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PROSITE entry PS00282


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General information about the entry

Entry name [info] KAZAL_1
Accession [info] PS00282
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00254

Name and characterization of the entry

Description [info] Kazal serine protease inhibitors family signature.
Pattern [info] 
C-x(4)-{C}-x(2)-C-x-{A}-x(4)-Y-x(3)-C-x(2,3)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 245 in 216 different sequences
Number of true positive hits 243 in 214 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 65
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.18 %
Recall (true positives / (true positives + false negatives)) 78.90 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 7
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 11
Site [info] disulfide at position 13
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 214 sequences 

AGA_ANOGA   (Q7Q3J5), DPGN_DIPMA  (O96790), IAC1_BOVIN  (P01000), 

IACA_PIG(P00999), IACS_PIG(P26461), IBD3_HIRME  (P09865), 
ICHY_CAIMO  (P83039), IKP1_PHYSA  (P83578), IKP2_PHYSA  (P83579), 
IMSP6_RUDPH (P86987), IOV7_CHICK  (P10184), IOVO_ACRVU  (P68469), 
IOVO_AEPAR  (P52241), IOVO_AFRCO  (P52258), IOVO_AIXGA  (P68144), 
IOVO_AIXSP  (P68145), IOVO_ALECH  (P68146), IOVO_ALERU  (P68147), 
IOVO_ALOAE  (P68148), IOVO_ANACA  (P68149), IOVO_ANAPL  (P68150), 
IOVO_ANHNO  (P05565), IOVO_ANSAN  (P68389), IOVO_ANSCA  (P68394), 
IOVO_ANSIN  (P68437), IOVO_ANSSE  (P05567), IOVO_ANTVI  (P68381), 
IOVO_ANTVP  (P68382), IOVO_AQUAU  (P68376), IOVO_ARBTO  (P05601), 
IOVO_ARGAR  (P05608), IOVO_AYTAM  (P68391), IOVO_BALPA  (P52239), 
IOVO_BAMTH  (P52259), IOVO_BONUM  (P05585), IOVO_BRACA  (P68393), 
IOVO_BUGCA  (P68383), IOVO_CALCC  (P68387), IOVO_CALGM  (P68388), 
IOVO_CALSC  (P05589), IOVO_CALSP  (P05588), IOVO_CARPF  (P52265), 
IOVO_CARRE  (P05616), IOVO_CASBE  (P62336), IOVO_CASCA  (P62337), 
IOVO_CATWA  (P67957), IOVO_CENUR  (P67945), IOVO_CERNO  (P05575), 
IOVO_CHACH  (P67887), IOVO_CHATO  (P67888), IOVO_CHICK  (P01005), 
IOVO_CHLPI  (P68151), IOVO_CHRAM  (P68128), IOVO_CHRPC  (P68127), 
IOVO_CHRRI  (P68386), IOVO_CIRAE  (P05579), IOVO_COLMD  (P52244), 
IOVO_COLVI  (P05591), IOVO_CORAL  (P52243), IOVO_COSCO  (P05571), 
IOVO_COTDE  (P05600), IOVO_COTJA  (P01003), IOVO_CROAU  (P67951), 
IOVO_CROCS  (P52245), IOVO_CROMA  (P67952), IOVO_CYACY  (P68152), 
IOVO_CYGAT  (P68129), IOVO_CYGOL  (P68130), IOVO_CYRMO  (P05592), 
IOVO_DACNO  (P05617), IOVO_DENAC  (P67890), IOVO_DENAR  (P67889), 
IOVO_DENAU  (P67891), IOVO_DENBI  (P67892), IOVO_DENEY  (P05569), 
IOVO_DENVD  (P05570), IOVO_DRONO  (P05560), IOVO_EUDEL  (P05562), 
IOVO_FRAFR  (P05597), IOVO_FRAPO  (P05598), IOVO_FULAT  (P68378), 
IOVO_GALAS  (P52266), IOVO_GALCH  (P68379), IOVO_GALVA  (P52267), 
IOVO_GEOCA  (P05615), IOVO_GRUJA  (P68380), IOVO_GUIGU  (P52246), 
IOVO_GUTPU  (P52260), IOVO_GYPCO  (P68374), IOVO_HAEME  (P52242), 
IOVO_HALAL  (P52268), IOVO_HALIN  (P05577), IOVO_LAGLU  (P67961), 
IOVO_LARMA  (P68385), IOVO_LEIOC  (P05581), IOVO_LEUAL  (P67940), 
IOVO_LOPBU  (P52261), IOVO_LOPCU  (P68154), IOVO_LOPDI  (P67893), 
IOVO_LOPED  (P67953), IOVO_LOPIG  (P67894), IOVO_LOPIM  (P67950), 
IOVO_LOPLE  (P52262), IOVO_LOPNY  (P67954), IOVO_LOPSP  (P68153), 
IOVO_LOPSW  (P67955), IOVO_MEGFR  (P05580), IOVO_MELGA  (P68390), 
IOVO_MELOE  (P68436), IOVO_NECMO  (P68377), IOVO_NEOJU  (P68155), 
IOVO_NETRU  (P68392), IOVO_NOTCI  (P05561), IOVO_NOTPE  (P52248), 
IOVO_NUMME  (P68468), IOVO_NYCNY  (P05566), IOVO_OPIHO  (P52249), 
IOVO_OREPI  (P05587), IOVO_ORTVE  (P05582), IOVO_OXYJA  (P68131), 
IOVO_OXYVI  (P68132), IOVO_PAVCR  (P05609), IOVO_PAVMU  (P52263), 
IOVO_PELCO  (P05595), IOVO_PENJC  (P67895), IOVO_PENSU  (P67896), 
IOVO_PERPE  (P05599), IOVO_PHACO  (P68470), IOVO_PHASU  (P05564), 
IOVO_PHAVE  (P68471), IOVO_PIPPP  (P05584), IOVO_PODST  (P52264), 
IOVO_POLBI  (P05607), IOVO_POLNP  (P52250), IOVO_POLRA  (P68375), 
IOVO_PTEAF  (P05594), IOVO_PTEER  (P05596), IOVO_PUCMA  (P67956), 
IOVO_PYGAD  (P67941), IOVO_RADRA  (P68157), IOVO_RHEAM  (P67942), 
IOVO_RHEPE  (P67943), IOVO_RHYFU  (P52251), IOVO_ROLRO  (P52252), 
IOVO_SARME  (P68156), IOVO_SCYNO  (P52253), IOVO_SPHHU  (P05563), 
IOVO_STRCA  (P05557), IOVO_SYREL  (P67958), IOVO_SYRHU  (P67959), 
IOVO_SYRMI  (P52269), IOVO_SYRRE  (P05605), IOVO_SYRSO  (P67960), 
IOVO_TINMA  (P52254), IOVO_TRABL  (P67946), IOVO_TRACA  (P67947), 
IOVO_TRASA  (P67948), IOVO_TRATE  (P67949), IOVO_TURME  (P52256), 
IOVO_TURSY  (P05611), IOVO_TYMCU  (P67944), IOVO_VANSP  (P68384), 
IOVO_VULGR  (P20846), IPSG_CANLF  (P01002), IPSG_FELCA  (P08480), 
IPSG_MARMT  (P81482), IPSG_MELME  (P16226), IPSG_MUSLU  (P81481), 
IPSG_PANLE  (P08481), IPSG_PANUN  (P81262), IPSG_VULVU  (P08479), 
ISK10_MOUSE (Q8CAC8), ISK11_MOUSE (Q09TK7), ISK12_MOUSE (Q9D256), 
ISK13_MOUSE (Q3UTS8), ISK13_RAT   (D3ZVP0), ISK14_HUMAN (Q6IE38), 
ISK14_RAT   (Q6IE46), ISK1L_CHICK (P85000), ISK1L_RAT   (P09656), 
ISK1_ANGAN  (P11706), ISK1_BOVIN  (P00996), ISK1_CANLF  (P04542), 
ISK1_HORSE  (P81634), ISK1_HUMAN  (P00995), ISK1_MONDO  (P81635), 
ISK1_MOUSE  (P09036), ISK1_PIG(P00998), ISK1_RAT(P09655), 
ISK1_SHEEP  (P00997), ISK1_STRCA  (Q9PSM2), ISK2_HUMAN  (P20155), 
ISK2_MACFA  (P34953), ISK2_MOUSE  (Q8BMY7), ISK2_RAT(Q6IE49), 
ISK4_HUMAN  (O60575), ISK4_MOUSE  (O35679), ISK4_PIG(P37109), 
ISK5_HUMAN  (Q9NQ38), ISK6_BOVIN  (P01001), ISK6_HUMAN  (Q6UWN8), 
ISK6_MOUSE  (Q8BT20), ISK6_RAT(Q6IE47), ISK7_HUMAN  (P58062), 
ISK7_MOUSE  (Q6IE32), ISK7_RAT(Q6IE51), ISK9_HUMAN  (Q5DT21), 
KTIL_BOTSC  (C0HL51), LDTI_HIRME  (P80424), RECK_CHICK  (A0A1D5PUP4), 
RECK_DANRE  (A0A0R4IKU3), RECK_HUMAN  (O95980), RECK_MOUSE  (Q9Z0J1), 
THBI_RHOPR  (Q06684)
» more

UniProtKB/Swiss-Prot
False negative sequences		 65 sequences 

CALT_CAVPO  (P22074), COW_DROME   (Q9VCR3), EPI10_PHYIN (Q6PQG3), 

EPI10_PHYIT (D0NJ41), ESM1_DROME  (O97176), ESM1_DROSI  (B4QW11), 
FSTA_DANRE  (Q9YHV4), FSTL1_HUMAN (Q12841), FSTL1_MOUSE (Q62356), 
FSTL1_PONAB (Q5R9Y1), FSTL1_RAT   (Q62632), FSTL3_BOVIN (Q1LZB9), 
FSTL3_HUMAN (O95633), FSTL3_MOUSE (Q9EQC7), FSTL3_RAT   (Q99PW7), 
FSTL4_HUMAN (Q6MZW2), FSTL4_MOUSE (Q5STE3), FSTL5_HUMAN (Q8N475), 
FSTL5_MOUSE (Q8BFR2), FST_BOVIN   (P50291), FST_BUBBU   (A5YT95), 
FST_CHICK   (Q90844), FST_HORSE   (O62650), FST_HUMAN   (P19883), 
FST_MOUSE   (P47931), FST_PIG (P10669), FST_RAT (P21674), 
FST_SHEEP   (P31514), FST_XENLA   (P31515), HTR1B_DANRE (A9JRB3), 
HTRA1_BOVIN (F1N152), HTRA1_RAT   (Q9QZK5), HTRA1_XENLA (A6YFB5), 
HTRA1_XENTR (A4IHA1), HTRA3_HUMAN (P83110), HTRA3_MOUSE (Q9D236), 
HTRA3_RAT   (D3ZA76), HTRA4_BOVIN (E1BJW1), HTRA4_HUMAN (P83105), 
IELA_ANESU  (P16895), IGFBP_CUPSA (G4V4G1), IPK2_CENMR  (P84755), 
MCPI_MELCP  (P82968), PEG_DROME   (Q9VDG1), SO74D_DROME (Q9VVH9), 
SPIKL_MOUSE (Q8CEK3), TU11_LOPAL  (P0DKM9), TU91_GEMLI  (P0DKT5), 
TU91_IOTCI  (P0DKM8), TU91_IOTOL  (P0DKM7), TU92_GEMSO  (P0DKT2), 
TU92_IOTCI  (P0DKT4), TU92_POLAB  (P0DKT1), TU93_GEMSP  (P0DKT3), 
VASO1_TABYA (C1IBZ2), VASO2_TABYA (C8YJB3), VASO3_TABYA (C8YJB4), 
VASOT_HYBBI (P84843), WFKN1_HUMAN (Q96NZ8), WFKN1_MOUSE (Q8R0S6), 
WFKN1_RAT   (P0C5J5), WFKN2_BOVIN (Q08E66), WFKN2_HUMAN (Q8TEU8), 
WFKN2_MOUSE (Q7TQN3), WFKN_DANRE  (Q6NUX0)
» more

UniProtKB/Swiss-Prot
False positive sequences		 2 sequences 

MADD_CAEEL  (O02626), TUL1_YEAST  (P36096)


				
	

	

		PDB
[Detailed view]		
		
			72 PDB
			


			1AN1; 1BUS; 1CGI; 1CGJ; 1CHO; 1CSO; 1CT0; 1CT2; 1CT4; 1DS2; 1DS3; 1HJA; 
			
				1HPT; 1IY5; 1IY6; 1KMA; 1LDT; 1M8B; 1M8C; 1OMT; 1OMU; 1OVO; 1PCE; 1PPF; 
				1R0R; 1SGD; 1SGE; 1SGN; 1SGP; 1SGQ; 1SGR; 1SGY; 1TBQ; 1TBR; 1TGS; 1TUR; 
				1TUS; 1UVF; 1UVG; 1Y1C; 1YU6; 1Z7K; 2BUS; 2GKR; 2GKT; 2GKV; 2JXD; 2KMO; 
				2KMP; 2KMQ; 2KMR; 2LEO; 2N52; 2NU0; 2NU1; 2NU2; 2NU3; 2NU4; 2OVO; 2SGD; 
				2SGE; 2SGF; 2SGP; 2SGQ; 3OVO; 3SGB; 3SGQ; 4OVO; 6KBR; 7QE8; 7QE9; 8TZP
			
			

			» more