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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00302


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PURL: https://purl.expasy.org/prosite/signature/PS00302

Direct ScanProsite submission
General information about the entry

Entry name [info] IF5A_HYPUSINE
Accession [info] PS00302
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00274

Name and characterization of the entry

Description [info] Eukaryotic initiation factor 5A hypusine signature.
Pattern [info] 
[PT]-G-K-H-G-x-A-K.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 112 in 112 different sequences
Number of true positive hits 111 in 111 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.11 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes
Maximum number of repetitions [info] 1
Site [info] hypusine at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 111 sequences 

IF5A1_ARATH (Q9XI91), IF5A1_BOVIN (Q6EWQ7), IF5A1_CAEEL (P34563), 

IF5A1_CHICK (Q09121), IF5A1_DANRE (Q6NX89), IF5A1_HUMAN (P63241), 
IF5A1_MEDSA (P26564), IF5A1_MOUSE (P63242), IF5A1_NICPL (P69039), 
IF5A1_RABIT (P10160), IF5A1_RAT   (Q3T1J1), IF5A1_SCHPO (P56289), 
IF5A1_SOLLC (Q9AXQ6), IF5A1_SOLTU (P56333), IF5A1_TOBAC (P69040), 
IF5A1_XENLA (Q7ZXG3), IF5A1_YEAST (P23301), IF5A2_ARATH (Q93VP3), 
IF5A2_CAEEL (Q20751), IF5A2_CHICK (Q07460), IF5A2_HUMAN (Q9GZV4), 
IF5A2_MEDSA (Q945F4), IF5A2_MOUSE (Q8BGY2), IF5A2_NICPL (P24922), 
IF5A2_PONAB (Q5R898), IF5A2_SCHPO (Q9UST4), IF5A2_SOLLC (Q9AXQ5), 
IF5A2_YEAST (P19211), IF5A3_ARATH (Q9C505), IF5A3_SOLLC (Q9AXQ4), 
IF5A3_SOLTU (P56335), IF5A4_SOLLC (Q9AXQ3), IF5A4_SOLTU (P56336), 
IF5A5_SOLTU (P56337), IF5AL_HUMAN (Q6IS14), IF5A_AERPE  (Q9YA53), 
IF5A_ARCFU  (O29612), IF5A_CALMQ  (A8MD73), IF5A_CANAL  (O94083), 
IF5A_DESA1  (B8D4W8), IF5A_DIACA  (Q9AXQ7), IF5A_DICDI  (P13651), 
IF5A_DROME  (Q9GU68), IF5A_HALLT  (B9LP76), IF5A_HALMA  (Q5V103), 
IF5A_HALS3  (B0R6B4), IF5A_HALSA  (Q9HP78), IF5A_HALWD  (Q18F19), 
IF5A_HYPBU  (A2BNB6), IF5A_IGNH4  (A8ABK3), IF5A_KORCO  (B1L7A5), 
IF5A_LEIDO  (A4GVE9), IF5A_LEIMU  (E9AXF0), IF5A_MAIZE  (P80639), 
IF5A_MANES  (Q9AXJ4), IF5A_META3  (A6UVH4), IF5A_METAC  (Q8TJ03), 
IF5A_METAR  (Q0W941), IF5A_METB6  (A7I807), IF5A_METBF  (Q46EL9), 
IF5A_METBU  (Q12UU7), IF5A_METHJ  (Q2FQ93), IF5A_METJA  (Q58625), 
IF5A_METKA  (Q8TXD5), IF5A_METM5  (A4FXY5), IF5A_METM6  (A9AAZ2), 
IF5A_METM7  (A6VFP3), IF5A_METMA  (Q8PYE0), IF5A_METMJ  (A3CU49), 
IF5A_METMP  (Q6LYN8), IF5A_METPE  (B8GEC0), IF5A_METS3  (A5ULK4), 
IF5A_METS5  (A4YHK9), IF5A_METST  (Q2NEM4), IF5A_METTH  (O26955), 
IF5A_METTP  (A0B9S8), IF5A_METVS  (A6UNS4), IF5A_NANEQ  (Q74N24), 
IF5A_NATPD  (Q3IN38), IF5A_NEUCR  (P38672), IF5A_PICTO  (Q6L150), 
IF5A_PYRAB  (Q9V0M2), IF5A_PYRAE  (P56635), IF5A_PYRAR  (A4WLN5), 
IF5A_PYRCJ  (A3MTA0), IF5A_PYRFU  (Q8U1E4), IF5A_PYRHO  (O50089), 
IF5A_PYRIL  (A1RS27), IF5A_PYRNV  (B1Y9U5), IF5A_SACI1  (C3NHT8), 
IF5A_SACI2  (C3MPN5), IF5A_SACI3  (C3N5B1), IF5A_SACI4  (C3MYM9), 
IF5A_SACI6  (C4KGX7), IF5A_SACI7  (C3NDW5), IF5A_SACS2  (Q97ZE8), 
IF5A_SCHMA  (Q26571), IF5A_SENVE  (Q9SC12), IF5A_SPOEX  (P62924), 
IF5A_SPOFR  (P62925), IF5A_STAMF  (A3DNK3), IF5A_SULAC  (P28461), 
IF5A_SULTO  (Q971T0), IF5A_THEAC  (Q9HJB1), IF5A_THEGJ  (C5A5M5), 
IF5A_THEKO  (Q5JI42), IF5A_THEON  (B6YTM4), IF5A_THEPD  (A1RX88), 
IF5A_THESM  (C6A117), IF5A_THEVO  (Q97BB9), IF5A_TRYB2  (Q387H6)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

APTX_RAT(Q8K4H4)


				
	

	

		PDB
[Detailed view]		
		
			35 PDB
			


			pdb_00001bkb; pdb_00001eif; pdb_00001iz6; pdb_00001xtd; pdb_00002eif; pdb_00003cpf; pdb_00003er0; pdb_00003hks; pdb_00005dat; pdb_00005dc3; pdb_00005dge; pdb_00005dgf; 
			
				pdb_00005dlq; pdb_00005gak; pdb_00005hy6; pdb_00005mc6; pdb_00006q84; pdb_00006tnu; pdb_00007nrc; pdb_00007oya; pdb_00007oyc; pdb_00007oyd; pdb_00008a0e; pdb_00008aaf; 
				pdb_00008agt; pdb_00008agu; pdb_00008agv; pdb_00008agx; pdb_00008agz; pdb_00008bn3; pdb_00008k2d; pdb_00008put; pdb_00008ut0; pdb_00008y0u; pdb_00008y0w
			
			

			» more