA6_HUMAN (P05013), IFNA6_MOUSE (P07350), IFNA7_HUMAN (P01567), 
IFNA7_MOUSE (P06799), IFNA8_HUMAN (P32881), IFNA9_MOUSE (P09235), 
IFNAA_BOVIN (P05007), IFNAB_BOVIN (P05008), IFNAB_MOUSE (Q61716), 
IFNAC_BOVIN (P05009), IFNAC_MOUSE (Q80SS5), IFNAD_BOVIN (P05010), 
IFNAD_MOUSE (Q80SU4), IFNAF_BOVIN (P49876), IFNAG_BOVIN (P49877), 
IFNAH_BOVIN (P49878), IFNA_FELCA  (P35849), IFNA_MELGA  (P51527), 
IFNB2_BOVIN (P01576), IFNB3_BOVIN (P01577), IFNB_BOVIN  (P01578), 
IFNB_CHICK  (Q90873), IFNB_FELCA  (Q9N2J0), IFNB_HORSE  (P05012), 
IFNB_HUMAN  (P01574), IFNB_MACFA  (O77812), IFNB_MOUSE  (P01575), 
IFNB_RAT(P70499), IFNB_TACAC  (Q6XZW6), IFNE_HUMAN  (Q86WN2), 
IFNE_MOUSE  (Q80ZF2), IFNE_PIG(A7UHZ5), IFNK_HUMAN  (Q9P0W0), 
IFNK_MOUSE  (Q7TSL0), IFNT1_BOVIN (P15696), IFNT1_SHEEP (P56828), 
IFNT2_BOVIN (P56830), IFNT2_SHEEP (P56829), IFNT3_BOVIN (P56831), 
IFNT3_SHEEP (P56832), IFNT4_SHEEP (Q28594), IFNT5_SHEEP (Q28595), 
IFNT6_SHEEP (Q29429), IFNT7_SHEEP (Q08071), IFNT8_SHEEP (Q08072), 
IFNT9_SHEEP (Q08070), IFNTA_SHEEP (Q08053), IFNTB_SHEEP (P28169), 
IFNT_CAPHI  (P28171), IFNT_CEREL  (O46633), IFNT_GIRCA  (Q95187), 
IFNT_OVIMO  (P28172), IFNW1_BOVIN (P07352), IFNW1_HORSE (P05001), 
IFNW1_HUMAN (P05000), IFNW2_HORSE (P05002), IFN_ANAPL   (P51526)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

CNTP2_MOUSE (Q9CPW0)


				
	

	

		PDB
[Detailed view]		
		
			20 PDB
			


			pdb_00001au1; pdb_00001b5l; pdb_00001ifa; pdb_00001itf; pdb_00001rh2; pdb_00001wu3; pdb_00002hym; pdb_00002kz1; pdb_00002lag; pdb_00002lms; pdb_00003oq3; pdb_00003s9d; 
			
				pdb_00003se3; pdb_00003se4; pdb_00003ux9; pdb_00003wcy; pdb_00004ypg; pdb_00004z5r; pdb_00006jhd; pdb_00007e0e
			
			

			» more