PROSITE logo

PROSITE entry PS00269


View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] DEFENSIN
Accession [info] PS00269
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE;
03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00242

Name and characterization of the entry

Description [info] Mammalian defensins signature.
Pattern [info] 
C-x-C-x(3,5)-C-x(7)-G-x-C-x(9)-C-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.


Total number of hits 60 in 60 different sequences
Number of true positive hits 59 in 59 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 12
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 98.33 %
Recall (true positives / (true positives + false negatives)) 83.10 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 3
Site [info] disulfide at position 5
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 12
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 59 sequences 

DEF1A_CAVPO (P11478    ), DEF1B_CAVPO (Q64365    ), DEF1_HUMAN  (P59665    ), 

DEF1_MACMU  (P60030    ), DEF1_MESAU  (P81465    ), DEF1_PANTR  (Q5G863    ), 
DEF1_PAPHA  (P84757    ), DEF1_RABIT  (P07469    ), DEF1_RAT    (Q62716    ), 
DEF2_CAVPO  (P49112    ), DEF2_MACMU  (P82317    ), DEF2_MESAU  (P81466    ), 
DEF2_RABIT  (P07468    ), DEF2_RAT    (Q62715    ), DEF3A_RAT   (Q62713    ), 
DEF3B_RAT   (Q9Z1F1    ), DEF3_HUMAN  (P59666    ), DEF3_MACMU  (P60031    ), 
DEF3_MESAU  (P81467    ), DEF3_PAPHA  (P84758    ), DEF3_RABIT  (P01376    ), 
DEF4_HUMAN  (P12838    ), DEF4_MACMU  (P82319    ), DEF4_MESAU  (P81468    ), 
DEF4_PANTR  (Q5G862    ), DEF4_PAPHA  (P86724    ), DEF4_RABIT  (P01377    ), 
DEF4_RAT    (Q62714    ), DEF5_HUMAN  (Q01523    ), DEF5_PANTR  (Q5G861    ), 
DEF5_RABIT  (P07467    ), DEF5_RAT    (P82106    ), DEF6_HUMAN  (Q01524    ), 
DEF6_MACMU  (P82320    ), DEF6_PANTR  (Q5G860    ), DEF6_RABIT  (P07466    ), 
DEF7_RABIT  (P80223    ), DEF8_MACMU  (P60032    ), DEFA1_MOUSE (P11477    ), 
DEFA1_ORNAN (P0C8A1    ), DEFA2_MOUSE (P28309    ), DEFA2_ORNAN (P0C8A2    ), 
DEFA3_MOUSE (P28310    ), DEFA3_ORNAN (P0C8A3    ), DEFA5_MOUSE (P28312    ), 
DEFA6_MOUSE (P50704    ), DEFA7_MOUSE (P50705    ), DEFA8_MOUSE (P50706    ), 
DEFA9_MOUSE (P50707    ), DFA10_MOUSE (P50708    ), DFA11_MOUSE (P50709    ), 
DFA13_MOUSE (P50711    ), DFA14_MOUSE (P50712    ), DFA15_MOUSE (P50713    ), 
DFA16_MOUSE (P50714    ), DFA17_MOUSE (Q64016    ), DFA23_MOUSE (Q5G866    ), 
DFA24_MOUSE (Q5G865    ), DFA26_MOUSE (Q3L180    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 12 sequences 

BTDA_PAPAN  (B6ULW4    ), BTDB_PAPAN  (B6ULW5    ), BTDC_PAPAN  (B6ULW6    ), 

BTDD_PAPAN  (B6ULW7    ), DEF7_PANTR  (Q5G859    ), DEFA1_HORSE (A6YB85    ), 
DEFA4_MOUSE (P28311    ), DEFA4_ORNAN (P0C8A4    ), RK1_RABIT   (P81655    ), 
RTD1A_MACMU (P82270    ), RTD1B_MACMU (P82271    ), RTD3_MACMU  (Q9GLR2    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

BTDA_PAPHA  (P86722    ), BTDB_PAPHA  (P86723    )


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
KRUC_SHEEP  (P26372    )


				
	

	

		PDB
[Detailed view]		
		
			38 PDB
			


			1DFN; 1ZMM; 1ZMP; 1ZMQ; 2KHT; 2LXZ; 2MIT; 2PM1; 2PM4; 2PM5; 3GNY; 3H6C; 
			
				3HJ2; 3HJD; 3I5W; 3LO1; 3LO2; 3LO4; 3LO6; 3LO9; 3LOE; 3LVX; 3QTE; 4E82; 
				4E83; 4E86; 4LB1; 4LB7; 4LBB; 4LBF; 4RBW; 4RBX; 5CUI; 5CUJ; 5CUM; 6DMM; 
				6DMQ; 6KRA
			
			

			» more