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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00365


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PURL: https://purl.expasy.org/prosite/signature/PS00365

Direct ScanProsite submission
General information about the entry

Entry name [info] NIR_SIR
Accession [info] PS00365
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00314

Name and characterization of the entry

Description [info] Nitrite and sulfite reductases iron-sulfur/siroheme-binding site.
Pattern [info] 
[STVN]-G-C-x(3)-C-x(6)-[DE]-[LIVMF]-[GAT]-[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 206 in 205 different sequences
Number of true positive hits 205 in 204 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 8
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.51 %
Recall (true positives / (true positives + false negatives)) 96.24 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Site [info] iron_sulfur at position 3
Site [info] iron_sulfur/siroheme at position 5
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 204 sequences 

ASRC_SALTI  (P0A1Y3), ASRC_SALTY  (P0A1Y2), CBIH_PRIMG  (O87689), 

COBG_SINSX  (P21637), CYSI1_KLEP3 (B5XV25), CYSI1_PECCP (C6DCZ7), 
CYSI2_KLEP3 (B5Y1B5), CYSI2_PECCP (C6DDH3), CYSI_ACIF2  (B7JAM6), 
CYSI_ACIF5  (B5EQW2), CYSI_ACTP2  (A3N3D8), CYSI_ACTP7  (B3GZ95), 
CYSI_ACTPJ  (B0BT17), CYSI_ACTPL  (Q8VSR0), CYSI_ACTSZ  (A6VPZ1), 
CYSI_AERHH  (A0KNL0), CYSI_AFIC5  (B6JCW3), CYSI_ALIF1  (Q5E840), 
CYSI_ALIFM  (B5FGI9), CYSI_ALISL  (B6ELM5), CYSI_ALTMD  (B4RYS6), 
CYSI_ANOFW  (B7GJU8), CYSI_BACLD  (Q65L57), CYSI_BACP2  (A8FDY3), 
CYSI_BACSU  (O32213), CYSI_BACVZ  (A7Z8R5), CYSI_BAUCH  (Q1LTP2), 
CYSI_BLOFL  (Q7VQH1), CYSI_BLOPB  (Q493N3), CYSI_BORPD  (A9IT77), 
CYSI_BUCA5  (B8D9K5), CYSI_BUCAI  (P57502), CYSI_BUCAP  (P0C0B2), 
CYSI_BUCAT  (B8D7V7), CYSI_CHRSD  (Q1QU16), CYSI_CITK8  (A8ANX0), 
CYSI_COLP3  (Q47UW8), CYSI_CROS8  (A7MJ64), CYSI_DICC1  (C6CLS0), 
CYSI_ECO24  (A7ZQK6), CYSI_ECO27  (B7UHH5), CYSI_ECO45  (B7MKN0), 
CYSI_ECO55  (B7LEI2), CYSI_ECO57  (Q8X7U2), CYSI_ECO5E  (B5Z3C6), 
CYSI_ECO7I  (B7NTA0), CYSI_ECO81  (B7MYR1), CYSI_ECO8A  (B7LXH6), 
CYSI_ECOBD  (C5W865), CYSI_ECOBR  (C6UCN7), CYSI_ECOBW  (C4ZZR7), 
CYSI_ECOHS  (A8A3P4), CYSI_ECOK1  (A1AEU9), CYSI_ECOL5  (Q0TEA3), 
CYSI_ECOL6  (Q8FEI8), CYSI_ECOLC  (B1IU78), CYSI_ECOLI  (P17846), 
CYSI_ECOLU  (B7N6Z7), CYSI_ECOSE  (B6I6F7), CYSI_ECOSM  (B1LQ86), 
CYSI_ECOUT  (Q1R7T5), CYSI_ENT38  (A4WDW0), CYSI_ERWT9  (B2VG06), 
CYSI_ESCF3  (B7LWN9), CYSI_GEOKA  (Q5L041), CYSI_GEOTN  (A4IMT6), 
CYSI_HALH5  (Q9KF75), CYSI_KLEP7  (A6TD48), CYSI_LEPBA  (B0SF75), 
CYSI_LEPBP  (B0SNL6), CYSI_LYSSC  (B1HXC1), CYSI_MANSM  (Q65T54), 
CYSI_METC4  (B7L0Y4), CYSI_METEA  (C5APZ1), CYSI_METEP  (A9W4X6), 
CYSI_METNO  (B8IRY2), CYSI_METPB  (B1Z7C5), CYSI_METRJ  (B1LS97), 
CYSI_METS4  (B0U8Y9), CYSI_METSB  (B8EKI5), CYSI_MUSP7  (C6CAW9), 
CYSI_MYXXD  (Q1D9W9), CYSI_NEIM0  (A9LZ72), CYSI_NEIMA  (Q9JUD9), 
CYSI_NEIMB  (Q9JS33), CYSI_NEIMF  (A1KU05), CYSI_NITEC  (Q0AGU3), 
CYSI_NITEU  (Q82W45), CYSI_NITHX  (Q1QQC7), CYSI_NITOC  (Q3JBJ1), 
CYSI_NITWN  (Q3SV33), CYSI_OCEIH  (Q8EQP0), CYSI_PECAS  (Q6D1A2), 
CYSI_PHOLL  (Q7N8L5), CYSI_PHOPR  (Q6LM59), CYSI_PROMH  (B4F234), 
CYSI_PSEA6  (Q15NK1), CYSI_PSYIN  (A1T054), CYSI_SALA4  (B5F430), 
CYSI_SALAR  (A9MF17), CYSI_SALCH  (Q57KH8), CYSI_SALDC  (B5FTU2), 
CYSI_SALEP  (B5QW35), CYSI_SALG2  (B5RDS0), CYSI_SALHS  (B4TFY4), 
CYSI_SALNS  (B4T474), CYSI_SALPA  (Q5PEH8), CYSI_SALPB  (A9N2E5), 
CYSI_SALPC  (C0PXC5), CYSI_SALPK  (B5BEZ8), CYSI_SALSV  (B4TTX8), 
CYSI_SALTI  (Q8Z459), CYSI_SALTY  (P17845), CYSI_SERP5  (A8G9X7), 
CYSI_SHEB2  (B8EE51), CYSI_SHEB5  (A3D829), CYSI_SHEB8  (A6WJT5), 
CYSI_SHEB9  (A9L2P8), CYSI_SHEDO  (Q12QQ5), CYSI_SHEFN  (Q07Y86), 
CYSI_SHEHH  (B0TTE4), CYSI_SHELP  (A3QAP0), CYSI_SHEON  (Q8EB00), 
CYSI_SHEPA  (A8H094), CYSI_SHEPC  (A4Y9Z3), CYSI_SHEPW  (B8CJV9), 
CYSI_SHESA  (A0KTH5), CYSI_SHESH  (A8FZY7), CYSI_SHESM  (Q0HFL7), 
CYSI_SHESR  (Q0HYB3), CYSI_SHESW  (A1RGD7), CYSI_SHEWM  (B1KE86), 
CYSI_SHIB3  (B2TZH1), CYSI_SHIBS  (Q31XM5), CYSI_SHIDS  (Q32CG4), 
CYSI_SHIF8  (Q0T1I7), CYSI_SHIFL  (Q83QE0), CYSI_SHISS  (Q3YY95), 
CYSI_SODGM  (Q2NVN3), CYSI_STAEQ  (Q5HKZ7), CYSI_STAES  (Q8CMX5), 
CYSI_STAHJ  (Q4L9F1), CYSI_STAS1  (Q49UL9), CYSI_THIRO  (P52673), 
CYSI_TOLAT  (C4L9J8), CYSI_VIBA3  (B7VI85), CYSI_VIBC1  (A7MSZ7), 
CYSI_VIBC3  (A5F3I5), CYSI_VIBCH  (Q9KUX3), CYSI_VIBCM  (C3LRB7), 
CYSI_VIBPA  (Q87L91), CYSI_VIBVU  (Q8DCK1), CYSI_VIBVY  (Q7MHA6), 
CYSI_XANAC  (Q8PHC8), CYSI_XANC8  (Q4UY08), CYSI_XANCB  (B0RPG6), 
CYSI_XANCP  (Q8P608), CYSI_XANE5  (Q3BPY4), CYSI_XANOM  (Q2P0H2), 
CYSI_XANOP  (B2SI05), CYSI_XANOR  (Q8KQT8), CYSI_XYLF2  (B2IA31), 
CYSI_XYLFA  (Q9PD81), CYSI_XYLFM  (B0U6W0), CYSI_XYLFT  (Q87DH0), 
CYSI_YERE8  (A1JJS3), CYSI_YERP3  (A7FLY9), CYSI_YERPA  (Q1C3Z1), 
CYSI_YERPB  (B2K566), CYSI_YERPE  (Q8ZBN7), CYSI_YERPN  (Q1CLS7), 
CYSI_YERPP  (A4TPY6), CYSI_YERPS  (Q66ED3), CYSI_YERPY  (B1JK04), 
CYSI_ZYMMO  (Q5NRM2), FSR_METJA   (Q58280), MET5_YEAST  (P47169), 
NASD_HALMT  (I3R637), NIRB_ECOLI  (P08201), NIRB_KLEOX  (Q06458), 
NIR_ARATH   (Q39161), NIR_BETPN   (P38500), NIR_EMENI   (P22944), 
NIR_LEPLM   (Q51879), NIR_MAIZE   (P17847), NIR_NEUCR   (P38681), 
NIR_ORYSJ   (Q42997), NIR_PINSY   (Q43090), NIR_SPIOL   (P05314), 
NIR_SYNE7   (P39661), SIR1_MYCPA  (Q73YC1), SIR1_TOBAC  (O82802), 
SIR2_MYCPA  (Q73XV0), SIR_ARATH   (Q9LZ66), SIR_MAIZE   (O23813), 
SIR_MYCBO   (Q7TYP6), SIR_MYCTO   (P9WJ02), SIR_MYCTU   (P9WJ03), 
SIR_NITV2   (Q05805), SIR_PEA (Q75NZ0), SIR_SOYBN   (Q9AWB2), 
SIR_SYNE7   (P30008), SIR_SYNY3   (P72854), Y551_METJA  (Q57971)
» more

UniProtKB/Swiss-Prot
False negative sequences		 8 sequences 

CYSI_BREBN  (C0Z9X2), CYSI_PAESJ  (C6CXN6), CYSI_PSET1  (Q3IFM1), 

CYSI_SHEAM  (A1S9I4), CYSI_SHOC1  (Q5WKE7), CYSI_STACT  (B9DLM4), 
MET5_SCHPO  (Q1K9C2), NASD_BACSU  (P42435)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

NIR_LEPMC   (P43504)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
ARGJ_DESPS  (Q6AJL0)


				
	

	

		PDB
[Detailed view]		
		
			25 PDB
			


			pdb_00001aop; pdb_00001zj8; pdb_00001zj9; pdb_00002akj; pdb_00002aop; pdb_00002gep; pdb_00003aop; pdb_00003geo; pdb_00004aop; pdb_00004g38; pdb_00004g39; pdb_00004gep; 
			
				pdb_00004htr; pdb_00005aop; pdb_00005gep; pdb_00005h8v; pdb_00005h8y; pdb_00005h92; pdb_00006c3m; pdb_00006c3x; pdb_00006c3y; pdb_00006gep; pdb_00007gep; pdb_00007np8; 
				pdb_00008gep
			
			

			» more