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PROSITE entry PS00275


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00275
Entry name [info] SHIGA_RICIN
Accession [info] PS00275
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00248

Name and characterization of the entry

Description [info] Shiga/ricin ribosomal inactivating toxins active site signature.
Pattern [info] 
[LIVMA]-x-[LIVMSTA](2)-x-E-[SAGV]-[STAL]-R-[FY]-[RKNQST]-x-[LIVM]-[EQS]-
x(2)-[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 59 in 59 different sequences
Number of true positive hits 57 in 57 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 7
Number of 'partial' sequences 12
Precision (true positives / (true positives + false positives)) 96.61 %
Recall (true positives / (true positives + false negatives)) 89.06 %

Comments [info]

Taxonomic range [info] Bacteriophages, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 57 sequences 

ABRA_ABRPR  (P11140), ABRB_ABRPR  (Q06077), ABRC_ABRPR  (P28590), 

ABRD_ABRPR  (Q06076), AGGL_ABRPR  (Q9M6E9), AGGL_RICCO  (P06750), 
ALB3_MAIZE  (P10593), JI60_HORVU  (Q00531), NIGB_SAMNI  (P33183), 
RICI_RICCO  (P02879), RIP0_DIACA  (P24476), RIP1_BRYDI  (P33185), 
RIP1_CUCFI  (Q9FRX4), RIP1_GYNPE  (Q5F0I3), RIP1_HORVU  (P22244), 
RIP1_MOMCH  (P16094), RIP1_PHYAM  (P10297), RIP1_SAMNI  (P93543), 
RIP2_BRYDI  (P98184), RIP2_HORVU  (P04399), RIP2_MOMBA  (P29339), 
RIP2_PHYAM  (Q40772), RIP2_PHYDI  (P34967), RIP2_SAPOF  (P27559), 
RIP3_MAIZE  (P25891), RIP3_MOMCH  (P24817), RIP3_SAPOF  (P27560), 
RIP5_SAPOF  (Q41389), RIP6_SAPOF  (P20656), RIP7_SAPOF  (Q41391), 
RIP9_MAIZE  (P25892), RIPA_LUFAE  (Q00465), RIPA_PHYAM  (Q03464), 
RIPB_LUFAE  (P22851), RIPD2_PHYDI (P85208), RIPG_SURMU  (P33186), 
RIPL1_PHYDI (P84853), RIPL2_PHYDI (P84854), RIPLY_SILCH (P85101), 
RIPM_POLML  (Q9M654), RIPP_MIRJA  (P21326), RIPS_PHYAM  (P23339), 
RIPS_TRIKI  (P24478), RIPT_POLML  (Q9M653), RIPT_TRIKI  (P09989), 
RIPX_MAIZE  (P28522), RIP_CUCMO   (P84531), RIP_LUFAC   (P84530), 
SNAIB_SAMNI (Q41358), SNAIF_SAMNI (O22415), STXA_BP788  (Q779K4), 
STXA_BP933  (P09385), STXA_BPH19  (P08026), STXA_BPH30  (P10149), 
STXA_SHIDS  (Q32GM1), STXA_SHIDY  (Q9FBI2), VOLK_ADEVO  (Q70US9)
» more

UniProtKB/Swiss-Prot
False negative sequences		 7 sequences 

ML1_VISAL   (P81446), ML2_VISAL   (Q6H266), ML3_VISAL   (P82683), 

RIP1_TRIAN  (P56626), RIP4_PHYHE  (Q6EH50), RIP9_SAPOF  (Q7M1Z2), 
RIP_DRIMA   (P84786)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 12 sequences 

ARALA_ARAEL (P83572), LECA_IRIHO  (P36230), RIP1_SAPOF  (P98185), 

RIP2_DIACA  (P24477), RIP2_TRIKI  (P23029), RIP3_SURMU  (P24475), 
RIP4_SAPOF  (P27561), RIPD1_PHYDI (P86144), RIPK_TRIKI  (P16093), 
RIPS_MOMCO  (P20655), RIPX_CUCPE  (P80750), RIP_SIRGR   (P83323)
» more

UniProtKB/Swiss-Prot
False positive sequences		 2 sequences 

RIP1_GYPVA  (Q7M1L6), RIP2_GYPVA  (C0HM39)


				
	

	

		PDB
[Detailed view]		
		
			177 PDB
			


			1ABR; 1AHA; 1AHB; 1AHC; 1APA; 1BR5; 1BR6; 1BRY; 1CF5; 1D6A; 1D8V; 1DM0; 
			
				1F8Q; 1GIK; 1GIS; 1GIU; 1IFS; 1IFT; 1IFU; 1IL3; 1IL4; 1IL5; 1IL9; 1J1M; 
				1J1Q; 1J1R; 1J1S; 1J4G; 1LLN; 1LP8; 1LPC; 1LPD; 1MOM; 1MRG; 1MRH; 1MRI; 
				1MRJ; 1MRK; 1NIO; 1PAF; 1PAG; 1QCG; 1QCI; 1QCJ; 1QD2; 1QI7; 1R4P; 1R4Q; 
				1RL0; 1RTC; 1RZO; 1TCS; 1UQ4; 1UQ5; 2AAI; 2G5X; 2GA4; 2JDL; 2JJR; 2K6H; 
				2OQA; 2P8N; 2PJO; 2PQG; 2PQI; 2PQJ; 2Q3N; 2QES; 2QET; 2R2X; 2R3D; 2VS6; 
				2Z4U; 2Z53; 2ZR1; 3BWH; 3EJ5; 3H5K; 3HIO; 3KTZ; 3KU0; 3LC9; 3LE7; 3MK9; 
				3PX8; 3PX9; 3RTI; 3RTJ; 3SRP; 4ESI; 4FB9; 4FBA; 4FBB; 4FBC; 4FBH; 4HUO; 
				4HUP; 4HV3; 4HV7; 4IMV; 4KUC; 4LGP; 4LGR; 4LGS; 4LHJ; 4LHQ; 4MX1; 4MX5; 
				4Q2V; 4YP2; 4Z9K; 5BOZ; 5CF9; 5DDZ; 5E1H; 5GU4; 5J56; 5J57; 5SV3; 5U4L; 
				5U4M; 5Z37; 5Z3I; 5Z3J; 6CWG; 6LOQ; 6LOR; 6LOV; 6LOW; 6LOY; 6LOZ; 6LP0; 
				6OBC; 6OBE; 6OBG; 6OBM; 6OBO; 6OCA; 6OCD; 6URW; 6URX; 6URY; 7KBI; 7KBK; 
				7KC9; 7KD0; 7KD2; 7KDM; 7KDU; 7MLN; 7MLO; 7MLP; 7MLT; 7TGF; 7TGI; 7TH2; 
				7TH3; 7UJJ; 7XZS; 7XZT; 7XZU; 7XZW; 7Y02; 7Y03; 7Y05; 7Y06; 7Y07; 7Y08; 
				7Y4K; 7Y4M; 8I7P; 8SZ2; 8T9V; 8TAB; 8TAD; 8TFH; 8TFL
			
			

			» more