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PROSITE entry PS00318


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00318
Entry name [info] HMG_COA_REDUCTASE_2
Accession [info] PS00318
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-1990 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00064

Name and characterization of the entry

Description [info] Hydroxymethylglutaryl-coenzyme A reductases signature 2.
Pattern [info] 
[LIVM]-G-x-[LIVM]-G-G-[AG]-T.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 67 in 67 different sequences
Number of 'unknown' hits 0
Number of false positive hits 26 in 26 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 72.04 %
Recall (true positives / (true positives + false negatives)) 97.10 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 67 sequences 

HMDH1_ARATH (P14891), HMDH1_ASPFU (Q4WHZ1), HMDH1_DICDI (P34135), 

HMDH1_GIBZE (I1RXX1), HMDH1_GOSHI (O64966), HMDH1_HEVBR (P29057), 
HMDH1_ORYSI (A2X8W3), HMDH1_ORYSJ (Q0DY59), HMDH1_SOLTU (P48020), 
HMDH1_YEAST (P12683), HMDH2_ARATH (P43256), HMDH2_ASPFU (Q4WSY2), 
HMDH2_CAPAN (Q9XEL8), HMDH2_DICDI (P34136), HMDH2_GOSHI (O64967), 
HMDH2_HEVBR (P29058), HMDH2_SOLLC (P48022), HMDH2_SOLTU (Q41437), 
HMDH2_YEAST (P12684), HMDH3_HEVBR (Q00583), HMDH3_ORYSJ (Q9XHL5), 
HMDH3_SOLTU (Q41438), HMDH_AERPE  (Q9YAS4), HMDH_AGRIP  (O76819), 
HMDH_ARCFU  (O28538), HMDH_ASPTE  (Q9Y7D2), HMDH_ASPTN  (Q0C8L9), 
HMDH_BLAGE  (P54960), HMDH_BOVIN  (A7Z064), HMDH_CAMAC  (P48021), 
HMDH_CANAL  (A0A1D8PD39), HMDH_CATRO  (Q03163), HMDH_CRIGR  (P00347), 
HMDH_CYBJA  (O74164), HMDH_DROME  (P14773), HMDH_GANLU  (B2KX91), 
HMDH_GIBF5  (S0DQM8), HMDH_GIBFU  (P0CT44), HMDH_HALS3  (B0R6J9), 
HMDH_HALVD  (Q59468), HMDH_HUMAN  (P04035), HMDH_MAIZE  (O24594), 
HMDH_MESAU  (P09610), HMDH_METJA  (Q58116), HMDH_MOUSE  (Q01237), 
HMDH_NICSY  (Q01559), HMDH_PHYB8  (Q12649), HMDH_PIG(Q1W675), 
HMDH_PONAB  (Q5R6N3), HMDH_PYRAB  (Q9V1R3), HMDH_PYRHO  (O59469), 
HMDH_RABIT  (Q29512), HMDH_RAT(P51639), HMDH_SACS2  (O08424), 
HMDH_SCHMA  (P16237), HMDH_SCHPO  (Q10283), HMDH_STRPU  (P16393), 
HMDH_XENLA  (P20715), HMGR1_CANSA (A0A7J6H013), HMGR1_PANGI (A0A0A1C3I2), 
HMGR2_CANSA (A0A803NI27), HMR2A_PANGI (A0A0A1C930), HMR2B_PANGI (U5JCC6), 
MLCD_PENCI  (Q8J0F4), MOKG_MONPI  (Q3S2U3), MVAA_PSEMV  (P13702), 
PBCC_EMENI  (C8VN86)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

HMDH_BORBU  (O51628), HMDH_METTH  (O26662)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			26 sequences
			


			
AMIC_STRPN  (P0A4M7), AMIC_STRR6  (P0A4M8), ARO1_SCLS1  (A7F7H0), 

			
ARO1_SCLSC  (Q5XNP0), C3390_DROME (Q7KT91), CDX4_HUMAN  (O14627), 
CND1_MOUSE  (Q8K2Z4), DHOM_METGL  (P37143), DHOM_PSEAE  (P29365), 
DHON_METGL  (P37144), GBA2_HUMAN  (Q9HCG7), GBA2_MOUSE  (Q69ZF3), 
GBA2_RAT(Q5M868), HIMH_ASPJA  (A0A2Z5TIQ0), INIB_MYCTO  (P9WJ96), 
INIB_MYCTU  (P9WJ97), MSRA_LACSA  (Q9SEC2), MURC_ERYLH  (Q2NCY9), 
NU4C_SYNPW  (A5GP41), SECY_METJA  (Q60175), SIGJ_DICDI  (Q6TMJ3), 
SYYM_ARATH  (Q9M876), SYY_MESFL   (Q6F0M8), SYY_STRAW   (Q829F2), 
THIM_DESDA  (B8J4C1), Y3023_ACIAD (P70736)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			38 PDB
			


			1DQ8; 1DQ9; 1DQA; 1HW8; 1HW9; 1HWI; 1HWJ; 1HWK; 1HWL; 1QAX; 1QAY; 1R31; 
			
				1R7I; 1T02; 2Q1L; 2Q6B; 2Q6C; 2R4F; 3BGL; 3CCT; 3CCW; 3CCZ; 3CD0; 3CD5; 
				3CD7; 3CDA; 3CDB; 4I4B; 4I56; 4I64; 4I6A; 4I6W; 4I6Y; 7ULI; 8ECG; 8GDN; 
				8SZ6; 8VLQ
			
			

			» more