PROSITE logo

PROSITE entry PS00279


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] MACPF_1
Accession [info] PS00279
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-1990 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00251

Name and characterization of the entry

Description [info] Membrane attack complex/perforin (MACPF) domain signature.
Pattern [info] 
Y-x(6)-[FY]-G-T-H-[FY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 30 in 30 different sequences
Number of true positive hits 30 in 30 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 25
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 54.55 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 30 sequences 

CO6_BOVIN   (Q29RU4), CO6_HUMAN   (P13671), CO6_PANTR   (P61134), 

CO6_PONPY   (P61135), CO6_RAT (Q811M5), CO7_BOVIN   (Q29RQ1), 
CO7_HUMAN   (P10643), CO7_PIG (Q9TUQ3), CO7_PONAB   (Q5RAD0), 
CO8A_HUMAN  (P07357), CO8A_MOUSE  (Q8K182), CO8A_RABIT  (P98136), 
CO8B_HUMAN  (P07358), CO8B_MOUSE  (Q8BH35), CO8B_ONCMY  (Q90X85), 
CO8B_PAROL  (Q9PVW7), CO8B_RAT(P55314), CO9_BOVIN   (Q3MHN2), 
CO9_HORSE   (P48770), CO9_HUMAN   (P02748), CO9_MOUSE   (P06683), 
CO9_ONCMY   (P06682), CO9_RABIT   (P48747), CO9_RAT (Q62930), 
CO9_TAKRU   (P79755), PERF_HUMAN  (P14222), PERF_MOUSE  (P10820), 
PERF_RAT(P35763), PV21_POMCA  (P0C8G6), PV21_POMMA  (P0DQO9)
» more

UniProtKB/Swiss-Prot
False negative sequences		 25 sequences 

BRNP1_BOVIN (Q5E9L2), BRNP1_CHICK (Q7ZZR3), BRNP1_HUMAN (O60477), 

BRNP1_MOUSE (Q920P3), BRNP1_RAT   (Q925T8), BRNP2_HUMAN (Q9C0B6), 
BRNP2_MOUSE (Q6DFY8), BRNP2_PONAB (Q5RDR5), BRNP2_RAT   (Q8K1M8), 
BRNP3_HUMAN (Q76B58), BRNP3_MOUSE (Q499E0), BRNP3_RAT   (Q8K1M7), 
CAD1_ARATH  (Q9C7N2), CO8B_RABIT  (P98137), MACP1_ARATH (Q8L612), 
MACP2_ARATH (Q9STW5), MPEG1_BOVIN (Q2KJC3), MPEG1_HUMAN (Q2M385), 
MPEG1_MOUSE (A1L314), MPEG1_PONAB (Q5RBP9), MPEG1_RAT   (Q9WV57), 
NSL1_ARATH  (Q9SGN6), TX60A_ACTVL (Q76DT2), TX60A_PHYSE (P58911), 
TX60B_PHYSE (P58912)
» more

PDB
[Detailed view]		 19 PDB

2QQH; 2RD7; 3NSJ; 3OJY; 3T5O; 4A5W; 4E0S; 5FMW; 6CXO; 6DLW; 6H03; 6H04; 7NYC; 7NYD; 7PAG; 8B0F; 8B0G; 8B0H; 8DE6
» more