PROSITE entry PS00279

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00279
Entry name [info]	MACPF_1
Accession [info]	PS00279
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-APR-1990 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00251

Name and characterization of the entry

Description [info]	Membrane attack complex/perforin (MACPF) domain signature.
Pattern [info]	Y-x(6)-[FY]-G-T-H-[FY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	30 in 30 different sequences
Number of true positive hits	30 in 30 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	25
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	54.55 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

30 sequences

CO6_BOVIN   (Q29RU4), CO6_HUMAN   (P13671), CO6_PANTR   (P61134),

CO6_PONPY   (P61135), CO6_RAT (Q811M5), CO7_BOVIN   (Q29RQ1), 
CO7_HUMAN   (P10643), CO7_PIG (Q9TUQ3), CO7_PONAB   (Q5RAD0), 
CO8A_HUMAN  (P07357), CO8A_MOUSE  (Q8K182), CO8A_RABIT  (P98136), 
CO8B_HUMAN  (P07358), CO8B_MOUSE  (Q8BH35), CO8B_ONCMY  (Q90X85), 
CO8B_PAROL  (Q9PVW7), CO8B_RAT(P55314), CO9_BOVIN   (Q3MHN2), 
CO9_HORSE   (P48770), CO9_HUMAN   (P02748), CO9_MOUSE   (P06683), 
CO9_ONCMY   (P06682), CO9_RABIT   (P48747), CO9_RAT (Q62930), 
CO9_TAKRU   (P79755), PERF_HUMAN  (P14222), PERF_MOUSE  (P10820), 
PERF_RAT(P35763), PV21_POMCA  (P0C8G6), PV21_POMMA  (P0DQO9)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

25 sequences

BRNP1_BOVIN (Q5E9L2), BRNP1_CHICK (Q7ZZR3), BRNP1_HUMAN (O60477),

BRNP1_MOUSE (Q920P3), BRNP1_RAT   (Q925T8), BRNP2_HUMAN (Q9C0B6), 
BRNP2_MOUSE (Q6DFY8), BRNP2_PONAB (Q5RDR5), BRNP2_RAT   (Q8K1M8), 
BRNP3_HUMAN (Q76B58), BRNP3_MOUSE (Q499E0), BRNP3_RAT   (Q8K1M7), 
CAD1_ARATH  (Q9C7N2), CO8B_RABIT  (P98137), MACP1_ARATH (Q8L612), 
MACP2_ARATH (Q9STW5), MPEG1_BOVIN (Q2KJC3), MPEG1_HUMAN (Q2M385), 
MPEG1_MOUSE (A1L314), MPEG1_PONAB (Q5RBP9), MPEG1_RAT   (Q9WV57), 
NSL1_ARATH  (Q9SGN6), TX60A_ACTVL (Q76DT2), TX60A_PHYSE (P58911), 
TX60B_PHYSE (P58912)

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PDB
[Detailed view]

19 PDB

2QQH; 2RD7; 3NSJ; 3OJY; 3T5O; 4A5W; 4E0S; 5FMW; 6CXO; 6DLW; 6H03; 6H04; 7NYC; 7NYD; 7PAG; 8B0F; 8B0G; 8B0H; 8DE6
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