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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00318


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PURL: https://purl.expasy.org/prosite/signature/PS00318

Direct ScanProsite submission
General information about the entry

Entry name [info] HMG_COA_REDUCTASE_2
Accession [info] PS00318
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-1990 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00064

Name and characterization of the entry

Description [info] Hydroxymethylglutaryl-coenzyme A reductases signature 2.
Pattern [info] 
[LIVM]-G-x-[LIVM]-G-G-[AG]-T.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 67 in 67 different sequences
Number of 'unknown' hits 0
Number of false positive hits 26 in 26 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 72.04 %
Recall (true positives / (true positives + false negatives)) 97.10 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 67 sequences 

HMDH1_ARATH (P14891), HMDH1_ASPFU (Q4WHZ1), HMDH1_DICDI (P34135), 

HMDH1_GIBZE (I1RXX1), HMDH1_GOSHI (O64966), HMDH1_HEVBR (P29057), 
HMDH1_ORYSI (A2X8W3), HMDH1_ORYSJ (Q0DY59), HMDH1_SOLTU (P48020), 
HMDH1_YEAST (P12683), HMDH2_ARATH (P43256), HMDH2_ASPFU (Q4WSY2), 
HMDH2_CAPAN (Q9XEL8), HMDH2_DICDI (P34136), HMDH2_GOSHI (O64967), 
HMDH2_HEVBR (P29058), HMDH2_SOLLC (P48022), HMDH2_SOLTU (Q41437), 
HMDH2_YEAST (P12684), HMDH3_HEVBR (Q00583), HMDH3_ORYSJ (Q9XHL5), 
HMDH3_SOLTU (Q41438), HMDH_AERPE  (Q9YAS4), HMDH_AGRIP  (O76819), 
HMDH_ARCFU  (O28538), HMDH_ASPTE  (Q9Y7D2), HMDH_ASPTN  (Q0C8L9), 
HMDH_BLAGE  (P54960), HMDH_BOVIN  (A7Z064), HMDH_CAMAC  (P48021), 
HMDH_CANAL  (A0A1D8PD39), HMDH_CATRO  (Q03163), HMDH_CRIGR  (P00347), 
HMDH_CYBJA  (O74164), HMDH_DROME  (P14773), HMDH_FUSFU  (P0CT44), 
HMDH_GANLU  (B2KX91), HMDH_GIBF5  (S0DQM8), HMDH_HALS3  (B0R6J9), 
HMDH_HALVD  (Q59468), HMDH_HUMAN  (P04035), HMDH_MAIZE  (O24594), 
HMDH_MESAU  (P09610), HMDH_METJA  (Q58116), HMDH_MOUSE  (Q01237), 
HMDH_NICSY  (Q01559), HMDH_PHYB8  (Q12649), HMDH_PIG(Q1W675), 
HMDH_PONAB  (Q5R6N3), HMDH_PYRAB  (Q9V1R3), HMDH_PYRHO  (O59469), 
HMDH_RABIT  (Q29512), HMDH_RAT(P51639), HMDH_SACS2  (O08424), 
HMDH_SCHMA  (P16237), HMDH_SCHPO  (Q10283), HMDH_STRPU  (P16393), 
HMDH_XENLA  (P20715), HMGR1_CANSA (A0A7J6H013), HMGR1_PANGI (A0A0A1C3I2), 
HMGR2_CANSA (A0A803NI27), HMR2A_PANGI (A0A0A1C930), HMR2B_PANGI (U5JCC6), 
MLCD_PENCI  (Q8J0F4), MOKG_MONPI  (Q3S2U3), MVAA_PSEMV  (P13702), 
PBCC_EMENI  (C8VN86)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

HMDH_BORBU  (O51628), HMDH_METTH  (O26662)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			26 sequences
			


			
AMIC_STRPN  (P0A4M7), AMIC_STRR6  (P0A4M8), ARO1_SCLS1  (A7F7H0), 

			
ARO1_SCLSC  (Q5XNP0), C3390_DROME (Q7KT91), CDX4_HUMAN  (O14627), 
CND1_MOUSE  (Q8K2Z4), DHOM_METGL  (P37143), DHOM_PSEAE  (P29365), 
DHON_METGL  (P37144), GBA2_HUMAN  (Q9HCG7), GBA2_MOUSE  (Q69ZF3), 
GBA2_RAT(Q5M868), HIMH_ASPJA  (A0A2Z5TIQ0), INIB_MYCTO  (P9WJ96), 
INIB_MYCTU  (P9WJ97), MSRA_LACSA  (Q9SEC2), MURC_ERYLH  (Q2NCY9), 
NU4C_SYNPW  (A5GP41), SECY_METJA  (Q60175), SIGJ_DICDI  (Q6TMJ3), 
SYYM_ARATH  (Q9M876), SYY_MESFL   (Q6F0M8), SYY_STRAW   (Q829F2), 
THIM_DESDA  (B8J4C1), Y3023_ACIAD (P70736)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			40 PDB
			


			pdb_00001dq8; pdb_00001dq9; pdb_00001dqa; pdb_00001hw8; pdb_00001hw9; pdb_00001hwi; pdb_00001hwj; pdb_00001hwk; pdb_00001hwl; pdb_00001qax; pdb_00001qay; pdb_00001r31; 
			
				pdb_00001r7i; pdb_00001t02; pdb_00002q1l; pdb_00002q6b; pdb_00002q6c; pdb_00002r4f; pdb_00003bgl; pdb_00003cct; pdb_00003ccw; pdb_00003ccz; pdb_00003cd0; pdb_00003cd5; 
				pdb_00003cd7; pdb_00003cda; pdb_00003cdb; pdb_00004i4b; pdb_00004i56; pdb_00004i64; pdb_00004i6a; pdb_00004i6w; pdb_00004i6y; pdb_00007uli; pdb_00008ecg; pdb_00008gdn; 
				pdb_00008pkn; pdb_00008s6b; pdb_00008sz6; pdb_00008vlq
			
			

			» more