PROSITE entry PS00333

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00333
Entry name [info]	DNA_LIGASE_A2
Accession [info]	PS00333
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00295

Name and characterization of the entry

Description [info]	ATP-dependent DNA ligase signature 2.
Pattern [info]	E-G-[LIVMA]-[LIVM]-[LIVMA]-[KR]-x(5,8)-[YW]-[QNEKTI]-x(2,6)-[KRH]-x(3,5)- K-[LIVMFY]-K.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	106 in 106 different sequences
Number of true positive hits	106 in 106 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	54
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	66.25 %

Comments [info]

Taxonomic range [info]	Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	1
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

106 sequences

DNLI1_ARATH (Q42572), DNLI1_CAEEL (Q27474), DNLI1_DICDI (Q869E1),

DNLI1_DROME (Q9W1H4), DNLI1_HALWD (Q18HT7), DNLI1_HUMAN (P18858), 
DNLI1_KORCO (B1L3K8), DNLI1_MOUSE (P37913), DNLI1_RAT   (Q9JHY8), 
DNLI1_SCHPO (P12000), DNLI1_XENLA (P51892), DNLI1_YEAST (P04819), 
DNLI2_KORCO (B1L3V2), DNLI3_DICDI (Q54QM4), DNLI3_HUMAN (P49916), 
DNLI3_MOUSE (P97386), DNLI4_ARATH (Q9LL84), DNLI4_CANAL (P52496), 
DNLI4_CHICK (Q90YB1), DNLI4_COPC7 (A8N936), DNLI4_COPCI (Q7Z7W5), 
DNLI4_CRIGR (G3GTP0), DNLI4_CRYNB (P0CN09), DNLI4_CRYNJ (P0CN08), 
DNLI4_HUMAN (P49917), DNLI4_MOUSE (Q8BTF7), DNLI4_ORYSJ (Q7X7E9), 
DNLI4_PONAB (Q5R6L3), DNLI4_YEAST (Q08387), DNLI_ACIAM  (Q02093), 
DNLI_AERPE  (Q9YD18), DNLI_ANAD2  (B8JBM1), DNLI_ANADE  (Q2IH69), 
DNLI_ANADF  (A7HID3), DNLI_ANASK  (B4UIS1), DNLI_ARCFU  (O29632), 
DNLI_ASFB7  (P35970), DNLI_ASFK5  (P0C992), DNLI_ASFM2  (P26813), 
DNLI_ASFP4  (P0C990), DNLI_ASFWA  (P0C991), DNLI_BEUC1  (C5BW79), 
DNLI_BPT3   (P07717), DNLI_BPT4   (P00970), DNLI_BPT6   (P19088), 
DNLI_BPT7   (P00969), DNLI_DICT6  (B5YD88), DNLI_DICTD  (B8DZX8), 
DNLI_HAEIN  (P44121), DNLI_HYPBU  (A2BJX6), DNLI_IGNH4  (A8AB20), 
DNLI_META3  (A6UVC4), DNLI_METB6  (A7IAA9), DNLI_METHJ  (Q2FTH4), 
DNLI_METJA  (Q57635), DNLI_METKA  (Q8TWN3), DNLI_METM5  (A4FY19), 
DNLI_METM6  (A9AAX4), DNLI_METM7  (A6VFQ9), DNLI_METMJ  (A3CWP1), 
DNLI_METMP  (Q6LYM1), DNLI_METS3  (A5UKX2), DNLI_METS5  (A4YD25), 
DNLI_METTF  (P54875), DNLI_METTH  (Q50566), DNLI_METTP  (A0B7F9), 
DNLI_METVS  (A6UNY0), DNLI_MONPV  (A0A7H0DNE6), DNLI_MYCA1  (A0QJL0), 
DNLI_MYCGI  (A4TDS2), DNLI_MYCPA  (Q73V97), DNLI_MYCS2  (A0QUP1), 
DNLI_MYCSJ  (A3PXE2), DNLI_MYCSK  (A1UDY9), DNLI_MYCSS  (Q1BB26), 
DNLI_MYCVP  (A1T6P2), DNLI_NITMS  (A9A3K1), DNLI_NOCSJ  (A1SKL2), 
DNLI_OPITP  (B1ZZL9), DNLI_PYRAB  (P0CL75), DNLI_PYRAY  (P0CL74), 
DNLI_PYRFU  (P56709), DNLI_PYRHO  (O59288), DNLI_SACS2  (Q980T8), 
DNLI_SACSH  (Q9P9K9), DNLI_SORC5  (A9GU24), DNLI_STAMF  (A3DP49), 
DNLI_SULAC  (Q4JAM1), DNLI_SULIA  (C3MZR1), DNLI_SULIK  (C4KIZ2), 
DNLI_SULIL  (C3MJ14), DNLI_SULIM  (C3MYD2), DNLI_SULIN  (C3NF77), 
DNLI_SULIY  (C3N834), DNLI_SULTO  (Q976G4), DNLI_SULZI  (D2CJS7), 
DNLI_THEAC  (Q9HJ26), DNLI_THEFM  (Q9HH07), DNLI_THEKO  (Q9HHC4), 
DNLI_THEON  (B6YTR4), DNLI_THEVO  (Q979A1), DNLI_VACCA  (O57250), 
DNLI_VACCC  (P20492), DNLI_VACCW  (P16272), DNLI_VAR67  (P0DOO3), 
DNLI_VARV   (P0DOO4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

54 sequences

DNLI1_METAC (Q8TSR7), DNLI1_METBF (Q46C04), DNLI1_METMA (Q8PVR7),

DNLI1_THEPD (A1RXA6), DNLI2_HALWD (Q18GX5), DNLI2_METAC (Q8TMT1), 
DNLI2_METBF (Q46BA3), DNLI2_METMA (Q8PTK1), DNLI2_THEPD (A1RY72), 
DNLI3_SCHPO (Q9C1W9), DNLI4_SCHPO (O74833), DNLI_AQUAE  (O67398), 
DNLI_CALMQ  (A8MDU6), DNLI_CENSY  (A0RWD6), DNLI_FOWPN  (Q67480), 
DNLI_HALLT  (B9LUZ9), DNLI_HALMA  (Q5V4R0), DNLI_HALS3  (B0R4C9), 
DNLI_HALSA  (Q9HR35), DNLI_HALVD  (D4GYZ4), DNLI_KINRD  (A6WG40), 
DNLI_KORVE  (Q1II25), DNLI_METAR  (Q0W0X1), DNLI_METBU  (Q12X08), 
DNLI_METLZ  (A2SR38), DNLI_METPE  (B8GGB8), DNLI_METST  (Q2NHF9), 
DNLI_MYCBO  (Q7TTR7), DNLI_MYCBP  (A1KN60), DNLI_MYCBT  (C1AGI1), 
DNLI_MYCMM  (B2HHE1), DNLI_MYCTA  (A5U776), DNLI_MYCTO  (P9WNV4), 
DNLI_MYCTU  (P9WNV5), DNLI_MYCUA  (A0PTC0), DNLI_NANEQ  (Q74M64), 
DNLI_NATPD  (Q3IPX0), DNLI_NOCFA  (Q5YNY7), DNLI_NPVLD  (Q9YMV2), 
DNLI_PERMH  (C0QSL7), DNLI_PICTO  (Q6L195), DNLI_PSECP  (B8HCE1), 
DNLI_PYRAE  (O93723), DNLI_PYRAR  (A4WH24), DNLI_PYRCJ  (A3MS62), 
DNLI_PYRIL  (A1RTK4), DNLI_PYRNV  (B1YA52), DNLI_RHOJR  (Q0SG75), 
DNLI_RHOOB  (C1AX87), DNLI_SACEN  (A4F870), DNLI_STRAW  (Q826P6), 
DNLI_STRCO  (Q9FCB1), DNLI_STRGG  (B1W5J2), LIGD_BACSU  (O34398)

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PDB
[Detailed view]

53 PDB

1A0I; 1X9N; 2CFM; 2HIV; 2HIX; 3GDE; 3L2P; 3W1B; 3W1G; 3W5O; 6BKF; 6BKG; 6DT1; 6IMJ; 6IMK; 6IML; 6IMN; 6P09; 6P0A; 6P0B; 6P0C; 6P0D; 6P0E; 6Q1V; 7KR3; 7KR4; 7L34; 7L35; 7LSY; 7LT3; 7NFC; 7NFE; 7QNZ; 7QO1; 7RPO; 7RPW; 7RPX; 7SUM; 7SX5; 7SXE; 8BH3; 8BHV; 8BHY; 8BOT; 8EZA; 8EZB; 8VDN; 8VDS; 8VDT; 8VZL; 8VZM; 9BS3; 9BS4
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