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Amos Bairoch

PROSITE entry PS00260


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PURL: https://purl.expasy.org/prosite/signature/PS00260

Direct ScanProsite submission
General information about the entry

Entry name [info] GLUCAGON
Accession [info] PS00260
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00233

Name and characterization of the entry

Description [info] Glucagon / GIP / secretin / VIP family signature.
Pattern [info] 
[YH]-[STAIVGD]-[DEQ]-[AGF]-[LIVMSTE]-[FYLR]-x-[DENSTAK]-[DENSTA]-
[LIVMFYG]-x(8)-{K}-[KREQL]-[KRDENQL]-[LVFYWG]-[LIVQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 188 in 123 different sequences
Number of true positive hits 182 in 117 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 1
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.81 %
Recall (true positives / (true positives + false negatives)) 99.45 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 117 sequences 

EXE1_HELHO  (P0DJ94), EXE1_HELSU  (P04203), EXE2_HELSC  (C6EVG2), 

EXE2_HELSU  (P04204), EXE3_HELHO  (P20394), EXE4_HELSC  (C6EVG1), 
EXE4_HELSU  (P26349), GIP_BOVIN   (P09680), GIP_HUMAN   (P09681), 
GIP_MOUSE   (P48756), GIP_PIG (P01281), GIP_RAT (Q06145), 
GLUC1_HUSDA (C0HJJ3), GLUC1_LOPAM (P01278), GLUC1_ONCKI (P07449), 
GLUC1_ONCMY (Q91971), GLUC1_ORENI (P81026), GLUC1_PETMA (Q9PUR1), 
GLUC1_XENLA (O42143), GLUC2_LOPAM (P04092), GLUC2_ONCMY (Q91189), 
GLUC2_PETMA (Q9PUR0), GLUC2_XENLA (O42144), GLUC3_HUSDA (C0HJJ5), 
GLUC4_HUSDA (C0HJJ2), GLUC5_HUSDA (C0HJJ6), GLUCL_ANGAN (P63294), 
GLUCL_ANGRO (P63295), GLUCL_HYDCO (P23063), GLUC_ALLMI  (P68954), 
GLUC_AMICA  (P33528), GLUC_ANAPL  (P68952), GLUC_AQUCT  (P15438), 
GLUC_ATRSP  (P09566), GLUC_BOVIN  (P01272), GLUC_CALMI  (P13189), 
GLUC_CAMDR  (P68273), GLUC_CANLF  (P29794), GLUC_CARAU  (P79695), 
GLUC_CAVPO  (P05110), GLUC_CHICH  (P31297), GLUC_CHICK  (P68259), 
GLUC_DIDVI  (P18108), GLUC_HELSU  (O12956), GLUC_HUMAN  (P01275), 
GLUC_HYDCO  (P09682), GLUC_ICTPU  (P04093), GLUC_LAMFL  (Q9PRQ9), 
GLUC_MELGA  (P68260), GLUC_MESAU  (P01273), GLUC_MOUSE  (P55095), 
GLUC_MYOSC  (P09686), GLUC_OCTDE  (P22890), GLUC_PIAME  (P81880), 
GLUC_PIG(P01274), GLUC_PLAFE  (P68956), GLUC_POLSE  (P0C235), 
GLUC_RABIT  (P68274), GLUC_RAT(P06883), GLUC_SAISC  (P68275), 
GLUC_SCYCA  (P09687), GLUC_SHEEP  (Q8MJ25), GLUC_STRCA  (P68953), 
GLUC_THUOB  (P68957), GLUC_TORMA  (P09567), GLUC_TRASC  (P68955), 
PACA_BOVIN  (Q29W19), PACA_CHICK  (P41534), PACA_CLAMA  (P48144), 
PACA_HELSU  (P0DJ95), PACA_HUMAN  (P18509), PACA_MOUSE  (O70176), 
PACA_ONCNE  (P41585), PACA_PELRI  (Q09169), PACA_PIG(P41535), 
PACA_RAT(P13589), PACA_SHEEP  (P16613), PACA_URAJA  (P81039), 
SECR_BOVIN  (P63296), SECR_CANLF  (P09910), SECR_CAVPO  (P63297), 
SECR_CHICK  (P01280), SECR_HUMAN  (P09683), SECR_MOUSE  (Q08535), 
SECR_PIG(P63298), SECR_RABIT  (P32647), SECR_RAT(P11384), 
SECR_SHEEP  (P31299), SLIB_BOVIN  (P63292), SLIB_CAPHI  (P63293), 
SLIB_CYPCA  (P42692), SLIB_HUMAN  (P01286), SLIB_MESAU  (Q60549), 
SLIB_MOUSE  (P16043), SLIB_PIG(P01287), SLIB_RAT(P09916), 
SLIB_SHEEP  (P07217), VIP_ALLMI   (P48142), VIP_AMICA   (P84771), 
VIP_BOVIN   (P81401), VIP_CANLF   (P63289), VIP_CAPHI   (P63290), 
VIP_CAVPO   (P04566), VIP_CHICK   (P48143), VIP_DIDVI   (P39089), 
VIP_GADMO   (P09684), VIP_HUMAN   (P01282), VIP_MACMU   (P84488), 
VIP_MELGA   (P45644), VIP_MOUSE   (P32648), VIP_ONCMY   (P84772), 
VIP_PELRI   (P81016), VIP_PIG (P01284), VIP_RABIT   (P32649), 
VIP_RAT (P01283), VIP_SCYCA   (P09685), VIP_SHEEP   (P63291)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

GLUC2_ORENI (P81027)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			6 sequences
			


			
CREST_HUMAN (O75177), GLR13_ARATH (Q9FH75), HOA1_PARXL  (Q143P7), 

			
HOA_POLSJ   (Q120N9), PORC_ZOBGA  (D7GXG1), SRB8_PICST  (A3GF47)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			64 PDB
			


			pdb_00001bh0; pdb_00001d0r; pdb_00001gcn; pdb_00001jrj; pdb_00001kx6; pdb_00001t5q; pdb_00002b4n; pdb_00002d2p; pdb_00002g49; pdb_00002l63; pdb_00002l64; pdb_00002l70; 
			
				pdb_00002l71; pdb_00002m5p; pdb_00002m5q; pdb_00002mj9; pdb_00002obu; pdb_00002qkh; pdb_00002rrh; pdb_00002rri; pdb_00003iol; pdb_00004apd; pdb_00004zgm; pdb_00005niq; 
				pdb_00005vai; pdb_00006eds; pdb_00006gdz; pdb_00006ge2; pdb_00006lmk; pdb_00006lml; pdb_00006lpb; pdb_00006m1i; pdb_00006nzn; pdb_00006p9y; pdb_00006phi; pdb_00006phj; 
				pdb_00006phk; pdb_00006phl; pdb_00006php; pdb_00006vcb; pdb_00006vn7; pdb_00006wi9; pdb_00006wzg; pdb_00006x18; pdb_00007cz5; pdb_00007d3s; pdb_00007d68; pdb_00007dty; 
				pdb_00007duq; pdb_00007ki0; pdb_00007ki1; pdb_00007lll; pdb_00007lly; pdb_00007mll; pdb_00007ra3; pdb_00007v9m; pdb_00007vqx; pdb_00007wbj; pdb_00007xm8; pdb_00008e3x; 
				pdb_00008e3y; pdb_00008e3z; pdb_00008gji; pdb_00008jrv
			
			

			» more