PROSITE logo

PROSITE entry PS00288


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00288

Direct ScanProsite submission
General information about the entry

Entry name [info] TIMP
Accession [info] PS00288
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUL-1999 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00260

Name and characterization of the entry

Description [info] Tissue inhibitors of metalloproteinases signature.
Pattern [info] 
C-x-C-x-P-x-H-P-Q-x(2)-[FIV]-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 33 in 33 different sequences
Number of true positive hits 33 in 33 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 4
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 89.19 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 3
Site [info] disulfide at position 12
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 33 sequences 

TIMP1_BOVIN (P20414), TIMP1_HORSE (O02722), TIMP1_HUMAN (P01033), 

TIMP1_MOUSE (P12032), TIMP1_PAPCY (P49061), TIMP1_PIG   (P35624), 
TIMP1_PONAB (Q5RC60), TIMP1_RABIT (P20614), TIMP1_RAT   (P30120), 
TIMP1_SHEEP (P50122), TIMP2_BOVIN (P16368), TIMP2_CANLF (Q9TTY1), 
TIMP2_CAVPO (Q9WUC6), TIMP2_CHICK (O42146), TIMP2_CRILO (Q60453), 
TIMP2_HUMAN (P16035), TIMP2_MOUSE (P25785), TIMP2_RABIT (Q9TRZ7), 
TIMP2_RAT   (P30121), TIMP3_BOVIN (P79121), TIMP3_CHICK (P26652), 
TIMP3_HORSE (Q9TUL9), TIMP3_HUMAN (P35625), TIMP3_MACFA (P61269), 
TIMP3_MACMU (Q5PXZ9), TIMP3_MOUSE (P39876), TIMP3_RAT   (P48032), 
TIMP3_SCYTO (Q9W6B4), TIMP3_XENLA (O73746), TIMP4_BOVIN (O97563), 
TIMP4_HUMAN (Q99727), TIMP4_MOUSE (Q9JHB3), TIMP4_RAT   (P81556)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

TIMP1_CANLF (P81546), TIMP1_MACMU (Q95KL9), TIMPL_CAEEL (Q21265), 

TIMP_DROME  (Q9VH14)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

TIMP3_RABIT (O97590), TIMP4_RABIT (O97591)


				
	

	

		PDB
[Detailed view]		
		
			18 PDB
			


			1BQQ; 1BR9; 1BUV; 1D2B; 1GXD; 1OO9; 1UEA; 2E2D; 2J0T; 2TMP; 3CKI; 3MA2; 
			
				3V96; 4ILW; 6MAV; 6N9D; 7S7L; 7S7M
			
			

			» more