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PROSITE entry PS00269


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00269
Entry name [info] DEFENSIN
Accession [info] PS00269
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00242

Name and characterization of the entry

Description [info] Mammalian defensins signature.
Pattern [info] 
C-x-C-x(3,5)-C-x(7)-G-x-C-x(9)-C-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 60 in 60 different sequences
Number of true positive hits 59 in 59 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 12
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 98.33 %
Recall (true positives / (true positives + false negatives)) 83.10 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 3
Site [info] disulfide at position 5
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 12
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 59 sequences 

DEF1A_CAVPO (P11478), DEF1B_CAVPO (Q64365), DEF1_HUMAN  (P59665), 

DEF1_MACMU  (P60030), DEF1_MESAU  (P81465), DEF1_PANTR  (Q5G863), 
DEF1_PAPHA  (P84757), DEF1_RABIT  (P07469), DEF1_RAT(Q62716), 
DEF2_CAVPO  (P49112), DEF2_MACMU  (P82317), DEF2_MESAU  (P81466), 
DEF2_RABIT  (P07468), DEF2_RAT(Q62715), DEF3A_RAT   (Q62713), 
DEF3B_RAT   (Q9Z1F1), DEF3_HUMAN  (P59666), DEF3_MACMU  (P60031), 
DEF3_MESAU  (P81467), DEF3_PAPHA  (P84758), DEF3_RABIT  (P01376), 
DEF4_HUMAN  (P12838), DEF4_MACMU  (P82319), DEF4_MESAU  (P81468), 
DEF4_PANTR  (Q5G862), DEF4_PAPHA  (P86724), DEF4_RABIT  (P01377), 
DEF4_RAT(Q62714), DEF5_HUMAN  (Q01523), DEF5_PANTR  (Q5G861), 
DEF5_RABIT  (P07467), DEF5_RAT(P82106), DEF6_HUMAN  (Q01524), 
DEF6_MACMU  (P82320), DEF6_PANTR  (Q5G860), DEF6_RABIT  (P07466), 
DEF7_RABIT  (P80223), DEF8_MACMU  (P60032), DEFA1_MOUSE (P11477), 
DEFA1_ORNAN (P0C8A1), DEFA2_MOUSE (P28309), DEFA2_ORNAN (P0C8A2), 
DEFA3_MOUSE (P28310), DEFA3_ORNAN (P0C8A3), DEFA5_MOUSE (P28312), 
DEFA6_MOUSE (P50704), DEFA7_MOUSE (P50705), DEFA8_MOUSE (P50706), 
DEFA9_MOUSE (P50707), DFA10_MOUSE (P50708), DFA11_MOUSE (P50709), 
DFA13_MOUSE (P50711), DFA14_MOUSE (P50712), DFA15_MOUSE (P50713), 
DFA16_MOUSE (P50714), DFA17_MOUSE (Q64016), DFA23_MOUSE (Q5G866), 
DFA24_MOUSE (Q5G865), DFA26_MOUSE (Q3L180)
» more

UniProtKB/Swiss-Prot
False negative sequences		 12 sequences 

BTDA_PAPAN  (B6ULW4), BTDB_PAPAN  (B6ULW5), BTDC_PAPAN  (B6ULW6), 

BTDD_PAPAN  (B6ULW7), DEF7_PANTR  (Q5G859), DEFA1_HORSE (A6YB85), 
DEFA4_MOUSE (P28311), DEFA4_ORNAN (P0C8A4), RK1_RABIT   (P81655), 
RTD1A_MACMU (P82270), RTD1B_MACMU (P82271), RTD3_MACMU  (Q9GLR2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

BTDA_PAPHA  (P86722), BTDB_PAPHA  (P86723)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
KRUC_SHEEP  (P26372)


				
	

	

		PDB
[Detailed view]		
		
			39 PDB
			


			1DFN; 1ZMM; 1ZMP; 1ZMQ; 2KHT; 2LXZ; 2MIT; 2PM1; 2PM4; 2PM5; 3GNY; 3H6C; 
			
				3HJ2; 3HJD; 3I5W; 3LO1; 3LO2; 3LO4; 3LO6; 3LO9; 3LOE; 3LVX; 3QTE; 4E82; 
				4E83; 4E86; 4LB1; 4LB7; 4LBB; 4LBF; 4RBW; 4RBX; 5CUI; 5CUJ; 5CUM; 6DMM; 
				6DMQ; 6KRA; 7YOA
			
			

			» more