PROSITE logo

PROSITE entry PS00282


View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] KAZAL_1
Accession [info] PS00282
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00254

Name and characterization of the entry

Description [info] Kazal serine protease inhibitors family signature.
Pattern [info] 
C-x(4)-{C}-x(2)-C-x-{A}-x(4)-Y-x(3)-C-x(2,3)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.


Total number of hits 244 in 215 different sequences
Number of true positive hits 242 in 213 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 64
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.18 %
Recall (true positives / (true positives + false negatives)) 79.08 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 7
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 11
Site [info] disulfide at position 13
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 213 sequences 

DPGN_DIPMA  (O96790    ), IAC1_BOVIN  (P01000    ), IACA_PIG    (P00999    ), 

IACS_PIG    (P26461    ), IBD3_HIRME  (P09865    ), ICHY_CAIMO  (P83039    ), 
IKP1_PHYSA  (P83578    ), IKP2_PHYSA  (P83579    ), IMSP6_RUDPH (P86987    ), 
IOV7_CHICK  (P10184    ), IOVO_ACRVU  (P68469    ), IOVO_AEPAR  (P52241    ), 
IOVO_AFRCO  (P52258    ), IOVO_AIXGA  (P68144    ), IOVO_AIXSP  (P68145    ), 
IOVO_ALECH  (P68146    ), IOVO_ALERU  (P68147    ), IOVO_ALOAE  (P68148    ), 
IOVO_ANACA  (P68149    ), IOVO_ANAPL  (P68150    ), IOVO_ANHNO  (P05565    ), 
IOVO_ANSAN  (P68389    ), IOVO_ANSCA  (P68394    ), IOVO_ANSIN  (P68437    ), 
IOVO_ANSSE  (P05567    ), IOVO_ANTVI  (P68381    ), IOVO_ANTVP  (P68382    ), 
IOVO_AQUAU  (P68376    ), IOVO_ARBTO  (P05601    ), IOVO_ARGAR  (P05608    ), 
IOVO_AYTAM  (P68391    ), IOVO_BALPA  (P52239    ), IOVO_BAMTH  (P52259    ), 
IOVO_BONUM  (P05585    ), IOVO_BRACA  (P68393    ), IOVO_BUGCA  (P68383    ), 
IOVO_CALCC  (P68387    ), IOVO_CALGM  (P68388    ), IOVO_CALSC  (P05589    ), 
IOVO_CALSP  (P05588    ), IOVO_CARPF  (P52265    ), IOVO_CARRE  (P05616    ), 
IOVO_CASBE  (P62336    ), IOVO_CASCA  (P62337    ), IOVO_CATWA  (P67957    ), 
IOVO_CENUR  (P67945    ), IOVO_CERNO  (P05575    ), IOVO_CHACH  (P67887    ), 
IOVO_CHATO  (P67888    ), IOVO_CHICK  (P01005    ), IOVO_CHLPI  (P68151    ), 
IOVO_CHRAM  (P68128    ), IOVO_CHRPC  (P68127    ), IOVO_CHRRI  (P68386    ), 
IOVO_CIRAE  (P05579    ), IOVO_COLMD  (P52244    ), IOVO_COLVI  (P05591    ), 
IOVO_CORAL  (P52243    ), IOVO_COSCO  (P05571    ), IOVO_COTDE  (P05600    ), 
IOVO_COTJA  (P01003    ), IOVO_CROAU  (P67951    ), IOVO_CROCS  (P52245    ), 
IOVO_CROMA  (P67952    ), IOVO_CYACY  (P68152    ), IOVO_CYGAT  (P68129    ), 
IOVO_CYGOL  (P68130    ), IOVO_CYRMO  (P05592    ), IOVO_DACNO  (P05617    ), 
IOVO_DENAC  (P67890    ), IOVO_DENAR  (P67889    ), IOVO_DENAU  (P67891    ), 
IOVO_DENBI  (P67892    ), IOVO_DENEY  (P05569    ), IOVO_DENVD  (P05570    ), 
IOVO_DRONO  (P05560    ), IOVO_EUDEL  (P05562    ), IOVO_FRAFR  (P05597    ), 
IOVO_FRAPO  (P05598    ), IOVO_FULAT  (P68378    ), IOVO_GALAS  (P52266    ), 
IOVO_GALCH  (P68379    ), IOVO_GALVA  (P52267    ), IOVO_GEOCA  (P05615    ), 
IOVO_GRUJA  (P68380    ), IOVO_GUIGU  (P52246    ), IOVO_GUTPU  (P52260    ), 
IOVO_GYPCO  (P68374    ), IOVO_HAEME  (P52242    ), IOVO_HALAL  (P52268    ), 
IOVO_HALIN  (P05577    ), IOVO_LAGLU  (P67961    ), IOVO_LARMA  (P68385    ), 
IOVO_LEIOC  (P05581    ), IOVO_LEUAL  (P67940    ), IOVO_LOPBU  (P52261    ), 
IOVO_LOPCU  (P68154    ), IOVO_LOPDI  (P67893    ), IOVO_LOPED  (P67953    ), 
IOVO_LOPIG  (P67894    ), IOVO_LOPIM  (P67950    ), IOVO_LOPLE  (P52262    ), 
IOVO_LOPNY  (P67954    ), IOVO_LOPSP  (P68153    ), IOVO_LOPSW  (P67955    ), 
IOVO_MEGFR  (P05580    ), IOVO_MELGA  (P68390    ), IOVO_MELOE  (P68436    ), 
IOVO_NECMO  (P68377    ), IOVO_NEOJU  (P68155    ), IOVO_NETRU  (P68392    ), 
IOVO_NOTCI  (P05561    ), IOVO_NOTPE  (P52248    ), IOVO_NUMME  (P68468    ), 
IOVO_NYCNY  (P05566    ), IOVO_OPIHO  (P52249    ), IOVO_OREPI  (P05587    ), 
IOVO_ORTVE  (P05582    ), IOVO_OXYJA  (P68131    ), IOVO_OXYVI  (P68132    ), 
IOVO_PAVCR  (P05609    ), IOVO_PAVMU  (P52263    ), IOVO_PELCO  (P05595    ), 
IOVO_PENJC  (P67895    ), IOVO_PENSU  (P67896    ), IOVO_PERPE  (P05599    ), 
IOVO_PHACO  (P68470    ), IOVO_PHASU  (P05564    ), IOVO_PHAVE  (P68471    ), 
IOVO_PIPPP  (P05584    ), IOVO_PODST  (P52264    ), IOVO_POLBI  (P05607    ), 
IOVO_POLNP  (P52250    ), IOVO_POLRA  (P68375    ), IOVO_PTEAF  (P05594    ), 
IOVO_PTEER  (P05596    ), IOVO_PUCMA  (P67956    ), IOVO_PYGAD  (P67941    ), 
IOVO_RHEAM  (P67942    ), IOVO_RHEPE  (P67943    ), IOVO_RHYFU  (P52251    ), 
IOVO_ROLRO  (P52252    ), IOVO_SARME  (P68156    ), IOVO_SCYNO  (P52253    ), 
IOVO_SPHHU  (P05563    ), IOVO_STRCA  (P05557    ), IOVO_SYREL  (P67958    ), 
IOVO_SYRHU  (P67959    ), IOVO_SYRMI  (P52269    ), IOVO_SYRRE  (P05605    ), 
IOVO_SYRSO  (P67960    ), IOVO_TADRA  (P68157    ), IOVO_TINMA  (P52254    ), 
IOVO_TRABL  (P67946    ), IOVO_TRACA  (P67947    ), IOVO_TRASA  (P67948    ), 
IOVO_TRATE  (P67949    ), IOVO_TURME  (P52256    ), IOVO_TURSY  (P05611    ), 
IOVO_TYMCU  (P67944    ), IOVO_VANSP  (P68384    ), IOVO_VULGR  (P20846    ), 
IPSG_CANLF  (P01002    ), IPSG_FELCA  (P08480    ), IPSG_MARMT  (P81482    ), 
IPSG_MELME  (P16226    ), IPSG_MUSLU  (P81481    ), IPSG_PANLE  (P08481    ), 
IPSG_PANUN  (P81262    ), IPSG_VULVU  (P08479    ), ISK10_MOUSE (Q8CAC8    ), 
ISK11_MOUSE (Q09TK7    ), ISK12_MOUSE (Q9D256    ), ISK13_MOUSE (Q3UTS8    ), 
ISK13_RAT   (D3ZVP0    ), ISK14_HUMAN (Q6IE38    ), ISK14_RAT   (Q6IE46    ), 
ISK1L_CHICK (P85000    ), ISK1L_RAT   (P09656    ), ISK1_ANGAN  (P11706    ), 
ISK1_BOVIN  (P00996    ), ISK1_CANLF  (P04542    ), ISK1_HORSE  (P81634    ), 
ISK1_HUMAN  (P00995    ), ISK1_MONDO  (P81635    ), ISK1_MOUSE  (P09036    ), 
ISK1_PIG    (P00998    ), ISK1_RAT    (P09655    ), ISK1_SHEEP  (P00997    ), 
ISK1_STRCA  (Q9PSM2    ), ISK2_HUMAN  (P20155    ), ISK2_MACFA  (P34953    ), 
ISK2_MOUSE  (Q8BMY7    ), ISK2_RAT    (Q6IE49    ), ISK4_HUMAN  (O60575    ), 
ISK4_MOUSE  (O35679    ), ISK4_PIG    (P37109    ), ISK5_HUMAN  (Q9NQ38    ), 
ISK6_BOVIN  (P01001    ), ISK6_HUMAN  (Q6UWN8    ), ISK6_MOUSE  (Q8BT20    ), 
ISK6_RAT    (Q6IE47    ), ISK7_HUMAN  (P58062    ), ISK7_MOUSE  (Q6IE32    ), 
ISK7_RAT    (Q6IE51    ), ISK9_HUMAN  (Q5DT21    ), KTIL_BOTSC  (C0HL51    ), 
LDTI_HIRME  (P80424    ), RECK_CHICK  (A0A1D5PUP4), RECK_DANRE  (A0A0R4IKU3), 
RECK_HUMAN  (O95980    ), RECK_MOUSE  (Q9Z0J1    ), THBI_RHOPR  (Q06684    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 64 sequences 

CALT_CAVPO  (P22074    ), COW_DROME   (Q9VCR3    ), EPI10_PHYIN (Q6PQG3    ), 

EPI10_PHYIT (D0NJ41    ), ESM1_DROME  (O97176    ), ESM1_DROSI  (B4QW11    ), 
FSTA_DANRE  (Q9YHV4    ), FSTL1_HUMAN (Q12841    ), FSTL1_MOUSE (Q62356    ), 
FSTL1_PONAB (Q5R9Y1    ), FSTL1_RAT   (Q62632    ), FSTL3_BOVIN (Q1LZB9    ), 
FSTL3_HUMAN (O95633    ), FSTL3_MOUSE (Q9EQC7    ), FSTL3_RAT   (Q99PW7    ), 
FSTL4_HUMAN (Q6MZW2    ), FSTL4_MOUSE (Q5STE3    ), FSTL5_HUMAN (Q8N475    ), 
FSTL5_MOUSE (Q8BFR2    ), FST_BOVIN   (P50291    ), FST_BUBBU   (A5YT95    ), 
FST_CHICK   (Q90844    ), FST_HORSE   (O62650    ), FST_HUMAN   (P19883    ), 
FST_MOUSE   (P47931    ), FST_PIG     (P10669    ), FST_RAT     (P21674    ), 
FST_SHEEP   (P31514    ), FST_XENLA   (P31515    ), HTR1B_DANRE (A9JRB3    ), 
HTRA1_BOVIN (F1N152    ), HTRA1_RAT   (Q9QZK5    ), HTRA1_XENLA (A6YFB5    ), 
HTRA1_XENTR (A4IHA1    ), HTRA3_HUMAN (P83110    ), HTRA3_MOUSE (Q9D236    ), 
HTRA3_RAT   (D3ZA76    ), HTRA4_BOVIN (E1BJW1    ), HTRA4_HUMAN (P83105    ), 
IELA_ANESU  (P16895    ), IGFBP_CUPSA (G4V4G1    ), IPK2_CENMR  (P84755    ), 
MCPI_MELCP  (P82968    ), SO74D_DROME (Q9VVH9    ), SPIKL_MOUSE (Q8CEK3    ), 
TU11_LOPAL  (P0DKM9    ), TU91_GEMLI  (P0DKT5    ), TU91_IOTCI  (P0DKM8    ), 
TU91_LOPOL  (P0DKM7    ), TU92_GEMSO  (P0DKT2    ), TU92_IOTCI  (P0DKT4    ), 
TU92_POLAB  (P0DKT1    ), TU93_GEMSP  (P0DKT3    ), VASO1_TABYA (C1IBZ2    ), 
VASO2_TABYA (C8YJB3    ), VASO3_TABYA (C8YJB4    ), VASOT_HYBBI (P84843    ), 
WFKN1_HUMAN (Q96NZ8    ), WFKN1_MOUSE (Q8R0S6    ), WFKN1_RAT   (P0C5J5    ), 
WFKN2_BOVIN (Q08E66    ), WFKN2_HUMAN (Q8TEU8    ), WFKN2_MOUSE (Q7TQN3    ), 
WFKN_DANRE  (Q6NUX0    )
» more

UniProtKB/Swiss-Prot
False positive sequences		 2 sequences 

MADD_CAEEL  (O02626    ), TUL1_YEAST  (P36096    )


				
	

	

		PDB
[Detailed view]		
		
			71 PDB
			


			1AN1; 1BUS; 1CGI; 1CGJ; 1CHO; 1CSO; 1CT0; 1CT2; 1CT4; 1DS2; 1DS3; 1HJA; 
			
				1HPT; 1IY5; 1IY6; 1KMA; 1LDT; 1M8B; 1M8C; 1OMT; 1OMU; 1OVO; 1PCE; 1PPF; 
				1R0R; 1SGD; 1SGE; 1SGN; 1SGP; 1SGQ; 1SGR; 1SGY; 1TBQ; 1TBR; 1TGS; 1TUR; 
				1TUS; 1UVF; 1UVG; 1Y1C; 1YU6; 1Z7K; 2BUS; 2GKR; 2GKT; 2GKV; 2JXD; 2KMO; 
				2KMP; 2KMQ; 2KMR; 2LEO; 2N52; 2NU0; 2NU1; 2NU2; 2NU3; 2NU4; 2OVO; 2SGD; 
				2SGE; 2SGF; 2SGP; 2SGQ; 3OVO; 3SGB; 3SGQ; 4OVO; 6KBR; 7QE8; 7QE9
			
			

			» more