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PROSITE entry PS00280


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PURL: https://purl.expasy.org/prosite/signature/PS00280

Direct ScanProsite submission
General information about the entry

Entry name [info] BPTI_KUNITZ_1
Accession [info] PS00280
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00252

Name and characterization of the entry

Description [info] Pancreatic trypsin inhibitor (Kunitz) family signature.
Pattern [info] 
F-x(2)-{I}-G-C-x(6)-[FY]-x(5)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 401 in 333 different sequences
Number of true positive hits 395 in 327 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 70
Number of 'partial' sequences 22
Precision (true positives / (true positives + false positives)) 98.50 %
Recall (true positives / (true positives + false negatives)) 84.95 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 11
Site [info] disulfide at position 5
Site [info] disulfide at position 9
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 327 sequences 

3API_HETMG  (C0HK72), 3BPI_HETMG  (C0HK73), 3CPI_HETMG  (C0HK74), 

3DPD_HETMG  (A0A3G2FQK2), A4_CAVPO(Q60495), A4_HUMAN(P05067), 
A4_MACFA(P53601), A4_MACMU(P29216), A4_MOUSE(P12023), 
A4_PANTR(Q5IS80), A4_PIG  (P79307), A4_RAT  (P08592), 
A4_SAISC(Q95241), A4_TAKRU(O93279), AMBP_BOVIN  (P00978), 
AMBP_HUMAN  (P02760), AMBP_MERUN  (Q62577), AMBP_MESAU  (Q60559), 
AMBP_MOUSE  (Q07456), AMBP_PIG(P04366), AMBP_PLEPL  (P36992), 
AMBP_RAT(Q64240), ANIS1_ANISI (Q7Z1K3), APLP2_HUMAN (Q06481), 
APLP2_RAT   (P15943), ATPI1_ACTTE (A0A6P8HC43), BMTI6_RHIMP (P83606), 
BMTIA_RHIMP (P83609), BPT1_BOVIN  (P00974), BPT2_BOVIN  (P04815), 
CO6A3_CHICK (P15989), CO6A3_HUMAN (P12111), CO7A1_HUMAN (Q02388), 
CO7A1_MOUSE (Q63870), COSA1_HUMAN (Q2UY09), COSA1_MOUSE (Q2UY11), 
CRPTI_RHIMP (P81162), CSTI_BOMMO  (P81902), ELAC_NOTEU  (O62845), 
ELAC_TRIVU  (Q29143), EPPI_HUMAN  (O95925), EPPI_MACMU  (Q9BDL1), 
EPPI_MOUSE  (Q9DA01), EPPI_RAT(D4A2Z2), HTIB_MANSE  (P26227), 
IATR_CAPHI  (P62756), IATR_HORSE  (P04365), IATR_SHEEP  (P62757), 
IBPC_BOVIN  (P00976), IBPI_TACTR  (P16044), IBPS_BOVIN  (P00975), 
IBP_CARCR   (P00993), IMAP_DROFU  (P11424), IRCPI_IXORI (Q9GP15), 
ISC1_BOMMO  (P10831), ISC2_BOMMO  (P10832), ISC3_BOMMO  (P07481), 
ISIK_HELPO  (P00994), ISPI2_GALME (P81906), IVBI3_HOPST (B5L5R6), 
IVBI4_NOTSC (B5L5R4), IVBI4_PSEPO (B5L5R0), IVBI5_PSEPO (B5L5R1), 
IVBI_AUSSU  (B5L5M7), IVBS5_OXYSC (B5L5Q3), KCP1_PINMA  (P86959), 
KCP1_PINMG  (H2A0M2), KCP2_PINMG  (H2A0N1), KCP3_PINMA  (P86964), 
KCP3_PINMG  (H2A0N5), KCP4_PINMG  (H2A0N9), KCP5_PINMG  (H2A0P0), 
KCP_HALAI   (P86733), KUN1_TABYA  (C1IBY4), KUN2_RHIHE  (I6VXS1), 
KUN2_TABYA  (C8YJ94), KUN3_TABYA  (C8YJ95), KUN4_TABYA  (C8YJ96), 
KUN5_TABYA  (C8YJ97), KUNIG_RHIMP (Q8WPI3), KUNIH_RHIMP (Q8WPI2), 
KUNI_AMBHE  (Q5VJG2), KUN_HAEDO   (C0HMC7), KUN_HAELO   (B6ZIW0), 
MAMB1_DENAN (A0A1Z0YU59), MAMB2_DENVI (C0HLA5), MAMB3_DENPO (C0HLA6), 
MAMB4_DENVI (C0HLA7), MAMB5_DENJA (C0HLA8), MAMB6_DENVI (C0HLA9), 
MAMB7_DENPO (P00983), MAMB9_DENVI (C0HLB0), MCPI_MELCP  (P82968), 
PCPI_SABMA  (P84875), PPN1_CAEEL  (O76840), PPN_DROME   (Q868Z9), 
PPN_HUMAN   (O95428), PPN_MOUSE   (Q9EPX2), SBPI_SARBU  (P26228), 
SPIT1_HUMAN (O43278), SPIT1_MOUSE (Q9R097), SPIT2_HUMAN (O43291), 
SPIT2_MOUSE (Q9WU03), SPIT3_HUMAN (P49223), SPIT4_MOUSE (Q9D263), 
SV66_SIMVI  (B5M0W4), TD1A_HADIN  (A0A1D0BND9), TFPI1_HUMAN (P10646), 
TFPI1_MACMU (Q28864), TFPI1_MOUSE (O54819), TFPI1_RABIT (P19761), 
TFPI1_RAT   (Q02445), TFPI2_BOVIN (Q7YRQ8), TFPI2_HUMAN (P48307), 
TFPI2_MOUSE (O35536), TKDP1_BOVIN (Q28201), TKDP1_SHEEP (Q29428), 
UPTI_PIG(Q29100), VKBH2_BUNCA (Q8AY45), VKGUA_SIMGU (F5GTK6), 
VKT11_CYRSC (B2ZBB6), VKT11_HOFGE (P0C8W3), VKT12_DENAN (P0DMJ6), 
VKT12_OLIMR (P0DJ47), VKT16_DRYCN (F8J2F4), VKT17_CYRHA (P0DJ66), 
VKT18_DRYCN (F8J2F6), VKT19_ANOSM (Q589G4), VKT1A_ANEVI (P0DN06), 
VKT1A_CYRSC (P68425), VKT1L_BUNMU (B4ESA2), VKT1_ANESU  (Q9TWG0), 
VKT1_ANTAF  (P81547), VKT1_ANTEL  (P86862), VKT1_ARAVE  (Q8T3S7), 
VKT1_AUSSU  (B5KL38), VKT1_BITGA  (Q6T6T5), VKT1_CRYNI  (B5KF95), 
VKT1_DABRR  (Q2ES50), VKT1_DEMVE  (A6MFL1), VKT1_HOPST  (B5KF94), 
VKT1_NOTSC  (Q6ITB3), VKT1_OXYMI  (Q6ITB5), VKT1_OXYSC  (Q6ITB7), 
VKT1_PALCA  (P0DQQ9), VKT1_PHIOL  (A7X3V7), VKT1_PSERS  (E7FL11), 
VKT1_PSETT  (Q90WA1), VKT1_STIHL  (P31713), VKT1_TELDH  (A7X3V4), 
VKT1_TRILK  (W4VSH9), VKT1_TROCA  (Q6ITB0), VKT1_VIPAA  (P00991), 
VKT1_WALAE  (C1IC50), VKT27_CYRSC (P0DJ82), VKT28_DRYCN (F8J2F3), 
VKT2B_RADCR (B2G331), VKT2C_RADCR (C0HJF4), VKT2D_RADCR (C0HJF3), 
VKT2E_RADCR (P0DMJ5), VKT2F_RADCR (C0HJU6), VKT2G_RADCR (C0HJU7), 
VKT2H_RADCR (P0DL86), VKT2I_RADCR (A0A6B7FBD3), VKT2J_RADCR (A0A6B7FA07), 
VKT2K_RADCR (A0A6B7FEJ3), VKT2L_BUNMU (B4ESA3), VKT2M_RADCR (P0DV03), 
VKT2N_RADCR (P0DV04), VKT2O_RADCR (P0DV05), VKT2P_RADCR (P0DV06), 
VKT2_ANESU  (Q9TWF9), VKT2_ANTAF  (P81548), VKT2_AUSSU  (B5KL39), 
VKT2_BITGA  (Q6T6S5), VKT2_CRYNI  (B5KF96), VKT2_DABSI  (P00990), 
VKT2_DEMVE  (A6MFL2), VKT2_HEMHA  (P00985), VKT2_HOPST  (B5L5R7), 
VKT2_NAJNI  (P00986), VKT2_NOTSC  (Q6ITB2), VKT2_OXYMI  (Q6ITB4), 
VKT2_OXYSC  (Q6ITB6), VKT2_PALCA  (P0DQR0), VKT2_PIMHY  (Q8T0W4), 
VKT2_PSEAU  (Q6ITC0), VKT2_PSEPO  (B5G6G6), VKT2_PSERS  (E7FL12), 
VKT2_PSETT  (Q90WA0), VKT2_STIHL  (P81129), VKT2_TROCA  (B5KL33), 
VKT2_WALAE  (C1IC52), VKT31_OLIMR (P0DJ50), VKT39_CYRSC (P0DMJ1), 
VKT3A_ACTEQ (P0DMW6), VKT3B_ACTEQ (P0DMW7), VKT3C_ACTEQ (P0DMJ2), 
VKT3L_BUNMU (B4ESA4), VKT3_ANESU  (Q9TWF8), VKT3_ANTAF  (P0DMX0), 
VKT3_AUSSU  (B5KL40), VKT3_BITGA  (Q6T269), VKT3_CRYNI  (B5KL34), 
VKT3_DABRR  (Q2ES48), VKT3_DEMVE  (A6MFL3), VKT3_NOTSC  (B5KL32), 
VKT3_OXYMI  (B5KL27), VKT3_OXYSC  (B5KL29), VKT3_PALCA  (P0DQR1), 
VKT3_PSEAU  (Q6ITB9), VKT3_PSEPO  (B5KL31), VKT3_PSERS  (E7FL13), 
VKT3_PSETT  (Q90W99), VKT3_STIHA  (B1B5I8), VKT3_VIPAA  (P00992), 
VKT3_WALAE  (C1IC51), VKT4_ANEVI  (P0DN07), VKT4_AUSSU  (B5KL41), 
VKT4_CRYNI  (B5KL35), VKT4_CYRSC  (P0DJ76), VKT4_DABRR  (Q2ES47), 
VKT4_DEMVE  (A6MFL4), VKT4_OXYMI  (B5KL28), VKT4_OXYSC  (B5KL30), 
VKT4_PSEAU  (Q6ITB8), VKT4_PSETT  (Q90W98), VKT4_WALAE  (C1IC53), 
VKT52_ANESU (P10280), VKT53_ANEVI (P0DN08), VKT5_ANEVI  (P0DN09), 
VKT5_BUNFL  (D5J9Q8), VKT5_CRYNI  (B5KL36), VKT5_DABRR  (Q2ES46), 
VKT5_DEMVE  (A6MGX9), VKT5_OXYMI  (B5L5Q6), VKT5_PSEAU  (B5L5Q8), 
VKT5_PSETT  (Q90W97), VKT6_ANEVI  (P0DN10), VKT6_CRYNI  (B5KL37), 
VKT6_PSETT  (Q90W96), VKT7_ANEVI  (P0DN11), VKT7_DEMVE  (A6MGY1), 
VKT7_PSETT  (B5L5Q1), VKT87_DRYCN (F8J2F5), VKT8_ANEVI  (P0DN12), 
VKT9_ANEVI  (P0DN13), VKT9_BUNFA  (P25660), VKTA_ANEVI  (P0DN14), 
VKTA_BUNCA  (Q8AY43), VKTB1_DABSI (A8Y7P1), VKTB2_DABSI (A8Y7P2), 
VKTB3_DABSI (A8Y7P3), VKTB4_DABSI (A8Y7P4), VKTB5_DABSI (A8Y7P5), 
VKTB6_DABSI (A8Y7P6), VKTB7_DABSI (A8Y7P0), VKTB_ANEVI  (P0DN15), 
VKTB_BUNCA  (Q8AY42), VKTC1_DABSI (A8Y7N4), VKTC2_DABSI (A8Y7N5), 
VKTC3_DABSI (A8Y7N6), VKTC4_DABSI (A8Y7N7), VKTC5_DABSI (A8Y7N8), 
VKTC6_DABSI (A8Y7N9), VKTCI_NAJNA (P19859), VKTCI_OPHHA (P82966), 
VKTCT_OPHHA (B6RLX2), VKTC_ANEVI  (P0DN16), VKTC_BUNCA  (Q8AY41), 
VKTD_ANEVI  (P0DN17), VKTE_ANEVI  (P0DN18), VKTE_DENPO  (P00984), 
VKTF_ANEVI  (P0DN19), VKTG_ANEVI  (P0DN20), VKTH1_BUNFA (B2KTG2), 
VKTH1_BUNMU (P00987), VKTH1_DENPO (P00979), VKTH1_PSEAU (Q6ITC1), 
VKTH2_BUNFA (B2KTG3), VKTH2_BUNMU (P00989), VKTH3_BUNCA (Q75S50), 
VKTH3_BUNMU (Q9W728), VKTH4_BUNCA (Q75S49), VKTH4_BUNMU (Q1RPT0), 
VKTH5_BUNMU (Q1RPS9), VKTH6_BUNMU (Q1RPS8), VKTH7_BUNCA (Q8AY44), 
VKTH7_BUNMU (Q0PL65), VKTHA_DENAN (P00980), VKTHB_BUNCA (Q8AY46), 
VKTHB_BUNFL (Q7T2Q6), VKTHC_DENAN (P81658), VKTHD_DENAN (P00982), 
VKTHE_DENAN (Q7LZE3), VKTHK_DENPO (P00981), VKTI1_ANTFU (P0DMJ3), 
VKTI3_ANTFU (P0DMJ4), VKTK1_DABRR (H6VC05), VKTK2_DABRR (H6VC06), 
VKTRE_DENAN (Q7LZS8), VKTTI_NAJNA (P20229), VKT_AUSLA   (B2BS84), 
VKT_BOMIG   (G3LH89), VKT_BOMTE   (D8KY58), VKT_BUNFA   (B2KTG1), 
VKT_ERIMA   (P24541), VKT_MACLN   (I2G9B4), VKT_NAJAT   (Q5ZPJ7), 
VKT_OXYSC   (B7S4N9), VKT_PSEPC   (C0HLB2), VKT_PSEPO   (Q6ITB1), 
VKT_SISCA   (A5X2X1), VKT_VIPNI   (E5AJX3), VKT_VIPRE   (P0DKL8), 
WFC6A_MOUSE (Q3UW55), WFC6B_MOUSE (F6ULY1), WFDC8_HUMAN (Q8IUA0), 
WFDC8_MOUSE (Q4KUS1), WFKN1_HUMAN (Q96NZ8), WFKN1_MOUSE (Q8R0S6), 
WFKN1_RAT   (P0C5J5), WFKN2_BOVIN (Q08E66), WFKN2_HUMAN (Q8TEU8), 
WFKN2_MOUSE (Q7TQN3), WFKN_DANRE  (Q6NUX0), YN81_CAEEL  (Q03610)
» more

UniProtKB/Swiss-Prot
False negative sequences		 70 sequences 

A4_DICFU(O73683), AXO_DROME   (M9PE65), BLI5_CAEEL  (O62247), 

BLI5_HAECO  (D3GGZ8), HA11_HYAAI  (A0A1Q1NL17), HAEM_HAELO  (C0HMD5), 
IRSPI_IXORI (W6HZ31), IXOSP_IXOSC (Q964Q0), KUN1_RHIHE  (D9IFL3), 
KUNI_ORNKA  (Q8WPG5), KUNI_ORNMO  (P56409), KUNP1_ARGMO (Q09JW4), 
KUNP2_ARGMO (Q09JW3), SPIT4_HUMAN (Q6UDR6), TAP_ORNMO   (P17726), 
TFPIL_IXOSC (Q8MVC4), VKT13_CYRSC (P0DJ79), VKT1A_CONCL (D2Y488), 
VKT1B_CONCL (D2Y489), VKT1C_CONCL (D2Y490), VKT1D_CONCL (D2Y491), 
VKT21_LYCMC (P0DJ46), VKT22_CYRSC (P0DJ80), VKT22_LYCMC (P0DJ45), 
VKT23_LYCMC (P0DJ48), VKT24_CYRSC (P0DJ81), VKT24_OLIMR (P0DJ49), 
VKT2A_RADCR (P16344), VKT2_CYRHA  (D2Y2F3), VKT2_CYRSC  (P0DJ75), 
VKT2_DABRR  (Q2ES49), VKT31_CYRHA (P0DJ64), VKT33_CYRSC (B2ZBB8), 
VKT34_CYRHA (P0DJ67), VKT35_CYRHA (P0DJ71), VKT40_CYRSC (P0DJ84), 
VKT45_CYRHA (P0DJ68), VKT45_CYRSC (P0DJ85), VKT4_CYRHA  (D2Y2F5), 
VKT52_CYRHA (P0DJ69), VKT53_CYRHA (P0DJ70), VKT68_CYRHA (P0DJ72), 
VKT6_CYRSC  (P0DJ78), VKT74_CYRHA (P0DJ73), VKT76_CYRHA (P0DJ74), 
VKT7_CYRHA  (P0DJ65), VKTA1_CYRHA (D2Y2C2), VKTA_MICTN  (G9I929), 
VKTB1_CONBU (P0CY85), VKTC1_CYRHA (D2Y2F4), VKTE1_CYRHA (D2Y2F6), 
VKTF1_CYRHA (D2Y2F7), VKTG1_CYRHA (D2Y2F8), VKTG6_CYRSC (B2ZBB9), 
VKTG9_CYRSC (B2ZBC0), VKTH1_CYRHA (D2Y2F9), VKTI1_CYRHA (D2Y2G0), 
VKTJ1_CYRHA (D2Y2G1), VKTK1_CYRHA (D2Y2G2), VKTL1_CYRHA (D2Y2Q1), 
VKTM1_CYRHA (D2Y2Q2), VKTN1_CYRHA (D2Y2Q5), VKTO1_CYRHA (D2Y2Q6), 
VKTP1_CYRHA (D2Y2Q7), VKTQ1_CYRHA (D2Y2Q8), VKTR1_CYRHA (D2Y2Q9), 
VKTS1_CONST (P0C1X2), VKT_VESBI   (C0LNR2), WFDC6_HUMAN (Q9BQY6), 
YL15_CAEEL  (Q11101)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 22 sequences 

BMTI2_RHIMP (P83603), BMTI3_RHIMP (P83604), BMTI4_RHIMP (P83605), 

BMTID_RHIMP (P83607), HTIA_MANSE  (P26226), TIQ2_RHISA  (P84554), 
TIQ7_RHISA  (P84555), TIS5_RHISA  (P84556), VKT10_DABSI (P85041), 
VKT25_CYRHA (P0CH75), VKT2L_RADCR (P0DV02), VKT33_ACTEQ (P0DMW8), 
VKT34_ACTEQ (P0DMW9), VKTC8_DABSI (P85039), VKTC9_DABSI (P85040), 
VKTG1_MICPY (P0CAR0), VKTH1_BUNCA (P84471), VKTH2_BUNCA (P84473), 
VKTH8_BUNCA (P84470), VKT_MICAT   (P0DM47), VKT_OXYMI   (P0DJ63), 
VT2K_RADCR  (P0DV07)
» more

UniProtKB/Swiss-Prot
False positive sequences		 6 sequences 

AB41G_ORYSJ (Q8GU83), LRIT2_HUMAN (A6NDA9), SSPO_HUMAN  (A2VEC9), 

TGB3_BNYVS  (Q65676), TNFA_TUPTA  (Q539C2), WAKLN_ARATH (Q0WNY5)
» more

PDB
[Detailed view]		 167 PDB

1AAP; 1ADZ; 1B0C; 1BF0; 1BHC; 1BIK; 1BPI; 1BPT; 1BRB; 1BRC; 1BTH; 1BTI; 1BUN; 1BZ5; 1BZX; 1CA0; 1CBW; 1CO7; 1D0D; 1DEM; 1DEN; 1DTK; 1DTX; 1EAW; 1EJM; 1F5R; 1F7Z; 1FAK; 1FY8; 1G6X; 1IRH; 1JC6; 1K6U; 1KNT; 1KTH; 1KUN; 1LD5; 1MTN; 1NAG; 1OA5; 1OA6; 1P2I; 1P2J; 1P2K; 1P2M; 1P2N; 1P2O; 1P2Q; 1PIT; 1QLQ; 1SHP; 1T7C; 1T8L; 1T8M; 1T8N; 1T8O; 1TAW; 1TFX; 1TPA; 1UUA; 1UUB; 1YC0; 1YKT; 1ZJD; 1ZR0; 2DDI; 2DDJ; 2FI4; 2FTL; 2FTM; 2HEX; 2IJO; 2JOT; 2KAI; 2KNT; 2M99; 2ODY; 2PTC; 2R9P; 2RA3; 2TGP; 2TPI; 3BTD; 3BTE; 3BTF; 3BTG; 3BTH; 3BTK; 3BTM; 3BTQ; 3BTT; 3BTW; 3BYB; 3D65; 3FP6; 3FP7; 3FP8; 3GYM; 3L33; 3LDI; 3LDJ; 3LDM; 3M7Q; 3OFW; 3OTJ; 3P92; 3P95; 3T62; 3TGI; 3TGJ; 3TGK; 3TPI; 3U1J; 3UIR; 3UOU; 4BD9; 4BNR; 4BQD; 4DG4; 4DTG; 4ISL; 4ISN; 4ISO; 4PTI; 4TPI; 4U30; 4U32; 4WWY; 4WXV; 4Y0Y; 4Y0Z; 4Y10; 4Y11; 5C67; 5EZD; 5H7V; 5JBT; 5M4V; 5NMV; 5PTI; 5YV7; 5YVU; 5YW1; 5ZJ3; 6A5I; 6BX8; 6F1F; 6GFI; 6KZF; 6PTI; 7PH1; 7QIQ; 7QIR; 7QIS; 7QIT; 7V1N; 8KEW; 8KF1; 8KF3; 8KF4; 8KF5; 8KF6; 8OTF; 8PTI; 8VC3; 9IJW; 9PTI
» more