We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00284
View entry in original PROSITE format
View entry in raw text format (no links)
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PURL: https://purl.expasy.org/prosite/signature/PS00284
Direct ScanProsite submission
General information about the entry
| Entry name [info] | SERPIN |
| Accession [info] | PS00284 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00256 |
Name and characterization of the entry
| Description [info] | Serpins signature. |
| Pattern [info] |
[LIVMFY]-{G}-[LIVMFYAC]-[DNQ]-[RKHQS]-[PST]-F-[LIVMFY]-[LIVMFYC]-x-
[LIVMFAH].
|
Numerical results [info]
| Total number of hits | 368 in 368 different sequences |
| Number of true positive hits | 251 in 251 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 117 in 117 different sequences |
| Number of false negative sequences | 40 |
| Number of 'partial' sequences | 12 |
| Precision (true positives / (true positives + false positives)) | 68.21 % |
| Recall (true positives / (true positives + false negatives)) | 86.25 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
251 sequences
A1AF_CAVPO (P22324), A1AF_RABIT (P23035), A1AS_CAVPO (P22325), A1AT1_HORSE (P38028), A1AT1_MOUSE (P07758), A1AT2_HORSE (P38029), A1AT2_MOUSE (P22599), A1AT3_MOUSE (Q00896), A1AT4_HORSE (P38031), A1AT4_MOUSE (Q00897), A1AT5_MOUSE (Q00898), A1AT6_MOUSE (Q9DCQ7), A1ATR_HUMAN (P20848), A1AT_BOMMO (P22922), A1AT_BOVIN (P34955), A1AT_CALCN (O54763), A1AT_CHLAE (O00394), A1AT_CYPCA (P32759), A1AT_HUMAN (P01009), A1AT_MUSCR (P26595), A1AT_MUSSA (Q63969), A1AT_NOTEU (P38027), A1AT_PAPAN (P01010), A1AT_PIG(P50447), A1AT_PONAB (Q5RCW5), A1AT_RAT(P17475), A1AT_SHEEP (P12725), A2AP_BOVIN (P28800), A2AP_HUMAN (P08697), A2AP_MOUSE (Q61247), A76A_DROME (Q9VVW1), AACT_HUMAN (P01011), AACT_PONAB (Q5R536), ACH1_BOMMO (Q03383), ACH2_BOMMO (P80034), ALLT_ICTTR (O54762), ALMM_TAMSI (O54757), ALMS_ICTTR (O54761), ALMS_TAMSI (O54758), ALSI_TAMSI (O54760), ALST_TAMSI (O54759), ANGT_BOVIN (P01017), ANGT_CALJA (Q9TSZ0), ANGT_GORGO (Q9GLP6), ANGT_HUMAN (P01019), ANGT_PANTR (Q9GLN8), ANGT_SHEEP (P20757), ANT3_HUMAN (P01008), ANT3_MOUSE (P32261), ANT3_PONAB (Q5R5A3), ANT3_SHEEP (P32262), BSZ7_HORVU (Q43492), CBG_BOVIN (E1BF81), CBG_HUMAN (P08185), CBG_MESAU (Q60543), CBG_MOUSE (Q06770), CBG_PIG (Q9GK37), CBG_PONAB (Q5R9E3), CBG_RABIT (P23775), CBG_RAT (P31211), CBG_SAISC (P50451), CBG_SHEEP (P49920), CBG_URSAR (B2D1U1), EP45_XENLA (Q00387), F12AI_BOVIN (P50448), GDN_HUMAN (P07093), GDN_MOUSE (Q07235), GDN_RAT (P07092), HEP2_HUMAN (P05546), HEP2_MOUSE (P49182), HEP2_RABIT (P47776), HEP2_RAT(Q64268), HP55_TAMSI (Q09055), IC1_HUMAN (P05155), IC1_MOUSE (P97290), IC1_RABIT (Q9TRG2), IC1_RAT (Q6P734), ILEUA_MOUSE (Q9D154), ILEUA_RAT (Q4G075), ILEUB_MOUSE (Q8VHP7), ILEUC_MOUSE (Q5SV42), ILEU_BOVIN (Q1JPB0), ILEU_HORSE (P05619), ILEU_HUMAN (P30740), ILEU_PIG(P80229), ILEU_XENLA (Q52L45), ILEU_XENTR (Q5I0S8), IPIS1_IXOPE (A0A090BX51), IPSP_BOVIN (Q9N2I2), IPSP_HUMAN (P05154), IRIS_IXORI (Q9GP13), IRS1_IXORI (Q06B75), IRS2_IXORI (Q06B74), IRS3_IXORI (A0A0K8RCY5), IRS4_IXORI (A0A0K8RJV9), IRS5_IXORI (A0A0K8RJ89), IRS8_IXORI (Q06B72), KAIN_HUMAN (P29622), KAIN_PONAB (Q5RCR2), LICI1_TACTR (Q27085), LICI2_TACTR (Q27086), LICI3_TACTR (Q94823), NEUS_CHICK (Q90935), NEUS_HUMAN (Q99574), NEUS_MOUSE (O35684), NEUS_RAT(Q9JLD2), OVALX_CHICK (P01013), OVALY_CHICK (P01014), OVAL_CHICK (P01012), OVAL_COTCO (Q6V115), OVAL_COTJA (P19104), OVAL_DRONO (E2RVI8), OVAL_MELGA (O73860), PAI1_BOVIN (P13909), PAI1_HUMAN (P05121), PAI1_MOUSE (P22777), PAI1_NEOVI (P50449), PAI1_PIG(P79335), PAI1_RAT(P20961), PAI2_HUMAN (P05120), PAI2_MOUSE (P12388), PAI2_RAT(P29524), PEDF_BOVIN (Q95121), PEDF_HUMAN (P36955), PEDF_MOUSE (P97298), SERA_MANSE (P14754), SERP3_BOVIN (A6QQ92), SERP3_DANRE (B0UYL8), SERP3_HUMAN (A8MV23), SERPH_BOVIN (Q2KJH6), SERPH_CHICK (P13731), SERPH_HUMAN (P50454), SERPH_MOUSE (P19324), SERPH_PONAB (Q5RBS3), SERPH_RAT (P29457), SP27A_DROME (Q9V3N1), SP2_ANOGA (Q7QIJ8), SP88E_DROME (Q9VFC2), SPA12_MOUSE (Q7TMF5), SPA31_BOVIN (Q9TTE1), SPA32_BOVIN (A2I7M9), SPA33_BOVIN (Q3ZEJ6), SPA34_BOVIN (A2I7N0), SPA35_BOVIN (A2I7N1), SPA36_BOVIN (A2I7N2), SPA37_BOVIN (A2I7N3), SPA38_BOVIN (A6QPQ2), SPA3C_MOUSE (P29621), SPA3F_MOUSE (Q80X76), SPA3G_MOUSE (Q5I2A0), SPA3K_CAVPO (P22323), SPA3K_MOUSE (P07759), SPA3K_RAT (P05545), SPA3L_RAT (P05544), SPA3M_MOUSE (Q03734), SPA3M_RAT (Q63556), SPA3N_MOUSE (Q91WP6), SPA3N_RAT (P09006), SPA9_HUMAN (Q86WD7), SPB10_BOVIN (A5PJK0), SPB10_CALJA (B0CMB0), SPB10_HUMAN (P48595), SPB10_MOUSE (Q8K1K6), SPB10_OTOGA (B4USX2), SPB10_PAPAN (A9RA96), SPB10_PLEMO (B1MTC3), SPB10_RAT (Q8K3K4), SPB10_RHIFE (B2KI30), SPB10_SORAR (B3RFC3), SPB11_HUMAN (Q96P15), SPB12_HUMAN (Q96P63), SPB12_MOUSE (Q9D7P9), SPB13_HUMAN (Q9UIV8), SPB13_MOUSE (Q8CDC0), SPB3_HUMAN (P29508), SPB4_HUMAN (P48594), SPB5_HUMAN (P36952), SPB5_MOUSE (P70124), SPB5_PLEMO (B1MTB7), SPB5_RAT(P70564), SPB5_XENLA (Q6GLQ1), SPB5_XENTR (Q5M8J5), SPB6_BOVIN (O02739), SPB6_HUMAN (P35237), SPB6_MACFA (Q4R3G2), SPB6_MOUSE (Q60854), SPB6_PONAB (Q5R899), SPB7_HUMAN (O75635), SPB7_MOUSE (Q9D695), SPB8_BOVIN (Q5BIR5), SPB8_HUMAN (P50452), SPB8_MOUSE (O08800), SPB9_HUMAN (P50453), SPI1_CWPXB (P42927), SPI1_MONPV (A0A7H0DNG4), SPI1_MYXVL (P12393), SPI1_RABPU (P42928), SPI1_VACCC (P20531), SPI1_VACCW (P15058), SPI1_VAR67 (P0DOT3), SPI1_VARV (P0DOT4), SPI21_RAT (P09005), SPI24_APOSY (Q60396), SPI2B_VACCC (P20842), SPI2_CWPXB (P07385), SPI2_HUMAN (O75830), SPI2_MONPV (A0A7H0DNF9), SPI2_MOUSE (Q9JK88), SPI2_MYXVL (P68565), SPI2_MYXVU (P68566), SPI2_RABPU (P42926), SPI2_VACCW (P15059), SPI2_VAR67 (P0DSW3), SPI2_VARV (P0DSW4), SPI_CYACP (Q6J201), SPZ10_ARATH (Q9SIR9), SPZ12_ORYSJ (Q5NBM0), SPZ1A_WHEAT (Q41593), SPZ1B_WHEAT (P93693), SPZ1C_WHEAT (Q9ST58), SPZ1_ARATH (Q9SH52), SPZ1_ORYSJ (Q94DW6), SPZ2A_WHEAT (Q9ST57), SPZ2B_WHEAT (P93692), SPZ2_ARATH (Q9ZQR6), SPZ3_ARATH (O48706), SPZ4_ARATH (Q9M1T7), SPZ4_HORVU (P06293), SPZ5_ARATH (O04582), SPZ9_ORYSJ (Q2R8P2), SPZXA_ORYSJ (Q75H81), SPZXB_ORYSJ (Q10GX0), SPZX_ARATH (Q9S7T8), SPZX_HORVU (Q40066), THBG_BOVIN (Q9TT36), THBG_HUMAN (P05543), THBG_PANTR (P61640), THBG_PIG(Q9TT35), THBG_RAT(P35577), THBG_SHEEP (P50450), UFAP2_PIG (P46202), UFAP_PIG(P16708), UTMP_BOVIN (P46201), UTMP_SHEEP (P21814), V044_FOWPN (Q9J5F9), V204_FOWPN (Q9J531), Y049_PYRAE (Q8ZZW3), Y1782_THEKO (Q5JJ64), Y2246_METAC (Q8TNN7), Y2678_METMA (Q8PTN8), Y3388_METAC (Q8TKL5)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
40 sequences
A1AT_DIDVI (Q03044), A1AT_MERUN (Q64118), A1AT_MESAU (P97277), ANGT_MOUSE (P11859), ANGT_RAT(P01015), ANT3_BOVIN (P41361), HMSD_HUMAN (A8MTL9), IPSP_MOUSE (P70458), PG040_VACCA (Q85339), PG040_VACCC (P20532), PG040_VACCW (P18384), PG040_VAR67 (P33831), SP28D_DROME (Q9VLU4), SP42D_DROME (Q7YTY6), SPA11_HUMAN (Q86U17), SPA11_MOUSE (Q8CIE0), SPA12_HUMAN (Q8IW75), SPA12_RAT (Q8R4Z1), SPA9_MOUSE (Q9D7D2), SPB10_CHICK (O73790), SPB11_MOUSE (Q9CQV3), SPI1_SWPVK (Q08519), SPI3_LONON (Q5MGH0), SPZ10_ORYSJ (Q7XMK1), SPZ11_ORYSJ (Q7XMK0), SPZ2A_ORYSJ (Q53KS8), SPZ2B_ORYSJ (Q53KS9), SPZ5_ORYSJ (Q53MD3), SPZ6A_ORYSJ (Q53Q31), SPZ6B_ORYSJ (Q53Q32), SPZ6C_ORYSJ (Q53MD1), SPZ8_ORYSJ (Q53P09), THBG_MOUSE (P61939), V010_FOWPN (Q9J5J1), V040_FOWPN (Q9J5G3), V251_FOWPN (P14369), Y2613_METAC (Q8TMP0), YR700_MIMIV (Q7T6X8), ZPI_HUMAN (Q9UK55), ZPI_RAT (Q62975)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
12 sequences
A1AT3_HORSE (P38030), A1AT_CHILA (P38026), A2AP_STRCA (P83168), ANGT1_BOTJA (Q10581), ANGT2_BOTJA (Q10582), ANGT_CHICK (P67885), ANGT_COTJA (P67886), ANGT_HORSE (P01016), ANGT_THETS (Q10757), ANT3_CHICK (Q03352), ANT3_MESAU (P81050), SPI_HALRO (Q10997)» more |
| UniProtKB/Swiss-Prot False positive sequences |
117 sequences
ARLY_BUCAI (P57159), AROB_BUCAI (P57604), BALAT_DROME (Q961J5), CADH2_DANRE (Q90275), CFT1_CANAL (Q5AFT3), CH60_CUPMC (Q1LQS4), CH60_CUPPJ (Q46XW6), CH60_MANSM (Q65VE4), CH60_PLUGE (O66194), CH60_PSEA6 (Q15PD3), CH60_SHEB5 (A3D8W9), CH60_SHEB8 (A6WJ17), CH60_SHEDO (Q12S61), CH60_SHEFN (Q07WX7), CH60_SHEON (Q8CX48), CH60_SHEPC (A4Y398), CH60_SHESA (A0L170), CH60_SHESM (Q0HEQ4), CH60_SHESR (Q0HZ97), CH60_SHESW (A1RNN6), CHA4_YEAST (P43634), CIDEC_HUMAN (Q96AQ7), CTR3_YEAST (Q06686), DCL4_ORYSJ (A7LFZ6), DISP1_MOUSE (Q3TDN0), DLG2_HUMAN (Q15700), EFTU_LEPBY (P50066), EIK1_PLAF7 (Q8IL26), ELCC_PHANO (Q0UI03), ENGB_EHRCJ (Q3YS22), ERA_AGRFC (Q8UGK1), ERA_BRUME (Q8YG75), ERA_BRUSU (Q8G1P9), FER7_MYCMD (A1A654), FPG_PARUW (Q6MCT3), HIR3_YEAST (P47171), HTS1_COCCA (Q01886), ICAC_STAA8 (Q9RQP6), ICAC_STAAM (Q931E4), ICAC_STAAN (Q7A348), ICAC_STAAR (Q6GDD5), ICAC_STAAS (Q6G605), ICAC_STAAW (Q79ZV2), IP5P3_ARATH (Q8H0Z6), KS6A3_HUMAN (P51812), KS6A3_MOUSE (P18654), KS6A6_DANRE (Q6PFQ0), KS6A6_HUMAN (Q9UK32), KS6A6_MOUSE (Q7TPS0), LSPA_WOLSU (Q7M9M1), MEK1_CAEEL (Q21307), MLCE_PENCI (Q8J0F3), MSH3_BOTFB (A6RPB6), MSH3_SCLS1 (A7EC69), MURC_WOLTR (Q5GTG5), NBDA_PSEAE (Q9HYT3), NHAA1_CAMJ8 (A8FNW6), NHAA1_CAMJD (A7H5Z9), NHAA1_CAMJE (Q0P7X4), NHAA1_CAMJJ (A1W1Q6), NHAA1_CAMJR (Q5HSD9), NLRP9_BOVIN (Q288C4), NU2M_PARTE (P15577), NU4M_MYXGL (Q9G2W9), NU6M_CHLRE (P10329), PFL3_SCHPO (Q874R4), PHNW_LYSSC (B1HPR6), PLXC1_HUMAN (O60486), PLXC1_MOUSE (Q9QZC2), POMT2_DANRE (F1Q8R9), POMT2_HUMAN (Q9UKY4), POMT2_MOUSE (Q8BGQ4), RELE4_METJA (Q58573), RLMKL_IDILO (Q5QX63), RLMKL_PSEA6 (Q15UB5), RNFE_VIBPA (Q87MW9), RNFE_VIBVU (Q8D885), RNFE_VIBVY (Q7MM86), S35F3_MOUSE (Q1LZI2), SID1_CAEEL (Q9GZC8), SPNS3_MOUSE (Q9D232), SRB8_PICST (A3GF47), STSY_RAUMA (P68174), STSY_RAUSE (P68175), SYA_BACAH (A0RJ00), SYA_BACAN (Q81LK0), SYA_BACC1 (P61697), SYA_BACCN (A7GT67), SYA_BACCR (Q817Z0), SYA_BACCZ (Q634F6), SYA_BACHK (Q6HDD7), SYA_BACLD (Q65GS5), SYA_BACMK (A9VI09), SYE1_CAMC5 (A7GXI1), SYI_ANTLO (Q27707), T214A_MARPO (P12221), TERT_ARATH (Q9SPU7), TOLB_CAMJE (Q9PJ14), TOLB_CAMJR (Q5HX54), TOLB_HELPH (Q1CSE0), TOLB_HELPJ (Q9ZK86), TOLB_HELPY (O25751), TPN50_TREPA (P38369), UL79_SHV21 (Q01003), UNC5D_HUMAN (Q6UXZ4), UNC5D_MOUSE (Q8K1S2), UNC5D_RAT (F1LW30), UVRC_WOLTR (Q5GSR4), VL3_HPV5B (P26541), VPR_LACPL (F9USN6), Y3085_AZOC5 (Q04855), Y3264_ARATH (P0C897), YHJN_BACSU (O07568), YIDC_STRAW (P59811), YIDC_STRCO (O54569), YQOA_CAEEL (Q09299), ZDHC5_DICDI (Q554E7)» more |
| PDB [Detailed view] |
187 PDB
pdb_00001a7c; pdb_00001ant; pdb_00001as4; pdb_00001ath; pdb_00001att; pdb_00001atu; pdb_00001azx; pdb_00001b3k; pdb_00001br8; pdb_00001by7; pdb_00001c5g; pdb_00001c8o; pdb_00001d5s; pdb_00001db2; pdb_00001dvm; pdb_00001dvn; pdb_00001dzg; pdb_00001dzh; pdb_00001e03; pdb_00001e04; pdb_00001e05; pdb_00001ezx; pdb_00001f0c; pdb_00001hle; pdb_00001hp7; pdb_00001imv; pdb_00001jjo; pdb_00001jmj; pdb_00001jmo; pdb_00001jrr; pdb_00001jti; pdb_00001jvq; pdb_00001k9o; pdb_00001kct; pdb_00001lj5; pdb_00001lk6; pdb_00001lq8; pdb_00001m93; pdb_00001nq9; pdb_00001oc0; pdb_00001oo8; pdb_00001oph; pdb_00001ova; pdb_00001oyh; pdb_00001psi; pdb_00001qlp; pdb_00001qmn; pdb_00001r1l; pdb_00001sek; pdb_00001sr5; pdb_00001t1f; pdb_00001tb6; pdb_00001uhg; pdb_00001wz9; pdb_00001xqg; pdb_00001xqj; pdb_00001xu8; pdb_00001yxa; pdb_00002ach; pdb_00002ant; pdb_00002arq; pdb_00002arr; pdb_00002b4x; pdb_00002b5t; pdb_00002beh; pdb_00002ceo; pdb_00002d26; pdb_00002gd4; pdb_00002hi9; pdb_00002hij; pdb_00002oay; pdb_00002ol2; pdb_00002qug; pdb_00002r9y; pdb_00002riv; pdb_00002riw; pdb_00002v95; pdb_00002vdx; pdb_00002vdy; pdb_00002wxw; pdb_00002x0b; pdb_00002xn3; pdb_00002xn5; pdb_00002xn6; pdb_00002xn7; pdb_00002znh; pdb_00002zv6; pdb_00003b9f; pdb_00003caa; pdb_00003cvm; pdb_00003cwl; pdb_00003cwm; pdb_00003drm; pdb_00003dru; pdb_00003dy0; pdb_00003eox; pdb_00003evj; pdb_00003f02; pdb_00003f5n; pdb_00003fgq; pdb_00003kcg; pdb_00003le2; pdb_00003lw2; pdb_00003nda; pdb_00003ndd; pdb_00003ndf; pdb_00003ne4; pdb_00003pb1; pdb_00003pzf; pdb_00003q02; pdb_00003q03; pdb_00003r4l; pdb_00003t1p; pdb_00003ut3; pdb_00004aqh; pdb_00004bb2; pdb_00004c41; pdb_00004c49; pdb_00004caa; pdb_00004dy0; pdb_00004dy7; pdb_00004eb1; pdb_00004g8o; pdb_00004g8r; pdb_00004ga7; pdb_00004ic0; pdb_00004pyw; pdb_00004ro9; pdb_00004roa; pdb_00004rob; pdb_00004rsq; pdb_00004x30; pdb_00004yia; pdb_00004zk0; pdb_00004zk3; pdb_00005brr; pdb_00005du3; pdb_00005duq; pdb_00005io1; pdb_00005m3x; pdb_00005m3y; pdb_00005nbu; pdb_00005nbv; pdb_00005zlz; pdb_00006bj5; pdb_00006f02; pdb_00006gwn; pdb_00006gwp; pdb_00006gwq; pdb_00006hge; pdb_00006hx4; pdb_00006i3f; pdb_00006i3i; pdb_00006i4v; pdb_00006i7u; pdb_00006i8s; pdb_00006iay; pdb_00006kga; pdb_00006los; pdb_00006rod; pdb_00006zrv; pdb_00007ael; pdb_00007ahp; pdb_00007akv; pdb_00007api; pdb_00007aqf; pdb_00007aqg; pdb_00007b2t; pdb_00007npk; pdb_00007npl; pdb_00007pmu; pdb_00007qtz; pdb_00007zas; pdb_00007zbf; pdb_00008api; pdb_00008p4j; pdb_00008p4u; pdb_00008pi2; pdb_00008qz5; pdb_00008r13; pdb_00008r21; pdb_00008w18; pdb_00008zcr; pdb_00009api; pdb_00009c2t; pdb_00009d7k; pdb_00009pai » more |